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Design and Synthesis of Novel Nitrogen-Containing Heterocyclic Fluorophores and Fluorescent Nanomaterials for pH and Metal-Ion Sensing

Principal investigator

Project type
Znanstveno-istraživački projekti
Programme
Research Projects
Financier
Croatian Science Foundation
Start date
Jun 1st 2015
End date
Jan 6th 2019
Status
Done
Total cost
968000 HRK
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This project brings together an interdisciplinary team of researchers with the aim to prepare novel and efficient functional materials to be used for metal-ion and pH sensing applications. Through a synergy in the synthetic, spectroscopic and computational techniques, we plan to focus our investigations on designing and characterizing a whole catalogue of compounds with desirable analytical and chemical features. Experimental work will involve traditional and ''click-chemistry'' strategies for the synthesis of a number of diverse benzimidazole, benzothiazole, 1,2,3-triazole, and coumarin derivatives, which will be incorporated into a range of organic, inorganic and hybrid polymeric matrices to form sensitive thin films or polymeric nanoparticles. Subsequently, through the UV/Vis and fluorescent spectroscopies, these will be assessed for their abilities to form both solution- and solid-phase complexes with metal cations in order to produce usable chemosensors. The choice of the metal analytes will be prompted by their biological significance or their presence in the environment, comprising cations such as Zn2+, Cu2+, Mn2+, Hg2+, Ag+, Cd2+, Fe2+/Fe3+, and Pb2+. All phases of experimental work will be supplemented with the computational support to aid in the interpretation of results. This will include calculating the conformational, tautomeric and pKa features of investigated systems, predicting the modes and free-energies of metal binding, and modeling the changes in the matching UV-Vis absorption and emission spectra induced by the metal complexation and solution pH variations. In addition, computations will be advanced by considering substituted derivatives of the prepared organic frameworks in order to fine-tune the preferred properties, thus helping in the guided selection of future directions. Overall, the presented research is intended to pose this team for the advancements in the field of chemosensors with the promise of a wide range of industrial applications.

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