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Radiolytically synthesized magnetic nanoparticles for hyperthermia effect on cancer cells

Principal investigator

Project type
Znanstveno-istraživački projekti
Research Projects
Croatian Science Foundation
Start date
Dec 30th 2023
End date
Dec 29th 2027
Total cost
190291 EUR
More information

Project focuses on the development of a gamma-irradiation method for the synthesis of magnetic nanoparticles, and the application of synthesized nanoparticles for hyperthermia treatment of cancer cells. Radiolytic synthesis (gamma-irradiation synthesis) is a relatively new method for nanoparticle synthesis. It is fast, efficient and it does not require the use of toxic/carcinogenic reducing agents, which gives her great advantages over classical methods of nanoparticle synthesis. The anisotropic magnetic nanoparticles of iron oxides and ferrites will be synthesized by γ-irradiation in the presence of suitable polymers. These nanoparticles exhibit high crystalline anisotropy and excellent magnetic properties and are nontoxic, making them suitable for magnetic hyperthermia (MF) treatment. Detailed microstructural characterization and magnetic and Mössbauer measurements will be performed to investigate the ferrimagnetic and/or superparamagnetic nature of the synthesized nanoparticles. These radiolytically synthesized nanoparticles will be used to kill cancer cells in the presence of an alternating magnetic field by releasing heat resulting in temperature rise. It is expected that the synthesized anisotropic magnetic nanoparticles will have a much higher SAR (specific absorption rate) than corresponding spherical nanoparticles. The magnetic heating efficiency of the samples will be analyzed to evaluate their potential for magnetic hyperthermia applications. These measurements will be performed using a commercial magnetic heating device to be purchased with funding from this project. The synthesized nanoparticles will be applied to cancer cells and their subcellular accumulation and the effect of magnetic heating on killing cancer cells will be measured. The cytotoxicity of nanoparticles will also be determined. Magnetic hyperthermia is thought to generate reactive oxygen species, leading to cancer cell death. We will specifically focus on elucidating the molecular mechanism of cell death.

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