Skip to main content

Regulation of intercellular signalling by rhomboid-like pseudoproteases

Project type
Znanstveno-istraživački projekti
The New International Fellowship Mobility Programme for Experienced Researchers in Croatia
Ministry of Science and Education of the Republic of Croatia
Start date
Dec 1st 2014
End date
Nov 30th 2017
Total cost
25999 EUR
More information

iRhoms, non-catalytic rhomboid-like proteins, regulate trafficking of signalling molecules like growth factors and cytokines. Epidermal growth factor receptor (EGFR) signaling in Drosophila is inhibited by iRhom which acts as a negative regulator of EGF proteolysis. In mammals, iRhoms are essential for trafficking and maturation of TACE (ADAM17), a metalloprotease crucial for the activation of growth factors like tumor necrosis factor (TNF). iRhoms are implicated in pathophysiology of inflammatory arthritisand oesophageal cancer which demonstrates their profound biological and medical significance. The central theme of this project is that iRhoms act as regulatory adapters in the endoplasmic reticulum (ER), linking client proteins with trafficking machinery. Most important questions are: what is the range of iRhom clients and how iRhoms are regulated? I will address these applying proteomics, cell biology and model organism methodology in outstanding environment of M. Freeman group.

This site uses cookies.. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and can only be disabled by changing your browser preferences.