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Project type
Znanstveno-istraživački projekti
Research Projects
Croatian Science Foundation
Start date
Dec 30th 2023
End date
Dec 29th 2027
Total cost
1458600 EUR
More information

Project is focused on study of intrinsic properties of guanidines, their high basicity and their utilization as catalysts and anion sensors. Research approach of the Space-G project is tightly connected combination of theoretical and experimental studies which include high level quantum-chemical calculations for the design, chemical synthesis and physico-chemical characterisation of properties of novel molecules.

The goal of Space-G is to investigate fundamental physico-chemical properties of (poly)cyclic guanidines which are spatially modulated by the presence of judiciously positioned functional groups.

The objectives are: a) Design of functionalized cyclic guanidine molecular systems; b) Synthesis of (poly)cyclic guanidine molecular systems possessing functional groups by employment of environmentally friendly synthetic methods and their spectroscopic and structural characterization; c) Detailed insight into the consequence of incorporating spatially close functional groups in guanidine structures on (super)basic properties and reaction mechanisms of applied organic reactions; d) Evaluation of anion binding, catalytic and supramolecular properties of functionalized guanidine systems.

The obtained results will enhance the fundamental understanding of influence of spatially close substituents on physico-chemical factors governing guanidine (super)basicity in cyclic systems. Expected results will advance design, spatial modulation and preparation of novel functionalized cyclic guanidine systems which could be applied in different research areas including anion sensing, catalysis and supramolecular chemistry.

Feasibility of the proposed research is justified by literature precedents and well documented experience of the research team on the research topics related to this project.

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