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The molecular links between cholesterol homeostasis, membrane trafficking and Alzheimer's disease

Project type
Znanstveno-istraživački projekti
Financier
Swiss National Science Foundation
Start date
Apr 1st 2014
End date
Mar 31st 2016
Status
Done
Total cost
75000 CHF
More information
CroRIS project page

Aberrant proteolytic cleavage of the amyloid precursor protein (APP) leading to increased formation/accumulation of b-amyloid peptide (Aβ) is considered a central event in the pahogenesis of Alzheimer's disease (AD). Although much has been known about the Aβ generation and its clearance, we still do not understand in great detail how Aβ metabolism is altered in the most common late-onset form of AD (LOAD) and what are the molecular trigger(s) that initiate these events. In this project we will test the hypothesis that cholesterol metabolism and membrane trafficking are tightly linked and that their dysregulation leads to Alzheimer's disease.