2008-2015, PhD in Biomedicine and Healthcare, University Postgraduate Interdisciplinary Doctoral Study of Molecular biosciences, Josip Juraj Strossmayer University of Osijek, University of Dubrovnik and Ruđer Bošković Institute, Croatia

2001–2007, B.Sc. in Molecular Biology, Faculty of Natural Sciences and Mathematics, University of Zagreb, Croatia

1997–2001, II High School, Split, Croatia (excellent grades)

1989-1997, Elementary School "Ostrog", Kaštel Lukšić, Croatia 

• 2018, Annual Director's Prize for best scientific papers
• 2015, EACR Meeting bursary for participation in the conference “Radiation Biology and Cancer” (Essen, Germany) 
• 2014, EACR Poster Prize for best poster at HDIR-3 “From Bench to Clinic” Meeting (Zagreb, Croatia)
• 2014, FEMS Young Scientist Meeting Grant for participation in “Power of Viral Vectors in Gene Therapy and Basic Science” Summer School (Primošten, Croatia)
• 2008, Scholarship of the French Government for three-months long practical training in France
• 1998 – 2007, Scholarship of the town of Kaštela 

• 2022-         , Assistant Professor/Lecturer on the University Postgraduate Interdisciplinary Doctoral Study of Molecular Biosciences, University of Osijek, Croatia
• 2011, 2012, 2015 and 2018, Teaching assistant in the courses „Methods in molecular biology and medicine“ and „Cell cycle control, genome integrity maintenance and cancerogenesis“ on the University Postgraduate Interdisciplinary Doctoral Study of Molecular Biosciences, University of Osijek, Croatia

1. Radić M, Vlašić I, Jazvinšćak Jembrek M, Horvat A, Tadijan A, Sabol M, Dužević M, Herak Bosnar M, Slade N (2022) Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance. International Journal of Molecular Sciences 23(17):9910.
2. Lossaint G*, Horvat A*, Gire V, Bačević K, Mrouj K, Charrier-Savournin F, Georget V, Fisher D, Dulić V (2022) Reciprocal regulation of p21 and Chk1 controls the cyclin D1-RB pathway to mediate senescence onset after G2 arrest. Journal of Cell Science 135(8):jcs259114. *equal contribution
3. Horvat A*, Tadijan A*, Vlašić I*, Slade N (2021) p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies. Cancers 13(12):2885. *equal contribution
4. Hanžić N*, Horvat A*, Bibić J, Unfried K, Jurkin T, Dražić G, Marijanović I, Slade N, Gotić M (2018) Syntheses of gold nanoparticles and their impact on the cell cycle in breast cancer cells subjected to megavoltage X-ray irradiation. Materials Science and Engineering C: Materials for Biological Applications 91:486-495. *equal contribution
5. Horvat A, Noto JM, Ramatchandirin B, Zaika E, Palrasu M, Wei J, Schneider BG, El-Rifai W, Peek Jr RM, Zaika AI (2018) Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells.  Oncogene 37(37):5054-5065.
6. Bhardwaj V, Gokulan RC, Horvat A, Yermalitskaya L, Korolkova O, Washington KM, El-Rifai W, Dikalov SI, Zaika AI (2017) Activation of NADPH oxidases leads to DNA damage in esophageal cells. Scientific Reports 7(1):9956.
7. Horvat A, Zaika AI (2017). How does bacterial pathogen Helicobacter pylori control responses to cellular stress. Future Microbiology 12: 105-108.
8. Bhardwaj V, Horvat A, Korolkova O, Washington MK, El-Rifai W, Dikalov SI, Zaika AI (2016). Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts. Carcinogenesis 37(12): 1161-1169.
9. Zorić A, Horvat A, Slade N (2013). Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis. Carcinogenesis 34: 522-529.
10. Zorić A, Horvat A, Balija M, Slade N (2012). The Arg72Pro Polymorphism of TP53 in Croatian Population. Croatica Chemica Acta 85: 239-243.
11. Slade N, Horvat A (2011). Targeting p73 – A Potential Approach in Cancer Treatment. Current Pharmaceutical Design 17: 591-602.
12. Zorić A, Horvat A, Slade N (2010). Obitelj gena p53 – uloga u razvoju organizma i tumorigenezi. Medicina Fluminensis 46: 135-143. (in Croatian)
13. Slade N, Zorić A, Horvat A (2010). The p53/p63/p73 family of proteins – the focus on isoforms and mutants in cancer. Periodicum biologorum 112: 425-432.

Pregledni rad (znanstveni)

• Horvat, Anđela; Vlašić, Ignacija; Štefulj, Jasminka; Oršolić, Nada; Jazvinšćak Jembrek, Maja | Flavonols as a Potential Pharmacological Intervention for Alleviating Cognitive Decline in Diabetes: Evidence from Preclinical Studies // Life, 13 (2023), 12; 2291, 33. doi: 10.3390/life13122291

  doi

• Vlašić, Ignacija ; Horvat, Anđela ; Tadijan, Ana ; Slade, Neda | p53 Family in Resistance to Targeted Therapy of Melanoma // International journal of molecular sciences, 24 (2023), 1; 65, 16. doi: 10.3390/ijms24010065

  doiwww.mdpi.comfulir.irb.hr

• Slade, Neda ; Zorić, Arijana ; Horvat, Anđela | The p53/p63/p73 family of proteins - the focus on isoforms and mutants in cancer // Periodicum biologorum, 112 (2010), 4; 425-432

  hrcak.srce.hr

• Slade, Neda ; Horvat, Anđela | Targeting p73 - a potential approach in cancer treatment // Current pharmaceutical design, 17 (2011), 6; 591-602. doi: 10.2174/138161211795222621

  doiwww.ingentaconnect.com

• Zorić, Arijana ; Horvat, Anđela ; Slade, Neda | Obitelj gena p53 – uloga u razvoju organizma i tumorigenezi // Medicina Fluminensis, 46 (2010), 2; 135-143

  hrcak.srce.hr

Izvorni znanstveni rad

• Vlašić, Ignacija; Krstačić-Galić, Antonio; Horvat, Anđela; Oršolić, Nada; Sadžak, Anja; Mandić, Lucija; Šegota, Suzana; Jazvinšćak Jembrek, Maja | Neurotoxic Effect of Myricitrin in Copper-Induced Oxidative Stress Is Mediated by Increased Intracellular Ca2+ Levels and ROS/p53/p38 Axis // Antioxidants, 14 (2025), 1; 46, 29. doi: 10.3390/antiox14010046

  doiwww.mdpi.comfulir.irb.hr

• Proust, Bastien; Horvat, Anđela; Tadijan, Ana; Vlašić, Ignacija; Herak Bosnar, Maja | Mitochondrial NME6 Influences Basic Cellular Processes in Tumor Cells In Vitro // International journal of molecular sciences, 25 (2024), 17; 9580, 15. doi: 10.3390/ijms25179580

  doiwww.mdpi.comfulir.irb.hr

• Radić, Martina ; Vlašić, Ignacija ; Jazvinšćak Jembrek, Maja ; Horvat, Anđela ; Tadijan, Ana ; Sabol, Maja ; Dužević, Marko ; Herak Bosnar, Maja ; Slade, Neda | Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance // International journal of molecular sciences, 23 (2022), 17; 9910, 19. doi: 10.3390/ijms23179910

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Lossaint Gérald, Horvat Anđela, Gire Véronique, Bačević Katarina, Mrouj Karim, Charrier-Savournin Fabienne, Georget Virginie, Fisher Dan, Dulić Vjekoslav | Reciprocal regulation of p21 and Chk1 controls the cyclin D1-RB pathway to mediate senescence onset after G2 arrest // Journal of cell science, 135 (2022), 8; cs259114, 15. doi: 10.1242/jcs.259114

  doijournals.biologists.comdoi.org

• Horvat, Anđela ; Tadijan, Ana ; Vlašić, Ignacija ; Slade, Neda | p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies // Cancers, 13 (2021), 12; 2885, 42. doi: 10.3390/cancers13122885

  doiwww.mdpi.comwww.ncbi.nlm.nih.govfulir.irb.hr

• Horvat, Anđela ; Noto, Jennifer M ; Ramatchandirin, Balamurugan ; Zaika, Elena ; Palrasu, Manikandan ; Wei, Jinxiong ; Schneider, Barbara G ; El-Rifai, Wael ; Peek Jr, Richard M ; Zaika, Alexander I | Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells // Oncogene, 37 (2018), 37; 5054-5065

• Bhardwaj, Vikas ; Gokulan, Ravindran C ; Horvat, Anđela ; Yermalitskaya, Liudmila ; Korolkova, Olga ; Washington, Kay M ; El-Rifai, Wael ; Dikalov, Sergey I ; Zaika, Alexander I | Activation of NADPH oxidases leads to DNA damage in esophageal cells // Scientific reports, 7 (2017), 1; 9956, 12

• Horvat, Anđela ; Zaika, Alexander I | How does bacterial pathogen Helicobacter pylori control responses to cellular stress? // Future microbiology, 12 (2017), 105-108

• Bhardwaj, Vikas ; Horvat, Anđela ; Korolkova, Olga ; Washington, Mary K ; El-Rifai, Wael ; Dikalov, Sergey I ; Zaika, Alexander I | Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts // Carcinogenesis, 37 (2016), 12; 1161-1169

• Hanžić, Nikolina ; Horvat, Anđela ; Bibić, Juraj ; Unfried, Klaus ; Jurkin, Tanja ; Dražić, Goran ; Marijanović, Inga ; Slade, Neda ; Gotić, Marijan | Syntheses of gold nanoparticles and their impact on the cell cycle in breast cancer cells subjected to megavoltage X-ray irradiation // Materials science & engineering. C, Biomimetic materials, sensors and systems, 91 (2018), 486-495. doi: 10.1016/j.msec.2018.05.066

  doiwww.sciencedirect.com

• Zorić, Arijana ; Horvat, Anđela ; Balija, Melita ; Slade, Neda | The Arg72Pro Polymorphism of TP53 in Croatian Population // Croatica chemica acta, 85 (2012), 2; 239-243. doi: 10.5562/cca1866

  doihrcak.srce.hr

• Zorić, Arijana ; Horvat, Anđela ; Slade, Neda | Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis // Carcinogenesis, 34 (2013), 3; 522-529. doi: 10.1093/carcin/bgs370

  doiwww.ncbi.nlm.nih.gov

Sažetak izlaganja sa skupa

• Horvat, Anđela; Lossaint, Gérald; Gire, Véronique; Bačević, Katarina; Mrouj, Karim; Charrier-Savournin, Fabienne; Georget, Virginie; Fisher, Daniel; Dulić, Vjekoslav | Reciprocal Regulation of p21 and Chk1 Controls the Cyclin D1-RB Pathway to Mediate Senescence Onset After G2 Arrest // “HDIR-6: Targeting Cancer” The 6th Meeting of the Croatian Association for Cancer Research with International Participation – Book of Abstracts / Ozretić, Petar (ur.). | Zagreb: Hrvatsko društvo za istraživanje raka (HDIR), 2022. str. 24-24

• Horvat, Anđela; Vlašić, Ignacija; Tadijan, Ana; Radić, Martina; Jazvinšćak Jembrek, Maja; Herak Bosnar, Maja; Slade, Neda | The Influence of Δ133p53 Isoforms’ Downregulation on Biological Processes Related to Resistance of Melanoma Cell Lines to Targeted Therapy // HDIR-7: Advances in Cancer Research and Treatment: Book of Abstracts / Ozretić, Petar (ur.). | Zagreb: Hrvatsko društvo za istraživanje raka (HDIR), 2024. str. 39-39

• Vlašić, Ignacija; Horvat, Anđela; Krstačić-Galić, Antonio; Jazvinšćak Jembrek, Maja | Synergistic Anticancer Effects of Flavonoid Myricitrin and Copper: Targeting Oxidative Stress and Apoptosis in Neuroblastoma Cells // HDIR-7: Advances in Cancer Research and Treatment: Book of Abstracts / Ozretić, Petar (ur.). | Zagreb: Hrvatsko društvo za istraživanje raka (HDIR), 2024. str. 30-30

• Proust, Bastien; Horvat, Anđela; Tadijan, Ana; Vlašić, Ignacija, Herak Bosnar, Maja | The Mitochondrial NME6 Protein Influences Tumor Cells Migration In Vitro // HDIR-7: Advances in Cancer Research and Treatment: Book of Abstracts / Ozretić, Petar (ur.). | Zagreb: Hrvatsko društvo za istraživanje raka (HDIR), 2024. str. 51-51

  stari.hdir.hr

• Horvat, Anđela; Vlašić, Ignacija; Tadijan, Ana; Radić, Martina; Jazvinšćak Jembrek, Maja; Herak Bosnar, Maja; Slade, Neda | Involvement of the Δ133p53 isoform in the resistance of melanoma cell lines to targeted therapy // 19th International p53 Workshop : book of abstracts. | Trst: ICGEB International Centre For Genetic Engineering And Biotechnology, 2024. str. 100-100

  www.icgeb.org

• Vlašić, Ignacija; Horvat, Anđela; Jazvinšćak Jembrek, Maja; Ozretić, Petar; Radić, Martina; Stepić, Doris; Tadijan, Ana; Slade, Neda | The role of ITIH5, a p53-regulated gene, in melanoma cell lines resistant to targeted therapy // 19th International p53 Workshop : book of abstracts. | Trst: ICGEB International Centre For Genetic Engineering And Biotechnology, 2024. str. 187-187

  www.icgeb.org

• Vlašić, Ignacija ; Radić, Martina ; Jazvinšćak Jembrek, Maja ; Horvat, Anđela ; Tadijan, Ana ; Sabol, Maja ; Dužević, Marko ; Herak Bosnar, Maja ; Slade, Neda | Unique Hallmarks of Targeted Therapy Resistant Melanoma Cell Lines // “HDIR-6: Targeting Cancer” The 6th Meeting of the Croatian Association for Cancer Research with International Participation : : Book of Abstracts. | Zagreb: Hrvatsko društvo za istraživanje raka (HDIR), 2022. str. 18-18

  stari.hdir.hr

• Hanžić, Nikolina ; Horvat, Anđela ; Marijanović, Inga ; Slade, Neda ; Gotić, Marijan | Synthesis and application of gold nanoparticles to breast cancer cells // HDIR-4 - 4thMeeting with International Participation “From Bench to Clinic”. | Zagreb: Libri Oncologici, 2016. str. 35-35

• Tučkar, Neven ; Zorić, Arijana ; Horvat, Anđela ; Medvedović, Mario ; Hanžić, Nikolina ; Slade, Neda | The Effect of p73 Isoforms on DNA Methylation in Cancer Cells // Game of Epigenomics. | Zagreb: Institut Ruđer Bošković, 2016. str. 65-65

  goe.irb.hr

• Zorić, Arijana ; Horvat, Anđela, Pfeiffer, Anamarija ; Slade, Neda | The interplay between p63/p73 and mutant p53 might be influenced by E3 ubiquitin ligase ITCH // 8th Interanational MDM2 Workshop. | New Orleans (LA), 2015

• Horvat, Anđela ; Dulić, Vjekoslav ; Zorić, Arijana ; Slade, Neda | ΔNp73α compromises G2/M checkpoint inducing genomic instability in response to DNA damage // 2nd International p53 Isoforms Conference. | Aix-en-Provence, 2015. str. 42-42

• Horvat, Anđela; Dulić, Vjekoslav; Zorić, Arijana; Slade, Neda | The role of ΔNp73α in DNA damage response in normal and tumor human cells // Power of viral vectors in gene therapy and basic science Book of Abstracts. | Zagreb: Recedo d.o.o, 2014. str. 55-55

• Zorić, Arijana; Horvat, Anđela; Slade, Neda | Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis // 16th International p53 Workshop. | Uppsala: Karolinsta Institutet, 2014. str. 266-266

• Horvat, Anđela; Dulić, Vjekoslav; Zorić, Arijana; Slade, Neda | The effect ΔNp73α on the cell cycle control after DNA damage in norma and tumor human cells // Knjiga sažetaka Kongresa Hrvatskog društva za biokemiju i molekularnu biologiju, "Međuigra biomolekula", HDBMB 2014 / Katalinić, Maja ; Kovarik, Zrinka (ur.). | Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2014. str. 68-68

• Zorić, Arijana ; Horvat, Anđela ; Slade, Neda. | Mutant p53 impact TAp73beta and TAp63alpha transcriptional activity and apoptosis // 6th p63/p73 International Workshop. | Chiba, 2013. str. 57-57

• Zorić, Arijana ; Horvat, Anđela ; Slade, Neda. | Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis // 6th p63/p73 International Workshop. | Chiba, 2013. str. 58-58

• Horvat, Anđela ; Dulić, Vjekoslav ; Zorić, Arijana ; Slade, Neda | The role of ΔNp73α in response to genotoxic stress in normal human fibroblasts // FEBS 3+ Meeting: From molecules to life and back. | Rijeka: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2012. str. 153-153

• Horvat, Anđela ; Dulić, Vjekoslav ; Zorić, Arijana ; Slade, Neda | The role of ΔNp73α in response to genotoxic stress in normal human fibroblasts // 5th p63/p73 Workshop, Conference Book. | 2011

• Zorić, Arijana ; Horvat, Anđela ; Slade, Neda | The effect of p53 isoforms on p73 activity // 5th p63/p73 Workshop, Conference Book. | Lyon, 2011. str. 99-99

• Zorić, Arijana ; Ružđak, Matija ; Horvat, Anđela ; Slade, Neda | Mutant p53 proteins inhibit transcriptional activity, but stabilize TAp73 due to hetereooligomer formation // 5th Mutant p53 Workshop. | Rim, 2011. str. 126-126

• Slade, Neda ; Zorić, Arijana ; Horvat, Anđela ; Hofstetter, Gerda ; Berger, Astrid ; Concin, Nicole ; Zeillinger, Robert | The effect of p53 isoforms/splice variants on p73 activity // 10th Congress of the Croatian Society of Biochemistry and Molecular Biology (HDBMB 2010) : The secret of biomolecules : Abstracts. | Rijeka: Hrvatsko Društvo za Biotehnologiju, 2010. str. 69-69

• Zorić, Arijana ; Horvat, Anđela ; Slade, Neda | The effect of p53 isoforms on p73 activity in tumor cells // 1st International p53 Isoforms Meeting : p53 isoforms through evolution : from identification to biological function : abstracts. | Lyon: International Agency for Research on Cancer (IARC), 2010. str. 42-42

• Zorić, Arijana ; Runje, Anđela ; Slade, Neda | p53 isoforms and p73 activity // 50 godina molekularne biologije u Hrvatskoj. | Zagreb: Institut Ruđer Bošković, 2008. str. 103-103

Ostalo

• Horvat, Anđela ; Zorić, Arijana ; Slade, Neda | p53/p63/p73 protein network // The Second Congress of the Serbian Association for Cancer Research with international participation „Cancer research: perspectives and application“ - proceedings book / Srpsko društvo istraživača raka (ur.). | Beograd: Srpsko društvo istraživača raka, 2015. str. 68-71

  www.sdir.ac.rs

Sažetak izlaganja sa skupa

• Hanžić, Nikolina ; Proust, Bastien Lucien Jean ; Ozretić, Petar ; Radić, Martina ; Horvat, Anđela ; Milas, Ivan ; Puljiz, Zvonimir ; Herak Bosnar, Maja ; Levanat, Sonja ; Slade, Neda | Functional interplay between p53 and p53/p73, NME and GLI protein families in human melanoma // Libri oncologici : Croatian journal of oncology, 2018. str. 51-51

  hrcak.srce.hr

• Horvat, Anđela ; Dulić, Vjekoslav ; Zorić, Arijana ; Slade, Neda | The role of ΔNp73α in response to genotoxic stress in normal and tumor human cells // Periodicum biologorum, 114, S1, 2012. str. 31-31

• Slade, Neda ; Horvat, Anđela ; Zorić, Arijana ; Poljak, Ljiljana | Smads-mediated activation of p65/NF-kappaB and Smad- 4 nuclear translocation in U4C fibrosarcoma cells // Periodicum biologorum, 114, S1, 2012. str. 68-68

• Zorić, Arijana ; Horvat, Anđela ; Slade, Neda | TAp73-mediated transcriptional activity and apoptosis are influenced by diverse p53 isoforms // Periodicum biologorum, 114, S1, 2012. str. 78-78

Neobjavljeni prilog sa skupa

• Horvat, Anđela; Vlašić, Ignacija; Tadijan, Ana; Radić, Martina; Jazvinšćak Jembrek, Maja; Herak Bosnar, Maja; Slade, Neda | Unravelling specific features of melanoma cell lines resistant to targeted therapy // EACR Conference, Persister Cells: from Bacteria to Cancer | Lyon, Francuska, 18.03.2025-20.03.2025

Diplomski rad (sveučilišni)

• Runje, Anđela | Differences in stability of p53 tumor-suppressor protein isoforms / Slade, Neda (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2007

Doktorski rad

• Horvat, Anđela | Utjecaj proteina ΔNp73α na kontrolu staničnog ciklusa nakon oštećenja DNA u stanicama čovjeka / Slade, Neda ; Dulić, Vjekoslav (mentor). | Osijek, Sveučilište Josipa Jurja Strossmayera u Osijeku, 2015

• European Association for Cáncer Research (EACR)
• Croatian Association for Cáncer Research (HDIR)
• Croatian Society of Biochemistry and Molecular Biology (HDBMB)
• Croatian Microbiological Society (HMD)