Dr. Anđela Horvat
10000 Zagreb
CROATIA
Education
2008-2015, PhD in Biomedicine and Healthcare, University Postgraduate Interdisciplinary Doctoral Study of Molecular biosciences, Josip Juraj Strossmayer University of Osijek, University of Dubrovnik and Ruđer Bošković Institute, Croatia
2001–2007, B.Sc. in Molecular Biology, Faculty of Natural Sciences and Mathematics, University of Zagreb, Croatia
1997–2001, II High School, Split, Croatia (excellent grades)
1989-1997, Elementary School "Ostrog", Kaštel Lukšić, Croatia
Awards and Achievements
- 2018, Annual Director's Prize for best scientific papers
- 2015, EACR Meeting bursary for participation in the conference “Radiation Biology and Cancer” (Essen, Germany)
- 2014, EACR Poster Prize for best poster at HDIR-3 “From Bench to Clinic” Meeting (Zagreb, Croatia)
- 2014, FEMS Young Scientist Meeting Grant for participation in “Power of Viral Vectors in Gene Therapy and Basic Science” Summer School (Primošten, Croatia)
- 2008, Scholarship of the French Government for three-months long practical training in France
- 1998 – 2007, Scholarship of the town of Kaštela
Classes
- 2022- , Assistant Professor/Lecturer on the University Postgraduate Interdisciplinary Doctoral Study of Molecular Biosciences, University of Osijek, Croatia
- 2011, 2012, 2015 and 2018, Teaching assistant in the courses „Methods in molecular biology and medicine“ and „Cell cycle control, genome integrity maintenance and cancerogenesis“ on the University Postgraduate Interdisciplinary Doctoral Study of Molecular Biosciences, University of Osijek, Croatia
Featured Publications
- Radić M, Vlašić I, Jazvinšćak Jembrek M, Horvat A, Tadijan A, Sabol M, Dužević M, Herak Bosnar M, Slade N (2022) Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance. International Journal of Molecular Sciences 23(17):9910.
- Lossaint G*, Horvat A*, Gire V, Bačević K, Mrouj K, Charrier-Savournin F, Georget V, Fisher D, Dulić V (2022) Reciprocal regulation of p21 and Chk1 controls the cyclin D1-RB pathway to mediate senescence onset after G2 arrest. Journal of Cell Science 135(8):jcs259114. *equal contribution
- Horvat A*, Tadijan A*, Vlašić I*, Slade N (2021) p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies. Cancers 13(12):2885. *equal contribution
- Hanžić N*, Horvat A*, Bibić J, Unfried K, Jurkin T, Dražić G, Marijanović I, Slade N, Gotić M (2018) Syntheses of gold nanoparticles and their impact on the cell cycle in breast cancer cells subjected to megavoltage X-ray irradiation. Materials Science and Engineering C: Materials for Biological Applications 91:486-495. *equal contribution
- Horvat A, Noto JM, Ramatchandirin B, Zaika E, Palrasu M, Wei J, Schneider BG, El-Rifai W, Peek Jr RM, Zaika AI (2018) Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells. Oncogene 37(37):5054-5065.
- Bhardwaj V, Gokulan RC, Horvat A, Yermalitskaya L, Korolkova O, Washington KM, El-Rifai W, Dikalov SI, Zaika AI (2017) Activation of NADPH oxidases leads to DNA damage in esophageal cells. Scientific Reports 7(1):9956.
- Horvat A, Zaika AI (2017). How does bacterial pathogen Helicobacter pylori control responses to cellular stress. Future Microbiology 12: 105-108.
- Bhardwaj V, Horvat A, Korolkova O, Washington MK, El-Rifai W, Dikalov SI, Zaika AI (2016). Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts. Carcinogenesis 37(12): 1161-1169.
- Zorić A, Horvat A, Slade N (2013). Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis. Carcinogenesis 34: 522-529.
- Zorić A, Horvat A, Balija M, Slade N (2012). The Arg72Pro Polymorphism of TP53 in Croatian Population. Croatica Chemica Acta 85: 239-243.
- Slade N, Horvat A (2011). Targeting p73 – A Potential Approach in Cancer Treatment. Current Pharmaceutical Design 17: 591-602.
- Zorić A, Horvat A, Slade N (2010). Obitelj gena p53 – uloga u razvoju organizma i tumorigenezi. Medicina Fluminensis 46: 135-143. (in Croatian)
- Slade N, Zorić A, Horvat A (2010). The p53/p63/p73 family of proteins – the focus on isoforms and mutants in cancer. Periodicum biologorum 112: 425-432.
Publications
Journal articles
Scientific and review papers
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Vlašić, I., Horvat, A., Tadijan, A. & Slade, N. (2023) p53 Family in Resistance to Targeted Therapy of Melanoma. International Journal of Molecular Sciences, 24 (1), 65, 16 doi:10.3390/ijms24010065.
doiwww.mdpi.comfulir.irb.hr -
Radić, M., Vlašić, I., Jazvinšćak Jembrek, M., Horvat, A., Tadijan, A., Sabol, M., Dužević, M., Herak Bosnar, M. & Slade, N. (2022) Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance. International journal of molecular sciences, 23 (17), 9910, 19 doi:10.3390/ijms23179910.
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Lossaint Gérald, Horvat Anđela, Gire Véronique, Bačević Katarina, Mrouj Karim, Charrier-Savournin Fabienne, Georget Virginie, Fisher Dan, Dulić Vjekoslav (2022) Reciprocal regulation of p21 and Chk1 controls the cyclin D1-RB pathway to mediate senescence onset after G2 arrest. Journal of cell science, 135 (8), cs259114, 15 doi:10.1242/jcs.259114.
doi -
Horvat, A., Tadijan, A., Vlašić, I. & Slade, N. (2021) p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies. Cancers, 13 (12), 2885, 42 doi:10.3390/cancers13122885.
doiwww.mdpi.comwww.ncbi.nlm.nih.govfulir.irb.hr Horvat, A., Noto, J., Ramatchandirin, B., Zaika, E., Palrasu, M., Wei, J., Schneider, B., El-Rifai, W., Peek Jr, R. & Zaika, A. (2018) Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells. Oncogene, 37 (37), 5054-5065.
-
Hanžić, N., Horvat, A., Bibić, J., Unfried, K., Jurkin, T., Dražić, G., Marijanović, I., Slade, N. & Gotić, M. (2018) Syntheses of gold nanoparticles and their impact on the cell cycle in breast cancer cells subjected to megavoltage X-ray irradiation. Materials science & engineering. C, Biomimetic materials, sensors and systems, 91, 486-495 doi:10.1016/j.msec.2018.05.066.
doi Bhardwaj, V., Gokulan, R., Horvat, A., Yermalitskaya, L., Korolkova, O., Washington, K., El-Rifai, W., Dikalov, S. & Zaika, A. (2017) Activation of NADPH oxidases leads to DNA damage in esophageal cells. Scientific Reports, 7 (1), 9956, 12.
Horvat, A. & Zaika, A. (2017) How does bacterial pathogen Helicobacter pylori control responses to cellular stress?. Future microbiology, 12, 105-108.
Bhardwaj, V., Horvat, A., Korolkova, O., Washington, M., El-Rifai, W., Dikalov, S. & Zaika, A. (2016) Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts. Carcinogenesis, 37 (12), 1161-1169.
-
Zorić, A., Horvat, A. & Slade, N. (2013) Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis. Carcinogenesis, 34 (3), 522-529 doi:10.1093/carcin/bgs370.
doi -
Zorić, A., Horvat, A., Balija, M. & Slade, N. (2012) The Arg72Pro Polymorphism of TP53 in Croatian Population. Croatica chemica acta, 85 (2), 239-243 doi:10.5562/cca1866.
doihrcak.srce.hr -
Slade, N. & Horvat, A. (2011) Targeting p73 - a potential approach in cancer treatment. Current pharmaceutical design, 17 (6), 591-602 doi:10.2174/138161211795222621.
doi -
Zorić, A., Horvat, A. & Slade, N. (2010) The p53 family of genes in development and tumor formation. Medicina Fluminensis, 46 (2), 135-143.
hrcak.srce.hr
Membership in professional associations / societies
- European Association for Cáncer Research (EACR)
- Croatian Association for Cáncer Research (HDIR)
- Croatian Society of Biochemistry and Molecular Biology (HDBMB)
- Croatian Microbiological Society (HMD)
Supervisor of diploma thesis:
- Marina Katić, The role of ΔNp73α protein in DNA damage-induced senescence in normal and cancer human cells, Faculty of Science, University of Zagreb, 2021
Training:
- 2016–2018, Postdoctoral training, Vanderbilt University Medical Center (VUMC, Nashville, TN, USA), Department of Surgery and Cancer Biology, Laboratory of Alexander Zaika, PhD, in the area of Helicobacter pylori infection related gastric tumorigenesis
- December 2014, AKH (Vienna General Hospital) Vienna (Austria), Laboratory for molecular oncology
- September – December 2008, Institute of Molecular Genetics in Montpellier (France) financed by the Scholarship of the French Government
- December 2007, July 2008 and June 2009, Institute of Molecular Genetics in Montpellier (France), Croatian-French Programme «Cogito» under the supervision of Vjekoslav Dulić, PhD
- January 2006 - March 2007, undergraduate thesis work, Laboratory of Molecular Oncology (Division of Molecular Medicine, Ruđer Bošković Institute) under the supervision of Neda Slade, PhD, in the area of tumor suppressor protein p53 isoforms
- July – September 2005, student training, Faculty of Science and Pharmacy, University of Navarra, Pamplona (Spain)
- April – June 2005, Department of Physics, Faculty of Medicine, Zagreb under the supervision of Professor Jasminka Brnjas-Kraljević, PhD
- March 2004 – January 2005, student training, Gene Regulation Laboratory (Division of Molecular Biology, Ruđer Bošković Institute) under the supervision of Mary Sopta, PhD, in the area of molecular genetics of yeast Saccharomyces cerevisiae