Laboratory for protein dynamics
The research activities of the laboratory are based on research and understanding of protein dynamics as the key determinant for the formation and development of tumors, metastasis, determining the therapeutic target and the basis for their response to therapy.
The main LPD research directions are:
- Identifying the tumor suppressor protein p53 interaction partners in melanoma, with an emphasis on the p53/p73 isoforms as well as NME / nm23 / NDPK and Gli protein family; and detecting the roles of identified proteins in context of p53 activity in melanoma.
- Studying p53 mutations in the context of endemic nephropathy, an environmental disease, which cause is related to the occurrence of the upper urinary tract carcinoma.
- Studying the influence of nucleoside diphosphate kinase subunits, Nme1 and Nme2, in cellular migration, and their potential synergistic role in this process in vitro. The members of the group II Nme proteins, in particular, Nme 6, including its localization and biological role in the cell will be investigated.
- Studying the effect of potentially neuroprotective compounds on the phosphorylation of tau protein in the culture of P19 neurons.