Dr. Davor Zahradka
Ruđer Bošković Institute
Bijenička 54
10000 Zagreb
Croatia
Education
1991 B.Sc. in Molecular Biology, Faculty of Science, University of Zagreb, Croatia
1994 M.Sc. in Molecular and Cellular Biology, Faculty of Science, University of Zagreb, Croatia
1999 Ph.D. in Biology, Faculty of Science, University of Zagreb, Croatia
2002 Postdoctoral training in Bacterial Genetics, Jacques Monod Institute, University Paris 6-7, Paris, France (Richard D'Ari group)
Projects
2014-2018 "DNA recombination, repair and maintenance of genome integrity: new pathways" (HRZZ-IP-11-2013-2978), Croatian Science Foundation - Principal Investigator
2007-2013 "Molecular mechanisms of DNA recombination and repair", Croatian Ministry of Science, Education and Sports - Principal Investigator
2002-2006 "Regulation of recombination and recombinational DNA repair", Croatian Ministry of Science, Education and Sports - Associate
1998-2000 "Role of DNA recombination in the regulation of cell division in Escherichia coli", Young Scientist Grant, Croatian Ministry of Science and Technology - Principal Investigator
1996-2002 "Regulation of DNA recombination and repair", Croatian Ministry of Science and Technology - Associate
1994-1997 "Genes and enzymes involved in inhibition of recombination" (CRP/CRO93-01), UNIDO/ICGEB - Associate
Awards and Achievements
2002 NATO Science Program Fellowship
1990 University of Zagreb Rector's Prize
Classes
Course "Genetic recombination and DNA repair", PhD Studies in Biology, Faculty of Science, University of Zagreb
Course "Mechanisms of DNA damage and repair", PhD Studies in Molecular Biosciences, University of Osijek, University of Dubrovnik and Ruđer Bošković Institute, Zagreb
Featured Publications
Zahradka, K., Repar, J., Đermić, D, Zahradka, D. (2023) Chromosome Segregation and Cell Division Defects in Escherichia coli Recombination Mutants Exposed to Different DNA-Damaging Treatments. Microorganisms 11(3):701. doi: 10.3390/microorganisms11030701
Repar, J., Zahradka, D., Sović, I., Zahradka, K. (2021) Characterization of gross genome rearrangements in Deinococcus radiodurans recA mutants. Scientific Reports 11:10939. doi: 10.1038/s41598-021-89173-9
Buljubašić, M., Hlevnjak, A., Repar, J., Đermić, D., Filić, V., Weber, I., Zahradka, K., Zahradka, D. (2019) RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli. DNA Repair 83: 102670. doi: 10.1016/j.dnarep.2019.102670
Repar, J., Supek, F., Klanjscek, T., Warnecke, T., Zahradka, K., Zahradka, D. (2017) Elevated rate of genome rearrangements in radiation-resistant bacteria. Genetics 205: 1677-1689.
Repar, J., Briški, N., Buljubašić, M., Zahradka, K., Zahradka, D. (2013) Exonuclease VII is involved in “reckless” DNA degradation in UV-irradiated Escherichia coli. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 750:96-104.
Buljubašić, M., Repar, J., Zahradka, K., Đermić, D., Zahradka, D. (2012) RecF recombination pathway in Escherichia coli cells lacking RecQ, UvrD and HelD helicases. DNA Repair 11: 419-430.
Repar, J., Cvjetan, S., Slade, D., Radman, M., Zahradka, D., Zahradka, K. (2010) RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans. DNA Repair 9: 1151-1161.
Zahradka, K., Buljubašić, M., Petranović, M., Zahradka, D. (2009) Roles of ExoI and SbcCD nucleases in "reckless" DNA degradation in recA mutants of Escherichia coli. Journal of Bacteriology 191: 1677-1687.
Zahradka, K., Šimić, S., Buljubašić, M., Petranović, M., Đermić, D., Zahradka, D. (2006) sbcB15 and delsbcB mutations activate two types of RecF recombination pathway in Escherichia coli. Journal of Bacteriology 188: 7562-7571.
Viguera, E., Petranović, M., Zahradka, D., Germain, K., Ehrlich, D. S., Michel, B. (2003) Lethality of bypass polymerases in Escherichia coli cells with a defective clamp loader complex of DNA polymerase III. Molecular Microbiology 50: 193-204.
Zahradka, D., Zahradka, K., Petranović, M., Đermić, D., Brčić-Kostić, K. (2002) The RuvABC resolvase is indispensable for recombinational repair in sbcB15 mutants of Escherichia coli. Journal of Bacteriology 184: 4141-4147.
Publications - book chapters
Izvorni znanstveni rad
Zahradka, Davor | Escherichia coli // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 3-10-x
Zahradka, Davor | Bakteriofag lambda // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 14-18-x
Zahradka, Davor ; Zahradka, Ksenija | Prijenos gena transdukcijom pomoću faga P1 // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 919-922-x
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Zahradka, Ksenija ; Zahradka, Davor | Reckless DNA Degradation // Brenner's Encyclopedia of Genetics (2nd ed.) / Maloy, Stanley ; Hughes, Kelly (ur.). San Diego (CA): Academic Press, 2013. str. 72-74 doi: 10.1016/B978-0-12-374984-0.01272-9
doidoi.orgwww.sciencedirect.com
Publications - journal articles
Izvorni znanstveni rad
Vlahović, Ksenija ; Petranović, Mirjana ; Zahradka, Davor ; Petranović, Dragutin | Effects of ruv and recG mutations on lambda prophage thermoinducibility in UV-irradiated Escherichia coli // Periodicum biologorum, 100 (1998), 3; 383-388-x
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Zahradka, Davor ; Vlahović, Ksenija ; Petranović, Mirjana ; Petranović, Drago | Chromosome segregation and cell division defects in recBC sbcBC ruvC mutants of Escherichia coli // Journal of bacteriology, 181 (1999), 19; 6179-6183. doi: 10.1128/JB.181.19.6179-6183.1999
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Petranović, Mirjana ; Vlahović, Ksenija ; Zahradka, Davor ; Džidić, Senka ; Radman, Miroslav | Mismatch repair in Xenopus egg extracts is not strand-directed by DNA methylation // Neoplasma, 47 (2000), 6; 375-381
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Vlahović, Ksenija ; Petranović, Mirjana ; Zahradka, Davor ; Petranović, Drago | Progressive loss of lambda prophage recombinogenicity in UV-irradiated Escherichia coli : the role of RecBCD enzyme // Research in microbiology, 151 (2000), 9; 727-738. doi: 10.1016/S0923-2508(00)01138-4
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Zahradka, Ksenija ; Zahradka, Davor ; Petranović, Mirjana | Loss of lambda prophage recombinogenicity in UV- irradiated Escherichia coli : the role of host genes ruvA, ruvB, ruvC and recG // Research in microbiology, 152 (2001), 10; 873-881. doi: 10.1016/S0923-2508(01)01270-0
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Petranović, Mirjana ; Zahradka, Ksenija ; Zahradka, Davor ; Petranović, Dina ; Nagy, Biserka ; Salaj-Šmic, Erika ; Petranović, Dragutin | Genetic evidence that the elevated levels of Escherichia coli helicase II antagonize recombinational DNA repair // Biochimie, 83 (2001), 11-12; 1041-1047. doi: 10.1016/S0300-9084(01)01346-3
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Zahradka, Davor ; Zahradka, Ksenija ; Petranović, Mirjana ; Đermić, Damir ; Brčić-Kostić, Krunoslav | The RuvABC resolvase is indispensable for recombinational repair in sbcB15 mutants of Escherichia coli // Journal of bacteriology, 184 (2002), 15; 4141-4147. doi: 10.1128/JB.184.15.4141-4147.2002
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Ivančić-Baće, Ivana ; Škrobot, Nikolina ; Zahradka, Davor ; Salaj-Šmic, Erika ; Brčić-Kostić, Krunoslav | Genetic requirements for conjugational recombination in the presence of lambda Gam protein in Escherichia coli // Food technology and biotechnology, 40 (2002), 4; 261-265-x
www.ftb.com.hrfulir.irb.hr Zahradka, Davor ; Zahradka, Ksenija ; Džidić, Senka ; Đermić, Damir ; Petranović, Mirjana | The rus-1 mutation suppresses cytological defects in recBC sbcBC ruv mutants of Escherichia coli // Periodicum biologorum, 104 (2002), 4; 389-397-x
Zahradka, Ksenija ; Zahradka, Davor ; Đermić, Damir ; Džidić, Senka ; Petranović, Mirjana | The inactivation of free phages in UV-irradiated Escherichia coli // Periodicum biologorum, 104 (2002), 4; 399-403
Viguera, Enrique ; Petranović, Mirjana ; Zahradka, Davor ; Germain, Karine ; Erlich, Dusko S. ; Michel, Benedicte | Lethality of bypass DNA polymerases in Escherichia coli cells with a defective clamp loader complex of DNA polymerase III // Molecular microbiology, 50 (2003), 1; 193-204-x
Đermić, Damir ; Halupecki, Edyta ; Zahradka, Davor ; Petranović, Mirjana | RecBCD enzyme overproduction impairs DNA repair and homologous recombination in Escherichia coli // Research in microbiology, 156 (2005), 3; 304-311
Đermić, Damir ; Đermić, Edyta ; Zahradka, Davor ; Petranović, Mirjana ; Lerš, Nella | Gamma-irradiated RecD overproducers become permanent recB-/C- phenocopies for extrachromosomal DNA processing due to prolonged titration of RecBCD enzyme on damaged Escherichia coli chromosome // Biochimie, 88 (2006), 3-4; 379-386-x
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Zahradka, Ksenija ; Šimić, Sanela ; Buljubašić, Maja ; Petranović, Mirjana ; Đermić, Damir ; Zahradka, Davor | sbcB15 and delsbcB mutations activate two types of RecF recombination pathway in Escherichia coli // Journal of bacteriology, 188 (2006), 21; 7562-7571. doi: 10.1128/JB.00613-06
doijournals.asm.org Đermić, Damir ; Zahradka, Davor ; Petranović, Mirjana | Exonuclease requirements for recombination of lambda phage in recD mutants of Escherichia coli // Genetics, 173 (2006), 4; 2399-2402-x
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Zahradka, Ksenija ; Buljubašić, Maja ; Petranović, Mirjana ; Zahradka, Davor | Roles of ExoI and SbcCD nucleases in "reckless" DNA degradation in recA mutants of Escherichia coli // Journal of bacteriology, 191 (2009), 5; 1677-1687. doi: 10.1128/JB.01877-07
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Repar, Jelena ; Cvjetan, Svjetlana ; Slade, Dea ; Radman, Miroslav ; Zahradka, Davor ; Zahradka, Ksenija | RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans // DNA repair, 9 (2010), 11; 1151-1161. doi: 10.1016/j.dnarep.2010.08.003
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Supek, Fran ; Šumanovac Ramljak, Tatjana ; Marjanović, Marko ; Buljubašić, Maja ; Kragol, Goran ; Ilić, Nataša ; Šmuc, Tomislav ; Zahradka, Davor ; Mlinarić-Majerski, Kata ; Kralj, Marijeta | Could LogP be a principal determinant of biological activity in 18-crown-6 ethers? Synthesis of biologically active adamantane-substituted diaza-crowns // European journal of medicinal chemistry, 46 (2011), 8; 3444-3454. doi: 10.1016/j.ejmech.2011.05.009
doiwww.ncbi.nlm.nih.govwww.sciencedirect.comdx.doi.org -
Buljubašić, Maja ; Repar, Jelena ; Zahradka, Ksenija ; Đermić, Damir ; Zahradka, Davor | RecF recombination pathway in Escherichia coli cells lacking RecQ, UvrD and HelD helicases // DNA repair, 11 (2012), 4; 419-430. doi: 10.1016/j.dnarep.2012.01.011
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Repar, Jelena ; Briški, Nina ; Buljubašić, Maja ; Zahradka, Ksenija ; Zahradka, Davor | Exonuclease VII is involved in "reckless" DNA degradation in UV-irradiated Escherichia coli // Mutation research. Genetic toxicology and environmental mutagenesis, 750 (2013), 1/2; 96-104. doi: 10.1016/j.mrgentox.2012.10.005
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Repar, Jelena ; Zahradka, Davor ; Zahradka, Ksenija | Accuracy of genome reassembly in gamma-irradiated Escherichia coli // Food technology and biotechnology, 51 (2013), 3; 327-337
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Buljubašić, Maja ; Zahradka, Davor ; Zahradka, Ksenija | RecQ helicase acts before RuvABC, RecG and XerC proteins during recombination in recBCD sbcBC mutants of Escherichia coli // Research in microbiology, 164 (2013), 10; 987-997. doi: 10.1016/j.resmic.2013.08.008
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Repar, Jelena ; Šućurović, Sandra ; Zahradka, Ksenija ; Zahradka, Davor ; Ćurković-Perica, Mirna | Stress resistance of Escherichia coli and Bacillus subtilis is modulated by auxins // Canadian journal of microbiology, 59 (2013), 11; 766-770. doi: 10.1139/cjm-2013-0266
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Repar, Jelena ; Supek, Fran ; Klanjšček, Tin ; Warnecke, Tobias ; Zahradka, Ksenija ; Zahradka, Davor | Elevated rate of genome rearrangements in radiation-resistant bacteria // Genetics, 205 (2017), 4; 1677-1689. doi: 10.1534/genetics.116.196154
doiwww.genetics.orgdoi.org -
Đermić, Edyta ; Zahradka, Davor ; Vujaklija, Dušica ; Ivanković, Siniša ; Đermić, Damir | 3'-terminated Overhangs Regulate DNA Double-Strand Break Processing in Escherichia coli // G3-Genes genomes genetics, 7 (2017), 9; 3091-3102. doi: 10.1534/g3.117.043521
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Feliciello, Isidoro ; Zahradka, Davor ; Zahradka, Ksenija ; Ivanković, Siniša ; Puc, Nikolina ; Đermić, Damir | RecF, UvrD, RecX and RecN proteins suppress DNA degradation at DNA double-strand breaks in Escherichia coli // Biochimie, 148 (2018), 116-126. doi: 10.1016/j.biochi.2018.03.005
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Buljubašić, Maja ; Hlevnjak, Ana ; Repar, Jelena ; Đermić, Damir ; Filić, Vedrana ; Weber, Igor ; Zahradka, Ksenija ; Zahradka, Davor | RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli // DNA repair, 83 (2019), 102670, 16. doi: 10.1016/j.dnarep.2019.102670
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Repar, Jelena ; Zahradka, Davor ; Sović, Ivan ; Zahradka, Ksenija | Characterization of gross genome rearrangements in Deinococcus radiodurans recA mutants // Scientific reports, 11 (2021), 1; 10939, 11. doi: 10.1038/s41598-021-89173-9
doiwww.nature.comdoi.orgfulir.irb.hr -
Feliciello, Isidoro ; Đermić, Edyta ; Malović, Helena ; Ivanković, Siniša ; Zahradka, Davor ; Ljubić, Sven ; Procino, Alfredo ; Đermić, Damir | Regulation of ssb Gene Expression in Escherichia coli // International journal of molecular sciences, 23 (2022), 18; 10917, 14. doi: 10.3390/ijms231810917
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Zahradka, Ksenija ; Repar, Jelena ; Đermić, Damir ; Zahradka, Davor | Chromosome Segregation and Cell Division Defects in Escherichia coli Recombination Mutants Exposed to Different DNA-Damaging Treatments // Microorganisms, 11 (2023), 3; 11030701, 30. doi: 10.3390/microorganisms11030701
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Zahradka, Ksenija ; Repar, Jelena ; Đermić, Damir ; Zahradka, Davor | Genetic analysis of transductional recombination in Escherichia coli reveals differences in the postsynaptic stages of RecBCD and RecFOR pathways // Periodicum biologorum, 124 (2022), 3-4; 97-106. doi: 10.18054/pb.v124i3-4.23604
doihrcak.srce.hrhrcak.srce.hrdoi.orgfulir.irb.hr
Sažetak izlaganja sa skupa
Petranović, Mirjana ; Vlahović, Ksenija ; Zahradka, Davor ; Petranović, Dragutin | RecBC(D) enzyme in UV-irradiated E. coli interferes with site-specific and general recombination of lambda prophage // FASEB journal / Marchesi, Vincent T. (ur.). 1997. str. A1194-x
Vlahović, Ksenija ; Petranović, Mirjana ; Zahradka, Davor ; Petranović, Dragutin | Recombination and antirecombination in UV-irradiated Escherichia coli: the role of ruvB, ruvC, and recG genes // Periodicum biologorum. Supplement / Vitale, Branko (ur.). 1998. str. 39-39
Petranović, Mirjana ; Zahradka, Davor ; Vlahović, Ksenija ; Petranović, Dragutin | Genetic analysis of the multiplicity reactivation of UV-inactivated lambda red phage // Periodicum biologorum. Supplement / Vitale, Branko (ur.). 1998. str. 39-39
Vlahović, Ksenija ; Petranović, Mirjana ; Zahradka, Davor ; Petranović, Drago | RecBC(D) enzyme in UV-irradiated E. coli interferes with lambda prophage recombinogenicity // Biochimie. 1999. str. s280-x
Zahradka, Davor ; Vlahović, Ksenija ; Petranović, Mirjana ; Petranović, Drago | Chromosome segregation and cell morphology in recBC sbcBC ruvC mutants of Escherichia coli // Biochimie. 1999. str. s280-x
Zahradka, Davor ; Buljubašić, Maja ; Zahradka, Ksenija ; Petranović, Mirjana | Homologous Recombination and DNA Repair in recBC sbcBC Mutants of Escherichia coli: Effects of a recG Mutation // Acta microbiologica et immunologica Hungarica / Marialigeti, K. ; Sipos, R. (ur.). 2005. str. 174-175
Neobjavljeni prilog sa skupa
Zahradka, Ksenija ; Buljubašić, Maja ; Petranović, Mirjana ; Zahradka, Davor | The role of ExoI and SbcCD nucleases in spontaneous DNA degradation in Escherichia coli recA mutants // Second John Innes-Rudjer Bošković summer school in Applied Molecular Microbiology "Microbial Secondary Metabolites: Genomes, Signals and Communities" | Dubrovnik, Hrvatska, 24.08.2008-01.09.2008
Hlevnjak, Ana ; Paradžik, Tina ; Kazazić, Saša ; Filić, Želimira ; Zahradka, Davor ; Vujaklija, Dušica | Phosphorylation of the SSB protein from E. coli // John Innes/Rudjer Bošković Summer School in Applied Molecular Microbiology: Microbial Diversity and Specialised Metabolites | Dubrovnik, Hrvatska, 10.09.2016-18.09.2016
Zahradka, Davor | RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli // FEMS Summer School for Postdocs | Split, Hrvatska, 28.08.2019-07.09.2019
Doktorska disertacija
Zahradka, Davor | Uloga genetičke rekombinacije u regulaciji stanične diobe bakterije Escherichia coli / Petranović, Mirjana (mentor); | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 1999
Buljubašić, Maja | Uloga nukleaza i helikaza na putu homologne rekombinacije RecF u bakteriji Escherichia coli / Zahradka, Davor (mentor); | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2012
Diplomski rad
Buljubašić, Maja | Učinak mutacije recG na homolognu rekombinaciju u bakteriji Escherichia coli / Zahradka, Davor (mentor); | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2005
Šupak, Vesna | Učinak mutacije sbcB15 na homolognu rekombinaciju tijekom transdukcije kod bakterije Escherichia coli - hiperrekombinacijski fenotip / Zahradka, Davor (mentor); | Zagreb, Farmaceutsko-biokemijski fakultet, . 2006
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Ćosić, Iva | Stabilnost genoma bakterije Escherichia coli nakon gama zračenja / Zahradka, Davor (mentor); | Zagreb, Prehrambeno-biotehnološki fakultet, . 2010
zir.nsk.hr Briški, Nina | Utjecaj egzonukleaze VII na neobuzdanu degradaciju DNA u recA mutantima bakterije Escherichia coli / Zahradka, Davor (mentor); | Zagreb, Prehrambeno-biotehnološki fakultet, . 2010
Šućurović, Sandra | UČINAK AUKSINA NA RAST BAKTERIJA Bacillus subtilis i Escherichia coli U STRESNIM UVJETIMA / Ćurković Perica, Mirna ; Zahradka, Davor (mentor); | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2011
Membership in professional associations / societies
Croatian Microbiological Society (affiliated to FEMS), President of the Bacteriology section (since 2020)
Croatian Genetic Society (affiliated to EEMGS)
Croatian Society for Biochemistry and Molecular Biology (affiliated to FEBS)
Mediterranean Institute for Life Sciences (MedILS), Split, Croatia - member of the Managing Board (2010-2021), member of the Scientific Board
Member of the RBI Expert Team (authorized by the Croatian Ministry of Health) for GMO risk assessment in the environment
Member of the Committee for the Evaluation and Defense of Doctoral Dissertations: Faculty of Science Uni-Zagreb, Faculty of Food Technology and Biotechnology Uni-Zagreb, University J. J. Strossmayer in Osijek, Croatia
Mentorship
PhD thesis:
2012 Maja Buljubašić: "The role of nucleases and helicases on the RecF pathway of homologous recombination in Escherichia coli", Faculty of Science, University of Zagreb
Diploma theses:
2011 Sandra Šućurović: "Effect of auxins on growth of Bacillus subtilis and Escherichia coli under stress conditions", Faculty of Science, University of Zagreb
2010 Nina Briški: "Impact of exonuclease VII on reckless DNA degradation in recA mutants of Escherichia coli", Faculty of Food Technology and Biotechnology, University of Zagreb
2010 Iva Ćosić: "Genome stability of Escherichia coli after gamma irradiation", Faculty of Food Technology and Biotechnology, University of Zagreb
2006 Vesna Šupak: "Effect of the sbcB15 mutation on homologous recombination during tranduction in Escherichia coli: a hyper-recombination phenotype", Faculty of Pharmacy and Biochemistry, University of Zagreb
2005 Maja Buljubašić: "Effect of recG mutation on homologous recombination in Escherichia coli", Faculty of Science, University of Zagreb
Organization of scientific meetings
Scientific Committee member:
2022 7th Croatian Congress of Microbiology with International Participation, Sv. Martin na Muri
2018 13th Croatian Biological Congress with International Participation, Poreč
2015 12th Croatian Biological Congress with International Participation, Sv. Martin na Muri
2009 10th Croatian Biological Congress with International Participation, Osijek
2008 Scientific Symposium "50 Years of Molecular Biology in Croatia", Zagreb