Dr. Igor Weber
HR-10000 Zagreb
CROATIA
Education
1995 Munich, Technische Universität München, Physik Department, Biophysics, PhD
1992 Zagreb, Zagreb University, Biophysics, MSc
1988 Zagreb, Zagreb University, Faculty of natural sciences and mathematics, Physics, BSc
Projects
Croatian Science Foundation & Swiss National Science Foundation, Croatian-Swiss Research Program (CSRP 2017–2023), Swiss-Croatian project: Phagocytosis and Macropinocytosis: a mechanistic view (with Pierre Cosson, University of Geneva) Croatian Science Foundation /European Social Fund, Young researchers’ career development project – training of doctoral students |
Classes
- Cytoskeleton and Cell Motility, graduate program in Biology, Faculty of natural sciences, University of Zagreb
- Cell Biophysics, postgraduate doctoral program in Biophysics, University of Split
- Advanced Light Microscopy, postgraduate doctoral program in Biophysics, University of Zagreb
Featured Publications
- Marinović, M., Mijanović, L., Šoštar, M., Vizovišek, M., Junemann, A., Fonović, M., Turk, B, Weber, I., Faix, J., Filić, V. (2019). IQGAP-related protein IqgC suppresses Ras signaling during large-scale endocytosis. Proc. Natl. Acad. Sci. USA 116(4):1289-1298.
- Filić, V., Marinović, M., Šoštar, M., Weber, I. (2018). Modulation of small GTPase activity by NME proteins. Lab. Investig. 98: 589.
- Marinović, M., Xiong, H., Rivero, F., Weber, I. (2018). Assaying Rho GTPase–dependent processes in Dictyostelium discoideum. Methods Mol. Biol. 1821: 371.
- Junemann, A., Filić, V., Winterhoff, M., Nordholz, B., Litschko, C., Schwellenbach, H., Stephan, T., Weber, I., Faix, J. (2016). A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis. Proc. Natl. Acad. Sci. USA 113: E7464.
- Ramalingam, N., Franke, C., Jaschinski, E., Winterhoff, M., Lu, Y., Brühmann, S., Junemann, A., Meier, H., Noegel, A.A., Weber, I., Zhao, H., Merkel, R., Schleicher, M., Faix, J. (2015). A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D-confinement. Nat. Commun. 6: 8496.
- Filić, V., Marinović, M., Faix, J., Weber, I. (2014). The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases. Cell. Mol. Life Sci. 71: 2775.
- Faix, J., Weber, I. (2013). A dual role model for active Rac1 in cell migration. Small GTPases 4: 110.
- Filić, V., Marinović, M., Faix, J., Weber, I. (2012). A dual role for Rac1 GTPases in the regulation of cell motility. J. Cell Sci. 125: 387.
Publications
Books and book chapters
Book chapters
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Marinović, M., Xiong, H., Rivero, F. & Weber, I. (2018) Assaying Rho GTPase–dependent processes in Dictyostelium discoideum. U: Rivero, F. (ur.) Rho GTPases. New York (NY), Humana Press, str. 371-392 doi:10.1007/978-1-4939-8612-5_25.
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Weber, I. (2011) Interference Reflection Microscopy. U: Zheng, Y. (ur.) Encyclopedia of Life Sciences (ELS). Chichester, John Wiley & Sons, str. 1-6 doi:10.1002/9780470015902.a0002636.pub2.
doi Weber, I. (2003) Dynamic organization of the actin cytoskeleton in Dictyostelium. U: Pandalai, S. (ur.) Recent Research Developments in Molecular Cellular Biology. Lahti, Research Signpost, str. 273-295.
Albrecht, R. & Weber, I. (2002) Interference reflection microscopy. Encyclopedia of Life Sciences. London : Delhi, Nature Publishing Group, str. Vol. 10, 369-371.
Weber, I. & Gerisch, G. (2002) Cortexillins. Wiley Encyclopedia of Molecular Medicine. New York (NY), John Wiley & Sons, str. Vol. 1, 914-916.
Dunn, G., Weber, I. & Zicha, D. (1997) Protrusion, retraction and the efficiency of cell locomotion. U: Alt, W., Deutsch, A. & Dunn, G. (ur.) Dynamics of Cell and Tissue Motion. Basel, Birkhäuser, str. 215-223.
Journal articles
Scientific and review papers
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Jagić, M., Vuk, T., Škiljaica, A., Markulin, L., Vičić Bočkor, V., Tokić, M., Miškec, K., Razdorov, G., Habazin, S., Šoštar, M., Weber, I., Bauer, N. & Leljak Levanić, D. (2022) BPM1 regulates RdDM-mediated DNA methylation via a cullin 3 independent mechanism. Plant Cell Reports, 41, 2139-2157 doi:10.1007/s00299-022-02911-9.
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Mijanović, L. & Weber, I. (2022) Adhesion of Dictyostelium Amoebae to Surfaces: A Brief History of Attachments. Frontiers in cell and developmental biology, 10, 910736, 9 doi:10.3389/fcell.2022.910736.
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Šafranko, S., Stanković, A., Hajra, S., Kim, H., Strelec, I., Dutour-Sikirić, M., Weber, I., Herak Bosnar, M., Grbčić, P., Kraljević Pavelić, S., Széchenyi, A., Mishra, Y., Jerković, I. & Jokić, S. (2021) Preparation of multifunctional N-doped carbon quantum dots from citrus clementina peel: investigating targeted pharmacological activities and the potential application for Fe3+ sensing. Pharmaceuticals, 14 (9), 857, 18 doi:10.3390/ph14090857.
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Filić, V., Mijanović, L., Putar, D., Talajić, A., Ćetković, H. & Weber, I. (2021) Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom. Cells, 10 (7), 1592, 39 doi:10.3390/cells10071592.
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Bodinier, R., Sabra, A., Leiba, J., Marchetti, A., Lamrabet, O., Ayadi, I., Filić, V., Kawata, T., Weber, I. & Cosson, P. (2021) Role of LrrkA in the Control of Phagocytosis and Cell Motility in Dictyostelium discoideum. Frontiers in cell and developmental biology, 9, 629200, 11 doi:10.3389/fcell.2021.629200.
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Radić, M., Šoštar, M., Weber, I., Ćetković, H., Slade, N. & Herak Bosnar, M. (2020) The Subcellular Localization and Oligomerization Preferences of NME1/NME2 upon Radiation-Induced DNA Damage. International journal of molecular sciences, 21 (7), 2363, 19 doi:10.3390/ijms21072363.
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Paradžik, M., Humphries, J., Stojanović, N., Nestić, D., Majhen, D., Dekanić, A., Samaržija, I., Sedda, D., Weber, I., Humphries, M. & Ambriović-Ristov, A. (2020) KANK2 links αVβ5 focal adhesions to microtubules and regulates sensitivity to microtubule poisons and cell migration. Frontiers in cell and developmental biology, 8, 125, 17 doi:10.3389/fcell.2020.00125.
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Buljubašić, M., Hlevnjak, A., Repar, J., Đermić, D., Filić, V., Weber, I., Zahradka, K. & Zahradka, D. (2019) RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli. DNA repair, 83, 102670, 16 doi:10.1016/j.dnarep.2019.102670.
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Marinović, M., Mijanović, L., Šoštar, M., Vizovišek, M., Junemann, A., Fonović, M., Turk, B., Weber, I., Faix, J. & Filić, V. (2019) IQGAP-related protein IqgC suppresses Ras signaling during large-scale endocytosis. Proceedings of the National Academy of Sciences of the United States of America, 116 (4), 1289-1298 doi:10.1073/pnas.1810268116.
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Benčić, P., Mandić, L., Džeba, I., Tartaro Bujak, I., Biczók, L., Mihaljević, B., Mlinarić-Majerski, K., Weber, I., Kralj, M. & Basarić, N. (2019) Application of 4-amino-N-adamantylphthalimide solvatochromic dye for fluorescence microscopy in selective visualization of lipid droplets and mitochondria. Sensors and actuators. B, Chemical, 286 (x), 52-61 doi:10.1016/j.snb.2019.01.102.
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Filić, V., Marinović, M., Šoštar, M. & Weber, I. (2018) Modulation of small GTPase activity by NME proteins. Laboratory investigation, 98 (5), 589-601 doi:10.1038/s41374-018-0023-x.
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Junemann, A., Filić, V., Winterhoff, M., Nordholz, B., Litschko, C., Schwellenbach, H., Stephan, T., Weber, I. & Faix, J. (2016) A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis. Proceedings of the National Academy of Sciences of the United States of America, 113 (47), E7464-E7473 doi:10.1073/pnas.1611024113.
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Marinović, M., Šoštar, M., Filić, V., Antolović, V. & Weber, I. (2016) Quantitative imaging of Rac1 activity in Dictyostelium cells with a fluorescently labelled GTPase-binding domain from DPAKa kinase. Histochemistry and cell biology, 146 (3), 267-279 doi:10.1007/s00418-016-1440-9.
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Ramalingam, N., Franke, C., Jaschinski, E., Winterhoff, M., Lu, Y., Brühmann, S., Junemann, A., Meier, H., Noegel, A., Weber, I., Zhao, H., Merkel, R., Schleicher, M. & Faix, J. (2015) A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D confinement. Nature Communications, 6, 8496-8496 doi:10.1038/ncomms9496.
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Filić, V., Marinović, M., Faix, J. & Weber, I. (2014) The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases. Cellular and molecular life sciences, 71 (15), 2775-2785 doi:10.1007/s00018-014-1606-3.
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Antolović, V., Marinović, M., Filić, V. & Weber, I. (2014) A simple optical configuration for cell tracking by dark-field microscopy. Journal of microbiological methods, 104, 9-11 doi:10.1016/j.mimet.2014.06.006.
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Weber, I. & Faix, J. (2013) A dual role model for active Rac1 in cell migration. Small GTPases, 4 (2), 110-115 doi:10.4161/sgtp.23476.
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Njegić-Džakula, B., Reggi, M., Falini, G., Weber, I., Brečević, L. & Kralj, D. (2013) The Influence of a Protein Fragment Extracted from Abalone Shell Green Layer on the Precipitation of Calcium Carbonate Polymorphs in Aqueous Media. Croatica chemica acta, 86 (1), 39-47 doi:10.5562/cca2197.
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Sabol, M., Car, D., Musani, V., Ozretić, P., Orešković, S., Weber, I. & Levanat, S. (2012) The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched. International journal of oncology, 41 (4), 1411-1418 doi:10.3892/ijo.2012.1554.
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Filić, V., Marinović, M., Faix, J. & Weber, I. (2012) A dual role for Rac1 GTPases in the regulation of cell motility. Journal of cell science, 125 (2), 387-398 doi:10.1242/jcs.089680.
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Annesley, S., Bago, R., Herak Bosnar, M., Filić, V., Marinović, M., Weber, I., Mehta, A. & Fisher, P. (2011) Dictyostelim discoideum nucleoside diphosphate kinase C plays a negative regulatory role in phagocytosis, macropinocytosis and exocytosis. PLoS One, 6 (10), e26024, 11 doi:10.1371/journal.pone.0026024.
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Jurašin, D., Weber, I. & Filipović-Vinceković, N. (2009) Phase Behavior in Mixtures of Cationic Dimeric and Anionic Monomeric Surfactants. Journal of dispersion science and technology, 30 (5), 622-633 doi:10.1080/01932690802598481.
doi Antica, M., Dubravčić, K., Weber, I., Rajić, L., Labar, B. & Batinić, D. (2007) A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia. Haematologica, 92 (2), 260-261.
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Gerisch, G. & Weber, I. (2007) Toward the Structure of Dynamic Membrane-Anchored Actin Networks: An Approach Using Cryo-Electron Tomography. Cell Adhesion & Migration, 1 (3), 145-148 doi:10.4161/cam.1.3.4662.
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Medalia, O., Beck, M., Ecke, M., Weber, I., Neujahr, R., Baumeister, W. & Gerisch, G. (2007) Organization of actin networks in intact filopodia. Current Biology, 17 (1), 79-84 doi:10.1016/j.cub.2006.11.022.
doi Weber, I. (2006) Is there a pilot in a pseudopod?. European Journal of Cell Biology, 85, 915-924.
Weber, I. (2005) Cryoelectron Tomography: Implications for Actin Cytoskeleton Research. Croatica chemica acta, 78, 325-331.
Weber, I. (2005) Receptor Occupancy on an Ellipsoidal Cell in the Presence of a Point Source of a Chemoattractant. Journal of chemical information and modeling, 45 (6), 1647 -1651.
Htun van der Horst, E., Weber, I. & Ulrich, A. (2005) Tyrosine phosphorylation of PYK2 mediates Heregulin-induced glioma invasion: Novel Heregulin/HER3-stimulated signaling pathway in glioma. International journal of cancer, 113, 689-698.
Barišić, K. & Weber, I. (2004) Dictyostelium discoideum: a model organism on the eve of the genome sequencing completion. Periodicum biologorum, 106, 103-114.
Gerisch, G., Benjak, A., Köhler, J., Weber, I. & Schneider, N. (2004) GFP-golvesin constructs to study Golgi tubulation and post-Golgi vesicle dynamics in phagocytosis. European journal of cell biology, 83, 297-303.
Herak Bosnar, M., de Gunzburg, J., Bago, R., Brečević, L., Weber, I. & Pavelić, J. (2004) Subcellular localization of A and B Nm23/NDPK subunits. Experimental Cell Research, 298 (1), 275-284.
Schneider, N., Weber, I., Faix, J., Prassler, J., Müller-Taubenberger, A., Köhler, J., Burghardt, E., Gerisch, G. & Marriott, G. (2003) A Lim protein involved in the progression of cytokinesis and regulation of the mitotic spindle. Cell Motility and the Cytoskeleton, 56, 130-139.
Weber, I. (2003) Confocal fluorescence microscopy of the plant cytoskeleton. Periodicum biologorum, 105 (3), 237-249.
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Weber, I. (2003) Reflection interference contrast microscopy. Methods in enzymology, 361, 34-47 doi:10.1016/S0076-6879(03)61004-9.
doi Bretschneider, T., Jonkman, J., Köhler, J., Medalia, O., Barišić, K., Weber, I., Stelzer, E., Baumeister, W. & Gerisch, G. (2002) Dynamic organization of the actin system in the motile cells of Dictyostelium. Journal of Muscle Research and Cell Motility, 23, 639-649.
Müller-Taubenberger, A., Bretschneider, T., Faix, J., Konzok, A., Simmeth, E. & Weber, I. (2002) Differential localization of the Dictyostelium PAKa kinase during cytokinesis and cell migration. Journal of Muscle Research and Cell Motility, 23 (7-8), 751-763.
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Medalia, O., Weber, I., Frangakis, A., Nicastro, D., Gerisch, n. & Baumeister, W. (2002) Macromolecular Architecture in Eukaryotic Cells Visualized by Cryoelectron Microscopy. Science, 298 (5596), 1209-1213 doi:10.1126/science.1076184.
doi Weber, I., Niewöhner, J., Du, A., Röhrig, U. & Gerisch, G. (2002) A talin fragment as an actin trap visualizing actin flow in chemotaxis, endocytosis, and cytokinesis. Cell Motility and the Cytoskeleton, 53, 136-149.
Weber, I. (2001) On the mechanism of cleavage furrow ingression in Dictyostelium. Cell Structure and Function, 26 (6), 577-584.
Insall, R., Müller-Taubenberger, A., Machesky, L., Köhler, J., Simmeth, E., Atkinson, S., Weber, I. & Gerisch, G. (2001) Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis. Cell Motility and the Cytoskeleton, 50 (3), 115-128.
Faix, J., Weber, I., Mintert, U., Köhler J., Lottspeich, F. & Marriott, G. (2001) Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins. EMBO Journal, 20 (14), 3705-3715.
Tuxworth, R., Weber, I., Wessels, D., Addicks, G., Soll, D., Gerisch, G. & Titus, M. (2001) A role for myosin VII in dynamic cell adhesion. Current Biology, 11 (5), 318-329.
Weber, I., Neujahr, R., Du, A., Köhler, J., Faix, J. & Gerisch, G. (2000) Two-step positioning of a cleavage furrow by cortexillin and myosin II. Current Biology, 10 (9), 501-506.
Gerisch, G. & Weber, I. (2000) Cytokinesis without myosin II. Current Opinion in Cell Biology, 12 (1), 126-132.
Stock, A., Steinmetz, M., Janmey, P., Aebi, U., Gerisch, G., Kammerer, R., Weber, I. & Faix, J. (1999) Domain analysis of cortexillin I: actin bundling, PIP2-binding and the rescue of cytokinesis. EMBO Journal, 18 (19), 5274-5284.
Weber, I. (1999) Computer-assisted morphometry of cell-substratum contacts. Croatian Medical Journal, 40, 334-339.
Konzok, A., Weber, I., Simmeth, E., Hacker, U., Maniak, M. & Müller-Taubenberger, A. (1999) Dictyostelium DAip1, a homologue of the yeast actin-interacting protein 1, is involved in endocytosis, cytokinesis and motility. Journal of Cell Biology, 146 (2), 453-464.
Weber, I., Gerisch, G., Heizer, C., Murphy, J., Badelt, K., Stock, A., Schwartz, J. & Faix, J. (1999) Cytokinesis mediated through the recruitment of cortexillins into the cleavage furrow. EMBO Journal, 18, 586-594.
Weber, I., Niewöhner, J. & Faix, J. (1999) Cytoskeletal protein mutations and cell motility in Dictyostelium. Biochemical Society Symposia, 65, 245-265.
Neujahr, R., Heizer, C., Albrecht, R., Ecke, M., Schwartz, J., Weber, I. & Gerisch, G. (1997) Three-dimensional patterns and redistribution of myosin II and actin in mitotic Dictyostelium cells. Journal of Cell Biology, 139, 1793-1804.
Niewöhner, J., Weber, I., Maniak, M., Müller-Taubenberger, A. & Gerisch, G. (1997) Talin-null cells of Dictyostelium are strongly defective in adhesion to particle and substrate surfaces and slightly impaired in cytokinesis. Journal of Cell Biology, 138, 349-361.
Weber, I. & Albrecht, R. (1997) Image processing for combined bright-field and reflection interference contrast video microscopy. Computer Methods and Programs in Biomedicine, 53 (2), 113-118.
Gimond, C., Mercier, I., Weber, I. & Aumailley, M. (1996) Adhesion complexes formed by OVCAR-4 cells on laminin 1 differ from those observed on fibronectin. Cell Communication and Adhesion, 3, 527-539.
Weber, I., Wallraff, E., Albrecht, R. & Gerisch, G. (1995) Motility and substratum adhesion of Dictyostelium wild-type and cytoskeletal mutant cells: a study by RICM/bright-field double-view image analysis. Journal of cell science, 108, 1519-1530.
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Weber, I. & Kirin, D. (1992) Low-frequency vibrational spectra of cytosine monohydrate single crystals. Journal of molecular structure, 267, 67-72 doi:10.1016/0022-2860(92)87011-J.
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Membership in professional associations / societies
Croatian Society for Natural Sciences
Croatian Society for Theoretical and Mathematical Biology (president 2005-2006)
Croatian Biophysical Society
Croatian Microscopy Society (president 2012-2016)
European microscopy society (member of the Executive board, 2016-2020)
ELMI, European Light Microscopy Initiative, member
EURO-BioImaging, ESFRI (European Strategic Forum for Research Infrastructure), member