2007: PhD degree in Molecular and Cell Biology

         Faculty of Science, University of Zagreb

2000: M.Sc. degree in Molecular and Cell Biology

         Faculty of Science, University of Zagreb

1996: B.Sc. degree in Molecular Biology

         Faculty of Science, University of Zagreb

Associate lecturer of graduate course Neuroimunology, Study of Experimental Biology, Faculty of Science, Zagreb

Jazvinšćak Jembrek M, Švob Štrac D, Vlainić Lazić J and Peričić D:The role of transcriptional and translational mechanisms in flumazenil-induced up-regulation of recombinant GABA-A receptors. Neurosci. Res. 61: 234-241 (2008) 

Peričić D, Jazvinšćak Jembrek M, Švob Štrac D, Lazić J, Rajčan Špoljarić I: Enhancement of benzodiazepine binding sites following chronic treatment with flumazenil: Eur. J. Pharmacol. 507 (1-3):7-13 (2005)

Peričić D, Lazić J, Jazvinšćak Jembrek M, Švob Štrac D, Rajčan I: Chronic exposure of cells expressing recombinant GABA_A  receptors to benzodiazepine antagonist flumazenil enhances the maximum number of benzodiazepine binding sites: Life Sci. 76(3): 303-317 (2004)

Peričić D, Jazvinšćak M, Mirković K: [³H]Flunitrazepam binding to recombinant a₁b₂g_2S GABA_A receptors stably expressed in HEK 293 cells: Biomed. Pharmacother. 55 (4): 221-228 (2001)

Peričić D, Švob D, Jazvinšćak M, Mirković K: Anticonvulsive effect of swim stress in mice. Pharmacol. Biochem. Beh. 66(4): 879-886 (2000)

Peričić D, Mirković K, Jazvinšćak M, Besnard F: [³H]t-butylbicycloorthobenzoate binding to recombinant a₁b₂g_2S GABA_A receptor. Eur. J. Pharmacol. 360(1):99-104 (1998)

Books and book chapters

Book chapters

• Kosalec, I., Jazvinšćak Jembrek, M. & Vlainić, J. (2022) The spectrum of berberine antibacterial and antifungal activities. U: Rai, M. & Kosalec, I. (ur.) Promising antimicrobials from natural products. Cham, Springer, str. 119-132 doi:10.1007/978-3-030-83504-0_7.

  doi

• Zubčić, K., Šimić, G. & Jazvinšćak Jembrek, M. (2020) p53-mediated neuroprotective effects of natural compounds in oxidative stress conditions. U: Stevens, M. (ur.) p53 – structure, function and role in disease. New York (NY), Nova Science Publishers, str. 127-181.

• Jazvinšćak Jembrek, M., Newberg, K. & Šimić, G. (2019) The Role of p53 in Alzheimer’s Disease: Impact on Tau Pathology. U: Singh, S. & Joshi, N. (ur.) Pathology, Prevention and Therapeutics of Neurodegenerative Disease. Singapur, Springer, str. 39-48 doi:10.1007/978-981-13-0944-1_4.

  doi

• Vlainić, J. & Jazvinšćak Jembrek, M. (2017) GABA(γ-Aminobutyric Acid). U: Sangdun Choi (ur.) Encyclopedia of Signaling Molecules. New York (NY), Springer, str. 1-6.

• Oršolić, N., Goluža, E. & Jazvinšćak Jembrek, M. (2015) The Effectiveness of Quercetin on Biomarkers for Osteoporosis. U: Malone, G. (ur.) Quercetin: Food Sources, Antioxidant Properties and Health Effects. New York (NY), Nova Science Publishers, str. 133-160.

• Jazvinšćak Jembrek, M., Vlainić, J. & Oršolić, N. (2015) Dual Effects of Quercetin in Physiological Conditions and During Oxidative Injury in P19 Neurons. U: Malone, G. (ur.) Quercetin: Food Sources, Antioxidant Properties and Health Effects. New York (NY), Nova Science Publishers, str. 111-132.

• Oršolić, N. & Jazvinšćak Jembrek, M. (2015) Multimodal Approach to Tumor Therapy with Quercetin, Chemotherapy, Radiotherapy and Hyperthermia. U: Malone, G. (ur.) Quercetin: Food Sources, Antioxidant Properties and Health Effects. New York (NY), Nova Science Publishers, str. 43-84.

• Jazvinšćak Jembrek, M., Babić, M., Pivac, N. & Šimić, G. (2015) Interplay between Aβ, Ceramides and Hyperphosphorylated Tau in Alzheimer’s Disease. U: Watkins, C. (ur.) Sphingomyelin and Ceramides: Occurrence, Biosynthesis and Role in Disease. New York (NY), Nova Science Publishers, str. 53-84.

• Jazvinšćak Jembrek, M., Vlainić, J. & Radovanović, V. (2014) The role of GABA in development and behaviour: emphasize on the effects of GABA receptor agonists and antagonists. U: Vlainić, J. & Jazvinšćak Jembrek, M. (ur.) Gamma-aminobutyric Acid (GABA): biosynthesis, medicinal uses and health effects. New York (NY), Nova Science Publishers, str. 49-70.

• Vlainić, J., Švob Štrac, D. & Jazvinšćak Jembrek, M. (2014) The effects of persistent activation of GABA-A receptors by neurotransmitter GABA. U: Vlainić, J. & Jazvinšćak Jembrek, M. (ur.) Gamma-aminobutyric Acid (GABA): biosynthesis, medicinal uses and health effects. New York (NY), Nova Science Publishers, str. 29-48.

• Švob Štrac, D., Vlainić, J., Jazvinšćak Jembrek, M., Muck-Šeler, D. & Pivac, N. (2012) The Effects of Benzodiazepines during Prolonged Administration and Under the Conditions of Stress. U: Soto, A. & Reyes, C. (ur.) Benzodiazepine: Abuse and Therapeutic Uses, Pharmacology and Health Effects. New York (NY), Nova Science Publishers, str. 1-54.

• Pivac, N., Nedić, G., Nikolac, M., Mustapić, M., Švob Štrac, D., Jazvinšćak Jembrek, M. & Muck-Šeler, D. (2011) Molecular mechanisms of traumatic brain injury. U: Wiederhold, B. (ur.) Traumatic brain injury. Wounds of war III.. Amsterdam, IOS Press, str. 81-111.

Journal articles

Scientific and review papers

• Vuić, B., Miloš, T., Tudor, L., Konjevod, M., Nikolac Perković, M., Jazvinšćak Jembrek, M., Nedić Erjavec, G. & Švob Štrac, D. (2022) Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential. Biomedicines, 10 (12), 3000, 31 doi:10.3390/biomedicines10123000.

  doiwww.ncbi.nlm.nih.govwww.mdpi.comfulir.irb.hr

• Oršolić, N. & Jazvinšćak Jembrek, M. (2022) Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer. International Journal of Molecular Sciences, 23 (18), 10479, 68 doi:10.3390/ijms231810479.

  doiwww.mdpi.comfulir.irb.hr

• Tadijan, A., Vlašić, I., Vlainić, J., Đikić, D., Oršolić, N. & Jazvinšćak Jembrek, M. (2022) Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions. Antioxidants, 11 (10), 2049, 36 doi:10.3390/antiox11102049.

  doiwww.mdpi.comfulir.irb.hr

• Radić, M., Vlašić, I., Jazvinšćak Jembrek, M., Horvat, A., Tadijan, A., Sabol, M., Dužević, M., Herak Bosnar, M. & Slade, N. (2022) Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance. International journal of molecular sciences, 23 (17), 9910, 19 doi:10.3390/ijms23179910.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Oršolić, N., Nemrava, J., Jeleč, Ž., Kukolj, M., Odeh, D., Jakopović, B., Jazvinšćak Jembrek, M., Bagatin, T., Fureš, R. & Bagatin, D. (2022) Antioxidative and Anti-Inflammatory Activities of Chrysin and Naringenin in a Drug-Induced Bone Loss Model in Rats. International journal of molecular sciences, 23, 2872, 24 doi:10.3390/ijms23052872.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Jazvinšćak Jembrek, M., Oršolić, N., Mandić, L., Sadžak, A. & Šegota, S. (2021) Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration. Antioxidants, 10 (10), 1628, 46 doi:10.3390/antiox10101628.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Oršolić, N., Sirovina, D., Odeh, D., Gajski, G., Balta, V., Šver, L. & Jazvinščak Jembrek, M. (2021) Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse. Molecules, 26 (11), 3262, 25 doi:10.3390/molecules26113262.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Sadžak, A., Vlašić, I., Kiralj, Z., Batarelo, M., Oršolić, N., Jazvinšćak Jembrek, M., Kušen, I. & Šegota, S. (2021) Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. Molecules, 26 (4), 845, 28 doi:10.3390/molecules26040845.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Zubčić, K., Hof, P., Šimić, G. & Jazvinšćak Jembrek, M. (2020) The Role of Copper in Tau-Related Pathology in Alzheimer’s Disease. Frontiers in Molecular Neuroscience, 13, 572308, 19 doi:10.3389/fnmol.2020.572308.

  doiwww.frontiersin.orgdoi.orgfulir.irb.hr

• Oršolić, N., Odeh, D., Jazvinšćak Jembrek, M., Knežević, J. & Kučan, D. (2020) Interactions between Cisplatin and Quercetin atPhysiological and Hyperthermic Conditions onCancer Cells In Vitro and In Vivo. Molecules, 25 (14), 3271, 25 doi:10.3390/molecules25143271.

  doiwww.mdpi.comfulir.irb.hr

• Zubčić, K., Radovanović, V., Vlainić, J., Hof, P., Oršolić, N., Šimić, G. & Jazvinšćak Jembrek, M. (2020) PI3K/Akt and ERK1/2 Signalling Are Involved in Quercetin-Mediated Neuroprotection against Copper-Induced Injury. Oxidative medicine and cellular longevity, 2020, 9834742, 14 doi:10.1155/2020/9834742.

  doiwww.hindawi.comdoi.orgfulir.irb.hr

• Radovanović, V., Vlainić, J., Hanžić, N., Ukić, P., Oršolić, N., Baranović, G. & Jazvinšćak Jembrek, M. (2019) Neurotoxic effect of ethanolic extract of propolis in the presence of copper ions is mediated through enhanced production of ROS and stimulation of caspase-3/7 activity. Toxins, 11 (5), 273, 18 doi:10.3390/toxins11050273.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Jazvinšćak Jembrek, M., Vlainić, J., Čadež, V. & Šegota, S. (2018) Atomic force microscopy reveals new biophysical markers for monitoring subcellular changes in oxidative injury: Neuroprotective effects of quercetin at the nanoscale. PLoS One, 13 (10), 0200119-0200141 doi:10.1371/journal.pone.0200119.

  doijournals.plos.orgwww.ncbi.nlm.nih.govfulir.irb.hr

• Jazvinšćak Jembrek, M., Radovanović, V., Vlainić, J., Vuković, L. & Hanžić, N. (2018) Neuroprotective effect of zolpidem against glutamate-induced toxicity is mediated via the PI3K/Akt pathway and inhibited by PK11195. Toxicology, 406-407, 58-69.

  www.sciencedirect.com

• Jazvinšćak Jembrek, M., Slade, N., Hof, P. & Šimić, G. (2018) The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease. Progress in neurobiology, 168, 104-127 doi:10.1016/j.pneurobio.2018.05.001.

  doi

• Jazvinšćak Jembrek, M., Auteri, M., Serio, R. & Vlainić, J. (2017) GABAergic System in Action: Connection to Gastrointestinal Stress-related Disorders.. Current pharmaceutical design, 23 (27), 4003-4011 doi:10.2174/1381612823666170209155753.

  doi

• Oršolić, N., Jazvinšćak Jembrek, M. & Terzić, S. (2017) Honey and quercetin reduce ochratoxin A-induced DNA damage in the liver and the kidney through the modulation of intestinal microflora. Food and agricultural immunology, 28 (5), 812-833 doi:10.1080/09540105.2017.1313819.

  doi

• Jazvinšćak Jembrek, M., Hof, P. & Šimić, G. (2015) Ceramides in Alzheimer’s Disease : Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation. Oxidative Medicine and Cellular Longevity,, 346783-1 doi:10.1155/2015/346783.

  doifulir.irb.hr

• Jazvinšćak Jembrek, M. & Vlainić, J. (2015) GABA receptors: pharmacological potential and pitfalls. Current Pharmaceutical Design, 21 (34), 4943-4959 doi:10.2174/1381612821666150914121624.

  doifulir.irb.hr

• Jazvinšćak Jembrek, M., Vlainić, J. & Šuran, J. (2015) Zolpidem withdrawal induced uncoupling of GABAA receptors in vitro associated with altered GABAA receptor subunit mRNA expression. Acta neurobiologiae experimentalis, 75 (2), 160-171. (https://www.bib.irb.hr/769819).

  fulir.irb.hr

• Jazvinšćak Jembrek, M., Šimić, G., Hof, P. & Šegota, S. (2015) Atomic force microscopy as an advanced tool in neuroscience. Translational Neuroscience, 6 (1), 117-130 doi:10.1515/tnsci-2015-0011.

  doiwww.degruyter.comfulir.irb.hr

• Jazvinšćak Jembrek, M., Vlainić, J., Radovanović, V., Erhardt, J. & Oršolić, N. (2014) Effects of copper overload in P19 neurons : impairment of glutathione redox homeostasis and crosstalk between caspase and calpain protease systems in ROS-induced apoptosis. BioMetals, 27 (6), 1303-1322 doi:10.1007/s10534-014-9792-x.

  doi

• Jazvinšćak Jembrek, M., Babić, M., Pivac, N., Hof, P. & Šimić, G. (2013) Hyperphosphorylation of tau by GSK-3β in Alzheimer’s disease: The interaction of Aβ and sphingolipid mediators as a therapeutic target. Translational Neuroscience, 4 (4), 466-476 doi:10.2478/s13380-013-0144-z.

  doifulir.irb.hrwww.degruyter.com

• Oršolić, N., Sirovina, D., Gajski, G., Garaj-Vrhovac, V., Jazvinšćak Jembrek, M. & Kosalec, I. (2013) Assessment of DNA damage and lipid peroxidation in diabetic mice : effects of propolis and epigallocatechin gallate (EGCG). Mutation research. Genetic toxicology and environmental mutagenesis, 757 (1), 36-44 doi:10.1016/j.mrgentox.2013.04.022.

  doi

• Jazvinšćak Jembrek, M., Čipak Gašparović, A., Vuković, L., Vlainić, J., Žarković, N. & Oršolić, N. (2012) Quercetin supplementation : Insight into the potentially harmful outcomes of neurodegenerative prevention. Naunyn-Schmiedeberg's archives of pharmacology, 385 (12), 1185-1197 doi:10.1007/s00210-012-0799-y.

  doi

• Jazvinšćak Jembrek, M., Vuković, L., Puhović, J., Erhardt, J. & Oršolić, N. (2012) Neuroprotective effect of quercetin against hydrogen peroxide-induced oxidative injury in P19 neurons. Journal of molecular neuroscience, 47 (2), 286-299 doi:10.1007/s12031-012-9737-1.

  doi

• Vlainić, J., Švob Štrac, D., Jazvinšćak Jembrek, M., Vlainić, T. & Peričić, D. (2012) The effects of zolpidem treatment on GABAA receptors in cultured cerebellar granule cells: Changes in functional coupling. Life sciences, 90 (23-24), 889-894 doi:10.1016/j.lfs.2012.04.021.

  doi

• Švob Štrac, D., Jazvinšćak Jembrek, M., Erhardt, J., Mirković Kos, K. & Peričić, D. (2012) Modulation of recombinant GABA-A receptors by neurosteroid dehydroepiandrosterone sulphate. Pharmacology, 89 (3/4), 163-171 doi:10.1159/000336058.

  doi

• Vlainić, J., Jazvinšćak Jembrek, M., Vlainić, T., Švob Štrac, D. & Peričić, D. (2012) Differential effects of short- and long-term zolpidem treatment on recombinant alpha 1 beta 2 gamma 2s subtype of GABA(A) receptors in vitro. Acta pharmacologica Sinica, 33 (12), 1469-1476 doi:10.1038/aps.2012.89.

  doi

• Vlainić, J., Jazvinšćak Jembrek, M., Švob Štrac, D. & Peričić, D. (2010) The effects of zolpidem treatment and withdrawal on the in vitro expression of recombinant alpha1beta2gamma2s GABA-A receptors expressed in HEK 293 cells. Naunyn-Schmiedeberg's archives of pharmacology, 382 (3), 201-212 doi:10.1007/s00210-010-0539-0.

  doi

• Švob Štrac, D., Vlainić Lazić, J., Jazvinšćak Jembrek, M. & Peričić Danka (2008) Differential effects of diazepam treatment and withdrawal on recombinant GABAA receptor expression and functional coupling. Brain research, 1246, 29-40 doi:10.1016/j.brainres.2008.09.093.

  doi

• Jazvinšćak Jembrek, M., Švob Štrac, D., Vlainić Lazić, J. & Peričić, D. (2008) The role of transcriptional and translational mechanisms in flumazenil-induced up-regulation of recombinant GABAA receptors. Neuroscience Research, 61 (3), 234-241.

• Peričić, D., Švob Štrac, D., Jazvinšćak Jembrek, M. & Vlainić Lazić, J. (2007) Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1 beta2 gamma2s subunits of GABA-A receptors. Naunyn-Schmiedeberg's Archives of Pharmacology, 375 (3), 177-187.

• Peričić, D., Lazić, J., Jazvinšćak Jembrek, M. & Švob Štrac, D. (2005) Stimulation of 5-HT1A receptors increases the seizure threshold for picrotoxin in mice. European Journal of Pharmacology, 527 (1-3), 105-110.

• Peričić, D., Jazvinšćak Jembrek, M., Švob Štrac, D., Vlainić (Lazić), J. & Rajčan Špoljarić, I. (2005) Enhancement of benzodiazepine binding sites following chronic treatment with flumazenil. European Journal of Pharmacology, 507 (1-3), 7-13.

• Peričić, D., Lazić, J., Jazvinšćak Jembrek, M., Švob Štrac, D. & Rajčan, I. (2004) Chronic exposure of cells expressing recombinant GABA A receptors to benzodiazepine antagonist flumazenil enhances the maximum number of benzodiazepine binding sites. Life Sciences, 76 (3), 303-317.

• Peričić, D., Švob Štrac, D., Jazvinšćak Jembrek, M. & Rajčan, I. (2003) Prolonged exposure to gamma-aminobutyric acid up-regulates stably expressed recombinant alpha1 beta2 gamma2s GABA A receptors. European Journal of Pharmacology, 482, 117-125.

• Peričić, D., Švob, D., Jazvinšćak Jembrek, M. & Mirković Kos, K. (2001) The involvement of alpha(2)-adrenoceptors in the anticonvulsive effect of swim stress in mice. Psychopharmacology, 158 (1), 87-93.

• Peričić, D., Jazvinšćak, M. & Mirković, K. (2001) [3H]Flunitrazepam binding to recombinant alpha1 beta2 gamma 2s GABA-A receptors stably expressed in HEK 293 cells. Biomedicine and pharmacotherapy, 55 (4), 221-228.

• Peričić, D., Jazvinšćak, M., Švob, D. & Mirković, K. (2001) Swim stress alters the behavioural response of mice to GABA-related and some GABA-unrelated convulsants. Epilepsy research, 43 (2), 145-152.

• Peričić, D., Jazvinšćak, M., Švob, D. & Mirković, K. (2000) Beta-1 adrenoceptor antagonists potentiate the anticonvulsive effect of swim stress in mice. Pharmacology Biochemistry and Behavior, 67 (3), 507-510.

• Peričić, D., Švob, D., Jazvinšćak, M. & Mirković, K. (2000) Anticonvulsive effect of swim stress in mice. Pharmacology biochemistry and behavior, 66 (4), 879-886.

• Peričić, D., Bujas, M., Mirković, K. & Jazvinšćak, M. (1999) The effects of adrenalectomy and gonadectomy on sex and stress-induced differences in the sensitivity of rats to bicuculline. Experimental brain research, 129 (3), 451-456.

• Peričić, D., Mirković, K., Jazvinšćak, M. & Besnard, F. (1998) (3H)t-butylbicycloorthobenzoate binding to recombinant alpha1 beta2 gamma2s GABA-A receptor. European journal of pharmacology, 360 (1), 99-104.

• Bujas, M., Peričić, D. & Jazvinšćak, M. (1997) Influence of gender and gonadectomy on bicuculline-induced convulsions and on GABA-A receptors. Brain research bulletin, 43 (4), 411-416.

Theses

Doctoral dissertation

• Jazvinšćak Jembrek, M. (2007) 'Adaptive changes of alpha1 beta2 gamma2s recombinant GABA-A receptors in cell culture after chronic exposure to flumazenil', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

Master thesis

• Jazvinšćak Jembrek, M. (2000) 'Alpha1 beta2 gamma2s recombinant GABA-A receptors - model for pharmacological studies', magistarski rad, Prirodoslovno-matematički fakultet, Zagreb.

Croatian Society for Neuroscience

Croatian Pharmacological Society