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Dr. Neda Slade

voditelj laboratorija znanstveni savjetnik u trajnom izboru
Telephone
+385 1 456 0926
Internal phone number
1511
Academic title
Associate Professor
Address
Bijenička cesta 54, 10000 Zagreb, Croatia

Education

1972-1980 Elementary school, Zagreb

1980-1984 High school (V gymnasium, Zagreb)

1984-1989 graduate school in molecular biology, Faculty of Science, University of Zagreb, B.Sc. in molecular biology

1989-1993 postgraduate study in molecular and cellular biology, Faculty of Science, University of Zagreb, M.Sc. in molecular and cellular biology

1993-1999 doctoral study, Faculty of Science, University of Zagreb, Ph.D. in molecular biology

Research Areas

Projects

2022-2023 donation of the Adris Foundation "Determining the role of microRNA in the acquisition of resistance to targeted therapy of metastatic melanoma cells" 

2014 - 2018 "New Protein Networks for Novel Therapeutic Avenues in Human Melanoma - ProNetMel", research project by Croatian Science Foundation, principal investigator 

2007 –2013 "The role of p53/p73 protein network in soft tissue sarcoma“, Ministry of Science, Education and Sports, Republic of Croatia, principal investigator

2007-2008 “The role of p73 in cell cycle control”, French-Croatian bilateral project “Cogito”, principal investigator

2006.-2007."p53/p73 Network in chemoresistance. The relevance of dominant - negative p73 isoforms for chemosenstivity“; Austrian-Croatian bilateral project, principal investigator 

Awards and Achievements

2007 "J.J. Strossmayer" Award by Croatian Academy of Sciences and Zagreb Fair for the best publishing venture:

University textbook “Methods in Molecular Biology”. Editors: Andreja Ambriović Ristov, Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade,  Dušica Vujaklija; Zagreb, Ruđer Bošković Institute

2010, 2012, 2018 and 2021 Annual Director's Prize for scientific paper in the field of molecular medicine 

2021 Branimir Jernej Award for best publication in the field of biology, biomedicine or neuroscience in 2021

Classes

2003-2013: teaching Methodological courses in biology and medicine, RBI

2006-present: Doctoral study of Molecular Biosciences, RBI in collaboration with Universities in Osijek and Dubrovnik, teaching courses:
"Basic methods in molecular biology and medicine"   
"Methods in molecular biology and medicine –practical course"
"Tumor suppressor gene p53 and its relatives"
"Cell cycle control, genomic integrity maintenance and carcinogenesis"

2010-present: Doctoral study of Biology, Faculty of Science, University of Zagreb, teaching course "Genetics of cancer and biology of tumor cells"/from 2015 Biology of tumor cells

Publications - authored books

Zbornik

Priručnik

Publications - book chapters

Izvorni znanstveni rad

Stručni rad

  • Slade, Neda | Retrovirusi // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 538-546-x

  • Slade, Neda | Imunohistokemijsko bojenje tkiva uklopljenih u parafin upotrebom kompleksa peroksidaza-antiperoksidaza // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 608-612-x

  • Slade, Neda | Imunocitokemijsko bojenje uporabom kompleksa peroksidaza-antiperokisdaza // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 614-616-x

  • Slade, Neda | Imunofluorescencija // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 616-618-x

  • Slade, Neda | Imunoprecipitacija // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 627-630-x

  • Slade, Neda | Koimunoprecipitacija // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 630-x

  • Zorić, Arijana ; Slade, Neda | Određivanje transkripcijske aktivnosti gena pomoću luciferaze // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 512-514

  • Slade, Neda | Utvrđivanje apoptoze fragmentacijom DNA (DNA ljestve) // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 783-785

  • Slade, Neda | Enzimatski test za utvrđivanje apoptoze u pojedinačnoj stanici (TUNEL) // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 787-789

  • Slade, Neda | Utvrđivanje i mjerenje apoptoze fluorescencijskim mikroskopom // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 790-791

Ostalo

Publications - journal articles

Izvorni znanstveni rad

Pregledni rad (znanstveni)

Kratko priopćenje

Publications - conference proceedings

Sažetak izlaganja sa skupa

Izvorni znanstveni rad

Ostalo

  • Horvat, Anđela ; Zorić, Arijana ; Slade, Neda | p53/p63/p73 protein network // The Second Congress of the Serbian Association for Cancer Research with international participation „Cancer research: perspectives and application“. Beograd: Srpsko društvo istraživača raka, 2015. str. 68-68

Sažetak izlaganja sa skupa

Neobjavljeni prilog sa skupa

Doktorska disertacija

Diplomski rad

Ostalo

Membership in professional associations / societies

Croatian Association for Cancer Research (branch of the European Association for Cancer Research), member of the Presidency, from, 2021 vice-president

Croatian Society of Biochemistry and Molecular Biology

Croatian Biological Society

Committee of genomics and proteomics in oncology by Croatian Academy of Sciences and Arts 

Croatian Society of Human Genetic

Supervisor of doctoral thesis:

Arijana Zorić, "The effect of p53 mutants and isoforms on p73 activity in tumor cells", Faculty of Science, University of Zagreb, 2009 

Neven Tučkar, "The role of p73 isoforms in DNA methylation in cancer cells", Faculty of Science, University of Zagreb, 2012

Anđela Horvat, "The effect of ΔNp73α on the cell cycle control after DNA damage in human cells", Interdisciplinary Doctoral Study of Molecular Biosciences, J. J. Strossmayer University of Osijek, University of Dubrovnik and Ruđer Bošković Institute, 2015

Nikolina Hanžić, "Functional interplay between p53 and p53/p73, NME and GLI protein families in human melanoma", Interdisciplinary Doctoral Study of Molecular Biosciences, J. J. Strossmayer University of Osijek, University of Dubrovnik and Ruđer Bošković Institute, 2018

Supervisor of diploma thesis:

Anđela Runje, "Characterization of p53 tumor-suppressor protein isoforms-differences in stability", Faculty of Science, University of Zagreb, 2007 

Dina Rambrot, "The effect of overexpressed p73 gene on cell survival after DNA damage", Faculty of Science, University of Zagreb, 2008 

Marina Kovačević, "Transcriptional activity of p53 isoforms", Faculty of Science, University of Zagreb, 2011 

Anamarija Pfeiffer, "Complex formation between protein p63 and mutant p53 in human tumor cell line“, Faculty of Science, University of Zagreb, 2014 

Lidija Petrović, "Expression of p53 and p73 protein isoforms in human melanoma cells after exposure to ɣ-irradiation", Faculty of Pharmacy and Biochemistry, University of Zagreb, 2016 

Bastien Proust, „The expression profile of p53 isoforms in healthy and melanoma tissues“, University of Orléans, Orléans, France, 2016.

Lana Grižančić, „Interactions between ITCH, p63/p73 and mutated p53 in tumor cells“, Faculty of Science, University of Zagreb,, 2018.

Ana Borić, „The expression of p53 and p73 protein isoforms in human soft tissue sarcoma cell lines“, Faculty of Science, University of Zagreb, 2019.

Training:

1999 Short-term fellowship of the French Republic, CNRS Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, CERVI, Hôpital de la Pitié, Paris, France

2001-2003 postoctoral training, Department of Pathology, SUNY at Stony Brook, NY, USA

Editor and author of several chapters in the textbook:

University textbook “Methods in Molecular Biology”. Editors: Andreja Ambriović Ristov, Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade,  Dušica Vujaklija; Zagreb, Ruđer Bošković Institute

Author of chapters in the textbooks and handbooks:

Slade N., Moll U.M. (2003) Mutational analysis of p53 in human tumors: immunocytochemistry. IN: Methods in Molecular Biology: p53 Protocols, Eds. Deb S, Palit Deb S. Totowa, New Jersey, USA : Humana Press, 234: 231-243.

Erster S., Slade N., Moll U.M. (2003) Mutational analysis of p53 in human tumors: direct DNA sequencing and SSCP. In: Methods in Molecular Biology: p53 Protocols, eds. Deb S, Palit Deb S. Totowa, New Jersey, USA : Humana Press,234:219-230.

Slade N., Pavelić J., Pavlić K. (2004) Osnovna načela sistemskog liječenja zloćudnih tumora - Gensko liječenje i kemoprevencija. In: Internistička onkologija, eds. Mršić-Krmpotić Z., Roth A et al. Medicinska naklada, Zagreb, 80-113.

Moll U.M., Slade N. (2005) The role of p53 and p73 genes in tumor formation. In: Handbook of Immunohistochemistry andin situhibridization of human carcinomas. Vol 3: Molecular Genetics: Liver Carcinoma and Pancreatic Carcinoma, ed; Hayat M.A. Academic Press, USA, 103-117.

Participation in organization of several international conferences:

1st International Conference on Signal Transduction, 08.-12. 10.1998, Cavtat-Dubrovnik

2nd International Conference on Signal Transduction, 26.-31. 10. 2000, Cavtat-Dubrovnik

"50 years of molecular biology in Croatia", 20.-21. 11. 2008, Zagreb

HDIR-1 - 1st Meeting with International Participation “From Bench to Clinic”, Zagreb, 11. 11. 2010

HDIR-2 – 2nd Meeting with International Participation “From Bench to Clinic”, Zagreb, 8.-9. 11.2012, scientific committee

HDIR-3 – 3rd Meeting with International Participation “From Bench to Clinic”, Zagreb, 6.-7. 11. 2014, scientific committee

HDIR-4 – 4th Meeting with International Participation “From Bench to Clinic”, Zagreb, 3.-4.11. 2016, scientific committee 

„10th International congress of  the NDP kinase/NM23/AWD gene family“, international conference, Dubrovnik 2016, organizing committee (https://ndpk2016.irb.hr/)

HDIR-5 – 5th Meeting with International Participation “Translating Science to Medicine – Targets and Therapeutics”, Zagreb, 8.-10.11.2018, scientific committee 

„International p53/p63/p73 Isoforms Workshop“, international conference, Dubrovnik 2019, scientific committee  and main organizer (https://p53p63p73isoforms.irb.hr/)

HDIR-6 – 6th Meeting with International Participation “Targeting Cancer””, Zagreb, 10.-12.11.2022, scientific committee 

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