Dr. Tamara Čačev
Division of molecular medicine
Rudjer Boskovic Institute
Bijenicka cesta 54
10000 Zagreb
Education
2011, Master of Business Administration, College for Business and Management B. A. Krcelic
2007, Ph.D. in Molecular and Cellular Biology, Faculty of Science, University of Zagreb
2003, M.Sc. in Molecular and Cellular Biology, Faculty of Science, University of Zagreb
1998, B.Sc. in Molecular Biology, Faculty of Science, University of Zagreb
Classes
2009- present, "Molecular diagnostics", graduate programme in Molecular Biology (MS degree), Faculty of Science, University of Zagreb
2008 - present, "Recombinant DNA methodology", Specialist study of Environmental Health Engineering (MA degree), University of Applied Health Studies
2007 - present, "Personalized medicine-predictive medicine & pharmacogenetics", postgraduate interdisciplinary study in Molecular Biosciences (PhD degree), RBI, University of Osijek and University of Dubrovnik joint study programme
2004 - present, "Molecular genetics of gastrointestinal cancers", postgraduate study in Biomedicine and Health Sciences (PhD degree), School of Medicine, University of Zagreb
Featured Publications
1. Čačev T, Jokić M, Lončar B, Križanac Š, Kapitanović S. Interleukin-6 -174 G/C polymorphism is not associated with IL-6 expression and susceptibility to sporadic colon cancer. DNA and Cell Biology 2010; 29(4): 177-182.
2. Kraljević Pavelić S, Sedić M, Hock K, Vučinić S, Jurišić D, Gehrig P, Scott M, Schlapbach R, Čačev T, Kapitanović S, Pavelić S. An integrated proteomics approach for studying the molecular pathogenesis of Dupuytren’s disease. J Pathol 2009; 217: 524-533.
3. Čačev T, Radošević S, Križanac Š, Kapitanović S. Influence of interleukin-8 and interleulin-10 on sporadic colon cancer development and progression. Carcinogenesis 2008; 29(8):1572-1580.
4. Čačev T, Lončar B, Seiwerth S, Spaventi Š, Kapitanović S. Vascular endothelial growth factor polymorphisms -1154 G/A and -460 C/T are not associated with VEGF mRNA expression and susceptibility to sporadic colon cancer. DNA and Cell Biology 2008; 27(10):569-574.
5. Kraljević Pavelić S, Čačev T, Kralj M. A dual role of p21 (waf1/cip1) gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther 2008; 15(9):576-590.
6. Sirotković-Skerlev M, Čačev T, Križanac S, Kulić A, Pavelić K, Kapitanović S. TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions. Exp Mol Pathol 2007; 83:54-58.
7. Berković M, Čačev T, Zjačić-Rotkvić V, Kapitanović S. TNF-alpha Promoter Single Nucleotide Polymorphisms in Gastroenteropancreatic Neuroendocrine Tumors. Neuroendocrinology 2007; 84:346-352.
8. Pavelić K, Dedivitis RA, Kapitanović S, Čačev T, Guirado CR, Danić D, Radošević S, Brkić K, Pegan B, Križanac S, Kusić Z, Spaventi S, Bura M. Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions. Mutat Res 2006; 599:45-57.
9. Čačev T, Jokić M, Spaventi R, Pavelić K, Kapitanović S. Loss of heterozygosity testing using real-time PCR analysis of single nucleotide polymorphisms. J Cancer Res Clin Oncol 2006; 132:200-204.
10. Kapitanović S, Čačev T, Antica M, Kralj M, Cavrić G, Pavelić K, Spaventi R. Effect of indomethacin on E-cadherin and beta-catenin expression in HT-29 colon cancer cells. Exp Mol Pathol 2006; 80:91-96.
11. Čačev T, Radošević S, Spaventi R, Pavelić K, Kapitanović S. NF1 gene loss of heterozygosity and expression analysis in sporadic colon cancer. Gut 2005; 54(8):1129-1135.
12. Kapitanović S, Čačev T, Berković M, Popović Hadžija M, Radošević S, Seiwerth S, Spaventi Š, Pavelić K, Spaventi R. Nm23-H1 expression and loss of heterozygosity in colon adenocarcinoma. J Clinical Pathology 2004; 57:1312-1318.
13. Kapitanović S, Čačev T, Radošević S, Spaventi Š, Spaventi R, Pavelić K. APC gene loss of heterozygosity, mutations, E1317Q, and I1307K germ-line variants in sporadic colon cancer in Croatia. Exp Mol Pathol 2004; 77(3):193-200.
14. Pavelić K, Križanac Š, Čačev T, Popović-Hadžija M, Radošević S, Crnić I, Levanat S, Kapitanović S. Aberration of FHIT gene associated with increased tumor proliferation and decreased apoptosis – clinical evidence in lung and head and neck carcinomas. Mol Med 2001; 7:442-453.
15. Kapitanović S, Čačev T, Spaventi R, Pavelić K. Submerged gel electrophoresis on Spreadex gels – a new method for APC gene mutation detection. J Mol Med 2001; 79:333-337.
16. Popović Hadžija M, Kapitanović S, Radošević S, Čačev T, Mirt M, Kovačević D, Lukač J, Hadžija M, Spaventi R, Pavelić K. Loss of heterozygosity of DPC4 tumor suppressor gene in human sporadic colon cancer. J Mol Med 2001; 79:128-132.
Publications
Journal articles
Scientific and review papers
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Nikolić, N., Radosavljević, D., Gavrilović, D., Nikolić, V., Stanić, N., Spasić, J., Čačev, T., Castellvi-Be, S., Čavić, M. & Janković, G. (2022) Prognostic factors for post-recurrence survival in stage II and III colorectal carcinoma patients. Medicina, 57 (10), 1108, 12 doi:10.3390/medicina57101108.
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Herman Mahečić, D., Cigrovski Berković, M., Zjačić-Rotkvić, V., Čačev, T., Kapitanović, S. & Ulamec, M. (2020) Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms. Bosnian journal of basic medical sciences, 20 (4), 445-450 doi:10.17305/bjbms.2020.4471.
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Cumbo, M., Tomić, B., Dunjić, S., Jovanović, T., Gvozdenov, M., Pruner, I., Aralica, G., Kapitanović, S., Čačev, T. & Đorđević, V. (2019) Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma. Anticancer research, 39 (11), 6067-6071 doi:10.21873/anticanres.13814.
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Čačev, T., Zapletal, E., Musani, V., Rako, I., Lončar, B., Aralica, G. & Kapitanović, S. (2018) Analysis of MSH2 Loss of Heterozygosity, Expression, and IVS10+12G>A Polymorphism in Sporadic Colon Cancer. Anticancer research, 38 (5), 2841-2848 doi:10.21873/anticanres.12529.
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Cigrovski Berković, M., Čačev, T., Catela Ivković, T., Marout, J., Ulamec, M., Zjačić-Rotkvić, V. & Kapitanović, S. (2016) High VEGF serum values are associated with locoregional spread of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Molecular and cellular endocrinology, 425, 61-68 doi:10.1016/j.mce.2016.01.013.
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Nikolić, A., Čačev, T., Aralica, G., Popović Hadžija, M., Kapitanović, S. & Radojković, D. (2015) Mononucleotide repeats in the SMAD4 gene promoter in colon carcinoma tissue of Croatian patients. Experimental and molecular pathology, 98 (2), 133-135 doi:10.1016/j.yexmp.2015.02.008.
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Kapitanović, S., Čačev, T., Catela Ivković Tina, Lončar, B. & Aralica, G. (2014) TNFα gene/protein in tumorigenesis of sporadic colon adenocarcinoma. Experimental and molecular pathology, 97 (2), 285-291 doi:10.1016/j.yexmp.2014.08.003.
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Cigrovski Berković, M., Čačev, T., Catela Ivković, T., Zjačić-Rotkvić, V. & Kapitanović, S. (2014) New insights into the role of chronic inflammation and cytokines in the etiopathogenesis of gastroenteropancreatic neuroendocrine tumors. Neuroendocrinology, 99 (2), 75-84 doi:10.1159/000362339.
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Kapitanović, S., Čačev, T., Lončar, B., Catela Ivković, T., Križanac, Š. & Pavelić, K. (2014) Reduced FHIT expression is associated with tumor progression in sporadic colon adenocarcinoma. Experimental and molecular pathology, 96 (1), 92-97 doi:10.1016/j.yexmp.2013.12.005.
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Čačev, T., Aralica, G., Lončar, B. & Kapitanović, S. (2014) Loss of NF2/Merlin expression in advanced sporadic colorectal cancer. Cellular oncology, 37 (1), 69-77 doi:10.1007/s13402-013-0164-2.
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Catela Ivković, T., Aralica, G., Čačev, T., Lončar, B. & Kapitanović, S. (2013) miR-106a overexpression and pRB downregulation in sporadic colorectal cancer. Experimental and molecular pathology, 93 (1), 148-154 doi:10.1016/j.yexmp.2012.11.002.
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Sirotković-Skerlev, M., Kulić, A., Bradić, L. & Čačev, T. (2012) Protumor effects of proinflammatory mediators in breast cancer. Periodicum biologorum, 114 (4), 489-496.
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Jaganjac, M., Čačev, T., Čipak, A., Kapitanović, S., Gall-Troselj, K. & Žarković, N. (2012) Even stressed cells are individuals: second messengers of free radicals in pathophysiology of cancer. Croatian medical journal, 53 (4), 304-309 doi:10.3325/cmj.2012.53.304.
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Čačev, T., Jokić, M., Lončar, B., Križanac, Š. & Kapitanović, S. (2010) Interleukin-6 -174 G/C polymorphism is not associated with IL-6 expression and susceptibility to sporadic colon cancer. DNA and cell biology, 29 (4), 177-182 doi:10.1089/dna.2009.0950.
doi -
Kraljević Pavelić, S., Sedić, M., Hock, K., Vučinić, S., Jurišić, D., Gehrig, P., Scott, M., Schlapbach, R., Čačev, T., Kapitanović, S. & Pavelić, K. (2009) An integrated proteomics approach for studying the molecular pathogenesis of Dupuytren's disease. Journal of pathology, 217 (4), 524-533 doi:10.1002/path.2483.
doi -
Čačev, T., Radošević, S., Križanac, Š. & Kapitanović, S. (2008) Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression. Carcinogenesis, 29 (8), 1572-1580 doi:10.1093/carcin/bgn164.
doi Čačev, T., Lončar, B., Seiwerth, S., Spaventi, Š. & Kapitanović, S. (2008) Vascular endothelial growth factor polymorphisms -1154 G/A and -460 C/T are not associated with VEGF mRNA expression and susceptibility to sporadic colon cancer. DNA and Cell Biology, 27 (10), 569-574.
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Kraljević Pavelić, S., Čačev, T. & Kralj, M. (2008) A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer gene therapy, 15 (9), 576-590 doi:10.1038/cgt.2008.28.
doi -
Sirotković-Skerlev, M., Čačev, T., Križanac, Š., Kulić, A., Pavelić, K. & Kapitanović, S. (2007) TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions. Experimental and molecular pathology, 83 (1), 54-58 doi:10.1016/j.yexmp.2006.11.004.
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Pavelić, K., Dedivitis, R., Kapitanović, S., Čačev, T., Guirado, C., Đanić, D., Radošević, S., Brkić, K., Pegan, B., Križanac, Š., Kusić, Z., Spaventi, Š. & Bura, M. (2006) Molecular genetic alterations of Fhit and p53 genes in benign and malignant thyroid gland lesions. Mutation research, 599 (1/2), 45-57 doi:10.1016/j.mrfmmm.2006.01.021.
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Boraska, V., Terzić, J., Škrabić, V., Čačev, T., Bučević-Popović, V., Peruzović, M., Markotić, A. & Zemunik, T. (2006) NeuroD1 gene and interleukin-18 gene polymorphisms in type 1 diabetes in Dalmatian population of Southern Croatia. Croatian medical journal, 47 (4), 571-578.
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Berković, M., Čačev, T., Zjačić-Rotkvić, V. & Kapitanović, S. (2006) TNF-alpha promoter SNPs in gastroenteropancreatic neuroendocrine tumors (GEP-NET). Neuroendocrinology, 84 (5), 346-352 doi:10.1159/000097988.
doi Sirotković-Skerlev, M., Čačev, T. & Kapitanović, S. (2006) Tumor necrosis factor alpha and breast cancer. Periodicum Biologorum, 108 (5), 541-546.
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Čačev, T., Jokić, M., Spaventi, R., Pavelić, K. & Kapitanović, S. (2006) Loss of heterozygosity testing using real-time PCR analysis of single nucleotide polymorphisms. Journal of cancer research and clinical oncology, 132 (3), 200-204 doi:10.1007/s00432-005-0051-y.
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Kapitanović, S., Čačev, T., Antica, M., Kralj, M., Cavrić, G., Pavelić, K. & Spaventi, R. (2006) Effect of indomethacin on E-cadherin and β-catenin expression in HT-29 colon cancer cells. Experimental and molecular pathology, 80 (1), 91-96 doi:10.1016/j.yexmp.2005.04.008.
doi Breljak, D., Ambriović-Ristov, A., Kapitanović, S., Čačev, T. & Gabrilovac, J. (2005) Comparison of three RT-PCR-based methods for relative quantification of mRNA.. Food technology and biotechnology, 43 (4), 379-388.
Čačev, T., Radošević, S., Spaventi, R., Pavelić, K. & Kapitanović, S. (2005) NF1 gene loss of heterozygosity and expression analysis in sporadic colon cancer. Gut, 54 (8), 1129-1135.
Čačev, T. & Kapitanović, S. (2004) Colon cancer: gone with the Wnt. Periodicum biologorum, 106 (3), 233-238.
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Kapitanović, S., Čačev, T., Berković, M., Popović Hadžija, M., Radošević, S., Seiwerth, S., Spaventi, Š., Pavelić, K. & Spaventi, R. (2004) nm23-H1 expression and loss of heterozygosity in colon adenocarcinoma. Journal of clinical pathology, 57 (12), 1312-1318 doi:10.1136/jcp.2004.017954.
doi Kapitanović, S., Čačev, T., Radošević, S., Spaventi, Š., Spaventi, R. & Pavelić, K. (2004) APC gene loss of heterozygosity, mutations, E1317Q, and I1317K germ-line variants in sporadic colon cancer in Croatia. Experimental and molecular pathology, 77 (3), 193-200.
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Kapitanović, S., Čačev, T., Spaventi, R. & Pavelić, K. (2001) Submerged gel electrophoresis on Spreadex gels — a new method for APC gene mutation detection. Journal of molecular medicine, 79 (5-6), 333-337 doi:10.1007/s001090100216.
doilink.springer.comd1wqtxts1xzle7.cloudfront.net Pavelić, K., Križanac, Š., Čačev, T., Popović Hadžija, M., Crnić, I., Levanat, S. & Kapitanović, S. (2001) Aberration of FIHT gene associated with increased tumor proliferation and decreased apoptosis - clinical evidence in lung and head and neck carcinomas. Molecular Medicine, 7 (7), 442-453.
Popović Hadžija, M., Kapitanović, S., Radošević, S., Čačev, T., Mirt, M., Kovačević, D., Lukač, J., Hadžija, M., Spaventi, R. & Pavelić, K. (2001) Loss of heterozygosity of DPC4 tumor suppressor gene in human sporadic colon cancer. Journal of Molecular Medicine, 79 (2-3), 128-132.
Conference proceedings papers
Scientific conference proceedings papers
Kopriva, I., Kapitanović, S. & Čačev, T. (2015) Nonlinear Sparse Component Analysis with a Reference: Variable Selection in Genomics and Proteomics. U: Vincent, E., Yeredor, A., Kolodovsky, Z. & Tichavsky, P. (ur.)12th International Conference, LVA/ICA 2015, Liberec, Czech Republic, August 25-28, 2015, Proceedings. (https://www.bib.irb.hr/773947).
Čačev, T., Švob Štrac, D. & Žarković, N. (2014) Project basis of an Interdisciplinary Education Centre. U: Šiber, G. (ur.)Scientific and Professional Conference with International Participation Management- Conference Proceedings,.
Švob Štrac, D., Čačev, T. & Žarković, N. (2014) Project of Stress Center Establishment. U: Šiber, G. (ur.)Scientific and Professional Conference with International Participation Management- Conference Proceedings.
Theses
Doctoral dissertation
Čačev, T. (2007) 'The role of cytokines in development and progression of sporadic colon cancer', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.
Master thesis
Čačev, T. (2003) 'Loss of heterozygosity and expression analysis of NF1 gene in sporadic colon cancer', magistarski rad, Prirodoslovno-matematički fakultet, Zagreb.
Membership in professional associations / societies
European Association for Cancer Research (EACR)
European Society of Human Genetics (ESHG)
Croatian Society for Human Genetics
Croatian Association for Cancer Research
2005 - present, Editorial Board, World Journal of Gastroenterology
Organization of international conferences and meetings
2010, HDIR-1 - First Meeting with International Participation: "From Bench to Clinic", Zagreb, member of the organizing committee
2004, "FEBS Lecture Course on Cellular Signaling & 4th Dubrovnik Signaling Conference", Dubrovnik, member of the organizing committee
2002, "3rd International Conference on Signal Transduction", Dubrovnik, member of the organizing committee
Popularization of science
2005, Open Days at RBI
2004, Open Days at RBI