We investigate the biophysical principles underlying the mitotic spindle assembly and function. In our interdisciplinary research, we combine cell and molecular biology and molecular biology, with state-of-the-art microscopy methods and techniques such as optogenetics and superresolution expansion microscopy, including optical manipulations such as laser scissors, and methods of mathematics, physics, and computing.
We are especially interested in the role of bridging fibers in spindle formation and force generation, as well as in the recently discovered chirality of the spindle.
The research focus of the Tolić Lab is the understanding of microtubule function in mitosis, whereas the Simunić Lab investigates the role of molecular chaperones in the context of cell division.
Lab website: tolic.irb.hr