Dr. Petar Ozretić
10000 Zagreb
Education
- 1995 - Grammar school, Čakovec
- 2005 - Department of Biology, Faculty of Science, University of Zagreb - B.Sc. in Molecular Biology
- 2013 - University Postgraduate Interdisciplinary Doctoral Study of Molecular biosciences at Josip Juraj Strossmayer University of Osijek PhD, University of Dubrovnik and Ruđer Bošković Institute - Ph.D. in Biomedicine and Health area
Awards and Achievements
- FEBS bursary for attending the 34th FEBS Congress in Prague, Czech Republic
- FEBS bursary for attending the 35th FEBS Congress in Gothenburg, Sweden
- EACR Travel Fellowship
- FEBS Collaborative Experimental Scholarships for Central & Eastern Europe
- Croatian Science Foundation’s Fellowship for Doctoral Students (project number 03.01/214)
Classes
- assistant (undergraduate courses):
- “Signalni putevi i interakcije”, Preddiplomski studij Biotehnologija i istraživanje lijekova, Zavod za biotehnologiju, Sveučilište u Rijeci
- “Metode rekombinantne DNA”, Specijalistički studij sanitarnog inženjerstva, Zdravstveno veleučilište u Zagrebu
- assistant (graduate courses):
- "Signalni putevi u stanici: onkogeni i tumor supresori", Doktroski studij, PMF, Sveučilište u Zagrebu
- "Metode istraživanja u molekularnoj onkologiji", Doktorski studij, Medicinski fakultet Sveučilišta u Zagrebu
Featured Publications
- Trnski D, Sabol M, Gojević A, Martinić M, Ozretić P, Musani V, Ramić S, Levanat S. GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer – Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation. BBA - Mol Basis Dis. 2015; 1852(12):2574-2584.
- Ozretić P, Bisio A, Musani V, Trnski D, Sabol M, Levanat S, Inga A. Regulation of human PTCH1b expression by different 5' untranslated region cis-regulatory elements. RNA Biol. 2015; 12(3):290-304.
- Sabol M*, Trnski D*, Uzarevic Z, Ozretic P, Musani V, Rafaj M, Cindric M, Levanat S. Combination of Cyclopamine and Tamoxifen Promotes Survival and Migration of MCF-7 Breast Cancer Cells - Interaction of Hedgehog-Gli and Estrogen Receptor Signaling Pathways. PLoS One. 2014; 9(12):e114510.
- Musani V, Sabol M, Car D, Ozretić P, Kalafatić D, Maurac I, Orešković S, Levanat S. PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele. Gene. 2013; 517(1):55-59.
- Levanat S, Musani V, Cvok ML, Susac I, Sabol M, Ozretic P, Car D, Eljuga D, Eljuga L, Eljuga D. Three novel BRCA1/BRCA2 mutations in breast/ovarian cancer families in Croatia. Gene. 2012; 498(2):169-76.
Publications
Books and book chapters
Book chapters
Musani, V., Ozretić, P. & Levanat, S. (2019) Molecular biology of breast cancer. U: Beketić-Orešković, L. & Šantek, F. (ur.) Breast cancer. Zagreb, Medicinska naklada, str. 34-45.
Musani, V., Ozretić, P. & Levanat, S. (2018) Molecular biology of breast cancer. U: Beketić-Orešković, L. & Šantek, F. (ur.) Karcinom dojke. Zagreb, Medicinska naklada, str. 34-45.
Musani, V., Ozretić, P. & Levanat, S. (2016) Molecular Biology of Breast Cancer. U: Beketić-Orešković, L. & Šantek, F. (ur.) Multidisciplinarno liječenje bolesnica s rakom dojke. Zagreb, Medicinski fakultet Sveučilišta u Zagrebu, str. 23-31.
Journal articles
Scientific and review papers
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Piteša, N., Kurtović, M., Bartoniček, N., Gkotsi, D., Čonkaš, J., Petrić, T., Musani, V., Ozretić, P., Riobo-Del Galdo, N. & Sabol, M. (2023) Signaling switching from Hedgehog-GLI to MAPK signaling potentially serves as a compensatory mechanism in melanoma cell lines resistant to GANT-61. Biomedicines, 11, 1353, 19 doi:10.3390/biomedicines11051353.
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Čonkaš, J., Sabol, M. & Ozretić, P. (2023) ‘Toxic Masculinity’: What Is Known about the Role of Androgen Receptors in Head and Neck Squamous Cell Carcinoma. International journal of molecular sciences, 24 (4), 3766, 18 doi:10.3390/ijms24043766.
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Krišto, M., Lugović-Mihić, L., Muñoz, M., Rupnik, M., Mahnic, A., Ozretić, P., Jaganjac, M., Ćesić, D. & Kuna, M. (2023) Gut Microbiome Composition in Patients with Chronic Urticaria: A Review of Current Evidence and Data. Life, 13 (1), 152, 14 doi:10.3390/life13010152.
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Budimir, I., Tomasović-Lončarić, Č., Kralik, K., Čonkaš, J., Eljuga, D., Žic, R., Gorjanc, B., Tucaković, H., Caktaš, D., Jaman, J., Lisek, V., Vlajčić, Z., Martić, K. & Ozretić, P. (2022) Higher expressions of SHH and AR are associated with a positive receptor status and have impact on survival in a cohort of Croatian breast cancer patients. Life, 12 (10), 1559, 19 doi:10.3390/life12101559.
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Kurtović, M., Piteša, N., Bartoniček, N., Ozretić, P., Musani, V., Čonkaš, J., Petrić, T., King, C. & Sabol, M. (2022) RNA-seq and ChIP-seq Identification of Unique and Overlapping Targets of GLI Transcription Factors in Melanoma Cell Lines. Cancers, 14 (18), 4540, 20 doi:10.3390/cancers14184540.
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(European Reference Genome Atlas (ERGA) Consortium) Formenti, G., Theissinger, K., Fernandes, C., Bista, I., Bombarely, A., Bleidorn, C., Ciofi, C., Crottini, A., Godoy, J., Hoglund, J., Malukiewicz, J., Mouton, A., Oomen, R., Paez, S., Palsboll, P., Pampoulie, C., Ruiz-Lopez, M., Svardal, H., Theofanopoulou, C., de Vries, J., Waldvogel, A., Zhang, G., Mazzoni, C., Jarvis, E., Balint, M., …, Ozretić, P., …, Pavlek, M., ... & Zammit, G. (2022) The era of reference genomes in conservation genomics. Trends in ecology & evolution, 37 (3), 197-202 doi:10.1016/j.tree.2021.11.008.
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Tadijan, A., Precazzini, F., Hanžić, N., Radić, M., Gavioli, N., Vlašić, I., Ozretić, P., Pinto, L., Škreblin, L., Barban, G., Slade, N. & Ciribilli, Y. (2021) Altered Expression of Shorter p53 Family Isoforms Can Impact Melanoma Aggressiveness. Cancers, 13 (20), 5231, 25 doi:10.3390/cancers13205231.
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Sabol, M., Calleja-Agius, J., Di Fiore, R., Suleiman, S., Ozcan, S., Ward, M. & Ozretić, P. (2021) (In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers. Cancers, 13, 5040, 36 doi:10.3390/cancers13205040.
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Trnski, D., Sabol, M., Tomić, S., Štefanac, I., Mrčela, M., Musani, V., Rinčić, N., Kurtović, M., Petrić, T., Levanat, S. & Ozretić, P. (2021) SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells. Scientific reports, 11 (1), 14880, 11 doi:10.1038/s41598-021-93971-6.
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Di Fiore, R., Suleiman, S., Felix, A., O'Toole, S., O'Leary, J., Ward, M., Beirne, J., Sabol, M., Ozretić, P., Yordanov, A., Vasileva-Slaveva, M., Kostov, S., Nikolova, M., Said-Huntingford, I., Ayers, D., Ellul, B., Pentimalli, F., Giordano, A. & Calleja-Agius, J. (2021) An Overview of the Role of Long Non-Coding RNAs in Human Choriocarcinoma. International journal of molecular sciences, 22 (12), 6506, 16 doi:10.3390/ijms22126506.
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Di Fiore, R., Suleiman, S., Pentimalli, F., O'Toole, S., O'Leary, J., Ward, M., Conlon, N., Sabol, M., Ozretić, P., Erson-Bensan, A., Reed, N., Giordano, A., Herrington, C. & Calleja-Agius, J. (2021) Could MicroRNAs Be Useful Tools to Improve the Diagnosis and Treatment of Rare Gynecological Cancers?A Brief Overview. International journal of molecular sciences, 22 (8), 3822, 26 doi:10.3390/ijms22083822.
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Zubčić, V., Rinčić, N., Kurtović, M., Trnski, D., Musani, V., Ozretić, P., Levanat, S., Leović, D. & Sabol, M. (2020) GANT61 and Lithium Chloride Inhibit the Growth of Head and Neck Cancer Cell Lines Through the Regulation of GLI3 Processing by GSK3beta. International journal of molecular sciences, 21, 6410, 13 doi:10.3390/ijms21176410.
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Šutić, M., Motzek, A., Bubanović, G., Linke, M., Sabol, I., Vugrek, O., Ozretić, P., Brčić, L., Seiwerth, S., Debeljak, Ž., Jakovčević, A., Janevski, Z., Stančić-Rokotov, D., Vukić-Dugac, A., Jakopović, M., Samaržija, M., Zechner, U. & Knežević, J. (2019) Promoter methylation status of ASC/TMS1/PYCARD is associated with decreased overall survival and TNM status in patients with early stage non-small cell lung cancer (NSCLC). Translational Lung Cancer Research, 8 (6), 1000-1015 doi:10.21037/tlcr.2019.12.08.
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Ozretić, P., da Silva Filho, M., Catalano, C., Sokolović, I., Vukić-Dugac, A., Šutić, M., Kurtović, M., Bubanović, G., Popović-Grle, S., Skrinjarić-Cincar, S., Vugrek, O., Jukić, I., Rumora, L., Bosnar, M., Samaržija, M., Bals, R., Jakopović, M., Försti, A. & Knežević, J. (2019) Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD). Genes, 10, 783, 16 doi:10.3390/genes10100783.
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Ozretić, P., Hanžić, N., Proust, B., Sabol, M., Trnski, D., Radić, M., Musani, V., Ciribilli, Y., Milas, I., Puljiz, Z., Bosnar Herak, M., Levanat, S. & Slade, N. (2019) Expression profiles of p53/p73, NME and GLI families in metastatic melanoma tissue and cell lines. Scientific Reports, 9 (1), 12470, 13 doi:10.1038/s41598-019-48882-y.
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Knezović Florijan, M., Ozretić, P., Bujak, M., Pezzè, L., Ciribilli, Y., Kaštelan, Ž., Slade, N. & Hudolin, T. (2019) The role of p53 isoforms’ expression and p53 mutation status in renal cell cancer prognosis. Urologic oncologic-seminars and original investigations, 37 (9), 578e, 10 doi:10.1016/j.urolonc.2019.03.007.
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Sušac, I., Ozretić, P., Gregorić, M., Levačić Cvok, M., Sabol, M., Levanat, S., Trnski, D., Eljuga, D., Seiwerth, S., Aralica, G., Stanec, M. & Musani, V. (2019) Polymorphisms in survivin (BIRC5 gene) are associated with age of onset in breast cancer patients. Journal of oncology, 2019, 3483192, 10 doi:10.1155/2019/3483192.
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Trnski, D., Gregorić, M., Levanat, S., Ozretić, P., Rinčić, N., Majić Vidaković, T., kalafatić, D., Maurac, I., Orešković, S., Sabol, M. & Musani, V. (2019) Regulation of Survivin Isoform Expression by GLI Proteins in Ovarian Cancer. Cells, 8 (2), 128, 13 doi:10.3390/cells8020128.
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Sabol, M., Trnski, D., Musani, V., Ozretić, P. & Levanat, S. (2018) Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets. International journal of molecular sciences, 19 (9), 2562, 37 doi:10.3390/ijms19092562.
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Mršić, G., Ozretić, P., Crnjac, J., Merkaš, S., Sukser, V., Račić, I., Rožić, S., Barbarić, L., Popović, M. & Korolija, M. (2018) Expanded Croatian 12 X-STR loci database with an overview of anomalous profiles. Forensic Science International-Genetics, 34, 249-256 doi:10.1016/j.fsigen.2018.03.004.
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Ozretić, P., Alvir, I., Šarčević, B., Vujašković, Ž., Rendić-Miočević, Z., Roguljić, A. & Beketić-Orešković, L. (2018) Apoptosis regulator Bcl-2 is an independent prognostic marker for worse overall survival in triple-negative breast cancer patients. The International Journal of Biological Markers, 33 (1), 109-115 doi:10.5301/ijbm.5000291.
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Ozretić, P., Trnski, D., Musani, V., Maurac, I., Kalafatić, D., Orešković, S., Levanat, S. & Sabol, M. (2017) Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas. International journal of oncology, 51 (6), 1869-1877 doi:10.3892/ijo.2017.4156.
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Barbarić, L., Ozretić, P., Horjan, I., Korolija, M. & Mršić, G. (2017) Forensic evaluation of the 20 STR loci in the population of Croatia. Forensic Science International-Genetics, 28, e49-e50 doi:10.1016/j.fsigen.2017.03.011.
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Mršić, G., Ozretić, P., Crnjac, J., Merkaš, S., Račić, I., Rožić, S., Sukser, V., Popović, M. & Korolija, M. (2017) Analysis of 12 X-STR loci in the population of south Croatia. Molecular biology reports, 44 (1), 183-189 doi:10.1007/s11033-017-4096-1.
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Crnjac, J., Ozretić, P., Merkaš, S., Ratko, M., Lozančić, M., Korolija, M., Popović, M. & Mršić, G. (2017) Investigator Argus X-12 study on the population of northern Croatia. Genetics and molecular biology, 40 (1), 80-83 doi:10.1590/1678-4685-gmb-2015-0261.
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Levanat, S., Sabol, M., Musani, V., Ozretić, P. & Trnski, D. (2017) Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors. Current pharmaceutical design, 23 (1), 73-94 doi:10.2174/1381612822666161006154705.
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Crnjac, J., Ozretić, P., Merkaš, S., Ratko, M., Lozančić, M., Rožić, S., Špoljarić, D., Korolija, M., Popović, M. & Mršić, G. (2016) Analysis of 12 X-chromosomal markers in the population of central Croatia. Legal Medicine, 21, 77-84 doi:10.1016/j.legalmed.2016.07.001.
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Trnski, D., Sabol, M., Gojević, A., Martinić, M., Ozretić, P., Musani, V., Ramić, S. & Levanat, S. (2015) GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer — Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852 (12), 2574-2584 doi:10.1016/j.bbadis.2015.09.005.
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Ozretić, P., Bisio, A., Musani, V., Trnski, D., Sabol, M., Levanat, S. & Inga, A. (2015) Regulation of human PTCH1b expression by different 5' untranslated region cis-regulatory elements. RNA Biology, 12 (3), 290-304 doi:10.1080/15476286.2015.1008929.
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Sabol, M., Trnski, D., Užarević, Z., Ozretić, P., Musani, V., Rafaj, M., Cindrić, M. & Levanat, S. (2014) Combination of cyclopamine and tamoxifen promotes survival and migration of MCF-7 breast cancer cells – interaction of Hedgehog-Gli and Estrogen receptor signaling pathways. PLOS ONE, 9 (12), e114510-1 doi:10.1371/journal.pone.0114510.
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Musani, V., Sabol, M., Car, D., Ozretić, P., Kalafatić, D., Maurac, I., Orešković, S. & Levanat, S. (2013) PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele. Gene, 517 (1), 55-59 doi:10.1016/j.gene.2012.12.089.
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Ozretić, P., Bisio, A., Inga, A. & Levanat, S. (2012) The growing relevance of cap-independent translation initiation in cancer-related genes. Periodicum biologorum, 114 (4), 471-478.
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Sabol, M., Car, D., Musani, V., Ozretić, P., Orešković, S., Weber, I. & Levanat, S. (2012) The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched. International journal of oncology, 41 (4), 1411-1418 doi:10.3892/ijo.2012.1554.
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Levanat, S., Musani, V., Levačić Cvok, M., Sušac, I., Sabol, M., Ozretić, P., Car, D., Eljuga, D., Eljuga, L. & Eljuga, D. (2012) Three novel BRCA1/BRCA2 mutations in breast/ovarian cancer families in Croatia. Gene, 498 (2), 169-176 doi:10.1016/j.gene.2012.02.010.
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Beketić-Orešković, L., Marić, P., Ozretić, P., Orešković, D., Ajduković, M. & Levanat, S. (2012) Assessing the clinical significance of tumor markers in common neoplasms. Frontiers in Bioscience- Elite edition, 4 (7), 2558-2578 doi:10.2741/566.
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Maurac, I., Sabol, M., Musani, V., Car, D., Ozretić, P., Kalafatić, D., Orešković, S., Babić, D. & Levanat, S. (2012) A low grade ovarian carcinoma case with coincident LOH of PTCH1 and BRCA1, and a mutation in BRCA1. International journal of gynecological pathology, 31 (3), 264-271 doi:10.1097/PGP.0b013e31823b6f0f.
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Musani, V., Sabol, M., Car, D., Ozretić, P., Orešković, S., Leović, D. & Levanat, S. (2012) LOH of PTCH1 region in BCC and ovarian carcinoma: microsatellite vs. HRM analysis. Frontiers in bioscience (Elite ed.), 4 (3), 1049-1057 doi:10.2741/E440.
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Leović, D., Sabol, M., Ozretić, P., Musani, V., Car, D., Marjanović, K., Zubčić, V., Sabol, I., Sikora, M., Grce, M., Glavaš-Obrovac, L. & Levanat, S. (2012) Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma. Head and neck, 34 (1), 104-112 doi:10.1002/hed.21696.
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Beketić-Orešković, L., Ozretić, P., Rabbani, Z., Jackson, I., Šarčević, B., Levanat, S., Marić, P., Babić, I. & Vujasković, Ž. (2011) Prognostic significance of carbonic anhydrase IX (CA-IX), endoglin (CD105) and 8-hydroxy-2'- deoxyguanosine (8-OHdG) in breast cancer patients. Pathology and Oncology Research, 17 (3), 593-603 doi:10.1007/s12253-010-9355-6.
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Marić, P., Ozretić, P., Levanat, S., Orešković, S., Antunac , K. & Beketić-Orešković, L. (2011) Tumor Markers in Breast Cancer – Evaluation of their Clinical Usefulness. Collegium Antropologicum, 35 (1), 241-247.
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Ozretić, P., Levačić Cvok, M., Musani, V., Sabol, M., Car, D. & Levanat, S. (2010) In silico analysis of potential structural and functional significance of human breast cancer gene BRCA2 sequence variants found in 5' untranslated region. Periodicum biologorum, 112 (4), 469-474.
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Car, D., Sabol, M., Musani, V., Ozretić, P. & Levanat, S. (2010) Epigenetic regulation of the Hedgehog-Gli signaling pathway in cancer. Periodicum biologorum, 112 (4), 419-423.
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Čretnik, M., Poje, G., Musani, V., Krušlin, B., Ozretić, P., Tomas, D., Šitum, M. & Levanat, S. (2009) Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma. International journal of oncology, 34 (4), 1045-1050 doi:10.3892/ijo_00000230.
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Levačić Cvok, M., Čretnik, M., Musani, V., Ozretić, P. & Levanat, S. (2008) New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia. Clinical Chemistry and Laboratory Medicine, 46 (10), 1376-1383 doi:10.1515/CCLM.2008.307.
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Conference proceedings papers
Scientific conference proceedings papers
Ozretić, P. (2015) Expression of PTCH1b Tumor Suppressor Gene Is Controlled by Different 5' Untranslated Region Cis-Regulatory Elements. U: Juranić, Z. (ur.)The Second Congress of the Serbian Association for Cancer Research "Cancer Research: Perspectives and Application" Proceedings Book.
Theses
Doctoral dissertation
Ozretić, P. (2013) 'Functional Analysis of the 5' Untranslated Region of the PTCH1 gene, transcript variant 1b', doktorska disertacija, Sveučilišni poslijediplomski interdisciplinarni doktorski studij Molekularne bioznanosti, Osijek.
Membership in professional associations / societies
- Croatian Society of Human Genetics (HDHG)
- Croatian Society of Biochemistry and Molecular Biology (HDBMB)
- Croatian Association for Cancer Research (HDIR) - secretary since 2009
- European Association for Cancer Research (EACR)
- Croatian Society for Theoretical and Mathematical Biology (HDTMB) - treasurer since 2015
- Croatian Biometric Society (HBMD)
Tour guide at RBI Open Days in 2008, 2010 and 2013.
Member of the Organizing Committee of HDIR-1, HDIR-2, HDIR-4 and HDIR-5 Conference.
One of the translators of the EuroGenTest booklets (from English to Croatian).