• 1991 University of Zagreb Faculty of Food Technology and Biotechnology, B.Sc.
• 1995 University of Zagreb Faculty of Science (field: Chemistry, branch: Biochemistry), M.Sc.
• 2000 University of Zagreb Faculty of Food Technology and Biotechnology, Ph.D.
• 2001-2004 St. Louis, MO, USA Washington University School of Medicine, post-doc.

COGITO programme, Croatian-French research project (2019-2021)

Title: The molecular links between lipidome, brain vulnerability and apolipoprotein E

Role: Principal Investigator

Croatian Science Foundation – call IP-06-2016 (2017-2021)

Title: Molecular mechanism of neurodegeneration in Niemann-Pick type C

Role: Principal Investigator

Bilateral project between DAAD (Germany) and MZOS (HR) (2016-2017)

Title: Elucidating BACE1 as a potential target for treating Niemann-Pick type C disease

Role: Principal Investigator

Bilateral project between Croatia and Serbia (2016-2017)

Ttile: Elucidating BACE1-substrate processing and distribution in a transgenic mouse model of Alzheimer’s disease and their potential role in the disease pathogenesis

Role: Principal Investigator

Croatian Science Foundation (HRZZ) - “Projekt razvoja karijera mladih istraživača - izobrazba novih doktora znanosti” (2015-2018)

Role: Mentor

FP7-PEOPLE-2013-IEF (Marie Curie) (2014-2016)

Title: Presenilin 2 - a protector against Alzheimer's disease

Role: Coordinator

• 1991 University of Zagreb dean's award for the best student work in the year 1990/91.
• 2001 Fulbright postdoctoral fellowship
• 2002 The John Douglas French Alzheimer’s Foundation postdoctoral fellowship
• 2005 NIH-Fogarty International Research Collaboration Award - USA
• 2008 Award J. J. Strossmayer (Croatian Academy of Sciences and Arts/ Zagreb fair), for the best publishing venture in science, for the book „Methods in molecular biology“by Andreja Ambriović Ristov (Editor-in-chief) and Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić, Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade, Dušica Vujaklija (Eds.).

• Lectures and laboratory practice of the "Polymerase Chain Reaction Method" at the course Methods in Biology and Medicine „DNA and RNA“ organized by Rudjer Boskovic Institute
• Lecturer of the course "Genetics of Neurodegenerative Diseases" at the graduate studies of the Faculty of Science, University of Zagreb
• Lecturer of the course "Genetics of Neurodegenerative Diseases" at the Interdisciplinary graduate studies Molecular Biosciences of the University „J.J. Strossmayera“ in Osijek and Ruđer Bošković Institute
• 2016 - Docent, Doctoral studies in "Molecular biosciences", J.J. Strossmayer University, Osijek

Avrahami L, Paz R, Dominko K, Hecimovic S, Bucci C, Eldar-Finkelman H. (2020) GSK-3-TSC axis governs lysosomal acidification through autophagy and endocytic pathways. Cell Signal. 71:109597. doi: 10.1016/j.cellsig.2020.109597.

Dominko K, Dikic D, Hecimovic S. (2018) Enhanced activity of superoxide dismutase is a common response to dietary and genetically induced increased cholesterol levels. Nutr Neurosci. 1-13. doi: 10.1080/1028415X.2018.1511027.

Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, Kuhn PH, Colombo A, Havas D, Flunkert S, McDonald J, Gunnersen JM, Hutter-Paier B, Tahirovic S, Windisch M, Krainc D, Lichtenthaler SF, Hecimovic S. (2018) BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains. PLoS One. 13(7):e0200344. doi: 10.1371/journal.pone.0200344.

Kosicek M, Gudelj I, Horvatic A, Jovic T, Vuckovic F, Lauc G, Hecimovic S. (2018) N-glycome of the lysosomal glycocalyx is altered in Niemann-Pick Type C disease model cells. Mol Cell Proteomics. pii: mcp.RA117.000129. doi: 10.1074/mcp.RA117.000129.

Cermak S, Kosicek M, Mladenovic-Djordjevic A, Smiljanic K, Kanazir S, Hecimovic S. (2016) Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins. PLoS One. 11(11):e0167428. doi: 10.1371/journal.pone.0167428.

Drechsler S, Lynch MA, Novella S, González-Navarro H, Hecimovic S, Barini E, Tucci V, Castro RE, Vandenbroucke RE, Osuchowski M, Potter PK. (2016) With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions. Mechanisms of Ageing and Development. 160:54-68. doi: 10.1016/j.mad.2016.07.005.

Malnar M, Hecimovic S, Mattsson M, Zetterberg H. (2014) Bidirectional links between Alzheimer's disease and Niemann-Pick type C disease. Neurobiology of Disease, Neurobiol Dis 72 Pt A: 37.

Kosicek M, Wunderlich P, Walter J, Hecimovic S. (2014) GGA1 overexpression attenuates amyloidogenic processing of APP in NPC1-null cells. Biochemical and Biophysical Research Communications, 450: 160-5.

Ting SK, Benzinger T, Kepe V, Fagan A, Coppola G, Porter V, Hecimovic S, Chakraverty S, Alvarez-Retuerto AI, Goate A, Ringman JM. (2014) A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman. Journal of Alzheimers Disease. 40: 271-5.

Kosicek M, Hecimovic S. (2013) Phospholipids and Alzheimer’s disease: alterations, mechanisms and potential biomerkers. International Journal of Molecular Sciences 14: 1310-22.

Mattsson N, Olsson M, Gustavsson MK, Kosicek M, Malnar M, Månsson JE, Blomqvist M, Gobom J, Andreasson U, Brinkmalm G, Vite C, Hecimovic S, Hastings C, Blennow K, Zetterberg H, Portelius E. (2012)  Amyloid-β metabolism in Niemann-Pick C disease models and patients. Metabolic Brain Disease. 27:573-585.

Malnar M, Kosicek M, Lisica A, Posavec M, Krolo A, Njavro J, Omerbasic D, Tahirovic S, Hecimovic S. (2012) Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease1822: 1270-83.

Kosicek M, Zetterberg H, Andreasen N, Peter-Katalinic J, Hecimovic S. (2012) Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease. Neuroscience Letters 516: 302-5.

Malnar M, Kosicek M, Mitterreiter S, Omerbasic D, Lichtenthaler SF, Goate A, Hecimovic S. (2010) Niemann Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface ad its increased processing through the beta-secretase pathway. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 1802: 682-91.

Kosicek M, Kirsch S, Bene R, Trkanjec Z, Titlic M, Bindila L, Peter-Katalinic J, Hecimovic S. (2010) Nano-HPLC-MS analysis of phospholipids in cerebrospinal fluid of Alzheimer's disease patients - a pilot study. Analytical and Bioanalytical Chemistry 398: 2929-37.

Kosicek M, Malnar M, Goate A, Hecimovic S. (2010) Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts. Biochemical and Biophysical Research Communications 393: 404-9.

Cam JA, Zerbinatti CV, Knisely JM, Hecimovic S, Yonghe L, Bu G (2004) The LDL receptor-related protein 1B retains APP at the cell surface and reduces amyloid-b peptide production. Journal of Biological Chemistry 279: 29639-46.

Hecimovic S, Wang J, Martinez M, Goate A (2004) Mutations in APP have independent effects on Ab and CTFg generation. Neurobiology of Disease 17: 205-218.

Wang J, Brunkan AL, Hecimovic S, Walker E, Goate A (2004) Conserved “PAL” sequence in presenilins is essential for g-secretase activity, but not required for formation or stabilization of g-secretase complex. Neurobiology of Disease 15: 654-666.

Schroeter EH, Ilagan MXG, Brunkan AL, Hecimovic S, Li Y-M, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Shearman M, Goate A, Wolfe MS, Kopan R (2003) A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences U S A 100: 13075-80.

Hećimović S, Barišić I, Muller A, Petković I, Barić I, Ligutić I, Pavelić K (1997) Expand Long PCR for fragile X mutation detection. Clinical Genetics 52: 147-154.

Books and book chapters

Book chapters

• Katušić Hećimović, S. (2007) Lipid raft isolation. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Ćetković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 780-782.

• Katušić Hećimović, S. (2007) Subcellular fractionation by centrifugation in a discontinuous gradient. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Ćetković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 777-780.

• Katušić Hećimović, S. (2007) Subcellular fractionation using differential centifugation. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Ćetković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 773-776.

• Katušić Hećimović, S. (2007) Generation of the competent bacteria using polyethileneglycol and transformation. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Ćetković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 453-454.

• Katušić Hećimović, S. (2007) Generation of competent bacteria using CaCl2 and transformation. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Ćetković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 450-453.

• Katušić Hećimović, S. (2007) In vitro mutagenesis using PCR method. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Ćetković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 442-446.

• Katušić Hećimović, S. (2007) Thermostable DNA polymerases. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Ćetković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 418-419.

• Katušić Hećimović, S. (2007) Polymerase chain reaction of DNA fragments rich in C+G nucleotides. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Ćetković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 370-371.

• Katušić Hećimović, S. (2007) RFLP PCR. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Ćetković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 368-370.

• Katušić Hećimović, S. (2007) Nested PCR. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Ćetković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 367-368.

• Katušić Hećimović, S. (2007) Multiplex PCR. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Ćetković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 366-367.

• Katušić Hećimović Silva (2007) The basic principles of PCR method. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Ćetković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 361-366.

• Hećimović, S. (2005) Molecular diagnosis of Huntington's disease. U: Barić, I. & Stavljenić Rukavina, A. (ur.) Racionalna dijagnostika nasljednih i prirođenih bolesti. Zagreb, Medicinska naklada, str. 89-94.

• Hećimović, S., Barišić, N. & Mitrović, Z. (2005) Rational methods use of Molecular Genetics in Diagnosis of Hereditary Aataxia. U: Barić, I. & Stavljenić Rukavina, A. (ur.) Racionalna dijagnostika nasljednih i prirođenih bolesti. Zagreb, Medicinska naklada, str. 81-88.

• Hećimović, S. & Barišić, N. (2005) Molecular diagnosis of myotonic dystrophy. U: Barić, I. & Stavljenić Rukavina, A. (ur.) Racionalna dijagnostika nasljednih i prirođenih bolesti. Zagreb, Medicinska naklada, str. 75-79.

• Brišić, N., Sertić, J. & Hećimović, S. (2005) Molecular diagnosis of Duchenne/Becker muscular dytrophies. U: Barić, I. & Stavljenić Rukavina, A. (ur.) Racionalna dijagnostika nasljednih i prirođenih bolesti. Zagreb, Medicinska naklada, str. 71-74.

• Hećimović, S. (2005) The fragile X syndrome. U: Barić, I. & Stavljenić Rukavina, A. (ur.) Racionalna dijagnostika nasljednih i prirođenih bolesti. Zagreb, Medicinska naklada, str. 51-54.

• Wang, J., Hećimović, S. & Goate, A. (2004) Alzheimer’s Disease. U: Meyers, R. (ur.) Encyclopedia of Molecular Cell Biology and Molecular Medicine. New York (NY), John Wiley & Sons, str. 214-230.

Journal articles

Scientific and review papers

• Dominko, K., Rastija, A., Smiljanić, K., Mladenović, A., Lešnjaković, L., Kanazir, S., Milanović, D. & Hećimović, S. (2022) Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6L. Mechanisms of ageing and development, 207, 111726, 11 doi:10.1016/j.mad.2022.111726.

  doi

• Dominko, K., Rastija, A., Sobočanec, S., Vidatić, L., Meglaj, S., Lovinčić Babić, A., Hutter-Paier, B., Colombo, Alessio-Vittorio, , Lichtenthaler, S., Tahirović, S. & Hećimović, S. (2021) Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation. International journal of molecular sciences, 22 (24), 13256, 27 doi:10.3390/ijms222413256.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Van Hoecke, L., Van Cauwenberghe, C., Dominko, K., Van Imschoot, G., Van Wonterghem, E., Castelein, J., Xie, J., Claeys, W., Vandendriessche, C., Kremer, A., Borghgraef, P., De Rycke, R., Hećimović, S. & Vandenbroucke , R. (2021) Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C. Frontiers in Cellular Neuroscience, 15, 757482, 14 doi:10.3389/fncel.2021.757482.

  doiwww.frontiersin.orgdoi.orgfulir.irb.hr

• Colombo, A., Dinkel, L., Müller, S., Sebastian Monasor, L., Schifferer, M., Cantuti-Castelvetri, L., König, J., Vidatić, L., Bremova-Ertl, T., Lieberman, A., Hećimović, S., Simons, M., Lichtenthaler, S., Strupp, M., Schneider, S. & Tahirović, S. (2021) Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nature communications, 12 (1), 1158, 20 doi:10.1038/s41467-021-21428-5.

  doiwww.nature.comdoi.orgfulir.irb.hr

• Avrahami, L., Paz, R., Dominko, K., Hećimović, S., Bucci, C. & Eldar-Finkelman, H. (2020) GSK-3-TSC axis governs lysosomal acidification through autophagy and endocytic pathways. Cellular signalling, 71, 109597, 11 doi:10.1016/j.cellsig.2020.109597.

  doiwww.sciencedirect.comfulir.irb.hr

• Čaušević, M., Dominko, K., Malnar, M., Vidatic, L., Čermak, S., Pigoni, M., Kuhn, P., Colombo, A., Havas, D., Flunkert, S., McDonald, J., Gunnersen, J., Hutter-Paier, B., Tahirovic, S., Windisch, M., Krainc, D., Lichtenthaler, S. & Hećimović, S. (2018) BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains. PLoS One, 13 (7), e0200344, 22 doi:10.1371/journal.pone.0200344.

  doifulir.irb.hrjournals.plos.orgwww.ncbi.nlm.nih.gov

• Dominko, K., Đikić, D. & Hećimović, S. (2018) Enhanced activity of superoxide dismutase is a common response to dietary and genetically induced increased cholesterol levels. Nutritional neuroscience, 1 (1), 1-13 doi:10.1080/1028415X.2018.1511027.

  doi

• Košiček, M., Gudelj, I., Horvatić, A., Jović, T., Vučković, F., Lauc, G. & Hećimović, S. (2018) N-glycome of the lysosomal glycocalyx is altered in Niemann-Pick Type C disease model cells. Molecular & cellular proteomics, 17 (4), 631-642 doi:10.1074/mcp.RA117.000129.

  doiwww.mcponline.org

• Cermak, S., Kosicek, M., Mladenovic-Djordjevic, A., Smiljanic, K., Kanazir, S. & Hecimovic, S. (2016) Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins. PLoS One, 11 (11), e0167428-1 doi:10.1371/journal.pone.0167428.

  doifulir.irb.hr

• Drechsler, S., Lynch, M., Novella, S., González-Navarro, H., Hećimović, S., Barini, E., Tucci, V., Castro, R., Vandenbroucke, R., Osuchowski, M. & Potter, P. (2016) With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions. Mechanisms of ageing and development, 160, 54-68 doi:10.1016/j.mad.2016.07.005.

  doi

• Dražić, T., Vazdar, K., Vazdar, M., Đaković, M., Mikecin, A., Kralj, M., Malnar, M., Hećimović, S. & Habuš, I. (2015) Synthesis of new 2-aminoimidazolones with antiproliferative activity via base promoted amino-β-lactam rearrangement. Tetrahedron, 71 (49), 9202-9215 doi:10.1016/j.tet.2015.10.048.

  doi

• Dražić, T., Sachdev, V., Leopold, C., Patankar, J., Malnar, M., Hećimović, S., Levak-Frank, S., Habuš, I. & Kratky, D. (2015) Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors. Bioorganic & medicinal chemistry, 23 (10), 2353-2359 doi:10.1016/j.bmc.2015.03.067.

  doi

• Ting, S., Benzinger, T., Kepe, V., Fagan, A., Coppola, G., Porter, V., Hećimović, S., Chakraverty, S., lvarez-Retuerto, A., Goate, A. & Ringman, J. (2014) A Novel PSEN1 Mutation (I238M) associated with Early-Onset Alzheimer's Disease in an African-American Woman. Journal of alzheimers disease, 40 (2), 271-275 doi:10.3233/JAD-131844.

  doi

• Dražić, T., Molčanov, K., Sachdev, V., Malnar, M., Hećimović, S., Patankar, J., Obrowsky, S., Levak-Frank, S., Habuš, I. & Kratky, D. (2014) Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors. European journal of medicinal chemistry, 87, 722-734 doi:10.1016/j.ejmech.2014.10.014.

  doi

• Košiček, M., Wunderlich, P., Walter, J. & Hećimović, S. (2014) GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells. Biochemical and biophysical research communications, 450 (1), 160-165 doi:10.1016/j.bbrc.2014.05.083.

  doi

• Malnar, M., Hećimović, S., Mattsson, N. & Zetterberg, H. (2014) Bidirectional links between Alzheimer's disease and Niemann-Pick type C disease. Neurobiology of disease, 72 (Part A), 37-47 doi:10.1016/j.nbd.2014.05.033.

  doi

• Košiček, M. & Hećimović, S. (2013) Phospholipids and Alzheimer’s disease: alterations, mechanisms and potential biomarkers. International journal of molecular sciences, 14 (1), 1310-1322 doi:10.3390/ijms14011310.

  doidoi.orgfulir.irb.hr

• Štefulj, J., Perić, M., Malnar, M., Košiček, M., Schweinzer, C., Živković, J., Scholler, M., Panzenboeck, U. & Hećimović, S. (2013) Pharmacological activation of LXRs decreases amyloid-β levels in Niemann-Pick type C model cells. Current pharmaceutical biotechnology, 14 (6), 582-593.

• von Einem, B., Weber, P., Wagner, M., Malnar, M., Košiček, M., Hećimović, S., von Arnim, C. & Schneckenburger, H. (2012) Cholesterol dependent energy transfer between fluorescent proteins - insights into protein proximity of APP and BACE1 in different membranes in Niemann-Pick type C disease cells. International journal of molecular sciences, 13 (12), 15801-15812 doi:10.3390/ijms131215801.

  doidoi.orgfulir.irb.hr

• Košiček, M., Zetterberg, H., Andreasen, N., Peter-Katalinić, J. & Hećimović, S. (2012) Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer’s disease. Neuroscience letters, 516 (2), 302-305 doi:10.1016/j.neulet.2012.04.019.

  doi

• Mattsson, N., Olsson, M., Gustavsson, M., Košiček, M., Malnar, M., Månsson, J., Blomqvist, M., Gobom, J., Andreasson, U., Brinkmalm, G., Vite, C., Hećimović, S., Hastings, C., Blennow, K., Zetterberg, H. & Portelius, E. (2012) Amyloid-β metabolism in Niemann-Pick C disease models and patients. Metabolic brain disease, 27 (4), 573-585 doi:10.1007/s11011-012-9332-8.

  doi

• Malnar, M., Košiček, M., Lisica, A., Posavec, M., Krolo, A., Njavro, J., Omerbašić, D., Tahirović, S. & Hećimović, S. (2012) Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells. Biochimica et biophysica acta-molecular basis of disease, 1822 (8), 1270-1283 doi:10.1016/j.bbadis.2012.04.002.

  doi

• Malnar, M., Košiček, M., Bene, R., Petek Tarnik, I., Pavelin, S., Babić, I., Brajenović-Milić, B., Hećimović, H., Titlić, M., Trkanjec, Z., Demarin, V. & Hećimović, S. (2012) Use of cerebrospinal fluid biomarker analysis and apolipoprotein E genotyping for improving Alzheimer’s disease diagnosis in a non-specialized setting. Acta neurobiologiae experimentalis, 72 (3), 264-271.

• Ringman, J., Gylys, K., Medina, L., Fox, M., Kepe, V., Flores, D., Apostolova, L., Barrio, J., Small, G., Silverman, D., Siu, E., Cederbaum, S., Hećimović, S., Malnar, M., Chakravertyg, S., Goate, A., Bird, T. & Leverenz, J. (2011) Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation. Neuroscience letters, 487 (3), 287-292 doi:10.1016/j.neulet.2010.10.039.

  doi

• Košiček, M., Kirsch, S., Bene, R., Trkanjec, Z., Titlić, M., Bindila, L., Peter-Katalinić, J. & Hećimović, S. (2010) Nano-HPLC-MS analysis of phospholipids in cerebrospinal fluid of Alzheimer’s disease patients–a pilot study. Analytical and bioanalytical chemistry, 398 (7/8), 2929-2937 doi:10.1007/s00216-010-4273-8.

  doi

• Košiček, M., Malnar, M., Goate, A. & Katušić Hećimović, S. (2010) Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts. Biochemical and biophysical research communications, 393 (3), 404-409 doi:10.1016/j.bbrc.2010.02.007.

  doi

• Malnar, M., Košiček, M., Mitterreiter, S., Omerbašić, D., Lichtenthaler, S., Goate, A. & Hećimović Katušić, S. (2010) Niemann Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the β-secretase pathway. Biochimica et biophysica acta : molecular basis of disease, 1802 (7-8), 682-691 doi:10.1016/j.bbadis.2010.05.006.

  doi

• Malnar, M., Košiček, M. & Hećimović, S. (2009) Alzheimer's disease: from molecular mechanism to early diagnosis. Medicina : glasilo Hrvatskoga liječničkoga zbora, Podružnica Rijeka, 45 (3), 234-243.

  hrcak.srce.hr

• Hećimović, S., Malnar, M., Košiček, M., Petek Karnik, I., Trkanjec, Z., Titlić, M., Demarin, V. & Goate, A. (2008) Amyloid-beta - from molecular biology to clinical practice. Neurologia Croatica supplement, 57 (Suppl 4), 16-17.

• Đokić, H., Barišić, I., Čulić, V., Lozić, B. & Hećimović, S. (2008) Haplotype and AGG Interspersion Analysis of the FMR1 Alleles in Croatian Population: no founder effect detected in patients with fragile X syndrome. Human biology, 80 (5), 581-587. (https://www.bib.irb.hr/396966).

• Klepac, N., Relja, M., Klepac, R., Hećimović, S., Babić, T. & Trkulja, V. (2007) Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington’ s disease gene carriers and healthy subjects. Journal of Neurology, 254 (12), 1676-1683 doi:10.1007/s00415-007-0611-y.

  doi

• Song, H., Hećimović, S., Goate, A., Hsu, F., Bao, S., Vidavsky, I., Ramanadham, S. & Turk, J. (2004) Characterization of N-terminal processing of group VIA phospholipase A2 and of potential cleavage sites of amyloid precursor protein constructs by automated identification of signature peptides in LC/MS/MS analyses of proteolytic digests. Journal of the American Society for Mass Spectrometry, 15, 1780-1793.

• Hećimović, S., Wang, J., Martinez, M. & Goate, A. (2004) Mutations in APP have independent effects on Abeta and CTFgamma generation. Neurobiology of disease, 17, 205-218 doi:10.1016/j.nbd.2004.04.018.

  doi

• Cam, J., Zerbinatti, C., Knisley, J., Hećimović, S., Yonghe, L. & Bu, G. (2004) The LDL receptor-related protein 1B retains APP at the cell surface and reduces amyloid-beta peptide production. The Journal of biological chemistry, 279, 29639-29646.

• Wang, J., Brunkan, A., Hećimović, S., Walker, E. & Goate, A. (2004) Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complex. Neurobiology of disease, 15, 654-666.

• Schroeter, E., Ilagan, M., Brunkan, A., Hećimović, S., Li, Y., Xu, M., Lewis, H., Saxena, M., De Strooper, B., Coonrod, A., Tomita, T., Iwatsubo, T., Moore, C., Shearman, M., Goate, A., Wolfe, M. & Kopan, R. (2003) A presenilin dimer at the core of the gamma-secretase enzyme : insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America, 100 (22), 13075-13080 doi:10.1073/pnas.1735338100.

  doi

• Barišić, I., Petković, I. & Hećimović, S. (2003) Evaluation of the genetic causes of mental retardation. Liječnički Vjesnik, 125 (3-4), 71-77.

• Petković, I., Barišić, I., Bastić, M., Hećimović, S. & Bago, R. (2003) Paternal origin of der(X)t(X;6) in a girl with trisomy 6p and unbalanced t(6;10) mosaicism in her mother. American journal of medical genetics. Part A, 120A (2), 266-271 doi:10.1002/ajmg.a.20017.

  doi

• Hećimović, S., Klepac, N., Vlašić, J., Vojta, A., Janko, D., Škarpa- Prpić, I., Canki-Klain, N., Marković, D., Božikov, J., Relja, M. & Pavelić, K. (2002) Genetic background of Huntington disease in Croatia: molecular analysis of CAG, CCG, and delta 642 (E2642del)polymorphisms. Human mutation, 20 (3), 233-241 doi:10.1002/humu.9055.

  doi

• Hećimović, S., Bago, R., Mužinić, D., Begović, D. & Pavelić, K. (2002) The first case of the FRAXE form of inherited mental retardation in Croatia. European Journal of Pediatrics, 161 (2), 112-113.

• Hećimović, S., Petek Tarnik, I., Barić, I., Čakarun, Ž. & Pavelić, K. (2002) Screening for fragile X syndrome: results from a school for mentally retarded children. Acta Paediatrica, 91 (5), 535-539.

• Hećimović, S., Vlašić, J., Barišić, I., Marković, D., Čulić, V. & Pavelić, K. (2001) A simple and rapid analysis of triplet repeat diseases by Expand Long PCR. Clinical Chemistry and Laboratory Medicine, 39 (12), 1259-1262.

• Tanacković, G., Barišić, I., Gjergja-Matejić, R., Hećimović, S. & Pavelić, J. (2000) the incidence of cystic fibrosis (CF) mutations among patients from Croatia. Clinical Genetics, 58 (4), 333-335.

• Barišić, I., Marušić–Dellamarina, B., Hećimović, S., Lujić, L. & Gjergja-Matejić, R. (1999) Ethics in clinical practice - before and today. Paediatria Croatica, 43 (1).

• Barišić, I., Marušić-Della Marina, B., Hećimović, S., Lujić, L. & Gjergja-Matejić, R. (1999) Epilepsy and EEG findings in patients with FMR1 gene mutation. Paediatria Croatica, 43 (3), 105-110.

• Hećimović, S., Barišić, I., Marković, D., Škarpa, I., Relja, M. & Pavelić, K. (1998) Trinucleotide Repeat Diseases - DNA molecular analysis using a simple Expand Long PCR assay. Periodicum Biologorum, 100 (3), 353-360.

• Hećimović, S., Barišić, I. & Pavelić, K. (1998) DNA analysis of the fragile X syndrome in an at risk pediatric population in Croatia: simple clinical preselection criteria can considerably improve the cost-effectiveness of fragile X screening studies. Human Heredity, 48 (5), 256-265.

• Hećimović, S., Barišić, I., Mueller, A., Petković, I., Barić, I., Ligutić, I. & Pavelić, K. (1997) Expand long PCR for fragile X mutation detection. Clinical genetics, 52 (3), 147-154.

• Reljić, R., Ries, M., Katušić, S. & Ries, B. (1991) Comparative studies of some substituted anilines as alternative hydrogen donors in peroxidase reaction. Periodicum biologorum. Supplement, 93, 27-30.

Conference proceedings papers

Scientific conference proceedings papers

• Hećimović, S. (2007) Fragile X syndrome – from genotype to phenotype. U: Suvremene spoznje u dijagnostici i liječenju genetičkih bolesti - mentalna retardacija i razvojno zaostajanje.

Theses

Doctoral dissertation

• Hećimović, S. (2000) 'DEVELOPMENT OF THE METHOD FOR SIMPLE AND RAPID DYNAMIC MUTATION ANALYSIS IN THE FRAGILE X SYNDROME', doktorska disertacija, Prehrambeno-biotehnološki fakultet, Zagreb.

• Croatian Society of Biochemistry and Molecular Biology
• Croatian Society for Alzheimer's Disease
• Croatian Society of Human Genetics
• Croatian Society of Clinical Genetics