The goal of the Laboratory for Neurodegenerative Disease Research (LAND) is to discover fundamental mechanisms of neurodegenerative diseases and to translate new understandings into prevention, diagnosis and treatments. The Laboratory combines independent and collaborative research on molecular and cellular neuroscience, the use of different in vitro, ex vivo and in vivo models and the biomarker research.
The Laboratory for Neurodegenerative Disease Research aims towards competitive and internationally recognized research, continuous training of the researchers and intensive national and international collaboration.
The main research areas of the Laboratory are:
- Molecular mechanism(s) of Alzheimer’s disease, in particular the role of lipids in the disease pathogenesis
- Molecular mechanism(s) of neurodegeneration in a rare inherited Niemann-Pick type C disease
- The role of lysosomal dysfunction and altered vesicular trafficking in the pathogenesis of neurodegenerative disorders
- Lipid biomarkers of neurodegenerative diseases
- The role of trefoil factor family protein (Tff3) in metabolism and neurodegeneration