26.05.2020. habilitated, University of Lübeck, Germany

2004 - 2009. doctoral study, Faculty of Science, University of Zagreb - PhD in biology

1996 - 2003. postgraduate study, Faculty of Food technology and Biotechnology, University of Zagreb

Scientific training and work at international institutions:

2016-2019. Research scientist, Institute of Pathology, University Medical Center Schleswig-Holstein (UKSH), Lübeck, Germany

2013-2019. Research scientist, University Hospital Cologne, Cologne, Germany

2012-2013. Guest scientist, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany

2011. Collaborator on NATO project, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany

2003. IAESTE Scientific trainee, Institute of Pharmaceutical Science, King's College London, University of London, London, United Kingdom

2018 - 2019. "The role of CDK8 and CDK19 Mediator complex subunits in progression and metastasis of lung adenocarcinoma" - University of Lübeck, Germany, principal investigator

The Željko Trgovčević Award for 2011

2022. Lecturer at the University Postgraduate Interdisciplinary Doctoral Study of Molecular biosciences, collaboration between Josip Juraj Strossmayer University of Osijek, University of Dubrovnik and RBI 

Ac. year 2005 / 2006: Teaching assistant, course "Molecular Genetics", Division of Biology, Faculty of Science, University of Zagreb

Ac. year 2003 / 2004: Teaching assistant, course "Analytical Chemistry", Department of Chemistry and Biochemistry, Faculty of Food technology and Biotechnology, University of Zagreb

Horvat A*, Tadijan A*, Vlašić I*, Slade N. p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies. Cancers (Basel). 2021; 13(12):2885. 

Sadžak A*, Vlašić I*, Kiralj Z, Batarelo M, Oršolić N, Jazvinšćak Jembrek M, Kušen I, Šegota S. Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. Molecules. 2021;26(4):845. 

Tadijan A, Precazzini F, Hanžić N, Radić M, Gavioli N, Vlašić I, Ozretić P, Pinto L, Škreblin L, Barban G, Slade N, Ciribilli Y. Altered Expression of Shorter p53 Family Isoforms Can Impact Melanoma Aggressiveness. Cancers (Basel). 2021;13(20):5231. 

Kirfel J, Kümpers CC, Fähnrich A, Heidel C, Jokic M, Vlasic I, Marwitz S, Goldmann T, Pasternack H, Bohnet S, Jonigk D, Kühnel MP, Offermann A, Busch H, Perner S. PD-L1 Dependent Immunogenic Landscape in Hot Lung Adenocarcinomas Identified by Transcriptome Analysis. Cancers (Basel). 2021;13(18):4562.

Meder L, Schuldt P, Thelen M, Schmitt A, Dietlein F, Klein S, Borchmann S, Wennhold K, Vlasic I, Oberbeck S, Riedel R, Florin A, Golfmann K, Schlößer HA, Odenthal M, Buettner R, Wolf J, Hallek M, Herling M, von Bergwelt-Baildon M, Reinhardt HC, Ullrich RT. Combined VEGF and PD-L1 Blockade Displays Synergistic Treatment Effects in an Autochthonous Mouse Model of Small Cell Lung Cancer. Cancer Res. 2018; 78(15):4270-4281.

Offermann A*, Vlasic I*, Syring I, Vogel W, Ruiz C, Zellweger T, Rentsch CA, Hagedorn S, Behrends J, Nowak M, Merseburger A, Bubendorf L, Kirfel J, Duensing S, Shaikhibrahim Z, Perner S. MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling. Oncotarget. 2017; 8(5):7964-7976.

Brägelmann J, Klümper N, Offermann A, von Mässenhausen A, Böhm D, Deng M, Queisser A, Sanders C, Syring I, Merseburger AS, Vogel W, Sievers E, Vlasic I, Carlsson J, Andrén O, Brossart P, Duensing S, Svensson MA, Shaikhibrahim Z, Kirfel J, Perner S. Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer. Clin Cancer Res. 2017; 23(7):1829-1840. 

Jokić M*, Vlašić I*, Rinneburger M*, Klümper N, Spiro J, Vogel W, Offermann A, Kümpers C, Fritz C, Schmitt A, Riabinska A, Wittersheim M, Michels S, Ozretić L, Florin A, Welcker D, Akyuz MD, Nowak M, Erkel M, Wolf J, Büttner R, Schumacher B, Thomale J, Persigehl T, Maintz D, Perner S, Reinhardt HC. Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner. Mol Cancer Res. 2016; 14(11):1110-1123.

Vlašić I, Mertens R, Seco EM, Carrasco B, Ayora S, Reitz G, Commichau FM, Alonso JC, Moeller R. Bacillus subtilis RecA and its accessory factors, RecF, RecO, RecR and RecX, are required for spore resistance to DNA double-strand break. Nucleic Acids Res. 2014; 42(4):2295-2307. 

George J, Lim JS, Jang SJ, Cun Y, Ozretić L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park K, Yang D, Karnezis A, Vaka D, Torres A, Wang M S, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer B, Bos M, Michels S, Vlašić I,  Seidel D, Pinther B, Schaub P, Becker C, Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vélez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansén S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK. Comprehensive genomic profiles of small cell lung cancer. Nature. 2015; 524(7563): 47-53.

Journal articles

Scientific and review papers

• Vlašić, I., Horvat, A., Tadijan, A. & Slade, N. (2023) p53 Family in Resistance to Targeted Therapy of Melanoma. International Journal of Molecular Sciences, 24 (1), 1-16 doi:10.3390/ijms24010065.

  doi

• Tadijan, A., Vlašić, I., Vlainić, J., Đikić, D., Oršolić, N. & Jazvinšćak Jembrek, M. (2022) Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions. Antioxidants, 11 (10), 2049, 36 doi:10.3390/antiox11102049.

  doiwww.mdpi.com

• Radić, M., Vlašić, I., Jazvinšćak Jembrek, M., Horvat, A., Tadijan, A., Sabol, M., Dužević, M., Herak Bosnar, M. & Slade, N. (2022) Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance. International journal of molecular sciences, 23 (17), 9910, 19 doi:10.3390/ijms23179910.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Kirfel, J., Charlotte Kümpers, C., Fähnrich, A., Heidel, C., Jokić, M., Vlašić, I., Marwitz, S., Goldmann, T., Pasternack, H., Bohnet, S., Jonigk, D., Kühnel, M., Offermann, A., Busch, H. & Perner, S. (2021) PD-L1 Dependent Immunogenic Landscape in Hot Lung Adenocarcinomas Identified by Transcriptome Analysis. Cancers, 13 (18), 4562, 16 doi:10.3390/cancers13184562.

  doifulir.irb.hrwww.mdpi.com

• Tadijan, A., Precazzini, F., Hanžić, N., Radić, M., Gavioli, N., Vlašić, I., Ozretić, P., Pinto, L., Škreblin, L., Barban, G., Slade, N. & Ciribilli, Y. (2021) Altered Expression of Shorter p53 Family Isoforms Can Impact Melanoma Aggressiveness. Cancers, 13 (20), 5231, 25 doi:10.3390/cancers13205231.

  doiwww.mdpi.comfulir.irb.hr

• Horvat, A., Tadijan, A., Vlašić, I. & Slade, N. (2021) p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies. Cancers, 13 (12), 2885, 42 doi:10.3390/cancers13122885.

  doiwww.mdpi.comwww.ncbi.nlm.nih.govfulir.irb.hr

• Sadžak, A., Vlašić, I., Kiralj, Z., Batarelo, M., Oršolić, N., Jazvinšćak Jembrek, M., Kušen, I. & Šegota, S. (2021) Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. Molecules, 26 (4), 845, 28 doi:10.3390/molecules26040845.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Meder, L., Schuldt, P., Thelen, M., Schmitt, A., Dietlein, F., Klein, S., Borchmann, S., Wennhold, K., Vlasic, I., Oberbeck, S., Riedel, R., Florin, A., Golfmann, K., Schlößer, H., Odenthal, M., Buettner, R., Wolf, J., Hallek, M., Herling, M., Bergwelt-Baildon, M., Reinhardt, H. & Ullrich, T. (2018) Combined VEGF and PD-L1 Blockade Displays Synergistic Treatment Effects in an Autochthonous Mouse Model of Small Cell Lung Cancer. Cancer research (Baltimore), 78 (15), 4270-4281.

• Offermann, A., Vlašić, I., Syring, I., Vogel, W., Ruiz, C., Zellweger, T., Rentsch, C., Hagedorn, S., Behrends, J., Nowak, M., Merseburger, A., Bubendorf, L., Kirfel, J., Duensing, S., Shaikhibrahim, Z. & Perner, S. (2017) MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling. Oncotarget, 8 (5), 7964-7976 doi:10.18632/oncotarget.13860.

  doi

• Brägelmann, J., Klümper, N., Offermann, A., von Mässenhausen, A., Böhm, D., Deng, M., Queisser, A., Sanders, C., Syring, I., S Merseburger, A., Vogel, W., Sievers, E., Vlašić, I., Carlsson, J., Andrén, O., Brossart, P., Duensing, S., A Svensson, M., Shaikhibrahim, Z., Kirfel, J. & Perner, S. (2017) Pan-cancer analysis of the Mediator complex transcriptome identifies CDK19 and CDK8 as therapeutic targets in advanced prostate cancer. Clinical cancer research, 23 (7), 1829-1840 doi:10.1158/1078-0432.CCR-16-0094.

  doi

• Jokić, M., Vlašić, I., Rinneburger, M., Klümper, N., Spiro, J., Vogel, W., Offermann, A., Kümpers, C., Fritz, C., Schmitt, A., Riabinska, A., Wittersheim, M., Michels, S., Ozretić, L., Florin, A., Welcker, D., Akyuz, M., Nowak, M., Erkel, M., Wolf, J., Büttner, R., Schumacher, B., Thomale, J., Persigehl, T., Maintz, D., Perner, S. & Reinhardt, H. (2016) Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a TP53 Context-specific Manner. Molecular cancer research, 14 (11), 1110-1123 doi:10.1158/1541-7786.MCR-16-0094.

  doi

• Šimatović, A., Mitrikeski, P., Vlašić, I., Sopta, M. & Brčić-Kostić, K. (2016) The Walker A motif mutation recA4159 abolishes the SOS response and recombination in a recA730 mutant of Escherichia coli. Research in microbiology, 167 (6), 462-471 doi:10.1016/j.resmic.2016.04.005.

  doi

• George, J., Lim, J., Jang, S., Cun, Y., Ozretić, L., Kong, G., Leenders, F., Lu, X., Fernández-Cuesta, L., Bosco, G., Müller, C., Dahmen, I., Jahchan, N., Park, K., Yang, D., Karnezis, A., Vaka, D., Torres, A., Wang, M., Korbel, J., Menon, R., Chun, S., Kim, D., Wilkerson, M., Hayes, N., Engelmann, D., Pützer, B., Bos, M., Michels, S., Vlašić, I., Seidel, D., Pinther, B., Schaub, P., Becker, C., Altmüller, J., Yokota, J., Kohno, T., Iwakawa, R., Tsuta, K., Noguchi, M., Muley, T., Hoffmann, H., Schnabel, P., Petersen, I., Chen, Y., Soltermann, A., Tischler, V., Choi, C., Kim, Y., Massion, P., Zou, Y., Jovanović, D., Kontić, M., Wright, G., Russell, P., Solomon, B., Koch, I., Lindner, M., Muscarella, L., la Torre, A., Field, J., Jakopović, M., Knežević, J., Castaños-Vélez, E., Roz, L., Pastorino, U., Brustugun, O., Lund-Iversen, M., Thunnissen, E., Köhler, J., Schuler, M., Botling, J., Sandelin, M., Sanchez-Cespedes, M., Salvesen, H., Achter, V., Lang, U., Bogus, M., Schneider, P., Zander, T. & Ansén, S. (2015) Comprehensive genomic profiles of small cell lung cancer. Nature, 524 (7563), 47-53 doi:10.1038/nature14664.

  doi

• Vlašić, I., Mertens, R., Seco, E., Carrasco, B., Ayora, S., Reitz, G., Commichau, F., Alonso, J. & Moeller, R. (2014) Bacillus subtilis RecA and its accessory factors, RecF, RecO, RecR and RecX, are required for spore resistance to DNA double-strand break. Nucleic acids research, 42 (4), 2295-2307 doi:10.1093/nar/gkt1194.

  doifulir.irb.hr

• Vlašić, I. & Brčić-Kostić, K. (2014) Rescuing a sinking ship: The role of recombination gene products in SOS induction in Escherichia coli. Periodicum biologorum, 116 (2), 159-166.

  hrcak.srce.hrfulir.irb.hr

• Vlašić, I., Šimatović, A. & Brčić-Kostić, K. (2012) The hybrid recombinational repair pathway operates in a χ activity deficient recC1004 mutant of Escherichia coli. Biochimie, 94 (9), 1918-1925 doi:10.1016/j.biochi.2012.05.008.

  doi

• Moeller, R., Vlašić, I., Reitz, G. & Nicholson, W. (2012) Role of altered rpoB alleles in Bacillus subtilis sporulation and spore resistance to heat, hydrogen peroxide, formaldehyde, and glutaraldehyde. Archives of microbiology, 194, 759-767 doi:10.1007/s00203-012-0811-4.

  doi

• Vlašić, I., Šimatović, A. & Brčić-Kostić, K. (2011) Genetic Requirements for High Constitutive SOS Expression in recA730 Mutants of Escherichia coli. Journal of bacteriology, 193 (18), 4643-4651 doi:10.1128/JB.00368-11.

  doi

• Vlašić, I., Šimatović, A. & Brčić-Kostić, K. (2011) The recA730 dependent suppression of recombination deficiency in RecA loading mutants of Escherichia coli. Research in microbiology, 162 (3), 262-269 doi:10.1016/j.resmic.2010.12.001.

  doi

• Vlašić, I., Ivančić-Baće, I., Imešek, M., Mihaljević, B. & Brčić-Kostić, K. (2008) RecJ nuclease is required for SOS induction after introduction of a double-strand break in a RecA loading deficient recB mutant of Escherichia coli. Biochimie, 90 (9), 1347-1355 doi:10.1016/j.biochi.2008.04.002.

  doi

• Ivančić-Baće, I., Vlašić, I., Čogelja-Čajo, G., Brčić-Kostić, K. & Salaj-Šmic, E. (2006) Roles of PriA protein and double-strand DNA break repair functions in UV-induced restriction alleviation in Escherichia coli. Genetics, 174 (4), 2137-2149. (https://www.bib.irb.hr/256890).

• Ivančić-Baće, I., Vlašić, I., Salaj-Šmic, E. & Brčić-Kostić, K. (2006) Genetic Evidence for the Requirement of RecA Loading Activity in SOS Induction after UV Irradiation in Escherichia coli. Journal of Bacteriology, 188 (14), 5024-5032.

• Meyer, P., Prodromou, C., Liao, C., Hu, B., Roe, S., Vaughan, K., Vlašić, I., Panaretou, B., Piper, W. & Pearl, H. (2004) Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO journal, 23, 511-519.

Theses

Doctoral dissertation

• Vlašić, I. (2009) 'The role of the products of recombination genes in the formation of the SOS inducing signal in Escherichia coli', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

Croatian Association for Cancer Research (branch of the European Association for Cancer Research)

Croatian Society of Biochemistry and Molecular Biology