Laboratory for Chiral Technologies (LKT)
The Laboratory for Chiral Technologies (LKT) focuses its research and services on the development and application of methods for obtaining optical isomers of chiral molecules. Since molecular chirality is of great importance in many areas of the pharmaceutical, cosmetic, and food industries, the goal of our research efforts is to establish effective protocols for the analysis, synthesis, and separation of desired chiral, optically active molecules.
Our laboratory is currently conducting research in four areas:
1. Preparation of new chiral stationary phases based on small homochiral molecules and polysaccharide derivatives for enantioselective liquid chromatography. The laboratory has many years of experience in this field, know-how in filling HPLC columns, and a pool of more than one hundred different "chiral" HPLC columns.
2. Preparation of chiral selectors for use in polymeric enantioselective membranes. This interdisciplinary research will be conducted with the goal of developing sensor prototypes for the detection of extremely low concentrations of chiral impurities (drugs and their metabolites, pesticides) and for the detection of biomarkers in various diseases and metabolic disorders.
3. Analysis and synthesis of natural compounds from marine organisms. This research focuses on biologically active chiral molecules of secondary metabolites (marine alkaloids, peptides, terpenes) isolated from marine bacteria and microalgae, as well as from higher organisms such as macroalgae, sponges, and tunicates.
4. Biotechnological application of microalgae cultures for the production of optically active chiral synthons. The research includes studies on the application of whole-cell cultures of selected microalgae and conditions for enantioselective reduction of prochiral substrates.
The laboratory is equipped with sophisticated instrumentation that allows scientists and students to work with state-of-the-art equipment. The laboratory proves its contribution to the development of the economy through continuous cooperation with various domestic and foreign companies, through joint projects or contract research.