Project funded by Croatian science foundation (HrZZ): IP-2018-01-4694

Project financed by Croatian science foundation (HrZZ)

The observation of chirality on inorganic nanoparticles (NPs) systems is an interesting and highly important phenomenon which has recently attracted considerable attention and has become a hot topic in nanoscience research.

RBI Project team of five young researchers and postdocs works on scientific research in medicinal chemistry, relevant for the Croatian pharmaceutical industry and Health sector. The enhacement of the leadership, entrapreneurship and research capabilities of young researchers and postdocs will be fullfiled by education on specific workshops. With the aim of establishing connection with the scientists in the European research area, the dissemination of the project results will be accomplished.

Ligands which bind receptors giving stable supramolecular systems are of utmost importance in biotechnology and technological applications. Cucurbituril systems (CB[n], n = 5, 6, 7, 8, 10) have recently been studied as efficient supramolecular receptors for molecular recognition in water. The water environment is a challenge when designing suitable ligands, seeing as they are usually small, hydrophobic organic molecules. The best binding interactions with CB[n] can be accomplished by ligands that combine cationic and hydrophobic subunits in their structure, like for example diamondoid compounds.

Photocages (photochemically cleavable protective groups) have wide spectrum of applications in chemistry, biology and medicine, and therefore, they have been intensively investigated recently. The main goal of this project is the design and synthesis of new photocleveable protective groups. Within the project implementation new aniline photocages with improved properties will be prepared and the photochemical reaction mechanisms of deprotection investigated. A series of carboxylic acid and alcohol derivatives protected with new aniline photocages will be prepared. These compounds are anticipated to react in the photochemical reaction of heterolysis, leading to deprotection.

The aim of this project is to elucidate the physiological roles, and disease relevance of DPP III by determining its interactors through the combined use of different molecular biology approaches

Dynamics of supramolecular systems facilitates control of the photochemical reactivity and opens opportunities for reactions which cannot be conducted by conventional synthetic methods, in the thermal reactions in isotropic solution. The main strategy of the proposed project is to apply different supramolecular systems to control photochemical reactivity.