Synthesis and photochemistry of aniline derivatives for development of new photocages
Photocages (photochemically cleavable protective groups) have wide spectrum of applications in chemistry, biology and medicine, and therefore, they have been intensively investigated recently. The main goal of this project is the design and synthesis of new photocleveable protective groups. Within the project implementation new aniline photocages with improved properties will be prepared and the photochemical reaction mechanisms of deprotection investigated. A series of carboxylic acid and alcohol derivatives protected with new aniline photocages will be prepared. These compounds are anticipated to react in the photochemical reaction of heterolysis, leading to deprotection.
Results from the project are expected to increase fundamental knowledge of photoinduced heterolysis reactions. Furthermore, a new class of photocages with improved properties will be developed, which may be used in different scientific disciplines including chemistry, biology and medicine.