2005     PhD degree, chemistry, Faculty of Natural Sciences and Mathematics, University of Zagreb, thesis: “Structural characteristics of some lipases from bacteria of genus Streptomyces”, mentors: Dr. Biserka Kojić-Prodić, IRB and Dr. Marija Luić, IRB

2001     MSc degree, chemistry, Faculty of Natural Sciences and Mathematics, University of Zagreb

1997     BSc degree, chemistry, Faculty of Natural Sciences and Mathematics, University of Zagreb

Leader of Austrian-Croatian bilateral project “Native mass spectrometry in analysis of transcription factors modus operandi - Interactions of manganese metallosensors with Mn²⁺ and DNA” 2022/23.

Leader of Austrian-Croatian bilateral project “The application of mass spectrometry-based „omics“ technologies to characterize products relevant for biotechnology and agriculture” 2016/17.

Leader of Austrian-Croatian bilateral project “Mass spectrometry-based proteomic analysis: characterization of horseradish esterases and snake venom proteins, and mapping of Fusarium parasites” 2010/11.

Leader of Austrian-Croatian bilateral project “Application of MALDI mass spectrometry in protein and intact cell analysis: characterisation of the novel SGNH-hydrolase family from Streptomyces and mapping of Fusarium parasites” 2008/09.

• Protein-protein interactions of Helicobacter pylori purine salvage pathway enzymes - PPI-HP

  20.12.2025 - 19.12.2028 | 199,927.50 EUR

  CroRISIRB

• Manganese Metallosensors - MaMes

  01.02.2021 - 31.01.2025 | 127,036.30 EUR

  CroRIS

• Allosteric communication pathways in oligomeric enzymes - ALOKOMP/ALOCOMP

  01.01.2020 - 31.05.2024 | 120,804.30 EUR

  CroRISIRB

• Protein ADP-ribosylation in a model prokaryote Streptomyces coelicolor and human

  15.10.2013 - 14.10.2015 | 1,348,064.28 HRK

  CroRISIRB

Best poster award at 1st South Eastern European Workshop on Practical Approaches to Computational Biology, Opatija (Croatia), 2005.

University of Zagreb scholarship 1996/97.

2008/9 – assistant – Molecular biophysics (Graduate study of molecular biology, Faculty of Science, University of Zagreb), Prof. Greta Pifat-Mrzljak

2007/8 – assistant – Basis of biochemistry (Undergraduate study of biology, Faculty of Science, University of Zagreb), Prof. Mirna Flögel

2007/8 – assistant – Biochemistry practicum (Graduate study of chemistry, Faculty of Science, University of Zagreb), Prof. Ivana Weygand-Đurašević

Mentor of one PhD and four diploma works 

Original scientific paper

• Jelić Matošević, Zoe; Radman, Katarina; Semenić, Lana; Neves, Rui P.P.; Brajković, Mislav; Crnolatac, Ivo; Bubić, Ante; Bzowska, Agnieszka; Kutrowska, Beata Wielgus; Merunka, Dalibor et al. | The biophysical characterization of the transcription factor MntR from Mycobacterium tuberculosis and its selected mutants // International journal of biological macromolecules, 358 (2026), 151718, 18. doi: 10.1016/j.ijbiomac.2026.151718

  doiwww.sciencedirect.com

• Kolman, Robert Junior; Milčić, Nevena; Leščić Ašler, Ivana; Štefanić, Zoran; Švaco, Petra; Stepanić, Višnja; Brkljača, Zlatko; Dokli, Irena; Findrik Blažević, Zvjezdana; Majerić Elenkov, Maja | Biocatalytic synthesis of fluorine-containing chiral azido compounds in a two-phase system // Tetrahedron letters, 178 (2026), 155982, 6. doi: 10.1016/j.tetlet.2026.155982

  doi

• Radman, Katarina; Crnolatac, Ivo; Bregović, Nikola; Jelić Matošević, Zoe; Fernandes, Pedro A.; Merunka, Dalibor; Žilić, Dijana; Piantanida, Ivo; Leščić Ašler, Ivana; Bertoša, Branimir | Conformational change induced by binding of Mn2+ ions activates SloR transcription factor in Streptococcus mutans // International journal of biological macromolecules, 290 (2025), 138828, 11. doi: 10.1016/j.ijbiomac.2024.138828

  doiwww.sciencedirect.comfulir.irb.hr

• Leščić Ašler, Ivana; Radman, Katarina; Jelić Matošević, Zoe; Bertoša, Branimir; Weiss, Victor U.; Marchetti-Deschmann, Martina | Exploring the manganese-dependent interaction between a transcription factor and its corresponding DNA: insights from gas-phase electrophoresis on a nES GEMMA instrument // Analytical & bioanalytical chemistry, 416 (2024), 24; 5377-5386. doi: 10.1007/s00216-024-05473-9

  doilink.springer.comfulir.irb.hr

• Wojtyś, Marta Ilona; Maksymiuk, Weronika; Narczyk, Marta; Bubić, Ante; Leščić Ašler, Ivana; Krzyżek, Paweł; Gościniak, Grażyna; Jagusztyn-Krynicka, Elżbieta Katarzyna; Bzowska, Agnieszka | Vitamin B6 inhibits activity of Helicobacter pylori adenylosuccinate synthetase and growth of reference and clinical, antibiotic-resistant H. pylori strains // Journal of enzyme inhibition and medicinal chemistry, 39 (2024), 1; 2372734, 16. doi: 10.1080/14756366.2024.2372734

  doifulir.irb.hr

• Mišković, Marija Zora; Wojtyś, Marta; Winiewska-Szajewska, Maria; Wielgus-Kutrowska, Beata; Matković, Marija; Domazet Jurašin, Darija; Štefanić, Zoran; Bzowska, Agnieszka; Leščić Ašler, Ivana | Location Is Everything: Influence of His-Tag Fusion Site on Properties of Adenylosuccinate Synthetase from Helicobacter pylori // International journal of molecular sciences, 25 (2024), 14; 7613, 20. doi: 10.3390/ijms25147613

  doiwww.mdpi.comfulir.irb.hr

• Radman, Katarina; Jelić Matošević, Zoe; Žilić, Dijana; Crnolatac, Ivo; Bregović, Nikola; Ilakovac Kveder, Marina; Piantanida, Ivo; Fernandes, Pedro A.; Leščić Ašler, Ivana; Bertoša, Branimir | Structural and dynamical changes of the Streptococcus gordonii metalloregulatory ScaR protein induced by Mn2+ ion binding // International journal of biological macromolecules, 253 (Part 8) (2023), 127572, 12. doi: 10.1016/j.ijbiomac.2023.127572

  doiwww.sciencedirect.comfulir.irb.hr

• Jelić Matošević, Zoe ; Radman, Katarina ; Loubser, Jolene ; Crnolatac, Ivo ; Piantanida, Ivo ; Cukrowski, Ignacy ; Leščić Ašler, Ivana ; Bertoša, Branimir | Structural Dynamics of the Bacillus subtilis MntR Transcription Factor Is Locked by Mn2+ Binding // International journal of molecular sciences, 24 (2023), 2; 957, 21. doi: 10.3390/ijms24020957

  doidoi.orgwww.mdpi.comfulir.irb.hr

• Bubić, Ante ; Narczyk, Marta ; Petek, Ana ; Wojtyś, Marta Ilona ; Maksymiuk, Weronika ; Wielgus-Kutrowska, Beata ; Winiewska-Szajewska, Maria ; Pavkov-Keller, Tea ; Bertoša, Branimir ; Štefanić, Zoran et al. | The pursuit of new alternative ways to eradicate Helicobacter pylori continues: Detailed characterization of interactions in the adenylosuccinate synthetase active site // International journal of biological macromolecules, 226 (2023), 37-50. doi: 10.1016/j.ijbiomac.2022.12.001

  doiwww.sciencedirect.comfulir.irb.hr

• Narczyk, Marta ; Wojtyś, Marta Ilona ; Leščić Ašler, Ivana ; Žinić, Biserka ; Luić, Marija ; Jagusztyn-Krynicka, Elżbieta Katarzyna ; Štefanić, Zoran ; Bzowska, Agnieszka | Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium // Journal of enzyme inhibition and medicinal chemistry, 37 (2022), 1; 1083-1097. doi: 10.1080/14756366.2022.2061965

  doiwww.tandfonline.comdoi.orgfulir.irb.hr

• Wojtyś, Marta Ilona ; Jaźwiec, Radosław ; Kazazić, Saša ; Leščić Ašler, Ivana ; Knežević, Petar ; Aleksić Sabo, Verica ; Luić, Marija ; Jagusztyn- Krynicka, Elżbieta Katarzyna ; Bzowska, Agnieszka | A comprehensive method for determining cellular uptake of purine nucleoside phosphorylase and adenylosuccinate synthetase inhibitors by H. pylori // Applied microbiology and biotechnology, 105 (2021), 7949-7967. doi: 10.1007/s00253-021-11510-9

  doilink.springer.comdoi.orgfulir.irb.hr

• Narczyk, Marta ; Bertoša, Branimir ; Papa, Lucija ; Vuković, Vedran ; Leščić Ašler, Ivana ; Wielgus- Kutrowska, Beata ; Bzowska, Agnieszka ; Luić, Marija ; Štefanić, Zoran | Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features // The FEBS journal, 285 (2018), 7; 1305-1325. doi: 10.1111/febs.14403

  doifebs.onlinelibrary.wiley.com

• Bubić, Ante ; Mrnjavac, Natalia ; Stuparević, Igor ; Łyczek, Marta ; Wielgus-Kutrowska, Beata ; Bzowska, Agnieszka ; Luić, Marija ; Leščić Ašler, Ivana | In the quest for new targets for pathogen eradication: the adenylosuccinate synthetase from the bacterium Helicobacter pylori // Journal of enzyme inhibition and medicinal chemistry, 33 (2018), 1; 1405-1414. doi: 10.1080/14756366.2018.1506773

  doiwww.tandfonline.comfulir.irb.hr

• Bošnjaković, Marta; Leščić Ašler, Ivana; Štefanić, Zoran | The Role of Phosphate Binding in Purine Nucleoside Phosphorylase of Helicobacter pylori // Croatica chemica acta, 91 (2018), 2; 171-175. doi: 10.5562/cca3335

  doihrcak.srce.hrhrcak.srce.hrfulir.irb.hr

• Leščić Ašler, Ivana ; Štefanić, Zoran ; Maršavelski, Aleksandra ; Vianello, Robert ; Kojić-Prodić, Biserka | Catalytic Dyad in the SGNH Hydrolase Superfamily: In-depth Insight into Structural Parameters Tuning the Catalytic Process of Extracellular Lipase from Streptomyces rimosus // Acs chemical biology, 12 (2017), 7; 1928-1936. doi: 10.1021/acschembio.6b01140

  doipubs.acs.org

• Štefanić, Zoran ; Mikleušević, Goran ; Luić, Marija ; Bzowska, Agnieszka ; Leščić Ašler, Ivana | Structural characterization of purine nucleoside phosphorylase from human pathogen Helicobacter pylori // International journal of biological macromolecules, 101 (2017), 518-526. doi: 10.1016/j.ijbiomac.2017.03.101

  doiwww.sciencedirect.comdoi.org

• Leščić Ašler, Ivana ; Peharec Štefanić, Petra ; Balen, Biljana ; Allmaier, Günter ; Marchetti- Deschmann, Martina ; Kojić-Prodić, Biserka | Horseradish esterases: detection, purification and identification // Plant cell, tissue and organ culture, 130 (2017), 1; 13-24. doi: 10.1007/s11240-017-1200-0

  doilink.springer.com

• Bertoša, Branimir ; Mikleušević, Goran ; Wielgus-Kutrowska, Beata ; Narczyk, Marta ; Hajnić, Matea ; Leščić Ašler, Ivana ; Tomić, Sanja ; Luić, Marija ; Bzowska, Agnieszka | Homooligomerization is needed for stability: a molecular modelling and solution study of E. coli purine nucleoside phosphorylase // The FEBS journal, 281 (2014), 7; 1860-1871. doi: 10.1111/febs.12746

  doi

• Leščić Ašler, Ivana ; Kovačić, Filip ; Marchetti-Deschmann, Martina ; Allmaier, Günter ; Štefanić, Zoran ; Kojić-Prodić, Biserka | Inhibition of extracellular lipase from Streptomyces rimosus with 3, 4-dichloroisocoumarin // Journal of enzyme inhibition and medicinal chemistry, 28 (2013), 5; 1094-1104. doi: 10.3109/14756366.2012.716834

  doiwww.pubfacts.com

• Leščić Ašler, Ivana ; Pigac, Jasenka ; Vujaklija, Dušica ; Luić, Marija ; Štefanić, Zoran | Crystallization and preliminary X-ray diffraction studies of a complex of extracellular lipase from Streptomyces rimosus with the inhibitor 3, 4- dichloroisocoumarin // Acta crystallographica. Section F, Structural biology and crystallization communications, 67 (2011), 11; 1378-1381. doi: 10.1107/S1744309111032222

  doijournals.iucr.orgonlinelibrary.wiley.comdoi.org

• Leščić Ašler, Ivana ; Ivić, Nives ; Kovačić, Filip ; Schell, Sabrina ; Knorr, Janina ; Krauss, Ulrich ; Wilhelm, Susanne ; Kojić-Prodić, Biserka ; Jaeger, Karl-Erich | Probing Enzyme Promiscuity of SGNH Hydrolases // ChemBioChem : a European journal of chemical biology, 11 (2010), 15; 2158-2167. doi: 10.1002/cbic.201000398

  doionlinelibrary.wiley.com

• Luić, Marija ; Štefanić, Zoran ; Ceilinger, Igor ; Hodošček, Milan ; Janežić, Dušanka ; Lenac, Tihana ; Leščić Ašler, Ivana ; Šepac, Dragan ; Tomić, Sanja | Combined X-Ray Diffraction and QM/MM Study of the Burkholderia cepacia Lipase-Catalyzed Secondary Alcohol Esterification // The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical, 112 (2008), 16; 4876-4883. doi: 10.1021/jp077717u

  doipubs.acs.org

• Leščić Ašler, Ivana ; Zehl, Martin ; Kovačić, Filip ; Müller, Roland ; Abramić, Marija ; Allmaier, Günter ; Kojić-Prodić, Biserka | Mass spectrometric evidence of covalently-bound tetrahydrolipstatin at the catalytic serine of Streptomyces rimosus lipase // Biochimica et biophysica acta. G, General subjects, 1770 (2007), 2; 163-170-x

  dx.doi.org

• Zehl, Martin ; Leščić, Ivana ; Abramić, Marija ; Rizzi, Andreas ; Kojić-Prodić, Biserka ; Allmaier, Günter | Characterization of covalently inhibited extracellular lipase from Streptomyces rimosus by matrix-assisted laser desorption/ionization time-of-flight and matrix-assisted laser desorption/ionization quadrupole ion trap reflectron time-of-flight mass spect // Journal of mass spectrometry, 39 (2004), 12; 1474-1483. doi: 10.1002/jms.750

  doionlinelibrary.wiley.comdoi.org

• Leščić, Ivana ; Zehl, Martin ; Müller, Roland ; Vukelić, Bojana ; Abramić, Marija ; Pigac, Jasenka ; Allmaier, Günter ; Kojić-Prodić, Biserka | Structural characterization of extracellular lipase from Streptomyces rimosus: Assignment of disulfide bridges pattern by mass spectrometry // Biological chemistry, 385 (2004), 12; 1147-1156-x

• Vujaklija, Dušica ; Abramić, Marija ; Leščić, Ivana ; Maršić, Tereza ; Pigac, Jasenka. | Streptomyces rimosus GDS(L) lipase: production, heterologous overexpression and structure-stability relationship // Food technology and biotechnology, 41 (2003), 1; 89-94-x

• Vujaklija, Dušica ; Schroeder, Werner ; Abramić, Marija ; Zou, Peijian ; Leščić, Ivana ; Franke, Peter ; Pigac, Jasenka | A novel streptomycete lipase: cloning, sequencing and high-level expression of the Streptomyces rimosus GDS(L)-lipase gene // Archives of microbiology, 178 (2002), 2; 124-130-x

• Luić, Marija ; Tomić, Sanja ; Leščić, Ivana ; Ljubović, Edina ; Šepac, Dragan ; Šunjić, Vitomir ; Vitale, Ljubinka ; Saenger, Wolfram ; Kojić-Prodić, Biserka | Complex of Burkholderia cepacia lipase with transition state analogue of 1-phenoxy-2-acetoxybutane, Biocatalytic, structural and modelling study. // European journal of biochemistry, 268 (2001), 14; 3964-3973-x

• Leščić, Ivana ; Vukelić, Bojana ; Majerić-Elenkov, Maja ; Saenger, Wolfram ; Abramić, Marija | Substrate specifity and effects of water-miscible solvents on the activity and stability of extracellular lipase from Streptomyces rimosus // Enzyme and microbial technology, 29 (2001), 548-553-x

• Abramić, Marija ; Leščić, Ivana ; Korica, Tamara ; Vitale, Ljubinka ; Saenger, Wolfram ; Pigac, Jasenka | Purification and properties of extracellular lipase from Streptomyces rimosus // Enzyme and microbial technology, 25 (1999), 6; 522-529-x

Short communication

• Luić, Marija ; Papa, Lucija ; Štefanić, Zoran ; Leščić Ašler, Ivana ; Knežević, Petar ; Bzowska, Agnieszka | H. pylori purine nucleoside phosphorylase: catalytic features and three-dimensional structure // Acta crystallographica. Section A, Foundations and advances, 73 (2017), a2; C160-C160. doi: 10.1107/s205327331709413x

  doijournals.iucr.org

Editorial

• Leščić Ašler, Ivana | Special Issue “Mechanism of Enzyme Catalysis: When Structure Meets Function” // International journal of molecular sciences, 27 (2026), 4; 1887, 3. doi: 10.3390/ijms27041887

  doiwww.mdpi.comwww.mdpi.comfulir.irb.hrfulir.irb.hr

Conference abstract

• Radetić, Ivana; Crnolatac, Ivo; Leščić Ašler, Ivana | In search of new treatments against Helicobacter pylori: characterization of adenylosuccinate lyase // HDBMB2026 Congress: Uniting Scientists - Book of Abstracts / Stuparević, Igor; Sinčić, Nino; Martinić Cezar, Tea et al. (ur.). | Zagreb: The Croatian Society of Biochemistry and Molecular Biology, 2026, 26, 1

  hdbmb.hr

• Franov, Silvia - Maria; Crnolatac,Ivo; Merunka,Dalibor; Piantanida,Ivo; Žilić,Dijana; Leščić-Ašler,Ivana; Bertoša,Branimir | Metal-Driven Allosteric Regulation of the MtsR Metalloregulator: Mechanistic Insights into Activation and DNA Binding // Computational Chemistry Day 2026 : Book of Abstracts / Babić, Darko (ur.). | Zagreb: Institut Ruđer Bošković, 2026. str. 34-34

• Franov, Silvia - Maria; Crnolatac,Ivo; Merunka,Dalibor; Piantanida,Ivo; Žilić,Dijana; Leščić-Ašler,Ivana; Bertoša,Branimir | Structural and dynamical changes of the Streptococcus pyogenes transcriptional regulator MtsR induced by Mn²⁺ binding // RBC2026 Regional Biophysics Conference 2026 Book of Abstracts / Radotić Hadži-Manić, Ksenija; Mojović, Miloš (ur.). | Beograd: Srpska akademija nauka i umetnosti, 2026. str. 21-21

• Leščić Ašler, Ivana; Radman, Katarina; Bertoša, Branimir | Exploring the interactions of manganese-dependent transcription regulators SloR and ScaR with DNA - an experimental study // FEBS3+ Meeting: Exploring Molecular Frontiers / Dulić, Morana; Sinčić, Nino; Stuparević, Igor (ur.). | Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju, 2024. str. 131-131

• Leščić Ašler, Ivana | Mass Spectrometry Contribution to the Study Of Extracellular Lipase from Bacterium Streptomyces rimosus // 2nd Workshop on Mass Spectrometry in Life Sciences : Book of abstracts / Novak, Ruđer ; Močibob, Marko ; Dulić, Morana et al. (ur.). | Zagreb: University of Zagreb Faculty of Science, 2024. str. 34-34

  repozitorij.pmf.unizg.hr

• Mišković, Marija Zora; Wojtys, Marta; Bzowska, Agnieszka; Štefanić, Zoran; Leščić Ašler, Ivana | Location is everything: Influence of His-tag fusion site on properties of adenylosuccinate synthetase from Helicobacter pylori // Hot Topics in Contemporary Crystallography 6 (HTCC 6) - Advanced macromolecular crystallography workshop: Programme Book / Bjelopetrović, Alen (ur.). | Zagreb: Croatian Association of Crystallographers, 2024. str. 60-60

• Radman, Katarina ; Leščić Ašler, Ivana ; Jelić Matošević, Zoe ; Crnolatac, Ivo ; Piantanida, Ivo ; Bertoša, Branimir | Influence of Mn2+ ion binding on structural changes in metalloregulatory proteins SloR (S. mutans) and ScaR (S. gordonii) // 28th Croatian Meeting of Chemists and Chemical Engineers (28HSKIKI): Book of Abstracts / Rogošić, Marko (ur.). | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023. str. 119-119

  www.hdki.hr

• Leščić Ašler, Ivana ; Jelić Matošević, Zoe ; Radman, Katarina ; Piantanida, Ivo ; Crnolatac, Ivo ; Bertoša, Branimir | Influence of engineered disulfide bridge on properties of metal sensing transcription factor MntR from Bacillus subtilis // HDBMB22 From Science to Knowledge : Book of Abstracts. | Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2022. str. 100-100

  congress2022.hdbmb.hr

• Bertoša, Branmir ; Jelić Matošević, Zoe ; Brajković, Mislav ; Leščić Ašler, Ivana ; Neves, Rui P. P. ; Fernandes, Pedro A. ; Cukrowski, Ignacy | MNTR PROTEINS AS MANGANESE METALLOSENZORS IN BACILUS SUBTILUS AND MYCOBACTERIUM TUBERCULOSIS // EuChems Chemistry Congress. | 2022. str. 536-536

• Bubić, Ante ; Štefanić, Zoran ; Bertoša, Branimir ; Leščić Ašler, Ivana | Adenylosuccinate Synthetase from Helicobacter pylori: Characterization of Active Site Using X- ray Diffraction and Molecular Dynamics Simulations // 27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts. | Zagreb: Hrvatsko kemijsko društvo, 2021. str. 194-194

  27hskiki.hkd.hr

• Bubić, Ante ; Bertoša, Branimir ; Leščić Ašler, Ivana ; Luić, Marija | Experimental and in silico characterization of adenylosuccinate synthetase from patogen Helicobacter pylori // Knjiga sažetaka. | 2019. str. 35-35

• Bubić, Ante ; Bertoša, Branimir ; Lešćić Ašler, Ivana ; Luić, Marija | Computational and experimental characterization of adenylosuccinate synthetase from Helicobacter pylori // 26. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka. | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019. str. 27-27

  www.hdki.hr

• Bubić, Ante ; Leščić Ašler, Ivana ; Bertoša, Branimir ; Luić, Marija | Characterization of adenylosuccinate synthetase from Helicobacter pylori using computational and experimental approach // Simpozij studenata doktorskih studija PMF-a : knjiga sažetaka. | Zagreb, 2019. str. 39-40

  www.pmf.unizg.hr

• Bertoša, Branimir ; Kazizić, Saša ; Mikleušević, Goran ; Štefanić, Zoran ; Narczyk, Marta ; Wielgus- Kutrowska, Beata ; Hajnić, Matea ; Leščić Ašler, Ivana ; Tomić, Sanja ; Tarnowski, Krzysztof et al. | Role of subunit-subunit interactions in the catalysis conducted by hexameric purine nucleoside phosphorylase. | 2015. str. 1-1

• Luić, Marija ; Gucunski, Karolina ; Leščić Ašler, Ivana ; Štefanić, Zoran | Structural investigations of purine nucleoside phosphorylase from Helicobacter pylori II // 29th European Crystallographic Meeting Book of Abstracts. | Zagreb, 2015. str. 204-204

• Štefanić, Zoran ; Leščić Ašler, Ivana ; Mikleušević, Goran ; Luić, Marija | Structural investigations of purine nucleoside phosphorylase from Helicobacter pylori I // 29th European Crystallographic Meeting Book of Abstracts. | Zagreb, 2015. str. 234-x

• Gucunski, Karolina ; Leščić Ašler, Ivana ; Luić, Marija | Purine nucleoside phosphorylase from bacterium Helicobacter pylori strain 26695: Cloning, Expression, Purification, Characterisation and Crystallisation // 29th European Crystallographic Meeting Book of Abstracts. | Zagreb, 2015. str. 214-x

• Leščić Ašler, Ivana ; Štefanić, Zoran ; Luić, Marija ; Kojić-Prodić, Biserka | Crystal structure of Streptomyces rimosus extracellular lipase // 29th European Crystallographic Meeting Book of Abstracts. | Zagreb, 2015. str. 206-x

• Leščić Ašler, Ivana ; Peharec Štefanić, Petra ; Balen, Biljana ; Marchetti-Deschmann, Martina ; Krsnik-Rasol, Marijana ; Kojić-Prodić, Biserka ; Allmaier, Günter | Identification of esterase isoenzymes related to cell differentiation in Armoracia lapathifolia Gilib. tissue culture by gel electrophoresis and mass spectrometry techniques // FEBS 3+ Meeting Book of Abstracts. | Rijeka: Hrvatsko Društvo za Biotehnologiju, 2012. str. 239-x

• Narczyk, Marta ; Wielgus-Kutrowska, Beata ; Mikleušević, Goran ; Leščić Ašler, Ivana ; Luić, Marija ; Bzowska, Agnieszka | Escherichia coli purine nucleoside phosphorylase validation of catalytic mechanism // Tenth International Summer School on Biophysics: Supramolecular Structure and Function, Book of Abstracts. | Zagreb: Institut Ruđer Bošković, 2009. str. 135-135

• Mikleušević, Goran ; Leščić Ašler, Ivana ; Luić, Marija ; Wielgus-Kutrowska, Beata ; Narczyk, Marta ; Bzowska, Agnieszka | Purin nukleozid fosforilaza iz bakterije Escherichia coli: Provjera modela katalitičkog djelovanja // 50 godina molekularne biologije u Hrvatskoj, Zbornik sažetaka. | Zagreb: Institut Ruđer Bošković, 2008. str. 38-38

• Mikleušević, Goran ; Leščić Ašler, Ivana ; Salopek-Sondi, Branka ; Narczyk, Marta ; Luić, Marija ; Bzowska, Agnieszka | How Escherichia coli purine nucleoside phosphorylase active site mutants help in understanding catalytic mechanism // 4th Croatian Congress of Microbiology with International Participation Book of Abstracts. | Zagreb: Hrvatsko mikrobiološko društvo, 2008. str. 67-67

• Peharec, Petra ; Leščić-Ašler, Ivana ; Balen, Biljana ; Kojić-Prodić, Biserka ; Krsnik-Rasol, Marijana | Aktivnost i izoforme esteraze povezane sa staničnom diferencijacijom u kulturi tkiva hrena Armoracia lapathifolia Gilib. // 50 godina molekularne biologije u Hrvatskoj. | Zagreb: Institut Ruđer Bošković, 2008. str. 71-71

• Leščić Ašler, Ivana ; Ivić, Nives, Kojić-Prodić, Biserka | How promiscuous are SGNH-hydrolases? // HDBMB2008 Book of Abstracts. | Osijek: Hrvatsko Društvo za Biotehnologiju, 2008. str. 100-100

• Leščić Ašler, Ivana ; Ivić, Nives ; Kojić-Prodić, Biserka | How promiscuous are SGNH-hydrolases? // 4th Central European Conference Chemistry towards Biology Book of Abstracts. | Budimpešta: Hungarian Chemical Society, 2008. str. 107-107

• Leščić Ašler, Ivana | Bioinformatic analysis of lipases from bacteria of genus Streptomyces // European Biomarkers Summit and Proteomics Europe. | Acton Sudbury, 2007. str. --x

• Leščić Ašler, Ivana ; Zehl, Martin ; Kovačić, Filip ; Abramić, Marija ; Kojić-Prodić, Biserka ; Allmaier, Guenter | Characterization of Streptomyces rimosus lipase complexes with inhibitors by kinetics and mass spectrometry // 2nd Summer Course on Mass Spectrometry in Biotechnology and Medicine Book of Abstracts. | Münster, 2007. str. 62-x

• Zehl, Martin ; Müller, Roland ; Leščić, Ivana ; Abramić, Marija ; Kojić-Prodić, Biserka ; Allmaier, Günter | CGE-on-theChip (Bioanalyzer) and MALDI mass spectrometry: tools for the characterization of Streptomyces lipase-inhibitor complexes // 25th International Symposium & Exhibit on the Separation of Proteins, Peptides & Polynucleotides Book of Abstracts. | 2005

• Leščić Ašler, Ivana | Bioinformatic analysis of lipases from bacteria of genus Streptomyces // 1st South Eastern European Workshop on Practical Approaches to Computational Biology Book of Abstracts. | Zagreb: Institut Ruđer Bošković, 2005. str. 52-x

• Leščić Ašler, Ivana ; Kovačić, Filip ; Kojić-Prodić, Biserka | 3D-Structure features of novel GDSL-enzyme by bioinformatic methods and mass spectrometry // FEBS Journal 272 Suppl. 1. | 2005. str. 110-110-x

• Zehl, Martin ; Leščić, Ivana ; Abramić, Marija ; Rizzi, Andreas ; Kojić-Prodić, Biserka ; Allmaier, Günter | Characterization of an extracellular lipase from Streptomyces rimosus by MALDI-TOF and MALDI-IT/RTOF multistage mass spectrometry: assignment of disulfide bridge pattern and localization of the active site serine // 6. Igler MS Tage book of abstracts. | Innsbruck, 2005

• Vujaklija, Dusica ; Leščić, Ivana ; Abramic, Marija ; Kojić-Prodić, Biserka ; Pigac, Jasenka | STREPTOMYCETES AS PRODUCERS OF LIPOLYTIC ENZYMES. | 2005. str. 173-174-x

• Leščić, Ivana ; Zehl, Martin ; Abramić, Marija ; Allmaier, Günter ; Kojić-Prodić, Biserka | Elements of Streptomyces rimosus extracellular lipase stability : Assignment of disulfide bridges. | Bratislava, 2004

• Leščić, Ivana ; Zehl, Martin ; Abramić, Marija ; Allmaier, Günter ; Kojić-Prodić, Biserka | Elements of Streptomyces rimosus extracellular lipase stability : Assignment of disulfide bridges // Zbornik sažetaka postera znanstvenih novaka, prikazanih u inozemstvu 2002., 2003. i 2004. godine / Prvi kongres hrvatskih znanstvenika iz domovine i inozemstva, Zagreb-Vukovar, 15. -19. studenoga 2004, I. dio: prirodne, tehničke i biotehničke znanosti. | Zagreb, 2004. str. 101-101-x

• Leščić, Ivana ; Kovačić, Filip ; Zehl, Martin ; Abramić, Marija ; Allmaier, Günter ; Luić, Marija ; Kojić-Prodić, Biserka | Inhibition of extracellular lipase from Streptomyces rimosus by three distinctive serine specific agents // 1st Workshop Enzyme Technology and Biocatalysis Book of Abstracts. | Graz, 2004. str. 5-5-x

• Vujaklija, Dušica ; Abramić, Marija ; Kojić-Prodić, Biserka ; Leščić, Ivana ; Jasenka, Pigac | A novel family of bacterial lipases // Third Croatian Congress of Microbiology with International with International Participation. | Zagreb: Hrvatsko mikrobiološko društvo, 2004. str. 147-147

• Leščić, Ivana ; Kovačić, Filip ; Zehl, Martin ; Abramić, Marija ; Allmaier, Günter ; Luić, Marija ; Kojić-Prodić, Biserka | Inhibition of extracellular lipase from Streptomyces rimosus by three distinctive serine specific agents // 2nd Central European Conference Chemistry towards Biology : Book of Abstracts. | Seggau, 2004

• Zehl, Martin ; Leščić, Ivana ; Abramić, Marija ; Kojić-Prodić, Biserka ; Allmaier, Günter | MALDI TOF- and MALDI low energy CID multistage MS-based characterization of an extracellular lipase from Streptomyces rimosus before and after covalent inhibition by 3, 4-dichloroisocoumarin. | Tokaj, 2004

• Pigac, Jasenka ; Abramić, Marija ; Leščić, Ivana ; Kojić-Prodić, Biserka ; Vujaklija, Dušica | The gene encoding for GDS(L) lipase was found in Streptomyces rimosus // 45 GODINA MOLEKULARNE BIOLOGIJE U HRVATSKOJ 50 GODINA DVOSTRUKE UZVOJNICE. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2003. str. 39-39-x

• Vujaklija, Dušica ; Abramić, Marija ; Leščić, Ivana ; Pigac, Jasenka | The third lipolytic-family in Streptomyces, represented by the novel GDS(L) lipase from S. rimosus // Power of microbes in industry and environment. | Zagreb: Prehrambeno-biotehnološki fakultet Sveučilišta u Zagrebu, 2002. str. 16-16-x

• Leščić, Ivana ; Vujaklija, Dušica ; Pigac, Jasenka ; Abramić, Marija | Protein sequence analysis of Streptomyces rimosus extracellular lipase // 1st Croatian Congress on Molecular Life Sciences with International Participation, Book of Abstracts. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2002

• Luić, Marija ; Leščić, Ivana ; Lenac, Tihana ; Kojić-Prodić, Biserka | Molecular basis of enantioselectivity of Burkholderia cepacia lipase toward secondary alcohols // 1st Central European Conference "Chemistry towards Biology", Book of abstracts. | Ljubljana, 2002. str. 96-96-x

• Abramić, Marija ; Leščić, Ivana ; Vujaklija, Dušica ; Pigac, Jasenka | Extracellular lipase from streptomyces rimosus: an unusual bacterial lipolytic enzyme // 1st Central European Conference "Chemistry towards Biology" - Book of Abstracts. | Ljubljana: Slovenian Chemical Society, 2002. str. 38-38-x

• Leščić, Ivana ; Vujaklija, Dušica ; Pigac, Jasenka ; Abramić, Marija | Extracellular lipase from bacterium Streptomyces rimosus: cloning, expression and purification for crystallization // 9th International Conference on the Crystallization of Biological Macromolecules - Book of Abstracts. | Jena, 2002

• Abramić, Marija ; Leščić, Ivana ; Luić, Marija ; Kojić-Prodić, Biserka ; Pigac, Jasenka ; Vujaklija, Duška | A novel type of extracellular lipase from Streptomyces rimosus: isolation, (bio)chemical characterisation, cloning and crystallisation // Applied Biocatalysis. | Zürich: ETH Zurich, 2002. str. 25-25-x

• Tomić, Sanja ; Luić, Marija ; Šepac, Dragan ; Leščić, Ivana ; Ljubović, Edina ; Kojić-Prodić, Biserka ; Šunjić, Vitomir | Molecular modeling of the complex of 1-phenoxy-2- butanol with acetyl -pseudomonas cepacia lipase (PCL), and its p-transition state analog in comparison with the experimental results // Rational approaches to drug design: Proceedings of the 13th European Symposium on Quantitative Structure-Activity Relationships. | Düsseldorf: Prous Science, Barcelona, 2001. str. 69-73

• Leščić, Ivana ; Vukelić, Bojana ; Majerić-Elenkov, Maja ; Abramić, Marija | Substratna specifičnost izvanstanične lipaze bakterije Streptomyces rimosus // Sažeci = Abstracts / XVII. hrvatski skup kemičara i kemijskih inženjera, Osijek, 10.-13. lipnja 2001.. | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo, 2001. str. 108-x

• Leščić, Ivana ; Luić, Marija ; Kojić-Prodić, Biserka | The crystal structure of Pseudomonas cepacia lipase with bound transition state analog // Seventh International Summer School on Biophysics: Supramolecular Structure and Function. | 2000. str. 103-103-x

• Leščić, Ivana ; Vitale, Ljubinka ; Abramić, Marija | Substrate specificity and regioselectivity of extracellular lipase from Streptomyces rimosus. // HB 2000; Kongres hrvatskih biokemičara i molekularnih biologa. Knjiga sažetaka.. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2000. str. 87-87-x

• Luić, Marija ; Leščić, Ivana ; Kojić-Prodić, Biserka | Crystal Structure of the Complex of Pseudomonas Cepacia Lipase with Transition State Analog // Ninth Slovenian-Croatian Crystallographic Meeting : Book of Abstracts and Programme. | Ljubljana: Slovenian crystallographic society ; Croatian crystallographic association, 2000. str. 23-23

• Abramić, Marija ; Kojić-Prodić, Biserka ; Leščić, Ivana ; Luić, Marija ; Ljubović, Edina ; Pigac, Jasenka ; Saenger, Wolfram ; Schröder, Werner ; Šunjić, Vitomir ; Tomić, Sanja et al. | "Structure is function": A contribution to understanding enzymatic activity of bacterial lipases. // Kongres hrvatskih biokemičara i molekularnih biologa, HB 2000. Knjiga sažetaka.. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2000. str. 46-46-x

• Abramić, Marija ; Kojić-Prodić, Biserka ; Leščić, Ivana ; Luić, Marija ; Ljubović, Edina ; Pigac, Jasenka ; Saenger, Wolfram ; Schroeder, Werner ; Šunjić, Vitomir ; Tomić, Sanja et al. | A contribution to understanding of enzymatic activity of bacterial lipases. // Workshop of Challenges in Crystallography of Macromolecular Assemblies. | Trst: Synchrotron Trieste, 2000. str. 24-24-x

• Leščić, Ivana ; Pigac, Jasenka ; Korica, Tamara ; Vitale, Ljubinka ; Abramić, Marija | Extracellular lipase from bacterium Streptomyces rimosus // HB98 - Godišnji sastanak hrvatskih biokemičara. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 1998. str. 63-63-x

Conference abstract

• Leščić Ašler, Ivana; Steinberger, Stephanie; Weiss, Victor U.; Jelić Matošević, Zoe; Radman, Katarina; Bertoša, Branimir | Protein dynamics and DNA binding of native metal-sensing transcription factor MntR from Bacillus subtilis and its D8C/E99C double mutant // FEBS Open Bio, 13, S2, 2023. str. 176-176

• Bubić, Ante ; Petek, Ana ; Štefanić, Zoran ; Leščić Ašler, Ivana | Biochemical characterization of His6-tagged adenylosuccinate synthetase from Helicobacter pylori: first step towards design of new inhibitors // FEBS Open Bio, 12, S1, 2022. str. 235-235

  febs.onlinelibrary.wiley.com

Unpublished conference paper

• Franov, Silvia - Maria; Crnolatac,Ivo; Merunka,Dalibor; Piantanida,Ivo; Žilić,Dijana; Leščić-Ašler,Ivana; Bertoša,Branimir | Metal-Driven Allosteric Regulation of the MtsR Metalloregulator: Mechanistic Insights into Activation and DNA Binding // Computational Chemistry Day 2026 | Zagreb, Hrvatska, 09.05.2026-09.05.2026

• Radman, Katarina; Leščić Ašler, Ivana; Bregović, Nikola; Crnolatac, Ivo; Piantanida, Ivo; Ilakovac Kveder, Marina; Žilić, Dijana; Bertoša, Branimir | Structural Changes in the Metalloregulatory Protein ScaR (Streptococcus gordonii) Influenced by Mn 2+ Ion Binding // EMBO workshop: ImmunoBiophysics #2 - From fundamental physics to understanding the immune response | Les Houches, Francuska, 09.04.2023-14.04.2023

• Narczyk, M. ; Leščić Ašler, Ivana ; Wojtyś, M. ; Štefanić, Zoran ; Luić, Marija ; Jagusztyn- Krynicka, K. ; Bzowska, A. | Inhibition of Helicobacter pylori purine nucleoside phosphorylase and bacteria cell cultures with 2-chloro-6-substituted purines // 45th FEBS 2020 Congress Molecules of Life: Towards New Horizons | Ljubljana, Slovenija, 03.07.2021-08.07.2021

• Bubić, Ante ; Narczyk, M. ; Maksymiuk, W. ; Štefanić, Zoran ; Bzowska, A. ; Leščić Ašler, Ivana | Conformational changes in adenylosuccinate synthetase from Helicobacter pylori upon ligand binding // EMBL Conference Bringing molecular structure to life: 50 years of the PDB | virtual, 20.10.2021-22.10.2021

• Bubić, Ante ; Leščić Ašler, Ivana ; Bertoša, Branimir ; Luić, Marija | Adenylosuccinate synthetase from pathogen Helicobacter pylori // Structural Bioinformatics | Hinxton, Ujedinjeno Kraljevstvo, 16.09.2019-20.09.2019

• Bubić, Ante ; Leščić Ašler, Ivana ; Luić, Marija | Catalytic Properties of Adenylosuccinate Synthetase from Pathogen Helicobacter pylori // FEBS Practical/Lecture Course 2018 - Ligand-binding theory and practice | Nové Hrady, Češka Republika, 24.06.2018-01.07.2018

• Leščić Ašler, Ivana ; Mrnjavac, Natalia ; Stuparević, Igor ; Štefanić, Zoran ; Luić, Marija | Adenylosuccinate synthetase from bacterium Helicobacter pylori strain 26695: purification and characterization // Proteins in action : biophysical techniques for protein research | České Budějovice, Češka Republika, 26.06.2017-28.06.2017

  www.xray.cz

• Leščić Ašler, Ivana; Štefanić, Zoran; Luić, Marija | Insights into catalytic mechanism of an enzyme // XVI International Conference on Science, Arts and Culture, INTERNATIONAL CONFERENCE ON SESAME In honour of Paolo Budinich | Veli Lošinj, Hrvatska, 29.08.2016-02.09.2016

  indico.cern.ch

• Leščić Ašler, Ivana ; Marchetti-Deschmann, Martina ; Kojić-Prodić, Biserka ; Allmaier, Günter | Mass spectrometric analysis of interaction of Streptomyces rimosus lipase with 3, 4-dichloroisocoumarin // Advances in Metabolic Profiling & Mass Spec Europe | Dublin, Irska, 08.11.2011-09.11.2011

• Kovačić, Filip ; Leščić, Ivana ; Zehl, Martin ; Abramić, Marija ; Allmaier, Günter ; Kojić-Prodić, Biserka | Determination of the catalytically active serine of extracellular lipase from Streptomyces rimosus by inhibition studies and mass spectrometry // Congress of the Croatian Society of Biochemistry and Molecular Biology HDBMB2004 | Hrvatska, 30.09.2004-02.10.2004

• Leščić, Ivana ; Kovačić, Filip ; Kojić-Prodić, Biserka | Strukturne osobine izvanstanične lipaze bakterije Streptomyces rimosus predviđene iz proteinske sekvence // Bioinformatika IRB - 2004 | Zagreb, Hrvatska, 10.12.2004-10.12.2004

  www.irb.hr

• Leščić, Ivana | Ghosts of enzyme past, present and future: Extracellular lipase from bacterium Streptomyces rimosus // EMBO Bioinformatics Course | Maynooth, Irska, 28.04.2003-03.05.2003

Master's thesis (university)

• Mišković, Marija Zora | Utjecaj položaja His6 privjeska na svojstva proteina, primjer adenilosukcinat-sintetaze iz bakterije Helicobacter pylori; O lijekovima kroz predtercijarnu nastavu kemije / Leščić Ašler, Ivana; Mrvoš Sermek, Draginja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2025

  repozitorij.pmf.unizg.hr

• Srnec, Karla | Utjecaj iona metala na aktivnost adenilosukcinat- sintetaze iz bakterije Helicobacter pylori ; Priča o želatini i voću / Leščić Ašler, Ivana ; Mrvoš-Sermek, Draginja (mentor); Bubić, Ante (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2021

  repozitorij.pmf.unizg.hr

• Petek, Ana | Utjecaj afinitetnog privjeska na svojstva adenilosukcinat-sintetaze iz bakterije Helicobacter pylori / Leščić Ašler, Ivana (mentor); Bubić, Ante (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2020

  urn.nsk.hrzir.nsk.hr

• Gucunski, Karolina | Purinska nukleozidna fosforilaza iz soja 26695 bakterije Helicobacter pylori: Ekspresija, pročišćavanje i karakterizacija / Luić, Marija (mentor); Leščić Ašler, Ivana (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2018

• Kovačić, Filip | Inhibicija izvanstanične lipaze bakterije Streptomyces rimosus / Kojić-Prodić, Biserka ; Weygand-Đurašević, Ivana (mentor); Leščić, Ivana (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2005

• Leščić, Ivana | Ekstracelularna lipaza bakterije Streptomyces rimosus: izolacija i karakterizacija / Weygand-Đurašević, Ivana ; Abramić, Marija (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 1997

Master of Science thesis

• Leščić, Ivana | Bakterijske lipaze: biokemijska i strukturna karakterizacija / Abramić, Marija ; Kojić-Prodić, Biserka (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2001

Doctoral thesis

• Radman, Katarina | Mehanizmi interakcija transkripcijskih faktora SloR iz Streptococcus mutans i ScaR iz Streptococcus gordonii s ionima mangana(II) i DNA / Leščić Ašler, Ivana; Bertoša, Branimir (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2025

  repozitorij.pmf.unizg.hr

• Bubić, Ante | Biokemijska karakterizacija adenilosukcinat- sintetaze bakterije Helicobacter pylori eksperimentalnim i računalnim metodama / Bertoša, Branimir ; Leščić Ašler, Ivana (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2021

  repozitorij.pmf.unizg.hr

• Leščić Ašler, Ivana | Strukturne odlike nekih lipaza iz bakterija roda Streptomyces / Kojić-Prodić, Biserka ; Luić, Marija (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2005

member of Croatian Chemical Society

member of Croatian Society of Biochemistry and Molecular Biology

member of Croatian Proteomics Society