2005.     Dr.sc., kemija (biokemija), Sveučilište u Zagrebu, disertacija: “Strukturne odlike nekih lipaza iz bakterija roda Streptomyces”, mentorice: dr.sc. Biserka Kojić-Prodić, IRB i dr.sc. Marija Luić, IRB

2001.     Mr.sc., kemija, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu

1997.     Dipl. inž. kemije, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu

Voditeljica Hrvatsko-Austrijskog bilateralnog projekta “The application of mass spectrometry-based „omics“ technologies to characterize products relevant for biotechnology and agriculture” 2016/17.

Suradnica na UKF projektu Research Cooperativity Program, Crossing Borders Grant "Protein ADP-ribosylation in a model prokaryote Streptomyces coelicolor and human" 2013/2015.

Suradnica na Hrvatsko-Njemačkom bilateralnom projektu "Biocatalysis of bacterial hydrolases of the GDSL–superfamily studied by a multidisciplinary approach" 2012/2013.

Suradnica na Hrvatsko-Austrijskom bilateralnom projektu "Using mass spectrometry for detailed characterization of proteins, glycoproteins, glycoconjugates and protein associated lipids" 2012/2013.

Voditeljica Hrvatsko-Austrijskog bilateralnog projekta “Mass spectrometry-based proteomic analysis: characterization of horseradish esterases and snake venom proteins, and mapping of Fusarium parasites” 2010/11.

Voditeljica Hrvatsko-Austrijskog bilateralnog projekta “Application of MALDI mass spectrometry in protein and intact cell analysis: characterisation of the novel SGNH-hydrolase family from Streptomyces and mapping of Fusarium parasites” 2008/09.

Suradnica na Hrvatsko-Austrijskom bilateralnom projektu “Functional organisation of noncovalent complexes of bacterial lipases” 2002/03 i 2004/05.

Suradnica na Hrvatsko-Austrijskom bilateralnom projektu “Molecular enzymology and genetic engineering of bacterial hydrolases” 2002/03.

Nagrada za najbolji poster na 1st South Eastern European Workshop on Practical Approaches to Computational Biology, Opatija, 2005.

Stipendija Sveučilišta u Zagrebu 1996/97.

2008/9 – asistentica – Molekularna biofizika (Diplomski studij molekularne biologije, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu), prof. Greta Pifat-Mrzljak

2007/8 – asistentica – Osnove biokemije (preddiplomski studij biologije, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu), prof. Mirna Flögel

2007/8 – asistentica – Praktikum iz biokemije (diplomski studij kemije, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu), prof. Ivana Weygand-Đurašević

Neposredna voditeljica diplomskog rada "Inhibicija izvanstanične lipaze bakterije Streptomyces rimosus" (Filip Kovačić, 24.03.2005., mentorice dr. sc. Biserka Kojić-Prodić i prof. dr. sc. Ivana Weygand-Đurašević)

Radovi u časopisima

Znanstveni i pregledni radovi

• Wojtyś, M., Jaźwiec, R., Kazazić, S., Leščić Ašler, I., Knežević, P., Aleksić Sabo, V., Luić, M., Jagusztyn- Krynicka, E. & Bzowska, A. (2021) A comprehensive method for determining cellular uptake of purine nucleoside phosphorylase and adenylosuccinate synthetase inhibitors by H. pylori. Applied microbiology and biotechnology, 105, 7949-7967 doi:10.1007/s00253-021-11510-9.

  doilink.springer.comdoi.orgfulir.irb.hr

• Bubić, A., Mrnjavac, N., Stuparević, I., Łyczek, M., Wielgus-Kutrowska, B., Bzowska, A., Luić, M. & Leščić Ašler, I. (2018) In the quest for new targets for pathogen eradication: the adenylosuccinate synthetase from the bacterium Helicobacter pylori. Journal of Enzyme Inhibition and Medicinal Chemistry, 33 (1), 1405-1414 doi:10.1080/14756366.2018.1506773.

  doiwww.tandfonline.comfulir.irb.hr

• Bošnjaković, M., Leščić Ašler, I. & Štefanić, Z. (2018) The Role of Phosphate Binding in Purine Nucleoside Phosphorylase of Helicobacter pylori. Croatica chemica acta, 91 (2), 171-175 doi:10.5562/cca3335.

  doihrcak.srce.hr

• Narczyk, M., Bertoša, B., Papa, L., Vuković, V., Leščić Ašler, I., Wielgus- Kutrowska, B., Bzowska, A., Luić, M. & Štefanić, Z. (2018) Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features. The FEBS journal, 285 (7), 1305-1325 doi:10.1111/febs.14403.

  doi

• Leščić Ašler, I., Štefanić, Z., Maršavelski, A., Vianello, R. & Kojić-Prodić, B. (2017) Catalytic Dyad in the SGNH Hydrolase Superfamily: In-depth Insight into Structural Parameters Tuning the Catalytic Process of Extracellular Lipase from Streptomyces rimosus. Acs chemical biology, 12 (7), 1928-1936 doi:10.1021/acschembio.6b01140.

  doi

• Štefanić, Z., Mikleušević, G., Luić, M., Bzowska, A. & Leščić Ašler, I. (2017) Structural characterization of purine nucleoside phosphorylase from human pathogen Helicobacter pylori. International journal of biological macromolecules, 101, 518-526 doi:10.1016/j.ijbiomac.2017.03.101.

  doi

• Leščić Ašler, I., Peharec Štefanić, P., Balen, B., Allmaier, G., Marchetti- Deschmann, M. & Kojić-Prodić, B. (2017) Horseradish esterases: detection, purification and identification. Plant cell, tissue and organ culture, 130 (1), 13-24 doi:10.1007/s11240-017-1200-0.

  doi

• Bertoša, B., Mikleušević, G., Wielgus-Kutrowska, B., Narczyk, M., Hajnić, M., Leščić Ašler, I., Tomić, S., Luić, M. & Bzowska, A. (2014) Homooligomerization is needed for stability: a molecular modelling and solution study of E. coli purine nucleoside phosphorylase. The FEBS journal, 281 (7), 1860-1871 doi:10.1111/febs.12746.

  doi

• Leščić Ašler, I., Kovačić, F., Marchetti-Deschmann, M., Allmaier, G., Štefanić, Z. & Kojić-Prodić, B. (2013) Inhibition of extracellular lipase from Streptomyces rimosus with 3, 4-dichloroisocoumarin. Journal of enzyme inhibition and medicinal chemistry, 28 (5), 1094-1104 doi:10.3109/14756366.2012.716834.

  doi

• Leščić Ašler, I., Pigac, J., Vujaklija, D., Luić, M. & Štefanić, Z. (2011) Crystallization and preliminary X-ray diffraction studies of a complex of extracellular lipase from Streptomyces rimosus with the inhibitor 3, 4-dichloroisocoumarin. Acta crystallographica section f-structural biology and crystallization communications, 67 (11), 1378-1381 doi:10.1107/S1744309111032222.

  doi

• Leščić Ašler, I., Ivić, N., Kovačić, F., Schell, S., Knorr, J., Krauss, U., Wilhelm, S., Kojić-Prodić, B. & Jaeger, K. (2010) Probing Enzyme Promiscuity of SGNH Hydrolases. ChemBioChem, 11 (15), 2158-2167 doi:10.1002/cbic.201000398.

  doi

• Luić, M., Štefanić, Z., Ceilinger, I., Hodošček, M., Janežić, D., Lenac, T., Leščić Ašler, I., Šepac, D. & Tomić, S. (2008) Combined X-Ray Diffraction and QM/MM Study of the Burkholderia cepacia Lipase-Catalyzed Secondary Alcohol Esterification. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical, 112 (16), 4876-4883 doi:10.1021/jp077717u.

  doi

• Leščić Ašler, I., Zehl, M., Kovačić, F., Müller, R., Abramić, M., Allmaier, G. & Kojić-Prodić, B. (2007) Mass spectrometric evidence of covalently-bound tetrahydrolipstatin at the catalytic serine of Streptomyces rimosus lipase. Biochimica et Biophysica Acta (BBA) - General Subjects, 1770 (2), 163-170.

• Zehl, M., Leščić, I., Abramić, M., Rizzi, A., Kojić-Prodić, B. & Allmaier, G. (2004) Characterization of covalently inhibited extracellular lipase from Streptomyces rimosus by matrix-assisted laser desorption/ionization time-of-flight and matrix-assisted laser desorption/ionization quadrupole ion trap reflectron time-of-flight mass spectrometry: localization of the active site serine. Journal of mass spectrometry, 39 (12), 1474-1483 doi:10.1002/jms.750.

  doi

• Leščić, I., Zehl, M., Müller, R., Vukelić, B., Abramić, M., Pigac, J., Allmaier, G. & Kojić-Prodić, B. (2004) Structural characterization of extracellular lipase from Streptomyces rimosus: Assignment of disulfide bridges pattern by mass spectrometry. Biological chemistry, 385 (12), 1147-1156.

• Vujaklija, D., Abramić, M., Leščić, I., Maršić, T. & Pigac, J. (2003) Streptomyces rimosus GDS(L) lipase: production, heterologous overexpression and structure-stability relationship. Food Technology and Biotechnology, 41 (1), 89-94.

• Vujaklija, D., Schroeder, W., Abramić, M., Zou, P., Leščić, I., Franke, P. & Pigac, J. (2002) A novel streptomycete lipase: cloning, sequencing and high-level expression of the Streptomyces rimosus GDS(L)-lipase gene. Archives of Microbiology, 178 (2), 124-130.

• Leščić, I., Vukelić, B., Majerić-Elenkov, M., Saenger, W. & Abramić, M. (2001) Substrate specifity and effects of water-miscible solvents on the activity and stability of extracellular lipase from Streptomyces rimosus. Enzyme and Microbial Technology, 29, 548-553.

• Luić, M., Tomić, S., Leščić, I., Ljubović, E., Šepac, D., Šunjić, V., Vitale, L., Saenger, W. & Kojić-Prodić, B. (2001) Complex of Burkholderia cepacia lipase with transition state analogue of 1-phenoxy-2-acetoxybutane, Biocatalytic, structural and modelling study.. European Journal of Biochemistry, 268 (14), 3964-3973.

• Abramić, M., Leščić, I., Korica, T., Vitale, L., Saenger, W. & Pigac, J. (1999) Purification and properties of extracellular lipase from Streptomyces rimosus. Enzyme and Microbial Technology, 25 (6), 522-529.

Ocjenski radovi

Doktorske disertacije

• Leščić Ašler, I. (2005) 'Strukturne odlike nekih lipaza iz bakterija roda Streptomyces', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

Magistarski radovi

• Leščić, I. (2001) 'Bakterijske lipaze: biokemijska i strukturna karakterizacija', magistarski rad, Prirodoslovno-matematički fakultet, Zagreb.

članica Hrvatskog Kemijskog Društva

članica Hrvatskog Društva za Biokemiju i Molekularnu Biologiju

članica Hrvatskog Društva za Proteomiku