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A new hypothesis on the physiology of cerebrospinal fluid

Jul 14th 2010

RBI scientist Dr. Darko Orešković from the laboratory of neurochemistry and molecular neurobiology in the Department of Molecular Biology and Dr. Marijan Klarica from the Faculty of Medicine, University of Zagreb have published an article in the prestigious journal Brain Research Reviews (IF 7.39) entitled, “The formation of cerebrospinal fluid: nearly a hundred years of interpretations and misinterpretations”. The journal is one of the top 8% of journals in the field of neuroscience.

The article, based on the authors previous experimental observations, discards the classical hypothesis formed about one hundred years ago on the formation, circulation and absorption of cerebrospinal fluid. The original hypothesis was until recently considered a given fact and was presented as such in the medical textbooks used by medical students. In addition to the physiology of cerebrospinal fluid the paper also discusses the onset of various disease states of the nervous system such as hydrocephalus, brain edema and pathological cerebrospinal pressures. The importance of the work of Orešković and Klarica lies in the presentation of a completely new hypothesis on the physiology of cerebrospinal fluid and thus opens new possibilities of discovering the causes of the aforementioned diseases as well as new avenues for their treatment.

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