The book provides an overview of the epigenetic and non-epigenetic mechanisms by which long non-coding RNA molecules regulate the genes in various biological systems. Due to their exceptional biological and medical importance, long non-coding RNAs have been intensively studied in recent years. The goal of the book is to provide the reader with an overview of the newest scientific findings and theories in this area. The book is intended for researchers, teachers and students in the medical and biomedical sciences.