RBI Scientists Publish Article in Chemistry-A European Journal
RBI scientists, Irena Dokli, and dr. Zdenko Hameršak in the Laboratory for Stereoselective Catalysis and Biocatalysis, in collaboration with dr. Ivana Matanović in the Theoretical Chemistry Group, have published an article entitled Sulfur Ylide Promoted Synthesis of N-Protected Aziridines: A Combined Experimental and Computational Approach in Chemistry-A European Journal (IF=5.382).
The article describes the asymmetric synthesis of N-protected aziridines in high enantiomeric excess , using a chiral benzyl sulfonium salt. The diastereoselectivities of the reactions are influenced by the imine N-protecting group, the imine substituent, and the sulfide structure. In the case of tert-butyl substituted aziridines, an unusual cis selectivity was observed, and this observation was explained using computational models.