Skip to main content

RBI Scientists Publish Article in Chemistry-A European Journal

Sep 29th 2010

RBI scientists, Irena Dokli, and dr. Zdenko Hameršak in the Laboratory for Stereoselective Catalysis and Biocatalysis, in collaboration with dr. Ivana Matanović in the Theoretical Chemistry Group, have published an article entitled Sulfur Ylide Promoted Synthesis of N-Protected Aziridines: A Combined Experimental and Computational Approach in Chemistry-A European Journal (IF=5.382).

The article describes the asymmetric synthesis of N-protected aziridines in high enantiomeric excess , using a chiral benzyl sulfonium salt. The diastereoselectivities of the reactions are influenced by the imine N-protecting group, the imine substituent, and the sulfide structure. In the case of tert-butyl substituted aziridines, an unusual cis selectivity was observed, and this observation was explained using computational models.

This site uses cookies.

Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and can only be disabled by changing your browser preferences.