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RBI Scientists Publish Article in PNAS

Aug 19th 2010

Thanks to the unique expertise of RBI scientists in crystal diffraction with macromolecules, Dr. Marija Luić and Nives Ivić made a significant contribution to the article "Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and nonribosomal peptide synthesis".

Their work consisted of determining the spatial structure of an enzyme which is involved in non-ribosomal protein synthesis. The article was published in the journal PNAS and was written as a collaboration with lead authors Dr. Ivana Weygand-Đurašević, Dr. Marko Močibob, and Dr. Silvija Bilokpaić from the Faculty of Natural and Mathematical Science at the University of Zagreb and Dr. Tim Maier and Dr. Nenad Ban at the Swiss Federal Institute of Technology. This work was supported by a joint research grant from the Unity Through Knowledge Fund (UKF).

The research results explain the evolution of macromolecules involved in ribosomal and non-ribosomal protein synthesis and point to the ancestry of synthetases and newly discovered enzymes. Although the research results are fundamental in nature, the implications in pharmacology have garnered interest within the pharmaceutical industry.

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