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Bioinspired asymmetric catalysis: backdoor induction of chirality using oxazoline based amino acid bioconjugates

Principal investigator

Project type
Znanstveno-istraživački projekti
Programme
The New International Fellowship Mobility Programme for Experienced Researchers in Croatia
Financier
Ministry of Science and Education of the Republic of Croatia
Start date
Nov 1st 2014
End date
Oct 31st 2016
Status
Done
Total cost
51998 EUR
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This research proposal describes the development of artificial metalloenzyme mimics with a minimal but functional outer-coordination sphere. Bioconjugates of chiral amino acids with oxazoline based nitrogen ligands and their metal complexes withCu(I) and Pd(II) will be synthesized from simple and inexpensive starting materials using organic, organometallic or inorganic synthetic methods and characterized by various physico-chemical methods. The metal complexes will be used as catalysts in asymmetric cyclopropanation and in asymmetric alkylation reactions. Within the proposed artificial catalysts, the metal centre dominates the chemical activity while the chiral amino acids of the outer-coordination sphere induce the selectivity by "backdoor induction" of chirality to the prochiral catalytic metal. The work proposed herein significantly extends the scope of chirality transmission by "backdoor induction" and narrows the gap betweennatural enzymes and their synthetic counterparts.

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