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Bioinspired asymmetric catalysis: backdoor induction of chirality using oxazoline based amino acid bioconjugates

Glavni istraživač

Tip projekta
Znanstveno-istraživački projekti
Program
The New International Fellowship Mobility Programme for Experienced Researchers in Croatia
Financijer
Ministarstvo znanosti i obrazovanja Republike Hrvatske
Datum početka
1.11.2014.
Datum završetka
31.10.2016.
Status
Završen
Ukupan iznos financiranja projekta
51998 EUR
Više informacija

This research proposal describes the development of artificial metalloenzyme mimics with a minimal but functional outer-coordination sphere. Bioconjugates of chiral amino acids with oxazoline based nitrogen ligands and their metal complexes withCu(I) and Pd(II) will be synthesized from simple and inexpensive starting materials using organic, organometallic or inorganic synthetic methods and characterized by various physico-chemical methods. The metal complexes will be used as catalysts in asymmetric cyclopropanation and in asymmetric alkylation reactions. Within the proposed artificial catalysts, the metal centre dominates the chemical activity while the chiral amino acids of the outer-coordination sphere induce the selectivity by "backdoor induction" of chirality to the prochiral catalytic metal. The work proposed herein significantly extends the scope of chirality transmission by "backdoor induction" and narrows the gap betweennatural enzymes and their synthetic counterparts.

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