Lysosomes are specific cellular organelles that are normally involved in degradation processes of proteins and other damaged organelles. Dysfunction of lysosomes may lead to abnormal protein accumulation which may cause cell degeneration and death. Such protein accumulation also occurs in the brain cells and triggers development of the devastating neurodegenerative diseases in humans, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).
This project will generate new ideas for an effective and highly specific therapy against neurodegenerative diseases, including AD and PD. Our results may provide evidence that lysosomal dysfunction is a common mechanism that leads to neurodegeneration and may lead to development of a novel therapeutic strategy against neurodegenerative disorders.