• Role of Indole Metabolism in Enhancing Abiotic Stress Tolerance in Brassicaceae - InMetaBra

  01.02.2026 - 31.01.2029 | 199,999.75 EUR

  CroRISIRB

• Integrated micro-system for enzymatic biohydrogen production - MicroBioH2

  31.12.2023 - 30.12.2027 | 164,059.71 EUR

  CroRIS

• Investigation of the peptidase activity of human DPP III against tynorphin - computational and experimental study

  23.11.2020 - 22.11.2021 | 4,000.00 HRK

  CroRISIRB

• Višestruki stresori u vodenom okolišu: razumijevanje svojstava stresora i receptora - UNDERSTANDOR

  07.01.2019 - 06.01.2023 | 132,718.83 EUR

  CroRISIRB

• Elucidation of the physiological roles of human dipeptidyl peptidase III

  15.12.2015 - 14.12.2017 | 1,409,411.76 HRK

  CroRISIRB

2015 FEBS Short-Term Fellowship, for project „Investigation of function of dipeptidyl peptidases III in moss Physcomitrella patens using targeted gene knockouts“

Karačić, Z., Ban, Ž. & Macheroux, P. (2017) A novel member of the dipeptidyl peptidase III family from Armillariella tabescens. Current Topics in Peptide & Protein Research, 18, 41-48. 

Karačić, Z., Vukelić, B., Ho, G., Jozić, I., Sučec, I., Salopek-Sondi, B., Kozlović, M., Brenner, S., Ludwig-Müller, J. & Abramić, M. (2017) A novel plant enzyme with dual activity: an atypical Nudix hydrolase and a dipeptidyl peptidase III. Biological chemistry, 398 (1), 101-112 doi:10.1515/hsz-2016-0141.

Karačić, Z., Špoljarić, J., Rožman, M. & Abramić, M. (2012) Molecular determinants of human dipeptidyl peptidase III sensitivity to thiol modifying reagents. Biological chemistry, 393 (12), 1523-1532 doi:10.1515/hsz-2012-0181.

Original scientific paper

• Vičević, Renata; Karačić, Zrinka; Milunić, Maja; Šalić, Anita; Jurinjak Tušek, Ana; Zelić, Bruno | Application of recombinant [NiFe]-hydrogenase for sustainable coenzyme regeneration // Catalysts, 16 (2026), 1; 10, 21. doi: 10.3390/catal16010010

  doiwww.mdpi.comfulir.irb.hr

• Agić, Dejan; Karnaš Babić, Maja; Hranjec, Marijana; Šubarić, Domagoj; Karačić, Zrinka; Abramić, Marija | New amidino-substituted benzimidazole derivatives as human dipeptidyl peptidase III inhibitors: synthesis, in vitro evaluation, QSAR, and molecular docking studies // International journal of molecular sciences, 26 (2025), 8; 3899, 25. doi: 10.3390/ijms26083899

  doifulir.irb.hrwww.mdpi.com

• Kokotović, Iva; Veseli, Marina; Ložek, Filip; Karačić, Zrinka; Rožman, Marko; Previšić, Ana | Pharmaceuticals and endocrine disrupting compounds modulate adverse effects of climate change on resource quality in freshwater food webs // Science of the total environment, 912 (2024), 168751, 13. doi: 10.1016/j.scitotenv.2023.168751

  doiwww.sciencedirect.comfulir.irb.hr

• Agić, Dejan; Karnaš, Maja; Tomić, Sanja; Komar, Mario; Karačić, Zrinka; Rastija, Vesna; Bešlo, Drago; Šubarić, Domagoj; Molnar, Maja | Experimental and computational evaluation of dipeptidyl peptidase III inhibitors based on quinazolinone-Schiff's bases // Journal of biomolecular structure & dynamics, 41 (2023), 16; 7567-7581. doi: 10.1080/07391102.2022.2123044

  doiwww.tandfonline.com

• Matić, Antonia; Šupljika, Filip; Brkić, Hrvoje; Jurasović, Jasna; Karačić, Zrinka; Tomić, Sanja | Identification of an Additional Metal-Binding Site in Human Dipeptidyl Peptidase III // International journal of molecular sciences, 24/2023 (2023), 16; 1-23. doi: 10.3390/ijms241612747

  doiwww.mdpi.comfulir.irb.hr

• Matić, Josipa ; Tandarić, Tana ; Radić Stojković, Marijana ; Šupljika, Filip ; Karačić, Zrinka ; Tomašić Paić, Ana ; Horvat, Lucija ; Vianello, Robert ; Tumir, Lidija-Marija | Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme // Beilstein journal of organic chemistry, 19 (2023), 550-565. doi: 10.3762/bjoc.19.40

  doiwww.beilstein-journals.orgfulir.irb.hr

• Tomić, Antonija ; Karačić, Zrinka ; Tomić, Sanja | Influence of Mutations of Conserved Arginines on Neuropeptide Binding in the DPP III Active Site // Molecules, 28 (2023), 4; 1976, 17. doi: 10.3390/molecules28041976

  doiwww.mdpi.comfulir.irb.hr

• Grgić, Ivana ; Cetinić, Katarina A. ; Karačić, Zrinka ; Previšić, Ana ; Rožman, Marko | Fate and effects of microplastics in combination with pharmaceuticals and endocrine disruptors in freshwaters: Insights from a microcosm experiment // Science of the total environment, 859 (2023), Part 2; 160387, 12. doi: 10.1016/j.scitotenv.2022.160387

  doiwww.sciencedirect.comfulir.irb.hr

• Karačić, Zrinka ; Šupljika, Filip ; Tomić, Antonija ; Brkljačić, Lidija ; Tomašić Paić, Ana ; Ćehić, Mirsada ; Tomić, Sanja | Neuropeptides, substrates and inhibitors of human dipeptidyl peptidase III, experimental and computational study — A new substrate identified // International journal of biological macromolecules, 220 (2022), 1390-1401. doi: 10.1016/j.ijbiomac.2022.09.119

  doiwww.sciencedirect.comfulir.irb.hr

• Ban, Željka ; Karačić, Zrinka ; Tomić, Sanja ; Amini, Hashem ; Marder, Todd B. ; Piantanida, Ivo | Triarylborane Dyes as a Novel Non‐Covalent and Non‐Inhibitive Fluorimetric Markers for DPP III Enzyme // Molecules, 26 (2021), 4816, 20. doi: 10.3390/molecules26164816

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Agić, Dejan ; Karnaš, Maja ; Šubarić, Domagoj ; Lončarić, Melita ; Tomić, Sanja ; Karačić, Zrinka ; Bešlo, Drago ; Rastija, Vesna ; Molnar, Maja ; Popović, Boris M. et al. | Coumarin derivatives act as novel inhibitors of human dipeptidyl peptidase III: combined in vitro and in silico study // Pharmaceuticals, 14 (2021), 6; 540, 19. doi: 10.3390/ph14060540

  doiwww.mdpi.comfulir.irb.hr

• Ćehić, Mirsada ; Suć Sajko, Josipa ; Karačić, Zrinka ; Piotrowski, Patryciusz ; Šmidlehner, Tamara ; Jerić, Ivanka ; Schmuck, Carsten ; Piantanida, Ivo ; Tomić, Sanja | The guanidiniocarbonylpyrrole - fluorophore conjugates as theragnostic tools for DPP III monitoring and inhibition // Journal of biomolecular structure & dynamics, 38 (2020), 13; 3790-3800. doi: 10.1080/07391102.2019.1664936

  doiwww.tandfonline.comfulir.irb.hr

• Kazazić, Saša ; Karačić, Zrinka ; Sabljić, Igor ; Agić, Dejan ; Tomin, Marko ; Abramić, Marija ; Dadlez, Michal ; Tomić, Antonija ; Tomić, Sanja | Conservation of the conformational dynamics and ligand binding within M49 enzyme family // RSC Advances, 8 (2018), 24; 13310-13322. doi: 10.1039/c7ra13059g

  doipubs.rsc.orgpubs.rsc.orgfulir.irb.hr

• Šmidlehner, Tamara ; Karačić, Zrinka ; Tomić, Sanja ; Schmuck, Carsten ; Piantanida, Ivo | Fluorescent cyanine-guanidiniocarbonyl-pyrrole conjugate with pH-dependent DNA/RNA recognition and DPP III fluorescent labelling and inhibition properties // Monatshefte für Chemie, 149 (2018), 7; 1307-1313. doi: 10.1007/s00706-018-2192-0

  doilink.springer.comfulir.irb.hr

• Karačić, Zrinka ; Ban, Željka ; Macheroux, Peter | A novel member of the dipeptidyl peptidase III family from Armillariella tabescens // Current topics in peptide & protein research, 18 (2017), 41-48

  www.researchtrends.net

• Hromić-Jahjefendić, Altijana ; Jajčanin Jozić, Nina ; Kazazić, Saša ; Grabar Branilović, Marina ; Karačić, Zrinka ; Schrittwieser, Jörg H. ; Das, Krishna Mohan Padmanabha ; Tomin, Marko ; Oberer, Monika ; Gruber, Karl et al. | A novel Porphyromonas gingivalis enzyme: An atypical dipeptidyl peptidase III with an ARM repeat domain // PLoS One, 12 (2017), 11; e0188915, 27. doi: 10.1371/journal.pone.0188915

  doijournals.plos.orgfulir.irb.hr

• Matovina, Mihaela ; Agić, Dejan ; Abramić, Marija ; Matić, Sara ; Karačić, Zrinka ; Tomić, Sanja | New findings about human dipeptidyl peptidase III based on mutations found in cancer // RSC Advances, 7 (2017), 58; 36326-36334. doi: 10.1039/C7RA02642K

  doipubs.rsc.orgdoi.orgfulir.irb.hr

• Karačić, Zrinka ; Vukelić, Bojana ; Ho, Gabrielle H. ; Jozić, Iva ; Sučec, Iva ; Salopek-Sondi, Branka ; Kozlović, Marija ; Brenner, Steven E. ; Ludwig-Müller, Jutta ; Abramić, Marija | A novel plant enzyme with dual activity: an atypical Nudix hydrolase and a dipeptidyl peptidase III // Biological chemistry, 398 (2017), 1; 101-112. doi: 10.1515/hsz-2016-0141

  doiwww.degruyter.com

• Agić, Dejan ; Brkić, Hrvoje ; Tomić, Sanja ; Karačić, Zrinka ; Špoljarević, Marija ; Lisjak, Miroslav ; Bešlo, Drago ; Abramić, Marija | Validation of flavonoids as potential dipeptidyl peptidase III inhibitors: experimental and computational approach // Chemical biology & drug design, 89 (2017), 4; 619-627. doi: 10.1111/cbdd.12887

  doionlinelibrary.wiley.com

• Gundić, Mario ; Tomić, Antonija ; Wade, Rebecca C. ; Matovina, Mihaela ; Karačić, Zrinka ; Kazazić, Saša ; Tomić, Sanja | Human DPP III – Keap1 Interactions : A Combined Experimental And Computational study // Croatica chemica acta, 89 (2016), 2; 217-228. doi: 10.5562/cca2916

  doihrcak.srce.hr

• Abramić, Marija ; Karačić, Zrinka ; Šemanjski, Maja ; Vukelić, Bojana ; Jajčanin-Jozić, Nina | Aspartate 496 from the subsite S2 drives specificity of human dipeptidyl peptidase III // Biological chemistry, 396 (2015), 4; 359-366. doi: 10.1515/hsz-2014-0247

  doiwww.degruyter.comfulir.irb.hr

• Karačić, Zrinka ; Špoljarić, Jasminka ; Rožman, Marko ; Abramić, Marija | Molecular determinants of human dipeptidyl peptidase III sensitivity to thiol modifying reagents // Biological chemistry, 393 (2012), 12; 1523-1532. doi: 10.1515/hsz-2012-0181

  doiwww.degruyter.com

Conference abstract

• Sučec, Iva ; Vlašić, Ana ; Sabljić, Igor ; Karačić, Zrinka | Investigating the possible evolution of isopentenyl diphosphate phosphohydrolase from isopentenyl diphosphate isomerase // FEBS Open Bio, 11, Suppl. 1, 2021. str. 134-134

  www.pmf.unizg.hr

• Tomić, Sanja ; Kazazić, Saša ; Abramić, Marija ; Tomin, Marko ; Agić, Dejan ; Karačić, Zrinka ; Grabar-Branilović, Marina | H/D exchange and MD simulation study of dipeptidyl peptidase III intrinsic dynamics and ligand binding // European biophysics journal, 46, 2017. str. S179-S179

  link.springer.comlink.springer.com

• Tomić, Sanja ; Kovačević, Borislav ; Tomić, Antonija ; Matovina, Mihaela ; Karačić, Zrinka ; Matić, Sara ; Abramić, Marija ; Agić, Dejan | Understanding h.DPP III mechanism – an aid in rationalization of the mutants (in)activity // European biophysics journal, 46, 2017. str. S179-S179

  link.springer.comlink.springer.com

Unpublished conference paper

• Vičević, Renata; Karačić, Zrinka; Šalić, Anita; Zelić, Bruno | Heterologous expression of an oxygen-tolerant hydrogenase from Cupriavidus necator for biohydrogen production // 15th European Congress of Chemical Engineering (ECCE) & 8th European Congress of Applied Biotechnology (ECAB) & 3rd Iberoamerican Congress on Chemical Engineering (CIBIQ) | Lisabon, Portugal, 08.09.2025-10.09.2025

• Vičević, Renata; Milunić, Maja; Karačić, Zrinka; Jurinjak Tušek, Ana; Šalić, Anita; Zelić, Bruno | One-pot two-enzyme system for biohydrogen production // 15th European Congress of Chemical Engineering (ECCE) & 8th European Congress of Applied Biotechnology (ECAB) & 3rd Iberoamerican Congress on Chemical Engineering (CIBIQ) | Lisabon, Portugal, 08.09.2025-10.09.2025

• Karačić, Zrinka ; Šupljika, Filip ; Tomašić Paić, Ana ; Brkljačić, Lidija ; Tomić, Sanja | Role of dipeptidyl peptidase III in pain regulation through cleavage of neuropeptides // 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI) and 5th Symposium Vladimir Prelog | Veli Lošinj, Hrvatska, 05.10.2021-08.10.2021

  27hskiki.hkd.hr

Master's thesis (university)

• Karačić, Zrinka | Uloga Cys176 i Cys509 u inaktivaciji ljudske dipeptidil-peptidaze III tiolnim reagensima / Abramić, Marija ; Weygand-Đurašević, Ivana (mentor); Špoljarić, Jasminka (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2010

Doctoral thesis

• Karačić, Zrinka | Biokemijska karakterizacija hidrolaze s dvojnom enzimskom aktivnošću iz mahovine Physcomitrella patens / Salopek Sondi, Branka (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2018

  urn.nsk.hrfulir.irb.hr