Dr. Ksenija Zahradka

1991   B.Sc. in Molecular Biology, Faculty of Science, University of Zagreb, Croatia

1994   M.Sc. in Biology, Faculty of Science, University of Zagreb, Croatia

1999   Ph.D. in Biology, Faculty of Science, University of Zagreb, Croatia 

2002   Postdoctoral training in the group of Prof. Miroslav Radman, Faculté de Médecine Necker, Université de Paris-Descartes, Paris, France

2014-2018 "DNA recombination, repair and maintenance of genome integrity: new pathways" (IP-11-2013-2978), Croatian Science Foundation ; associate

2011-2015 "Biology of Robustness",  Mediterranean Institute for Life Sciences  (MedILS), Split, Croatia; associate  

2007-2013 "Molecular mechanisms of DNA recombination and repair" (098-0982913-2862), Croatian Ministry of Science, Education and Sports ; associate

2007-2010 "Life under extreme conditions", Mediterranean Institute for Life Sciences  (MedILS), Split, Croatia; co-leader 

2007  National Annual Science Award 

2006  Excellence in Science Grant, Croatian Ministry of Science, Education and Sports 

2002  Necker Institute postdoctoral fellowship, Paris, France

Course “Genetic recombination and DNA repair”, PhD studies in Biology, Faculty of Science, University of Zagreb

Course “Mechanisms of DNA damage and repair”, PhD studies in Molecular Biosciences, University of Osijek, University of Dubrovnik and Ruđer Bošković Institute, Zagreb

Buljubašić, M., Hlevnjak, A., Repar, J., Đermić, D., Filić, V., Weber, I., Zahradka, K., Zahradka, D. (2019) RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli. DNA Repair 83: 102670. doi: 10.1016/j.dnarep.2019.102670 

Repar, J., Supek, F., Klanjscek, T., Warnecke, T., Zahradka, K., Zahradka, D. (2017) Elevated rate of genome rearrangements in radiation-resistant bacteria. Genetics 205: 1677-1689.

Buljubašić, M., Zahradka, D., Zahradka, K. (2013) RecQ helicase acts before RuvABC, RecG and XerC proteins during recombination in recBC sbcBC mutants of Escherichia coli. Res. Microbiol. 164: 987-997.

Buljubašić, M., Repar, J., Zahradka, K., Đermić, D., Zahradka, D. (2012) RecF recombination pathway in Escherichia coli cells lacking RecQ, UvrD and HelD helicases. DNA Repair 11: 419-430.

Repar, J., Cvjetan, S., Slade, D., Radman, M., Zahradka, D., Zahradka, K. (2010) RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans. DNA Repair 9: 1151-1161.

Zahradka, K., Buljubašić, M., Petranović, M., Zahradka, D. (2009) Roles of ExoI and SbcCD nucleases in "reckless" DNA degradation in recA mutants of Escherichia coli. J. Bacteriol. 191: 1677-1687.

Petranovic, D., Michelsen, O., Zahradka, K., Silva, C., Petranovic, M., Jensen, P. R., Mijakovic, I. (2007) Bacillus subtilis strain deficient for the protein-tyrosine kinase PtkA exhibits impaired DNA replication. Mol. Microbiol. 63: 1797-1805.

Zahradka, K., Slade, D., Bailone, A., Sommer, S., Averbeck, D., Petranovic, M., Lindner, A. B., Radman, M. (2006) Reassembly of shattered chromosomes in Deinococcus radiodurans. Nature 443: 569-573.

Zahradka, K., Šimić, S., Buljubašić, M., Petranović, M., Đermić, D., Zahradka, D. (2006) sbcB15 and delsbcB mutations activate two types of RecF recombination pathway in Escherichia coli. J. Bacteriol. 188: 7562-7571.

Zahradka, D., Zahradka, K., Petranović, M., Đermić, D., Brčić-Kostić, K. (2002) The RuvABC resolvase is indispensable for recombinational repair in sbcB15 mutants of Escherichica coli. J. Bacteriol. 184: 4141-4147.

Radovi u časopisima

Znanstveni i pregledni radovi

• Feliciello, I., Zahradka, D., Zahradka, K., Ivanković, S., Puc, N. & Đermić, D. (2018) RecF, UvrD, RecX and RecN proteins suppress DNA degradation at DNA double-strand breaks in Escherichia coli. Biochimie, 148, 116-126 doi:10.1016/j.biochi.2018.03.005.

  doi

• Repar, J., Supek, F., Klanjšček, T., Warnecke, T., Zahradka, K. & Zahradka, D. (2017) Elevated rate of genome rearrangements in radiation-resistant bacteria. Genetics, 205 (4), 1677-1689 doi:10.1534/genetics.116.196154.

  doi

• Repar, J., Šućurović, S., Zahradka, K., Zahradka, D. & Ćurković-Perica, M. (2013) Stress resistance of Escherichia coli and Bacillus subtilis is modulated by auxins. Canadian journal of microbiology, 59 (11), 766-770 doi:10.1139/cjm-2013-0266.

  doi

• Buljubašić, M., Zahradka, D. & Zahradka, K. (2013) RecQ helicase acts before RuvABC, RecG and XerC proteins during recombination in recBCD sbcBC mutants of Escherichia coli. Research in microbiology, 164 (10), 987-997 doi:10.1016/j.resmic.2013.08.008.

  doi

• Repar, J., Zahradka, D. & Zahradka, K. (2013) Accuracy of genome reassembly in gamma-irradiated Escherichia coli. Food technology and biotechnology, 51 (3), 327-337.

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• Repar, J., Briški, N., Buljubašić, M., Zahradka, K. & Zahradka, D. (2013) Exonuclease VII is involved in "reckless" DNA degradation in UV-irradiated Escherichia coli. Mutation research. Genetic toxicology and environmental mutagenesis, 750 (1/2), 96-104 doi:10.1016/j.mrgentox.2012.10.005.

  doi

• Buljubašić, M., Repar, J., Zahradka, K., Đermić, D. & Zahradka, D. (2012) RecF recombination pathway in Escherichia coli cells lacking RecQ, UvrD and HelD helicases. DNA repair, 11 (4), 419-430 doi:10.1016/j.dnarep.2012.01.011.

  doi

• Repar, J., Cvjetan, S., Slade, D., Radman, M., Zahradka, D. & Zahradka, K. (2010) RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans. DNA repair, 9 (11), 1151-1161 doi:10.1016/j.dnarep.2010.08.003.

  doi

• Zahradka, K., Buljubašić, M., Petranović, M. & Zahradka, D. (2009) Roles of ExoI and SbcCD nucleases in "reckless" DNA degradation in recA mutants of Escherichia coli. Journal of Bacteriology, 191 (5), 1677-1687 doi:10.1128/JB.01877-07.

  doi

• Petranovic, D., Michelsen, O., Zahradka, K., Silva, C., Petranovic, M., Jensen, P. & Mijakovic, I. (2007) Bacillus subtilis strain deficient for the protein-tyrosine kinase PtkA exhibits impaired DNA replication. Molecular Microbiology, 63 (6), 1797-1805.

• Zahradka, K., Slade, D., Bailone, A., Sommer, S., Averbeck, D., Petranović, M., Lindner, A. & Radman, M. (2006) Reassembly of shattered chromosomes in Deinococcus radiodurans. Nature, 443, 569-573 doi:10.1038/nature05160.

  doiwww.nature.com

• Zahradka, K., Šimić, S., Buljubašić, M., Petranović, M., Đermić, D. & Zahradka, D. (2006) sbcB15 and delsbcB mutations activate two types of RecF recombination pathway in Escherichia coli. Journal of Bacteriology, 188, 7562-7571.

• Zahradka, K., Zahradka, D., Đermić, D., Džidić, S. & Petranović, M. (2002) The inactivation of free phages in UV-irradiated Escherichia coli. Periodicum Biologorum, 104 (4), 399-403.

• Zahradka, D., Zahradka, K., Džidić, S., Đermić, D. & Petranović, M. (2002) The rus-1 mutation suppresses cytological defects in recBC sbcBC ruv mutants of Escherichia coli. Periodicum Biologorum, 104 (4), 389-397.

• Zahradka, D., Zahradka, K., Petranović, M., Đermić, D. & Brčić-Kostić, K. (2002) The RuvABC resolvase is indispensable for recombinational repair in sbcB15 mutants of Escherichia coli. Journal of Bacteriology, 184 (15), 4141-4147.

• Petranović, M., Zahradka, K., Zahradka, D., Petranović, D., Nagy, B., Salaj-Šmic, E. & Petranović, D. (2001) Genetic evidence that the elevated levels of Escherichia coli helicase II antagonize recombinational DNA repair. Biochimie, 83 (-), 1041-1047.

• Paškvan, I., Salaj-Šmic, E., Ivančić-Baće, I., Zahradka, K., Trgovčević, Ž. & Brčić-Kostić, K. (2001) The genetic dependence of RecBCD-Gam mediated double strand end repair in Escherichia coli. FEMS Microbiology Letters, 205 (02), 299-303.

• Zahradka, K., Zahradka, D. & Petranović, M. (2001) Loss of lambda prophage recombinogenicity in UV-irradiated Escherichia coli : the role of host genes ruvA, ruvB, ruvC and recG. Research in microbiology, 152, 873-881.

• Vlahović, K., Petranović, M., Zahradka, D. & Petranović, D. (2000) Progressive loss of lambda prophage recombinogenicity in UV-irradiated Escherichia coli : the role of RecBCD enzyme. Research in microbiology, 151 (9), 727-738.

• Petranović, M., Vlahović, K., Zahradka, D., Džidić, S. & Radman, M. (2000) Mismatch repair in Xenopus egg extracts is not strand-directed by DNA methylation. Neoplasma, 47 (6), 375-381.

• Zahradka, D., Vlahović, K., Petranović, M. & Petranović, D. (1999) Chromosome segregation and cell division defects in recBC sbcBC ruvC mutants of Escherichia coli. Journal of bacteriology, 181 (19), 6179-6183.

• Vlahović, K., Petranović, M., Zahradka, D. & Petranović, D. (1998) Effects of ruv and recG mutations on lambda prophage thermoinducibility in UV-irradiated Escherichia coli. Periodicum biologorum, 100 (3), 383-388.

Ocjenski radovi

Doktorske disertacije

• Vlahović, K. (1999) 'Genetic analysis of lambda prophage recombinogenicity in irradiated Escherichia coli', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

European Environmental Mutagenesis and Genomics Society (EEMGS)

Croatian Genetic Society

Croatian Society for Biochemistry and Molecular Biology

Croatian Microbiological Society