Although variants of uncertain significance (VUS) cannot be clearly defined and classified, VUS make up about 40% of the total variants in human, and their impact on the function or health of the organism is not known. It is necessary to implement a new and systematic experimental approach for the characterization of VUS at high throughput, and to contribute to the reduction of the amount of VUS in the relevant databases for a better understanding of genomic variation in humans.

The largest infrastructure project with the highest budget in natural sciences ever to be conducted in Croatia will foster a research pipeline at the RBI and facilitate innovation and technology for the investigation of relevant diseases such as cancer.

Uspostava istraživačke infrastrukture za translacijsku medicinu i primjenjenu genomiku s ciljem korištenja visoko-propusnih metoda temeljena na DNA čip tehnologiji za buduće aktivnosti tehnološkog transfera