Dr. Maja Herak Bosnar
Education
1976-1984 - elementary school, Zagreb
1984-1988 - 16. gymnasium, Zagreb
1988 - 1993 - graduate school, Faculty of Sciences and Mathematics, University of Zagreb, B.Sc. in molecular biology
1993-1996 - postgraduate study in molecular and cellular biology, Faculty of Sciences and Mathematics, University of Zagreb, M.Sc. in molecular and cellular biology
1996-2002 - doctoral study, Faculty of Sciences and Mathematics, University of Zagreb, PhD in molecular biology
Projects
2017.-2021. principal investigator - "Structure, function and evolution of Nme6/Nm23-H6 gene/protein-project of the Croatian Scientifc Foundation www.irb.hr/Nemo6 2014-today-collaborator- New protein networks for novel therapeutic avenues in human melanoma, PI dr.sc. Neda Slade, Croatian Scientific Foundation 2013.-today,work package leader-FP7-Regpot project „Enhancement of the Innovation Potential in SEE through new Molecular Solutions in Research and Development“ InnoMol– coordinator: dr.sc. Oliver Vugrek 2007-2013. -principal investigator- The role of nm23 genes in oral squamous cell carcinoma, Ministry of Science, Technology and Sports, Republic of Croatia 2009-2010 -principal investigator- The study of intracellular localization and dynamics of NDPK A and B subunits (Nm23-H1 and Nm23-H2) – French-Croatian bilateral project “Cogito” 2008. –principal investigator- The role of nm23 genes in oral squamous cell carcinoma, Lutrija Hrvatske (Croatian Lottery) 2002.- 2006 collaborator,“Gene therapy using tumor-suppressor genes“ Ministry of Science, Technology and Sports, Republic of Croatia, principal investigator dr. sc. Jasminka Pavelić 1996.-2002 collaborator, projekt MZOŠ „Human tumor DNA bank“ – Ministry of Science, Technology and Sports, Republic of Croatia, principal investigator acad. Šime Spaventi 1993.-1996.collaborator– „Formation of human tumor bank for basic research“ - Ministry of Science, Technology and Sports, Republic of Croatia, principal investigator, acad. Šime Spaventi
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Awards and Achievements
Annual reward of the Ruđer Bošković Institute for the scientific publication Radić M, Šoštar M, Weber I, Ćetković H, Slade N, Herak Bosnar M*. The Subcellular Localization and Oligomerization Preferences of NME1/NME2 upon Radiation-Induced DNA Damage, Int J Mol Sci 21: 2363, 2020.
Annual reward “Josip Juraj Strossmayer“ for the best scientific publication (Croatian Academy of Science and Arts and Zagreb Fair), 2007, for the textbook: Metode u molekularnoj biologiji(Methods in Molecular Biology) (editors): Andreja Ambriović Ristov, Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade and Dušica Vujaklija, publisher: Institut Ruđer Bošković, Zagreb, 2007. |
Classes
Course holder (PhD studies)
2008-present: Molekularne osnove metastaziranja (Molecular Basis of Metstasis Formation), doctoral study in Molekular Bioscience, University Josip Juraj Strossmayer Osijek), University in Dubrovnik and Rudjer Bošković Institute
2010-present: Genetika raka i biologija tumorskih stanica (Cancer Genetics and Tumor Cell Biology), doctoral study in Biology, Faculty of Science, University of Zagreb
Featured Publications
Stojanovic N, Brozovic A, Majhen D, Herak Bosnar M, Fritz G, Osmak M, Ambriovic-Ristov A. Integrin αβ3 expression in tongue squamous cell carcinoma cells Cal27 confers anticancer drug resistance trough loss of pSrc(Y418). BBA-Molecular Cell Research, 2016
Cetkovic H, Perina D, Harcet M, Mikoc A, Herak Bosnar M*. Nme family of proteins – clues from simple animals. N-S Arch Pharmacol 388, 133-142, 2015.
Franczalsky L, Monostori E, Farkas, Z, Pourkarimi E, Masoudi N, Hargitai B, Herak Bosnar M, Dezeljin M, Zsakaj A, Vellai T, Mehta A, Takacz-Vellai, K. NDK-1, the Homolog of NM23-H1/H” regulates cell migration and apoptotic engulfment in C. elegans. PLoS One, 9,e92687, 2014
Horvat T, Dezeljin M, Redzic I, Barisic D, Herak Bosnar M, Lauc G, Zoldos V. Reversibility of membrane N-Glycome of HeLa cells upon treatment with epigenetic inhibitors. PLoS One, 8, e54672.2013. Deželjin M, Herak Bosnar M*. Metastasis - recent scientific insights and challenging new therapeutic approaches. Periodicum biologorum 114: 453-459, 2012. Horvat T, Mužinić I, Barišić D, Herak Bosnar M, Zoldoš V. Epigenetic modulation od HeLa cell membrane N-glycome. BBA general subjects, 1820, SI, 1412-1419, 2012.
Annesley SJ, Bago R, Herak Bosnar M, Filić V, Marinović M, Weber I, Mehta A, Fisher PR. Dictyostelium discoideum nucleoside diphosphate kinase C plays a negative regulatory role in phagocytosis, macropinocytosis and exocytosis. PLoS One, 6:e26024. 2011.
Perina D+, Herak Bosnar M*+, Mikoč A, Müller WEG, Ćetković H. Characterization of Nme6-like gene/protein from marine sponge Suberites domuncula. N-S Arch Pharmacol 384:451-60, 2011. +Equal contribution
Perina D, Herak Bosnar M, Bago R, Mikoč A, Harcet M, Deželjin M, Ćetković H. Sponge non-metastatic Group I Nme gene/protein - structure and function is conserved from sponges to humans. BMC Evol Biol 11:87, 2011. |
Publications
Journal articles
Scientific and review papers
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Dominko, K., Talajić, A., Radić, M., Škrobot Vidaček, N., Vlahoviček, K., Herak Bosnar, M. & Ćetković, H. (2023) Transfection of Sponge Cells and Intracellular Localization of Cancer-Related MYC, RRAS2, and DRG1 Proteins. Marine drugs, 21 (2), 119, 21 doi:10.3390/md21020119.
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Radić, M., Vlašić, I., Jazvinšćak Jembrek, M., Horvat, A., Tadijan, A., Sabol, M., Dužević, M., Herak Bosnar, M. & Slade, N. (2022) Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance. International journal of molecular sciences, 23 (17), 9910, 19 doi:10.3390/ijms23179910.
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Beljan, S., Dominko, K., Talajić, A., Hloušek-Kasun, A., Škrobot Vidaček, N., Herak Bosnar, M., Vlahoviček, K. & Ćetković, H. (2022) Structure and function of cancer-related developmentally regulated GTP-binding protein 1 (DRG1) is conserved between sponges and humans. Scientific Reports, 12, 11379, 20 doi:10.1038/s41598-022-15242-2.
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Proust, B., Radić, M., Škrobot Vidaček, N., Cottet, C., Attia, S., Lamarche, F., Ačkar, L., Godinić Mikulčić, V., Tokarska-Schlattner, M., Ćetković, H., Schlattner, U. & Herak Bosnar, M. (2021) NME6 is a phosphotransfer-inactive, monomeric NME/NDPK family member and functions in complexes at the interface of mitochondrial inner membrane and matrix. Cell and Bioscience, 11 (1), 195, 23 doi:10.1186/s13578-021-00707-0.
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Šafranko, S., Stanković, A., Hajra, S., Kim, H., Strelec, I., Dutour-Sikirić, M., Weber, I., Herak Bosnar, M., Grbčić, P., Kraljević Pavelić, S., Széchenyi, A., Mishra, Y., Jerković, I. & Jokić, S. (2021) Preparation of multifunctional N-doped carbon quantum dots from citrus clementina peel: investigating targeted pharmacological activities and the potential application for Fe3+ sensing. Pharmaceuticals, 14 (9), 857, 18 doi:10.3390/ph14090857.
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Beljan, S., Herak Bosnar, M. & Ćetković, H. (2020) Rho Family of Ras-Like GTPases in Early-Branching Animals. Cells, 9 (10), 2279, 27 doi:10.3390/cells9102279.
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Radić, M., Šoštar, M., Weber, I., Ćetković, H., Slade, N. & Herak Bosnar, M. (2020) The Subcellular Localization and Oligomerization Preferences of NME1/NME2 upon Radiation-Induced DNA Damage. International journal of molecular sciences, 21 (7), 2363, 19 doi:10.3390/ijms21072363.
doiwww.mdpi.comfulir.irb.hr -
Perina, D., Korolija, M., Mikoč, A., Halasz, M., Herak Bosnar, M. & Ćetković, H. (2020) Characterization of Nme5-Like Gene/Protein from the Red Alga Chondrus Crispus. Marine drugs, 18 (1), 13, 20 doi:10.3390/md18010013.
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Ozretić, P., Hanžić, N., Proust, B., Sabol, M., Trnski, D., Radić, M., Musani, V., Ciribilli, Y., Milas, I., Puljiz, Z., Bosnar Herak, M., Levanat, S. & Slade, N. (2019) Expression profiles of p53/p73, NME and GLI families in metastatic melanoma tissue and cell lines. Scientific Reports, 9 (1), 12470, 13 doi:10.1038/s41598-019-48882-y.
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Ćetković, H., Herak Bosnar, M., Perina, D., Mikoč, A., Deželjin, M., Belužić, R., Bilandžija, H., Ruiz-Trillo, I. & Harcet, M. (2018) Characterization of a Group I Nme protein of Capsaspora owczarzaki – a close unicellular relative of animals. Laboratory investigation, 98 (3), 304-314 doi:10.1038/labinvest.2017.134.
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Herak Bosnar, M., Radić, M. & Ćetković, H. (2018) A young researcher’s guide to NME/Nm23/NDP Kinase. Periodicum biologorum, 120 (1), 3-9 doi:10.18054/pb.v120i1.6229.
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Ćetković, H., Harcet, M., Roller, M. & Herak Bosnar, M. (2018) A survey of metastasis suppressors in Metazoa. Laboratory investigation, 98, 554-570 doi:10.1038/s41374-018-0024-9.
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Ćetković, H., Halasz, M. & Herak Bosnar, M. (2018) Sponges: A Reservoir of Genes Implicated in Human Cancer. Marine drugs, 16 (1), 20, 17 doi:10.3390/md16010020.
doifulir.irb.hr Herak Bosnar, M. (2016) The Cell. Priroda, 106 (1049), 69-70.
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Stojanović, N., Brozovic, A., Majhen, D., Herak Bosnar, M., Fritz, G., Osmak, M. & Ambriović-Ristov, A. (2016) Integrin αvβ3 Expression in Tongue Squamous Carcinoma Cells Cal27 Confers Anticancer Drug Resistance Through Loss of pSrc(Y418). Biochimica et biophysica acta-molecular cell research, 1863 (8), 1969-1978 doi:10.1016/j.bbamcr.2016.04.019.
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Ćetković, H., Perina, D., Harcet, M., Mikoč, A. & Herak Bosnar, M. (2015) Nme family of proteins—clues from simple animals. Naunyn-Schmiedeberg's archives of pharmacology, 388 (2), 133-142 doi:10.1007/s00210-014-1017-x.
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Fanczalszky, L., Monostori, E., Farkas, Zsolt, Pourkarimi, Ahsan, Masoudi, N., Hargitai, B., Herak Bosnar, M., Deželjin, M., Zsakai, A., Vellai Tibor, Mehta, A., Mehta, A. & Takacz-Vellai, K. (2014) NDK-1, the Homolog of NM23-H1/H2 Regulates Cell Migration and Apoptotic Engulfment in C. elegans. PLoS One, 9 (3), e92687-e92687 doi:10.1371/journal.pone.0092687.
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Horvat, T., Deželjin, M., Redžić, I., Barišić, D., Herak Bosnar, M., Lauc, G. & Zoldoš, V. (2013) Reversibility of Membrane N-Glycome of HeLa Cells upon Treatment with Epigenetic Inhibitors. PLoS One, 8 doi:10.1371/journal.pone.0054672.
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Deželjin, M. & Herak Bosnar, M. (2012) Metastasis - recent scientific insights and challenging new therapeutic approaches. Periodicum biologorum, 114 (4), 453-459.
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Horvat, T., Mužinić, A., Barišić, D., Herak Bosnar, M. & Zoldoš, V. (2011) Epigenetic modulation of HeLa cell membrane N-glycome. Biochimica et biophysica acta. G, General subjects, 1820 (9), 1412-1420 doi:10.1016/j.bbagen.2011.12.007.
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Annesley, S., Bago, R., Herak Bosnar, M., Filić, V., Marinović, M., Weber, I., Mehta, A. & Fisher, P. (2011) Dictyostelim discoideum nucleoside diphosphate kinase C plays a negative regulatory role in phagocytosis, macropinocytosis and exocytosis. PLoS One, 6 (10), e26024, 11 doi:10.1371/journal.pone.0026024.
doiwww.plosone.orgfulir.irb.hr -
Perina, D., Herak Bosnar, M., Mikoč, A. & Ćetković, H. (2011) Characterization of Nme6-like gene/protein from marine sponge Suberites domuncula. Naunyn-Schmiedeberg's archives of pharmacology, 384 (4/5), 451-460 doi:10.1007/s00210-011-0635-9.
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Perina, D., Herak Bosnar, M., Bago, R., Mikoč, A., Harcet, M., Deželjin, M. & Ćetković, H. (2011) Sponge non-metastatic Group I Nme gene/protein - structure and function is conserved from sponges to humans. Bmc evolutionary biology, 11 doi:10.1186/1471-2148-11-87.
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Peršec, Z., Peršec, J., Sović, T., Romić, Ž., Herak Bosnar, M. & Hrgović, Z. (2010) Metastatic Prostate Cancer in an Asymptomatic Patient with an Initial Prostate-Specific Antigen (PSA) Serum Concentration of 21, 380 ng/ml. Onkologie, 33 (3), 110-112 doi:10.1159/000277743.
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Herak Bosnar, M., Bago, R. & Ćetković, H. (2009) Subcellular localization of Nm23/NDPK A and B isoforms : A reflection of their biological function?. Molecular and cellular biochemistry, 329 (1-2), 63-71 doi:10.1007/s11010-009-0107-4.
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Bago, R., Pavelić, J., Maravić Vlahoviček, G. & Herak Bosnar, M. (2009) Nm23-H1 promotes adhesion of CAL 27 cells in vitro. Molecular carcinogenesis, 48 (9), 779-789 doi:10.1002/mc.20536.
doi Herak Bosnar, M., Bago, R., Konjevoda, P. & Pavelić, J. (2008) Gene expression profiling of Nm23-H2 overexpressing CAL 27 cells using DNA microarray. Neoplasma, 55 (5), 447-454.
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Deželjin, M., Herak Bosnar, M., Dubravčić, K., Bago, R. & Pavelić, J. (2008) The utilization of pEGFP reporter system in cell-cycle analysis of adherent cells. Periodicum biologorum, 110 (1), 73-76.
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Herak Bosnar, M., Dubravčić, K., Bago, R. & Pavelić, J. (2008) Head and neck tumor cells exhibit altered proliferation upon overexpression of nm23 genes. Croatica Chemica Acta, 81 (1), 183-189.
hrcak.srce.hr Herak Bosnar, M., Bago, R., Gall-Trošelj, K., Streichert, T. & Pavelić, J. (2006) Downstream targets of nm23-H1: Gene expression profiling of CAL 27 cells using DNA microarray. Molecular Carcinogenesis, 45 (8), 627-633.
Popović Hadžija, M., Hrašćan, R., Herak Bosnar, M., Zeljko, Ž., Hadžija, M., Čadež, J., Pavelić, K. & Kapitanović, S. (2004) Alterations of the DPC4 tumor-suppressor gene in renal cell carcinoma. Urological research, 32 (3), 229-235.
Pavelić, J., Herak Bosnar, M. & Kralj, M. (2004) Gene therapy: concept, current status, moral and ethical aspects. Periodicum biologorum, 106 (3), 239-244.
Pavelić, J., Zeljko, Ž. & Herak Bosnar, M. (2003) Molecular genetic aspects of prostate transition zone lesions. Urology, 62, 607-613.
Pavelić, K., Hadžija, M., Bedrica, L., Pavelić, J., Đikić, I., Katić, M., Kralj, M., Herak Bosnar, M., Kapitanović, S., Poljak-Blaži, M., Križanac, Š., Stojković, R., Jurin, M., Subotić, B. & Čolić, M. (2001) Natural zeolite clinoptilolite: new adjuvant in anticancer therapy. Journal of Molecular Medicine, 78 (12), 708-720.
Pavelić, K., Čabrijan, T., Hrašćan, R., Vrkljan, M., Lipovac, M., Kapitanović, S., Gall-Trošelj, K., Herak Bosnar, M., Tomac, A., Gršković, B., Karapandža, N., Pavelić, L., Krušlin, B., Spaventi, Š. & Pavelić, J. (1998) Molecular pathology of hemangiopericytomas accompanied by severe hypoglycemia: oncogenes, tumor-suppressor genes and the insulin-like growth factor family. Journal of Cancer Research and Clinical Oncology, 124, 307-314.
Pavelić, J., Herak Bosnar, M. & Gall-Trošelj, K. (1998) Limitations of p53 gene intron 6 MSP1 restriction fragment lenght polymorphism analysis. European Journal of Cancer, 34 (6), 941-942.
Herak Bosnar, M., Pavelić, K., Križanac, Š., Slobodnjak, Z. & Pavelić, J. (1997) Squamous cell lung carcinomas - the role of nm23-H1 gene. Journal of molecular medicine, 75 (8), 609-613.
Herak Bosnar, M., Pavelić, K., Hrašćan, R., Zeljko, Ž., Krhen, I., Mareković, Z., Križanac, Š. & Pavelić, J. (1997) Loss of heterozygosity of the nm23-H1 gene in human renal cell carcinomas. Journal of cancer research and clinical oncology, 123 (9), 485-488.
Pavelić, J., Gall-Trošelj, K., Herak Bosnar, M., Kardum, M. & Pavelić, K. (1996) PCR amplification of DNA from archival specimens - A methodological approach. Neoplasma, 43 (2), 75-81.
Membership in professional associations / societies
Member of the Oversight Commitee of Croatian Association for Cancer Research (branch of the EACR) – 2015-today Member of the Executive Committee of Croatian Society of Biochemistry and Molecular Biology – 2013-today Membership in scientific societies: Croatian Association for Cancer Research (branch of the EACR) 2009 - today Croatian Biological Society 2007.-today Croatian Society of Biochemistry and Molecular Biology, 1996.-today Hrvatsko Society of Human Genetics, 1994.-today European Urology Association, 1995-2000. |
Supervisor of doctoral thesis:
Ružica Bago: Uloga gena nm23-H1 u adheziji stanica CAL 27, 2007
Zoran Peršec: The role of nm23-H1 in prostate cancer cells during the process of lipid peroxidation, 2010
Martina Deželjin – The effect of Nm23 gene expression level on metstatic potential of tumor cells in vitro, 2011
Supervisor of diploma thesis:
Nikolina Nakić: Formation of stable CAL 27 clones constitutively expressing the mutated form of nm23-H2, 2007
Ivana Barabaš – Formation of CAL clones with permanently silenced nm23-H2 gene
Training:
Short-term fellowship of the French Republic 1999. Laboratory for intracellular signaling and oncogenesis, Curie Institut, France
Editor and author of several chapters in the textbook:
“Metode u molekularnoj biologiji” urednice: Andreja Ambriović Ristov, Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade i Dušica Vujaklija, izdavač:Institut Ruđer Bošković, Zagreb, 2007.
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Main organizer, chair of the Organizing Committee and a member of the Scientific Committee of the 10th International Congress of the NDP Kinase/Nm23/awd Gene Family, October 9-13 2016, Dubrovnik, Croatia
Member of the organizing committee:
Member of the scientific committee:
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