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Dr. Maja Herak Bosnar

Member of the Board of Governors
znanstveni savjetnik u trajnom izboru
Telephone
+385 1 456 0996
Internal phone number
1752
Academic title
Associate Professor
Address
Bijenička 54, 10002 Zagreb
Curriculum vitae

Education

1976-1984 - elementary school, Zagreb

1984-1988 - 16. gymnasium, Zagreb

1988 - 1993 - graduate school, Faculty of Sciences and Mathematics, University of Zagreb, B.Sc. in molecular biology

1993-1996 - postgraduate study in molecular and cellular biology, Faculty of Sciences and Mathematics, University of Zagreb, M.Sc. in molecular and cellular biology

1996-2002 - doctoral study, Faculty of Sciences and Mathematics, University of Zagreb, PhD in molecular biology

Research Areas

Projects

2019-2021 – principal investigator -2019-2020- PI: Mitochondrial NME proteins: candidates for orchestrating mitochondrial shape and cell life and death– French-Croatian bilateral project “Cogito”

2017.-2021. principal investigator - "Structure, function and evolution of Nme6/Nm23-H6 gene/protein-project of the Croatian Scientifc Foundation www.irb.hr/Nemo6 

2014-today-collaborator- New protein networks for novel therapeutic avenues in human melanoma, PI dr.sc. Neda Slade, Croatian Scientific Foundation

2013.-today,work package leader-FP7-Regpot project „Enhancement of the Innovation Potential in SEE through new Molecular Solutions in Research and Development“ InnoMol– coordinator: dr.sc. Oliver Vugrek

2007-2013. -principal investigator- The role of nm23 genes in oral squamous cell carcinoma, Ministry of Science, Technology and Sports, Republic of Croatia

2009-2010 -principal investigator- The study of intracellular localization and dynamics of NDPK A and B subunits (Nm23-H1 and Nm23-H2) – French-Croatian bilateral project “Cogito”

2008. –principal investigator- The role of nm23 genes in oral squamous cell carcinoma, Lutrija Hrvatske (Croatian Lottery)

2002.- 2006 collaborator,“Gene therapy using tumor-suppressor genes“ Ministry of Science, Technology and Sports, Republic of Croatia, principal investigator dr. sc. Jasminka Pavelić

1996.-2002 collaborator, projekt MZOŠ „Human tumor DNA bank“ – Ministry of Science, Technology and Sports, Republic of Croatia, principal investigator  acad. Šime Spaventi

1993.-1996.collaborator– „Formation of human tumor bank for basic research“ - Ministry of Science, Technology and Sports, Republic of Croatia, principal investigator, acad. Šime Spaventi

 

Awards and Achievements

Annual reward of the Ruđer Bošković Institute for the scientific publication Radić M, Šoštar M, Weber I, Ćetković H, Slade N, Herak Bosnar M*. The Subcellular Localization and Oligomerization Preferences of NME1/NME2 upon Radiation-Induced DNA Damage, Int J Mol Sci 21: 2363, 2020.

 Annual reward of the Ruđer Bošković Institute for the scientific publication “Ćetković H, Herak Bosnar M, Perina D, Mikoč A, Deželjin M, Belužić R, Bilandžija H, Ruiz-Trillo I,  Harcet M. Characterization of a group I Nme protein of Capsaspora owczarzaki—a close unicellular relative of animals, Lab Invest  98,  304–314, 2018.

Annual reward “Josip Juraj Strossmayer“ for the best scientific publication (Croatian Academy of Science and Arts and Zagreb Fair), 2007, for the textbook: 

Metode u molekularnoj biologiji(Methods in Molecular Biology) (editors): Andreja Ambriović Ristov, Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade and Dušica Vujaklija, publisher: Institut Ruđer Bošković, Zagreb, 2007.

Classes

Course holder (PhD studies)

 2008-present:  Molekularne osnove metastaziranja (Molecular Basis of Metstasis Formation), doctoral  study in Molekular Bioscience, University Josip Juraj Strossmayer Osijek), University in Dubrovnik and Rudjer Bošković Institute

2010-present: Genetika raka i biologija tumorskih stanica (Cancer Genetics and Tumor Cell Biology), doctoral study in Biology, Faculty of Science, University of Zagreb

Publications

Journal articles

Scientific and review papers

Conference proceedings papers

Scientific conference proceedings papers

  • Herak Bosnar, M. (1998) Microsatellite instability and loss of heterozygosity in breast cancer patients. U: Prpić, I. & Unušić, J. (ur.)Zbornik radova osmog znanstvenog sastanka bolesti dojke.

Theses

Doctoral dissertation

  • Herak Bosnar, M. (2002) 'The role of nm23 in in vitro cell prolifereation and diferentiation', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

Membership in professional associations / societies

Member of the Oversight Commitee of  Croatian Association for Cancer Research (branch of the EACR) – 2015-today

Member of the Executive Committee of Croatian Society of Biochemistry and Molecular Biology – 2013-today

Membership in scientific societies:

Croatian Association for Cancer Research (branch of the EACR) 2009 - today

Croatian Biological Society 2007.-today

Croatian Society of Biochemistry and Molecular Biology, 1996.-today

Hrvatsko Society of Human Genetics, 1994.-today

European Urology Association, 1995-2000.

Supervisor of doctoral thesis:

Ružica Bago: Uloga gena nm23-H1 u adheziji stanica CAL 27, 2007

Zoran Peršec: The role of nm23-H1 in prostate cancer cells during the process of lipid peroxidation, 2010

Martina Deželjin – The effect of Nm23 gene expression level on metstatic potential of tumor cells in vitro, 2011

 

Supervisor of diploma thesis:

Nikolina Nakić: Formation of stable CAL 27 clones constitutively expressing the mutated form of nm23-H2, 2007

Ivana Barabaš – Formation of CAL clones with permanently silenced nm23-H2 gene

Training:

Short-term fellowship of the French Republic 1999. Laboratory for intracellular signaling and oncogenesis, Curie Institut, France

Editor and author of several chapters in the textbook:

“Metode u molekularnoj biologiji” urednice: Andreja Ambriović Ristov, Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade i Dušica Vujaklija, izdavač:Institut Ruđer Bošković, Zagreb, 2007.

  1. “nm23 gene – a target for gene therapy?” – 3rds Croatian Congress in Pharmacology, Zagreb, Croatia, September 18-21, 2001.

 

  1. Methods of visualization of gene products in living cells (GFP) (in Croatian) – 21st Memorial Meeting in Honor of Professor S. Saltikow, Zagreb, Croatia, October 10, 2003.

 

  1. Subcellular localization of Nm23/NDPK subunits in HEp-2 cells.  2nd Croatian Congress on Microscopy, Topusko, Croatia, May, 18-21, 2006.

 

  1. Herak Bosnar, Maja; de Gunzburg, Jean; Bago, Ružica; Weber, Igor; Pavelić, Jasminka; Perina, Dragutin; Mikoč, Andreja; Ćetković, Helena.; Subcellular localization of NDPKs: How far is a sponge from a human? 7th International Congress of the NDP Kinase/NM23/Awd Family, Dundee, UK, 2007.

 

  1. Herak Bosnar, Maja; de Gunzburg, J.; Bago, Ružica; Brečević, Lukrecija; Weber, Igor; Pavelić, Jasminka. NM23/NDPK Subunits in Head and Neck Tumor Cells : Where do they go? // Proceedings of Abstracts of the 12th World Congress on Advances in Oncology and 10th International Symposium of Molecular Medicine and Cancer Chemoprevention Symposium Heraklion, Crete, Greece, October 2007.

 

  1. Herak Bosnar, Maja; Perina, Dragutin; Bago, Ružica; Mikoč, Andreja; Harcet, Matija; Deželjin ,Martina; Ćetković, Helena. Characterization of ancestral-type Grope I Nm23 gene/protein - structure and function is conserved from sponges to humans // 8th International Congress of the NDP kinase/Nm23/awd Family-From Basic Science to Clinical Application 2010. Heidelberg, Germany, October 25-28, 2010.

 

  1. Herak Bosnar, Maja; Perina, Drago; Harcet, Matija; Mikoč, Andreja; Deželjin, Martina; Ćetković, Helena. Nme family members in non-bilaterian Metazoans. 9th International Congress on the NDP kinase/Nm23/ awd Family. A new frontier in cell and cancer biology. Boston July31-August 4, 2013.

 

Main organizer, chair of the Organizing Committee and a member of the Scientific Committee of the 10th International Congress of the NDP Kinase/Nm23/awd Gene Family, October 9-13 2016, Dubrovnik, Croatia

 

Member of the organizing committee:

  1. New Aspects in Molecular Medicine 3, Molecular Endocrinology, September 8-9, 1996, Zagreb, Croatia
  2. 2nd International Conference on Signal Transduction, May 26-31, 2000, Cavtat-Dubrovnik, Croatia
  3. 1st International Conference on Mechanisms of Action of Nutraceuticals, October 14-19, 2001, Zagreb, Croatia
  4. 3rd International Conference on Signal Transduction, May 17-23, 2002, Cavtat-Dubrovnik, Croatia
  5. HDBMB 2014, The Interplay of Biomolecules (biannual meeting of Croatian FEBS branch), September 24-27, 2014, Zadar Croatia

Member of the scientific committee:

  1. Second Meeting of the Croatian Association for Cancer Research, HDIR (Hrvatsko društvo za istraživanje raka, national branch of EACR) with international participation, November 8-9, 2012, Zagreb, Croatia
  2. Third Meeting of the Croatian Association for Cancer Research, HDIR (Hrvatsko društvo za istraživanje raka, national branch of EACR) with international participation, November 6-7, 2014, Zagreb, Croatia
  3. HDBMB 2014, The Interplay of Biomolecules (biannual meeting of Croatian FEBS branch), September 24-27, 2014, Zadar Croatia
  4. HDBMB2016 on the occasion of the 40th Anniversary,  (biannual meeting of Croatian FEBS branch), June 1-4, 2016, Split, Croatia
  5. Forth Meeting of the Croatian Association for Cancer Research, HDIR (Hrvatsko društvo za istraživanje raka, national branch of EACR) with international participation, November 3-4, 2016, Zagreb, Croatia

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