Dr. Mladen Paradžik
10000 Zagreb
Croatia
Education
2015- Faculty of science-Zagreb; Doctoral study of biology
2008- Faculty of science-Zagreb; Bachelor of science
Featured Publications
Cell Mol Life Sci. 2022 Mar 29;79(4):216.
miRNA-guided reprogramming of glucose and glutamine metabolism and its impact on cell
adhesion/migration during solid tumor progression
L Quirico, F Orso, S Cucinelli, M Paradzik, D Natalini, G Centonze, A Dalmasso, S La Vecchia, M Coco, V Audrito, C Riganti, P Defilippi, D Taverna
Front Cell Dev Biol. 2021 Dec 16;9:786758. The Tongue Squamous Carcinoma Cell Line Cal27 Primarily Employs Integrin α6β4-Containing Type II Hemidesmosomes for Adhesion Which Contribute to Anticancer Drug Sensitivity.A Tadijan, JD Humphries, I Samaržija, N Stojanović, J Zha, K Čuljak, M Tomić, M Paradžik, D Nestić, H Kang, MJ Humphries, AA-Ristov
Cancers (Basel) 2020 Jul 15 12(7):1910. Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates. I Samaržija, A Dekanić, JD Humphries, M Paradžik, N Stojanović, MJ Humphries, A Ambriović-Ristov
Antioxidants (Basel). 2020 Apr; 9(4):294. Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells. Pinterić M, Podgorski I, Popović Hadžija M, Filić V, Paradžik M, Proust BLJ, Dekanić A, Ciganek I, Pleše D, Marčinko D, Balog T, Sobočanec S
Front Cell Dev Biol. 2020 Mar; 8:125. KANK2 Links αVβ5 Focal Adhesions to Microtubules and Regulates Sensitivity to Microtubule Poisons and Cell Migration. Paradžik M, Humphries JD, Stojanović N, Nestić D, Majhen D, Dekanić A, Samaržija I, Sedda D, Weber I, Humphries MJ, Ambriović-Ristov A
Am J Hematol. 2009 Jun; 84(6):375-7. Ikaros family transcription factors in chronic and acute leukemia. Matulic M*, Paradzik M*, Cicin-Sain L, Kapitanovic S, Dubravcic K, Batinic D, Antica M.
Publications
Journal articles
Scientific and review papers
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Paradžik, T., Podgorski, I., Vojvoda Zeljko, T. & Paradžik, M. (2022) Ancient Origins of Cytoskeletal Crosstalk: Spectraplakin-like Proteins Precede the Emergence of Cortical Microtubule Stabilization Complexes as Crosslinkers. International journal of molecular sciences, 23 (10), 5594, 23 doi:10.3390/ijms23105594.
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Quirico, L., Orso, F., Cucinelli, S., Paradžik, M., Natalini, D., Centonze, G., Dalmasso, A., La Vecchia, S., Coco, M., Audrito, V., Riganti, C., Defilippi, P. & Taverna, D. (2022) miRNA-guided reprogramming of glucose and glutamine metabolism and its impact on cell adhesion/migration during solid tumor progression. Cellular and molecular life sciences, 79, 216, 16 doi:10.1007/s00018-022-04228-y.
doilink.springer.comdoi.orgfulir.irb.hr -
Tadijan, A., Humphries, J., Samaržija, I., Stojanović, N., Zha, J., Čuljak, K., Tomić, M., Paradžik, M., Nestić, D., Kang, H., Humphries, M. & Ambriović-Ristov, A. (2021) The Tongue Squamous Carcinoma Cell Line Cal27 Primarily Employs Integrin α6β4-Containing Type II Hemidesmosomes for Adhesion Which Contribute to Anticancer Drug Sensitivity. Frontiers in cell and developmental biology, 9, 786758, 17 doi:10.3389/fcell.2021.786758.
doiwww.frontiersin.orgdoi.orgfulir.irb.hr -
Samaržija, I., Dekanić, A., Humphries, J., Paradžik, M., Stojanović, N., Humphries, M. & Ambriović- Ristov, A. (2020) Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates. Cancers (Basel), 12 (7), 1910, 26. (https://www.bib.irb.hr/1073479).
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Pinterić, M., Podgorski, I., Popović- Hadžija, M., Filić, V., Paradžik, M., Proust, B., Dekanić, A., Ciganek, I., Pleše, D., Marčinko, D., Balog, T. & Sobočanec, S. (2020) Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells. Antioxidants, 9 (4), 294, 21 doi:10.3390/antiox9040294.
doiwww.mdpi.comfulir.irb.hr -
Paradžik, M., Humphries, J., Stojanović, N., Nestić, D., Majhen, D., Dekanić, A., Samaržija, I., Sedda, D., Weber, I., Humphries, M. & Ambriović-Ristov, A. (2020) KANK2 links αVβ5 focal adhesions to microtubules and regulates sensitivity to microtubule poisons and cell migration. Frontiers in cell and developmental biology, 8, 125, 17 doi:10.3389/fcell.2020.00125.
doidoi.orgwww.frontiersin.orgfulir.irb.hr -
Antunovic, M., Matic, I., Nagy, B., Caput Mihalic, K., Skelin, J., Stambuk, J., Josipovic, P., Dzinic, T., Paradzik, M. & Marijanovic, I. (2019) FADD-deficient mouse embryonic fibroblasts undergo RIPK1-dependent apoptosis and autophagy after NB-UVB irradiation. Journal of photochemistry and photobiology. B, Biology, 194, 32-45 doi:10.1016/j.jphotobiol.2019.03.007.
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Stojanović, N., Dekanić, A., Paradžik, M., Majhen, D., Ferenčak, K., Ruščic, J., Bardak, I., Supina, C., Tomičić, M., Christmann, M., Osmak, M. & Ambriović-Ristov, A. (2018) Differential effects of integrin αv knockdown and cilengitide on sensitisation of triple-negative breast cancer and melanoma cells to microtubule poisons. Molecular pharmacology, 94 (6), 1334-1351 doi:10.1124/mol.118.113027.
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Pinterić, M., Podgorski, I., Sobočanec, S., Popović Hadžija, M., Paradžik, M., Dekanić, A., Marinović, M., Halasz, M., Belužić, R., Davidović, G., Ambriović Ristov, A. & Balog, T. (2018) De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment. Free radical research, 52 (6), 672, 684 doi:10.1080/10715762.2018.1462495.
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Vrhovac Madunić, I., Madunić, J., Antunović, M., Paradžik, M., Garaj-Vrhovac, V., Breljak, D., Marijanović, I. & Gajski, G. (2018) Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells. Naunyn-Schmiedeberg's archives of pharmacology, 391 (5), 537-550 doi:10.1007/s00210-018-1486-4.
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Paradžik, M., Novak, S., Mokrović, G., Bordukalo Nikšić, T., Heckel, D., Stipić, J., Pavičić Baldani, D., Čičin-Šain, L. & Antica, M. (2012) Ikaros family transcription factors expression in rat thymus : detection of impaired development. International journal of immunopathology and pharmacology, 25 (4), 893-900 doi:10.1177/039463201202500407.
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Antica, M., Paradžik, M., Novak, S., Džebro, S. & Dominis, M. (2010) Gene expression in formalin-fixed paraffin-embedded lymph nodes. Journal of immunological methods, 359 (1/2), 42-46 doi:10.1016/j.jim.2010.05.010.
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Matulić, M., Paradžik, M., Jelić Puškarić, B., Stipić, J. & Antica, M. (2010) Analysis of Ikaros Family Splicing Variants in Human Hematopoietic Lineages. Collegium antropologicum, 34 (1), 59-62.
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Matulić, M., Paradžik, M., Čičin-Šain, L., Kapitanović, S., Dubravčić, K., Batinić, D. & Antica, M. (2009) Ikaros family transcription factors in chronic and acute leukemia. American journal of hematology, 84 (6), 375-377 doi:10.1002/ajh.21401.
doidoi.org
Membership in professional associations / societies
2010. – present – member of the Croatian Association for Cancer Research
2009. - present – member of the Croatian immunological society
2018. - present - member of the Croatian Society of Biochemsitry and Molecular Biology