2015 Dr., University of Zagreb, Faculty of Science, Department of Chemistry, Zagreb, Croatia

2008 B.Sc., University of Zagreb, Faculty of Science, Department of Chemistry, Zagreb, Croatia

• Cyclopeptide complexes with functional ions - CPepFunxIon

  09.12.2025 - 08.12.2028 | 199,900.00 EUR

  CroRIS

• Investigating Keap1 Protein Interactions to Uncover New Therapeutic Strategies - Keap1-InterThera

  05.12.2025 - 04.12.2028 | 199,985.00 EUR

  CroRISIRB

• Preliminary studies of the interaction between Keap1 protein and the actin cytoskeleton

  20.03.2025 - 19.03.2026 | 7,500.00 EUR

  CroRISIRB

• Preliminary study of inhibiting NRF2-dependent transcription by preventing the DPP III – KEAP1 interaction for more effective cancer treatment

  05.04.2024 - 04.04.2025 | 8,000.00 EUR

  CroRISIRB

• Dipeptidyl peptidase III interaction with SH2 domain-containing protein 3C – possible link between oxidative stress response and cell migration - OxMiLink

  01.03.2021 - 28.02.2025 | 128,873.85 EUR

  CroRISIRB

2007. award for excellent success during the study, Faculty of Science, Zagreb, Croatia

assistant in laboratory exercises in physical chemistry at Faculty of Science, University of Zagreb, Croatia

1. Antonija Tomić; Hrvoje Brkić; Antonia Matić; Sanja Tomić. Unravelling the inhibitory zinc ion binding site and the metal exchange mechanism in human DPP III. Physical chemistry chemical physics 23 (2021), 13267-13275.

2. Antonija Tomić; Gordan Horvat; Michael Ramek; Dejan Agić; Hrvoje Brkić; Sanja Tomić. New zinc ion parameters suitable for classical MD simulations of zinc metallo-peptidases. Journal of chemical information and modeling 59 (2019), 8; 3437-3453.

3. Antonija Tomić; Borislav Kovačević; Sanja Tomić. Concerted nitrogen inversion and hydrogen bonding to Glu451 are responsible for protein-controlled suppression of the reverse reaction in the human DPP III. Physical Chemistry Chemical Physics 18 (2016), 39; 27245-27256.

4. Antonija Tomić; Sanja Tomić. Hunting the human DPP III active conformation: combined thermodynamic and QM/MM calculations. Dalton transactions 43 (2015) 15503-15514.

5. Antonija Tomić; Miguel Gonzalez; Sanja Tomić. The large scale conformational change of the human DPP III - substrate preferes the "closed" form. Journal of chemical information and modeling 52 (2012) 1583-1594.

6. Antonija Tomić; Marija Abramić; Jasminka Špoljarić; Dejan Agić; David M. Smith; Sanja Tomić. Human Dipeptidyl Peptidase III: Insights into Ligand Binding from a Combined Experimental and Computational Approach, Journal of Molecular Recognition, 24 (2011) 804-814.

Original scientific paper

• Matić, Antonia; Šupljika, Filip; Petohleb, Luka; Tomašić Paić, Ana; Kindl, Domagoj C.; Horvat, Gordan; Barbarić, Lea; Oskomić, Marina; Matovina, Mihaela; Tomić, Antonija | Bidirectional crosstalk between the catalytic and moonlighting functions of human dipeptidyl peptidase 3: potential physiological implications // RSC Advances, (2026), doi: 10.1039/d6ra05272j

  doipubs.rsc.org

• Rinkovec, Tamara; Tarana, Siniša; Modrušan, Matija; Vidović, Nikolina; Tomić, Antonija; Cindro, Nikola; Speranza, Giovanna; Tomišić, Vladislav; Horvat, Gordan | Anion complexes of small Boc-protected lysine cyclopeptides in solution // Journal of molecular liquids, 433 (2025), 127837, 15. doi: 10.1016/j.molliq.2025.127837

  doiwww.sciencedirect.com

• Tomić, Antonija; Čonkaš, Josipa; Ozretić, Petar | Let’s Talk about Sex Hormone Receptors and Their Physical Interaction with Sonic Hedgehog Protein: A Computational Study with Emphasis on Progesterone Receptor // Applied sciences (Basel), 14 (2024), 2; 562, 17. doi: 10.3390/app14020562

  doifulir.irb.hrwww.mdpi.com

• Tomić, Antonija ; Karačić, Zrinka ; Tomić, Sanja | Influence of Mutations of Conserved Arginines on Neuropeptide Binding in the DPP III Active Site // Molecules, 28 (2023), 4; 1976, 17. doi: 10.3390/molecules28041976

  doiwww.mdpi.comfulir.irb.hr

• Karačić, Zrinka ; Šupljika, Filip ; Tomić, Antonija ; Brkljačić, Lidija ; Tomašić Paić, Ana ; Ćehić, Mirsada ; Tomić, Sanja | Neuropeptides, substrates and inhibitors of human dipeptidyl peptidase III, experimental and computational study — A new substrate identified // International journal of biological macromolecules, 220 (2022), 1390-1401. doi: 10.1016/j.ijbiomac.2022.09.119

  doiwww.sciencedirect.comfulir.irb.hr

• Tomić, Antonija ; Tomić, Sanja | Demystifying DPP III Catalyzed Peptide Hydrolysis— Computational Study of the Complete Catalytic Cycle of Human DPP III Catalyzed Tynorphin Hydrolysis // International journal of molecular sciences, 23 (2022), 3; 1858, 24. doi: 10.3390/ijms23031858

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Tomić, Antonija ; Brkić, Hrvoje ; Matić, Antonia ; Tomić, Sanja | Unravelling the inhibitory zinc ion binding site and the metal exchange mechanism in human DPP III // PCCP. Physical chemistry chemical physics, 23 (2021), 13267-13275. doi: 10.1039/D1CP01302E

  doipubs.rsc.orgdoi.org

• Agić, Dejan ; Brkić, Hrvoje ; Kazazić, Saša ; Tomić, Antonija ; Abramić, Marija | Aprotinin interacts with substrate-binding site of human dipeptidyl peptidase III // Journal of biomolecular structure & dynamics, 37 (2019), 14; 3596-3606. doi: 10.1080/07391102.2018.1521343

  doifulir.irb.hrdoi.orgwww.tandfonline.com

• Tomić, Antonija ; Horvat, Gordan ; Ramek, Michael ; Agić, Dejan ; Brkić, Hrvoje ; Tomić, Sanja | New zinc ion parameters suitable for classical MD simulations of zinc metallo-peptidases // Journal of chemical information and modeling, 59 (2019), 8; 3437-3453. doi: 10.1021/acs.jcim.9b00235

  doipubs.acs.orgdoi.org

• Tomin, Marko ; Tomić, Antonija ; Kovačević, Borislav ; Tomić, Sanja | The Mechanism of Peptide Hydrolysis Catalysed by Dipeptidyl Peptidase III from Bacteroides thetaiotaomicron // Croatica chemica acta, 91 (2018), 2; 187-193. doi: 10.5562/cca3343

  doihrcak.srce.hrfulir.irb.hr

• Kazazić, Saša ; Karačić, Zrinka ; Sabljić, Igor ; Agić, Dejan ; Tomin, Marko ; Abramić, Marija ; Dadlez, Michal ; Tomić, Antonija ; Tomić, Sanja | Conservation of the conformational dynamics and ligand binding within M49 enzyme family // RSC Advances, 8 (2018), 24; 13310-13322. doi: 10.1039/c7ra13059g

  doipubs.rsc.orgpubs.rsc.orgfulir.irb.hr

• Sabljić, Igor ; Tomin, Marko ; Matovina, Mihaela ; Sučec, Iva ; Tomašić Paić, Ana ; Tomić, Antonija ; Abramić, Marija ; Tomić, Sanja | The first dipeptidyl peptidase III from a thermophile: Structural basis for thermal stability and reduced activity // PLoS One, 13 (2018), 2; e0192488, 25. doi: 10.1371/journal.pone.0192488

  doijournals.plos.orgdoi.orgfulir.irb.hrfulir.irb.hr

• Gundić, Mario ; Tomić, Antonija ; Wade, Rebecca C. ; Matovina, Mihaela ; Karačić, Zrinka ; Kazazić, Saša ; Tomić, Sanja | Human DPP III – Keap1 Interactions : A Combined Experimental And Computational study // Croatica chemica acta, 89 (2016), 2; 217-228. doi: 10.5562/cca2916

  doihrcak.srce.hr

• Tomić, Antonija ; Kovačević, Borislav ; Tomić, Sanja | Concerted nitrogen inversion and hydrogen bonding to Glu451 are responsible for protein-controlled suppression of the reverse reaction in the human DPP III // PCCP. Physical chemistry chemical physics, 18 (2016), 39; 27245-27256. doi: 10.1039/C6CP04580D

  doipubs.rsc.org

• Tomić, Antonija ; Berynskyy, Mykhaylo ; Wade, Rebecca C. ; Tomić, Sanja | Molecular simulations reveal that the long range fluctuations of human DPP III change upon ligand binding // Molecular biosystems, 11 (2015), 3068-3080. doi: 10.1039/c5mb00465a

  doipubs.rsc.org

• Tomić, Antonija ; Tomić, Sanja | Hunting the human DPP III active conformation : combined thermodynamic and QM/MM calculations // Dalton transactions, 43 (2014), 15503-15514. doi: 10.1039/C4DT02003K

  doipubs.rsc.org

• Tomić, Antonija ; Gonzalez, Miguel ; Tomić, Sanja | The large scale conformational change of the human DPP III – substrate prefers the "closed" form // Journal of chemical information and modeling, 52 (2012), 6; 1583-1594. doi: 10.1021/ci300141k

  doipubs.acs.org

• Tomić, Antonija ; Abramić, Marija ; Špoljarić, Jasminka ; Agić, Dejan ; Smith, David M. ; Tomić, Sanja | Human Dipeptidyl Peptidase III: Insights into Ligand Binding from a Combined Experimental and Computational Approach // Journal of molecular recognition, 24 (2011), 5; 804-814. doi: 10.1002/jmr.1115

  doionlinelibrary.wiley.com

• Špoljarić, Jasminka ; Tomić, Antonija ; Vukelić, Bojana ; Salopek-Sondi, Branka ; Agić, Dejan ; Tomić, Sanja ; Abramić, Marija | Human Dipeptidyl Peptidase III : the Role of Asn406 in Ligand Binding and Hydrolysis // Croatica chemica acta, 84 (2011), 2; 259-268. doi: 10.5562/cca1808

  doihrcak.srce.hr

• Tomić, Antonija ; Živković, Tomislav | On the vibrational interlacing rule in deuterated thiophenes : I. Out-of-plane vibrations // Croatica chemica acta, 82 (2009), 2; 561-566

  hrcak.srce.hr

Review, commentary, critique

• Grabar Branilović, Marina ; Maršavelski, Aleksandra ; Tomić, Antonija ; Tomić, Sanja | Nobelova nagrada za kemiju za 2013. godinu // Kemija u industriji : časopis kemičara i tehnologa Hrvatske, 62 (2013), 11-12; 468-471

  fulir.irb.hrhrcak.srce.hr

Review article (scientific)

• Oskomić, Marina; Tomić, Antonija; Barbarić, Lea; Matić, Antonia; Kindl, Domagoj Christian; Matovina, Mihaela | KEAP1-NRF2 Interaction in Cancer: Competitive Interactors and Their Role in Carcinogenesis // Cancers, 17 (2025), 1-27. doi: 10.3390/cancers17030447

  doiwww.mdpi.comfulir.irb.hr

Conference abstract

• Tomić, Antonija | Position of the C-terminal α-helix could be important for understanding the molecular mechanism of cellular oxidative stress sensing by KEAP1 // 10th Regional Biophysics Conference & 15th International Summer School of Biophysics : Book of abstracts / Dolanski Babić, Sanja; Dutour Sikirić, Maja; Stepanić, Višnja et al. (ur.). | Split: Hrvatsko Biofizičko Društvo, 2024. str. 60-60

  rbc2024.biofizika.hr

• Tomić, Antonija | Molecular modeling study of the structure and dynamics of the KEAP1 dimer and its complex with the Neh2 domain of NRF2 // 8th BenBedPhar Scientific meeting : Abstract Book / Tenreiro, Sandra; Antunes, Fernando (ur.). | Lisabon: Cost, 2024. str. 43-43

  benbedphar.org

• Tomić, Antonija; Ozretić, Petar | Molecular Modeling Study of Sonic Hedgehog Protein Interaction with Sex Hormone Receptors // Computational Chemistry Day 2023 : Book of Abstracts / Hok, Lucija (ur.). | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2023. str. 24-24

  www.compchemday.org

• Tomić, Antonija; Tomić, Sanja | Understanding Binding and Hydrolysis of Neuropeptides in the Active Site of Human Dipeptidyl Peptidase III // Computational Chemistry Day 2022 : book of abstracts. | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2022. str. 19-19

  drive.google.com

• Matić, Antonia ; Karačić, Zrinka ; Tomić, Antonija ; Brkić, Hrvoje ; Tomić Sanja | Dipeptidyl peptidase iii inhibition tests by metal dications // Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology HDBMB22: From Science to Knowledge. | Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2022. str. 105-105

  congress2022.hdbmb.hr

• Tomić, Sanja ; Karačić, Zrinka ; Tomić, Antonija ; Brkljačić, Lidija ; Šupljika, Filip | Neuropeptides - substrates of dipeptidyl peptidase III // From Science to Knowledge. | Zagreb: Hrvatsko Društvo za Biotehnologiju, 2022. str. 151-151

  congress2022.hdbmb.hr

• Tomić, Antonija ; Karačić, Zrinka ; Šupljika, Filip ; Tomić, Sanja | Computational modelling an aid to understand binding and hydrolysis of neuropeptides in the active site of human DPP III // Book of abstracts of the 1st Central and Eastern European Conference on Physical Chemistry and Materials Science (CEEC-PCMS1). | 2022. str. 196-196

  www.ceec-physchem.org

• Tomić, Antonija ; Tomić, Sanja | Computational study of the human DPP III catalyzed peptide hydrolysis - difference between „good“ and „slow“ substrate // Math/Chem/Comp 2022 and 33rd MC2 Conference : Book of Abstracts. | Zagreb: Hrvatsko kemijsko društvo, 2022. str. 24-24

  mcc.hkd.hr

• Tomić, Antonija ; Tomić, Sanja | Understanding the human DPP iii substrate specificity : QM/MM and MD calculations // Math/Chem/Comp 2021 : 32nd MC2 Conference : book of abstracts. | Zagreb: Hrvatsko kemijsko društvo, 2021. str. 42-42

  mcc.hkd.hr

• Matić, Antonia ; Karačić, Zrinka ; Tomić, Antonija ; Brkić, Hrvoje ; Tomić, Sanja | Ispitivanja inhibicije dipeptidil peptidaze III metalnim dikationima // Knjiga sažetaka - 18. Ružičkini dani: Danas znanost - Sutra industrija. | Zagreb : Osijek: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku, 2020. str. 78-78

  www.hdki.hr

• Tomić, Antonija ; Horvat, Gordan ; Ramek, Michael ; Agić, Dejan ; Brkić, Hrvoje ; Tomić, Sanja | Development of new zinc ion parameters suitable for classical MD simulations of zinc metallo-peptidases // Computational Chemistry Day 2019 :Book of abstracts. | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2019. str. 3-3

  ccd19.pharma.hr

• Tomić, Antonija ; Ramek, Michael ; Tomić, Sanja | Development of new parameters for the Zn2+ ion for the specific environment of the DPP III enzyme catalytic site // Computational Chemistry Day Book of abstracts. | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2018. str. 15-15

• Tomić, Sanja ; Tomić, Antonija ; Gundić, Mario | Influence of ligands and protein binding to structure and flexybility of human dipeptidyl peptidase III // Conference proceedings of ICBMB 2016, International Conference on Biochemistry and Molecular Biology. | 2016. str. 9-9

  biochem.conference-site.com

• Tomić, Antonija ; Tomić, Sanja | The recent findings on the zinc ion coordination and ligand binding in the human DPP III active site – implication on the chemical reaction mechanism // XXIII. hrvatski skup kemičara i kemijskih inženjera, knjiga sažetaka. | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2013. str. 177-177

• Tomić, Antonija ; Tomić, Sanja | Molecular Mechanics - Poisson Boltzmann Surface Area calculations using AMBER program package - application to the human dipeptidyl petidase III // Computational Electrostatics for Biological Applications - Book of Abstract. | 2013. str. 39-39

• Tomić, Sanja ; Tomić, Antonija ; Gonzalez, Miguel | Molecular dynamics based studies on human DPP III revealed determinants for its broad substrate selectivity. | 2012

• Tomić, Antonija ; Tomić, Sanja | Further study of the zinc coordination in the active site of the human DPP III - ONIOM calculations // Book of abstracts, 11th Greta Pifat-Mrzljak International School of Biophysics, Biomolecular complexes and assemblies. | Zagreb: Institut Ruđer Bošković i Hrvatsko biofizičko društvo, 2012. str. 104-104

  www.irb.hr

• Tomić, Antonija ; Tomić, Sanja | QM/MM study of the zinc coordination in the active site of the human DPP III // Knjiga sažetaka - IX. Susret mladih kemijskih inženjera. | Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2012. str. 173-173

• Tomić, Antonija ; Tomić, Sanja | MD simulations showed large conformational changes of the human free DPP III // Book of Abstracts - The Conference on Molecular Simulations in Biosystems and Material Science. | Konstanz, 2011. str. 72-72

  cms.uni-konstanz.de

• Tomić, Antonija ; Tomić, Sanja | Human dipeptidyl-peptidases (h.DPP III), sampling the substrate binding site - computational analysis // Book of Abstracts of the "Fourth Humboldt Conference on Computational Chemistry". | Sofija, 2010. str. 63.-63.

• Tomić, Antonija ; Špoljarić, Jasminka ; Abramić, Marija ; Tomić, Sanja | Ligand binding to human DPP III and its mutant H568N - computational analyses // Abstracts of the 6th International Workshop on New Approaches in Drug Design & Discovery "The Interactions :From Atom-Atom Contacts to Networks in System Biology". | Marburg: University of Marburg, 2010. str. 87-87

• Tomić, Antonija ; Abramić, Marija ; Smith, David ; Tomić, Sanja | Computational and experimental approach to the study of ligands binding into the active site of the human dipeptidyl-peptidases (DPPIII) // Book of Abstracts of the "The 3rd Adriatic Meeting On Computational Solutions in the Life Sciences". | Zagreb: Centre for Computational Solutions in the Life Sciences, Ruđer Bošković Institute, 2009. str. 77-77

  www.compsols.irb.hr

• Tomić, Antonija ; Abramić, Marija ; Smith, David ; Tomić, Sanja | Molecular dynamics simulations of ligands binding into the active site of human dipeptidyl-peptidases (DPPIII) // Book of Abstracts of the EMBO Young Scientists Forum. | 2009. str. 53-53

  bioinfo.hr

• Horvat, Gordan ; Magdić, Katja ; Tomić, Antonija ; Pitarević Svedružić, Lovorka ; Rončević, Sanda | Analiza sedimenta i vode Moslavačkog područja // Zbornik radova i sažetaka Znanstveno-edukativnog projekta Studentskog odsjeka HGD-a "Voda i mi. II.". | Zagreb: Hrvatsko geološko društvo, 2007. str. 15-16-x

Other

• Tomić, Sanja ; Abramić, Marija ; Brkić, Hrvoje ; Tomić, Antonija | Sprega kristalografije i modeliranja u proučavanju bioloških makromolekula // Kristalografija u Hrvatskoj. | Zagreb: Hrvatska akademija znanosti i umjetnosti (HAZU), 2013. str. 129-137

Original scientific paper

• Tomić, Sanja ; Brkić, Hrvoje ; Grabar Branilović, Marina ; Tomić, Antonija ; Branimir, Bertoša ; Mile, Šikić | Proteini i nukleinske kiseline u vremenu i prostoru // Bioinformatics and biological physics: proceedings of the scientific meeting. | Zagreb: Hrvatska akademija znanosti i umjetnosti (HAZU), 2013. str. 149-157

Conference abstract

• Tomić, Sanja ; Kovačević, Borislav ; Tomić, Antonija ; Matovina, Mihaela ; Karačić, Zrinka ; Matić, Sara ; Abramić, Marija ; Agić, Dejan | Understanding h.DPP III mechanism – an aid in rationalization of the mutants (in)activity // European biophysics journal, 46, 2017. str. S179-S179

  link.springer.comlink.springer.com

• Tomić, Sanja ; Tomić, Antonija | Ligand binding to the flexible metaloenzymes: protein dynamics and the active enzyme conformation // European biophysics journal, 44, Suppl. 1, 2015. str. 243-243. doi: 10.1007/s00249-015-1045-6

  doilink.springer.com

Unpublished conference paper

• Tomić, Antonija | Designing Kelch Domain Mutants to Prevent DPP III Interference in NRF2 Binding to KEAP1 - Regulating Antioxidative Response in Breast Cancer Cells // Management Committee and Working Group Meeting of Cost Action CA21162 (COZYME2024) | Zagreb, Hrvatska, 24.04.2024-26.04.2024

• Tomić, Antonija | Using high-performance computing to reveal mechanism of the KEAP1 protein conformational changes induced by oxidative stress // Dani e-infrastrukture Srce DEI 2024 | Zagreb, Hrvatska, 16.04.2024-19.04.2024

Doctoral thesis

• Tomić, Antonija | Primjena računalnih pristupa različitih stupnjeva složenosti u svrhu razumijevanja strukture, dinamike i aktivnosti ljudske dipeptidil-peptidaze III / Tomić, Sanja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2015

  repozitorij.pmf.unizg.hr

Master of Science thesis

• Mah'D, Jasmin | Računalna studija vezanja malih molekula na dipeptidil peptidazu III (DPP III) s ciljem inhibicije njezine uloge u Keap1-Nrf2 signalnom putu / Šupljika, Filip; Tomić, Antonija (mentor). | Zagreb, Prehrambeno-biotehnološki fakultet, 2025

Member of the Croatian Chemical Society