A new approach in the structural characterization of drug delivery systems

Principal investigator

Project type
Znanstveno-istraživački projekti
Programme
NextGenerationEU
Financier
European Union
Start date
Jan 15th 2025
End date
Jan 14th 2026
Status
Done
Total cost
65659 EUR
More information

Liposomes, spherical structures that can incorporate water-soluble (in)soluble drugs, have proven to be very powerful therapeutics in the treatment of chronic conditions. The effectiveness of liposomes resulting from delivery to a targeted site in the body after a sufficiently long circulation in the bloodstream is, unfortunately, accompanied by shortcomings such as their aggregation and premature drug release. Since the quality of liposomes is validated by various structural and physicochemical techniques, this project proposal proposes the inclusion of two techniques in the routine protocol of their characterization. They will also improve the quality control of prepared drug carriers, and more precise design will facilitate the administration and final effect of personalized drugs.