Dr. Maja Sabol
10002 Zagreb
Croatia
Education
1999 – 2004: Univeristy of Zagreb, Faculty of Science, Department of Biology, graduate study of molecular biology
2005 – 2010: University of Zagreb, Faculty of Science, Department of Biology, postgraduate study of molecular and cell biology
2009 – 2013: Accredited private college for business and administration “Baltazar Adam Krčelić” – specialist study of project management (MBA equivalent)
workshops:
2015. Phenomin – European Advanced School for Mouse Phenogenomics, Alsace, France
2015. Processing and analysis of Microscopic Images in Biomedicine, Prague, Czech Republic
2012. International Workshop on miRNA and Virus-Associated Cancers, Dubrovnik, Croatia
10th International Summer School on Biophysics, Rovinj, Croatia, September 19 - October 1, 2009
DMMC: Epigenetics: From mechanisms to medicines, Dublin, Ireland, June 24-26, 2007
MedILS Summer School ’08: Hottest topics in protein research. Split, Croatia, July 19-26, 2008
EMBO Practical Course on Ubiquitin and SUMO, MedILS, Split, Croatia, September 12-19, 2008
Projects
2019-2022: IP-01-2018-4889 Differentail regulation of the GLI code in BRAF/NRAS driven tumors. funded by the Croatian Science Foundation
Awards and Achievements
Rector's award from the University of Zagreb in academic year 2002/2003
Best poster award (3rd place) at the IV Croatian Conference on Human Genetics, Malinska, Croatia 2007.
Best poster award at the Rudjer Boskovic Institute ZS3V festival (“Znanstveni susreti treće vrste”, eng. “Scientific Encounters of the Third Kind”), in the “Human – From Cell to Organism” topic
Classes
Teaching assistant in graduate courses:
- “Signaling pathways and interactions”, Division of Biotechnology, University of Rijeka 2009/10
- “Recombinant DNA methodology”, University of Applied Health Studies, Specialist study of environmental health engineering 2008/09, 2009/10
Teaching assistant in postgraduate courses:
- Signaling pathways in the cell (oncogenes and tumor suppressors), University of Zagreb, Faculty of Science 2009/10, 2010/11
- Genomic DNA, Molecular Biosciences, joint course of University of Dubrovnik, University of Osijek and Rudjer Boskovic Institute 2009/10
- Research methods in molecular oncology, University of Zagreb, School of Medicine 2009/10, 2010/11
Featured Publications
Cretnik M, Musani V, Oreskovic S, Leovic D, Levanat S. The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas. Int J Mol Med 2007; 19: 875-883.
Cvok ML, Cretnik M, Musani V, Ozretic P, Levanat S. New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia, Clin Chem Lab Med 2008;46(10):1376-1383.
Leovic D, Sabol M, Ozretic P, Musani V, Car D, Marjanovic K, Zubcic V, Sabol I, Sikora M, Grce M, Glavas-Obrovac Lj, Levanat S. Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma. Head Neck 2012, 34(1): 104-12.
Sabol M, Trnski D, Uzarevic Z, Ozretic P, Musani V, Rafaj M, Cindric M, Levanat S. Combination of cyclopamine and tamoxifen promotes survival and migration of breast cancer cells – interaction of Hedgehog-gli and estrogen receptor signaling pathways. PLoS ONE 2014, 9(12):e114510.
Trnski D,Sabol M, Gojević A, Martinić M, Ozretić P, Musani V, Ramić S, Levanat S. GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer – Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation. Biochym Biophys Acta 2015, 1852(12):2574-84.
Levanat S, Sabol M, Musani V, Ozretic P, Trnski D. Hedgehog signaling pathway as genetic and epigenetic target in ovarian tumors. Curr Pharm Des 2017, 23(1):73-94.
Ozretić P, Trnski, D, Musani V, Maurac I, Kalafatić D, Orešković S, Levanat S, Sabol M. Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas. International journal of oncology, 51 (2017), 6; 1869-1877.
Sabol M, Trnski D, Musani V, Ozretić P, Levanat S. Role of GLI transcription factors in pathogenesis and their potential as new therapeutic targets. Int J Mol Sci, 19 (2018), 2562.
Trnski D, Gregorić M, Levanat S, Ozretić P, Rinčić N, Majić Vidaković T, Kalafatić D, Maurac I, Orešković S, Sabol M, Musani V. Regulation of Survivin isoform expression by GLI proteins in ovarian cancer. Cells, 8 (2019) 128.
Publications
Books and book chapters
Book chapters
Sobočanec, S., Šarić, A., Korolija, M., Marjanović, M., Kralj, M., Knežević, J., Čretnik, M., Balog, T., Šverko, V., Kušić, B. & Marotti, T. (2008) Native propolis in vivo: On the oxidative/antioxidative effect and the mechanism of the action. U: Oršolić, N. & Bašić, I. (ur.) Scientific evidence of the Use of Propolis in Ethnomedicine. Lahti, Research Signpost, str. 121-131.
Čretnik, M., Grbeša, I., Levanat, S. & Gall-Trošelj, K. (2007) DNA methylation analysis by bisulfite sequencing. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Četković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 376-379.
Journal articles
Scientific and review papers
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Petrić, T. & Sabol, M. (2023) Why 3D in vitro cancer models are the futureof cancer research?. Periodicum biologorum, 124 (3-4), 69-83 doi:10.18054/pb.v124i3-4.24697.
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Piteša, N., Kurtović, M., Bartoniček, N., Gkotsi, D., Čonkaš, J., Petrić, T., Musani, V., Ozretić, P., Riobo-Del Galdo, N. & Sabol, M. (2023) Signaling switching from Hedgehog-GLI to MAPK signaling potentially serves as a compensatory mechanism in melanoma cell lines resistant to GANT-61. Biomedicines, 11, 1353, 19 doi:10.3390/biomedicines11051353.
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Čonkaš, J., Sabol, M. & Ozretić, P. (2023) ‘Toxic Masculinity’: What Is Known about the Role of Androgen Receptors in Head and Neck Squamous Cell Carcinoma. International journal of molecular sciences, 24 (4), 3766, 18 doi:10.3390/ijms24043766.
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Kurtović, M., Piteša, N., Bartoniček, N., Ozretić, P., Musani, V., Čonkaš, J., Petrić, T., King, C. & Sabol, M. (2022) RNA-seq and ChIP-seq Identification of Unique and Overlapping Targets of GLI Transcription Factors in Melanoma Cell Lines. Cancers, 14 (18), 4540, 20 doi:10.3390/cancers14184540.
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Radić, M., Vlašić, I., Jazvinšćak Jembrek, M., Horvat, A., Tadijan, A., Sabol, M., Dužević, M., Herak Bosnar, M. & Slade, N. (2022) Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance. International journal of molecular sciences, 23 (17), 9910, 19 doi:10.3390/ijms23179910.
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Sabol, M., Calleja-Agius, J., Di Fiore, R., Suleiman, S., Ozcan, S., Ward, M. & Ozretić, P. (2021) (In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers. Cancers, 13, 5040, 36 doi:10.3390/cancers13205040.
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Trnski, D., Sabol, M., Tomić, S., Štefanac, I., Mrčela, M., Musani, V., Rinčić, N., Kurtović, M., Petrić, T., Levanat, S. & Ozretić, P. (2021) SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells. Scientific reports, 11 (1), 14880, 11 doi:10.1038/s41598-021-93971-6.
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Di Fiore, R., Suleiman, S., Felix, A., O'Toole, S., O'Leary, J., Ward, M., Beirne, J., Sabol, M., Ozretić, P., Yordanov, A., Vasileva-Slaveva, M., Kostov, S., Nikolova, M., Said-Huntingford, I., Ayers, D., Ellul, B., Pentimalli, F., Giordano, A. & Calleja-Agius, J. (2021) An Overview of the Role of Long Non-Coding RNAs in Human Choriocarcinoma. International journal of molecular sciences, 22 (12), 6506, 16 doi:10.3390/ijms22126506.
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Di Fiore, R., Suleiman, S., Pentimalli, F., O'Toole, S., O'Leary, J., Ward, M., Conlon, N., Sabol, M., Ozretić, P., Erson-Bensan, A., Reed, N., Giordano, A., Herrington, C. & Calleja-Agius, J. (2021) Could MicroRNAs Be Useful Tools to Improve the Diagnosis and Treatment of Rare Gynecological Cancers?A Brief Overview. International journal of molecular sciences, 22 (8), 3822, 26 doi:10.3390/ijms22083822.
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Di Fiore, R., Suleiman, S., Ellul, B., O’Toole, S., Savona-Ventura, C., Felix, A., Napolioni, V., Conlon, N., Erson-Bensan, A., Kahramanoglu, I., Azzopardi, M., Dalmas, M., Calleja, N., Brincat, M., Muscat-Baron, Y., Sabol, M., Dimitrievska, V., Yordanov, A., Vasileva- Slaveva, M., von Brockdorff, K., Micallef, R., Kubelac, P., Achimas-Cadariu, P., Vlad, C., Tzortzatou, O., Poka, R., Giordano, A., Felice, A., Reed, N., Herrington, C., Faraggi, D. & Calleja-Agius, J. (2021) GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors—Current Challenges and Future Directions. Cancers, 13 (3), 493, 14 doi:10.3390/cancers13030493.
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Zubčić, V., Rinčić, N., Kurtović, M., Trnski, D., Musani, V., Ozretić, P., Levanat, S., Leović, D. & Sabol, M. (2020) GANT61 and Lithium Chloride Inhibit the Growth of Head and Neck Cancer Cell Lines Through the Regulation of GLI3 Processing by GSK3beta. International journal of molecular sciences, 21, 6410, 13 doi:10.3390/ijms21176410.
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Sabol, M., Akbudak, A., Fricova, D., Beck, I. & Sedlacek, R. (2020) Novel TALEN-generated mCitrine-FANCD2 fusion reporter mouse model for in vivo research of DNA damage response. DNA repair, 94, 102936, 6 doi:10.1016/j.dnarep.2020.102936.
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Ozretić, P., Hanžić, N., Proust, B., Sabol, M., Trnski, D., Radić, M., Musani, V., Ciribilli, Y., Milas, I., Puljiz, Z., Bosnar Herak, M., Levanat, S. & Slade, N. (2019) Expression profiles of p53/p73, NME and GLI families in metastatic melanoma tissue and cell lines. Scientific Reports, 9 (1), 12470, 13 doi:10.1038/s41598-019-48882-y.
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Sušac, I., Ozretić, P., Gregorić, M., Levačić Cvok, M., Sabol, M., Levanat, S., Trnski, D., Eljuga, D., Seiwerth, S., Aralica, G., Stanec, M. & Musani, V. (2019) Polymorphisms in survivin (BIRC5 gene) are associated with age of onset in breast cancer patients. Journal of oncology, 2019, 3483192, 10 doi:10.1155/2019/3483192.
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Trnski, D., Gregorić, M., Levanat, S., Ozretić, P., Rinčić, N., Majić Vidaković, T., kalafatić, D., Maurac, I., Orešković, S., Sabol, M. & Musani, V. (2019) Regulation of Survivin Isoform Expression by GLI Proteins in Ovarian Cancer. Cells, 8 (2), 128, 13 doi:10.3390/cells8020128.
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Sabol, M., Trnski, D., Musani, V., Ozretić, P. & Levanat, S. (2018) Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets. International journal of molecular sciences, 19 (9), 2562, 37 doi:10.3390/ijms19092562.
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Ozretić, P., Trnski, D., Musani, V., Maurac, I., Kalafatić, D., Orešković, S., Levanat, S. & Sabol, M. (2017) Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas. International journal of oncology, 51 (6), 1869-1877 doi:10.3892/ijo.2017.4156.
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Levanat, S., Sabol, M., Musani, V., Ozretić, P. & Trnski, D. (2017) Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors. Current pharmaceutical design, 23 (1), 73-94 doi:10.2174/1381612822666161006154705.
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Trnski, D., Sabol, M., Gojević, A., Martinić, M., Ozretić, P., Musani, V., Ramić, S. & Levanat, S. (2015) GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer — Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852 (12), 2574-2584 doi:10.1016/j.bbadis.2015.09.005.
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Ozretić, P., Bisio, A., Musani, V., Trnski, D., Sabol, M., Levanat, S. & Inga, A. (2015) Regulation of human PTCH1b expression by different 5' untranslated region cis-regulatory elements. RNA Biology, 12 (3), 290-304 doi:10.1080/15476286.2015.1008929.
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Sabol, M., Trnski, D., Užarević, Z., Ozretić, P., Musani, V., Rafaj, M., Cindrić, M. & Levanat, S. (2014) Combination of cyclopamine and tamoxifen promotes survival and migration of MCF-7 breast cancer cells – interaction of Hedgehog-Gli and Estrogen receptor signaling pathways. PLOS ONE, 9 (12), e114510-1 doi:10.1371/journal.pone.0114510.
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Musani, V., Sabol, M., Car, D., Ozretić, P., Kalafatić, D., Maurac, I., Orešković, S. & Levanat, S. (2013) PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele. Gene, 517 (1), 55-59 doi:10.1016/j.gene.2012.12.089.
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Sabol, M., Car, D., Musani, V., Ozretić, P., Orešković, S., Weber, I. & Levanat, S. (2012) The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched. International journal of oncology, 41 (4), 1411-1418 doi:10.3892/ijo.2012.1554.
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Levanat, S., Musani, V., Levačić Cvok, M., Sušac, I., Sabol, M., Ozretić, P., Car, D., Eljuga, D., Eljuga, L. & Eljuga, D. (2012) Three novel BRCA1/BRCA2 mutations in breast/ovarian cancer families in Croatia. Gene, 498 (2), 169-176 doi:10.1016/j.gene.2012.02.010.
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Maurac, I., Sabol, M., Musani, V., Car, D., Ozretić, P., Kalafatić, D., Orešković, S., Babić, D. & Levanat, S. (2012) A low grade ovarian carcinoma case with coincident LOH of PTCH1 and BRCA1, and a mutation in BRCA1. International journal of gynecological pathology, 31 (3), 264-271 doi:10.1097/PGP.0b013e31823b6f0f.
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Musani, V., Sabol, M., Car, D., Ozretić, P., Orešković, S., Leović, D. & Levanat, S. (2012) LOH of PTCH1 region in BCC and ovarian carcinoma: microsatellite vs. HRM analysis. Frontiers in bioscience (Elite ed.), 4 (3), 1049-1057 doi:10.2741/E440.
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Leović, D., Sabol, M., Ozretić, P., Musani, V., Car, D., Marjanović, K., Zubčić, V., Sabol, I., Sikora, M., Grce, M., Glavaš-Obrovac, L. & Levanat, S. (2012) Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma. Head and neck, 34 (1), 104-112 doi:10.1002/hed.21696.
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Ozretić, P., Levačić Cvok, M., Musani, V., Sabol, M., Car, D. & Levanat, S. (2010) In silico analysis of potential structural and functional significance of human breast cancer gene BRCA2 sequence variants found in 5' untranslated region. Periodicum biologorum, 112 (4), 469-474.
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Car, D., Sabol, M., Musani, V., Ozretić, P. & Levanat, S. (2010) Epigenetic regulation of the Hedgehog-Gli signaling pathway in cancer. Periodicum biologorum, 112 (4), 419-423.
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Lof-Ohlin, Z., Levanat, S., Sabol, M., Sorbe, B. & Nilsson, T. (2010) Promoter methylation in the PTCH gene in cervical epithelial cancer and ovarian cancer tissue as studied by eight novel Pyrosequencing assays. International journal of oncology, 38 (3), 685-692 doi:10.3892/ijo.2010.889.
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Musani, V., Čretnik, M., Šitum, M., Basta-Juzbašić, A. & Levanat, S. (2009) Gorlin Syndrome Patient with Large Deletion in 9q22.32-q22.33 Detected by Quantitative Multiplex Fluorescent PCR. Dermatology (Basel), 219 (2), 111-118 doi:10.1159/000219247.
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Čretnik, M., Poje, G., Musani, V., Krušlin, B., Ozretić, P., Tomas, D., Šitum, M. & Levanat, S. (2009) Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma. International journal of oncology, 34 (4), 1045-1050 doi:10.3892/ijo_00000230.
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Willems, P., Magri, V., Čretnik, M., Fasano, M., Jakubowska, A., Levanat, S., Lubinski, J., Marras, E., Musani, V., Thierens, H., Vandersickel, V., Perletti, G. & Vral, A. (2009) Characterization of the c.190T>C missense mutation in BRCA1 codon 64 (Cys64Arg). International journal of oncology, 34 (4), 1005-1015 doi:10.3892/ijo_00000226.
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Sabol, I., Čretnik, M., Hadžisejdić, I., Si-Mohammed, A., Matovina, M., Grahovac, B., Levanat, S. & Grce, M. (2009) A New Approach for the Evaluation of the Human Papillomavirus Type 16 Variability with High Resolution Melting Analysis. Journal of Virological Methods, 162 (1-2), 142-147 doi:10.1016/j.jviromet.2009.07.029.
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Levačić Cvok, M., Čretnik, M., Musani, V., Ozretić, P. & Levanat, S. (2008) New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia. Clinical Chemistry and Laboratory Medicine, 46 (10), 1376-1383 doi:10.1515/CCLM.2008.307.
doifulir.irb.hr Levanat, S., Čretnik, M. & Musani, V. (2008) Hh-Gli Signaling Pathway Functions and its Therapeutic Potential in Cancer. Croatica Chemica Acta, 81 (1), 1-5.
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Bura, M., Musani, V., Čretnik, M., Botica, I. & Levanat, S. (2008) Hedgehog-Patched pathway aberrations in a malignant triton tumor case study. Oncology Reports, 20 (2), 347-352 doi:10.3892/or_00000013.
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Čretnik, M., Musani, V., Orešković, S., Leović, D. & Levanat, S. (2007) The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas. International Journal of Molecular Medicine, 19 (6), 875-883 doi:10.3892/ijmm.19.6.875.
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Membership in professional associations / societies
Member of HGD (Croatian Society of Human Genetics) – affiliate of ESHG (European Society of Human Genetics)
Member of HDBMB (Croatian Society of Biochemistry and Molecular Biology) – affiliate of FEBS (Federation of the Societies of Biochemistry and Molecular Biology)
Treasurer of HDIR (Croatian Association for Cancer Research) – affiliate of EACR (European Association of Cancer Research)
Participation in RBI Open Days in 2005, 2008 and 2010
Member of the organizing committee of MedILS Summer School 2008 “Hottest topics in protein research”
Assistant on a workshop “EMBO Practical Course on Ubiquitin and SUMO” 2008
Member of the Organizing Committee of the HDIR-1, HDIR-2 and HDIR-4 “From Bench to Clinics” – first, second and fourth meeting of the Croatian Association for Cancer Research 2010
One of the translators of EuroGenTest official brochures (English to Croatian)
Member of the Assistants Council at Rudjer Boskovic Institute 2007-2011