dr. sc. Maja Sabol
10002 Zagreb
Obrazovanje
1999 – 2004: Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet, Biološki odsjek, dodiplomski studij molekularne biologije
2005 – 2010: Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet, Biološki odsjek, poslijediplomski studij molekularne i stanične biologije
2009 – 2013: Visoka škola za poslovanje i upravljanje "Baltazar Adam Krčelić", specijalistički stručni studij projektnog menadžmenta
sudjelovanje na radionicama:
2015. Phenomin – European Advanced School for Mouse Phenogenomics, Alsace, France
2015. Processing and analysis of Microscopic Images in Biomedicine, Prague, Czech Republic
2012. International Workshop on miRNA and Virus-Associated Cancers, Dubrovnik, Croatia
10th International Summer School on Biophysics, Rovinj, Hrvatska, 19.9. - 1.10. 2009.
DMMC: Epigenetics: From mechanisms to medicines, Dublin, Irska, 24-26. 6. 2007.
MedILS Summer School ’08: Hottest topics in protein research. Split, Hrvatska, 19-26. 7. 2008.
EMBO Practical Course on Ubiquitin and SUMO, MedILS, Split, Hrvatska, 12-19. 9. 2008.
Projekti
2019-2022 HRZZ IP-01-2018-4889 "Regulacija GLI koda u tumorima ovisnim o BRAF/NRAS mutacijama"
Nagrade i priznanja
Rektorova nagrada Sveučilišta u Zagrebu, školske godine 2002/2003.
Nagrada za najbolji poster (3. mjesto) na IV Hrvatskom kongresu humane genetike (Malinska, Hrvatska) 2007.
Nagrada za najbolji poster unutar teme "Čovjek - od stanice do organizma" na ZS3V, IRB (Zagreb, Hrvatska) 2011.
Nastava
asistent u nastavi (dodiplomski studiji):
- “Signalni putevi i interakcije”, Sveučilište u Rijeci, Zavod za biotehnologiju, šk.g. 2009/10.
- “Metode rekombinantne DNA”, Zdravstveno veleučilište u Zagrebu, specijalistički studij sanitarnog inženjerstva, šk.g. 2008/09, 2009/10.
asistent u nastavi (poslijediplomski studiji):
- "Signalni putevi u stanici: onkogeni i tumor supresori" Sveučilište u Zagrebu, PMF, šk.g. 2009/10, 2010/11.
- "Genomska DNA" Molekularne bioznanosti, združeni studij Sveučilišta u Dubrovniku, Sveučilišta u Osijeku i Instituta "Ruđer Bošković", šk.g. 2009/10.
- "Metode istraživanja u molekularnoj onkologiji", Sveučilište u Zagrebu, Medicinski fakultet, šk.g. 2009/10, 2010/11.
Istaknute publikacije
Cretnik M, Musani V, Oreskovic S, Leovic D, Levanat S. The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas. Int J Mol Med 2007; 19: 875-883.
Cvok ML, Cretnik M, Musani V, Ozretic P, Levanat S. New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia, Clin Chem Lab Med 2008;46(10):1376-1383.
Leovic D, Sabol M, Ozretic P, Musani V, Car D, Marjanovic K, Zubcic V, Sabol I, Sikora M, Grce M, Glavas-Obrovac Lj, Levanat S. Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma. Head Neck 2012, 34(1): 104-12.
Sabol M, Trnski D, Uzarevic Z, Ozretic P, Musani V, Rafaj M, Cindric M, Levanat S. Combination of cyclopamine and tamoxifen promotes survival and migration of breast cancer cells – interaction of Hedgehog-gli and estrogen receptor signaling pathways. PLoS ONE 2014, 9(12):e114510.
Trnski D,Sabol M, Gojević A, Martinić M, Ozretić P, Musani V, Ramić S, Levanat S. GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer – Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation. Biochym Biophys Acta 2015, 1852(12):2574-84.
Levanat S, Sabol M, Musani V, Ozretic P, Trnski D. Hedgehog signaling pathway as genetic and epigenetic target in ovarian tumors. Curr Pharm Des 2017, 23(1):73-94.
Ozretić P, Trnski, D, Musani V, Maurac I, Kalafatić D, Orešković S, Levanat S, Sabol M. Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas. International journal of oncology, 51 (2017), 6; 1869-1877.
Sabol M, Trnski D, Musani V, Ozretić P, Levanat S. Role of GLI transcription factors in pathogenesis and their potential as new therapeutic targets. Int J Mol Sci, 19 (2018), 2562.
Trnski D, Gregorić M, Levanat S, Ozretić P, Rinčić N, Majić Vidaković T, Kalafatić D, Maurac I, Orešković S, Sabol M, Musani V. Regulation of Survivin isoform expression by GLI proteins in ovarian cancer. Cells, 8 (2019) 128.
Publikacije
Knjige i poglavlja u knjigama
Poglavlja u knjigama
Sobočanec, S., Šarić, A., Korolija, M., Marjanović, M., Kralj, M., Knežević, J., Čretnik, M., Balog, T., Šverko, V., Kušić, B. & Marotti, T. (2008) Native propolis in vivo: On the oxidative/antioxidative effect and the mechanism of the action. U: Oršolić, N. & Bašić, I. (ur.) Scientific evidence of the Use of Propolis in Ethnomedicine. Lahti, Research Signpost, str. 121-131.
Čretnik, M., Grbeša, I., Levanat, S. & Gall-Trošelj, K. (2007) Određivanje metiliranosti DNA obradom DNA bisulfitom te određivanjem slijeda nukleotida. U: Ambriović Ristov, A., Brozović, A., Bruvo Mađarić, B., Četković, H., Herak Bosnar, M., Hranilović, D., Katušić Hećimović, S., Meštrović Radan, N., Mihaljević, S., Slade, N. & Vujaklija, D. (ur.) Metode u molekularnoj biologiji. Zagreb, Institut Ruđer Bošković, str. 376-379.
Radovi u časopisima
Znanstveni i pregledni radovi
-
Petrić, T. & Sabol, M. (2023) Why 3D in vitro cancer models are the futureof cancer research?. Periodicum biologorum, 124 (3-4), 69-83 doi:10.18054/pb.v124i3-4.24697.
doihrcak.srce.hr -
Piteša, N., Kurtović, M., Bartoniček, N., Gkotsi, D., Čonkaš, J., Petrić, T., Musani, V., Ozretić, P., Riobo-Del Galdo, N. & Sabol, M. (2023) Signaling switching from Hedgehog-GLI to MAPK signaling potentially serves as a compensatory mechanism in melanoma cell lines resistant to GANT-61. Biomedicines, 11, 1353, 19 doi:10.3390/biomedicines11051353.
doiwww.mdpi.comfulir.irb.hr -
Čonkaš, J., Sabol, M. & Ozretić, P. (2023) ‘Toxic Masculinity’: What Is Known about the Role of Androgen Receptors in Head and Neck Squamous Cell Carcinoma. International journal of molecular sciences, 24 (4), 3766, 18 doi:10.3390/ijms24043766.
doiwww.mdpi.comfulir.irb.hr -
Kurtović, M., Piteša, N., Bartoniček, N., Ozretić, P., Musani, V., Čonkaš, J., Petrić, T., King, C. & Sabol, M. (2022) RNA-seq and ChIP-seq Identification of Unique and Overlapping Targets of GLI Transcription Factors in Melanoma Cell Lines. Cancers, 14 (18), 4540, 20 doi:10.3390/cancers14184540.
doiwww.mdpi.comwww.ncbi.nlm.nih.govfulir.irb.hr -
Radić, M., Vlašić, I., Jazvinšćak Jembrek, M., Horvat, A., Tadijan, A., Sabol, M., Dužević, M., Herak Bosnar, M. & Slade, N. (2022) Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance. International journal of molecular sciences, 23 (17), 9910, 19 doi:10.3390/ijms23179910.
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Sabol, M., Calleja-Agius, J., Di Fiore, R., Suleiman, S., Ozcan, S., Ward, M. & Ozretić, P. (2021) (In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers. Cancers, 13, 5040, 36 doi:10.3390/cancers13205040.
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Trnski, D., Sabol, M., Tomić, S., Štefanac, I., Mrčela, M., Musani, V., Rinčić, N., Kurtović, M., Petrić, T., Levanat, S. & Ozretić, P. (2021) SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells. Scientific reports, 11 (1), 14880, 11 doi:10.1038/s41598-021-93971-6.
doiwww.nature.comdoi.orgfulir.irb.hr -
Di Fiore, R., Suleiman, S., Felix, A., O'Toole, S., O'Leary, J., Ward, M., Beirne, J., Sabol, M., Ozretić, P., Yordanov, A., Vasileva-Slaveva, M., Kostov, S., Nikolova, M., Said-Huntingford, I., Ayers, D., Ellul, B., Pentimalli, F., Giordano, A. & Calleja-Agius, J. (2021) An Overview of the Role of Long Non-Coding RNAs in Human Choriocarcinoma. International journal of molecular sciences, 22 (12), 6506, 16 doi:10.3390/ijms22126506.
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Di Fiore, R., Suleiman, S., Pentimalli, F., O'Toole, S., O'Leary, J., Ward, M., Conlon, N., Sabol, M., Ozretić, P., Erson-Bensan, A., Reed, N., Giordano, A., Herrington, C. & Calleja-Agius, J. (2021) Could MicroRNAs Be Useful Tools to Improve the Diagnosis and Treatment of Rare Gynecological Cancers?A Brief Overview. International journal of molecular sciences, 22 (8), 3822, 26 doi:10.3390/ijms22083822.
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Di Fiore, R., Suleiman, S., Ellul, B., O’Toole, S., Savona-Ventura, C., Felix, A., Napolioni, V., Conlon, N., Erson-Bensan, A., Kahramanoglu, I., Azzopardi, M., Dalmas, M., Calleja, N., Brincat, M., Muscat-Baron, Y., Sabol, M., Dimitrievska, V., Yordanov, A., Vasileva- Slaveva, M., von Brockdorff, K., Micallef, R., Kubelac, P., Achimas-Cadariu, P., Vlad, C., Tzortzatou, O., Poka, R., Giordano, A., Felice, A., Reed, N., Herrington, C., Faraggi, D. & Calleja-Agius, J. (2021) GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors—Current Challenges and Future Directions. Cancers, 13 (3), 493, 14 doi:10.3390/cancers13030493.
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Zubčić, V., Rinčić, N., Kurtović, M., Trnski, D., Musani, V., Ozretić, P., Levanat, S., Leović, D. & Sabol, M. (2020) GANT61 and Lithium Chloride Inhibit the Growth of Head and Neck Cancer Cell Lines Through the Regulation of GLI3 Processing by GSK3beta. International journal of molecular sciences, 21, 6410, 13 doi:10.3390/ijms21176410.
doiwww.mdpi.comfulir.irb.hr -
Sabol, M., Akbudak, A., Fricova, D., Beck, I. & Sedlacek, R. (2020) Novel TALEN-generated mCitrine-FANCD2 fusion reporter mouse model for in vivo research of DNA damage response. DNA repair, 94, 102936, 6 doi:10.1016/j.dnarep.2020.102936.
doi -
Ozretić, P., Hanžić, N., Proust, B., Sabol, M., Trnski, D., Radić, M., Musani, V., Ciribilli, Y., Milas, I., Puljiz, Z., Bosnar Herak, M., Levanat, S. & Slade, N. (2019) Expression profiles of p53/p73, NME and GLI families in metastatic melanoma tissue and cell lines. Scientific Reports, 9 (1), 12470, 13 doi:10.1038/s41598-019-48882-y.
doiwww.nature.comfulir.irb.hr -
Sušac, I., Ozretić, P., Gregorić, M., Levačić Cvok, M., Sabol, M., Levanat, S., Trnski, D., Eljuga, D., Seiwerth, S., Aralica, G., Stanec, M. & Musani, V. (2019) Polymorphisms in survivin (BIRC5 gene) are associated with age of onset in breast cancer patients. Journal of oncology, 2019, 3483192, 10 doi:10.1155/2019/3483192.
doifulir.irb.hrwww.hindawi.comdoi.org -
Trnski, D., Gregorić, M., Levanat, S., Ozretić, P., Rinčić, N., Majić Vidaković, T., kalafatić, D., Maurac, I., Orešković, S., Sabol, M. & Musani, V. (2019) Regulation of Survivin Isoform Expression by GLI Proteins in Ovarian Cancer. Cells, 8 (2), 128, 13 doi:10.3390/cells8020128.
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Sabol, M., Trnski, D., Musani, V., Ozretić, P. & Levanat, S. (2018) Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets. International journal of molecular sciences, 19 (9), 2562, 37 doi:10.3390/ijms19092562.
doiwww.mdpi.comfulir.irb.hrwww.mdpi.com -
Ozretić, P., Trnski, D., Musani, V., Maurac, I., Kalafatić, D., Orešković, S., Levanat, S. & Sabol, M. (2017) Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas. International journal of oncology, 51 (6), 1869-1877 doi:10.3892/ijo.2017.4156.
doi -
Levanat, S., Sabol, M., Musani, V., Ozretić, P. & Trnski, D. (2017) Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors. Current pharmaceutical design, 23 (1), 73-94 doi:10.2174/1381612822666161006154705.
doi -
Trnski, D., Sabol, M., Gojević, A., Martinić, M., Ozretić, P., Musani, V., Ramić, S. & Levanat, S. (2015) GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer — Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852 (12), 2574-2584 doi:10.1016/j.bbadis.2015.09.005.
doi -
Ozretić, P., Bisio, A., Musani, V., Trnski, D., Sabol, M., Levanat, S. & Inga, A. (2015) Regulation of human PTCH1b expression by different 5' untranslated region cis-regulatory elements. RNA Biology, 12 (3), 290-304 doi:10.1080/15476286.2015.1008929.
doi -
Sabol, M., Trnski, D., Užarević, Z., Ozretić, P., Musani, V., Rafaj, M., Cindrić, M. & Levanat, S. (2014) Combination of cyclopamine and tamoxifen promotes survival and migration of MCF-7 breast cancer cells – interaction of Hedgehog-Gli and Estrogen receptor signaling pathways. PLOS ONE, 9 (12), e114510-1 doi:10.1371/journal.pone.0114510.
doifulir.irb.hr -
Musani, V., Sabol, M., Car, D., Ozretić, P., Kalafatić, D., Maurac, I., Orešković, S. & Levanat, S. (2013) PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele. Gene, 517 (1), 55-59 doi:10.1016/j.gene.2012.12.089.
doi -
Sabol, M., Car, D., Musani, V., Ozretić, P., Orešković, S., Weber, I. & Levanat, S. (2012) The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched. International journal of oncology, 41 (4), 1411-1418 doi:10.3892/ijo.2012.1554.
doifulir.irb.hr -
Levanat, S., Musani, V., Levačić Cvok, M., Sušac, I., Sabol, M., Ozretić, P., Car, D., Eljuga, D., Eljuga, L. & Eljuga, D. (2012) Three novel BRCA1/BRCA2 mutations in breast/ovarian cancer families in Croatia. Gene, 498 (2), 169-176 doi:10.1016/j.gene.2012.02.010.
doi -
Maurac, I., Sabol, M., Musani, V., Car, D., Ozretić, P., Kalafatić, D., Orešković, S., Babić, D. & Levanat, S. (2012) A low grade ovarian carcinoma case with coincident LOH of PTCH1 and BRCA1, and a mutation in BRCA1. International journal of gynecological pathology, 31 (3), 264-271 doi:10.1097/PGP.0b013e31823b6f0f.
doi -
Musani, V., Sabol, M., Car, D., Ozretić, P., Orešković, S., Leović, D. & Levanat, S. (2012) LOH of PTCH1 region in BCC and ovarian carcinoma: microsatellite vs. HRM analysis. Frontiers in bioscience (Elite ed.), 4 (3), 1049-1057 doi:10.2741/E440.
doifulir.irb.hrwww.imrpress.com -
Leović, D., Sabol, M., Ozretić, P., Musani, V., Car, D., Marjanović, K., Zubčić, V., Sabol, I., Sikora, M., Grce, M., Glavaš-Obrovac, L. & Levanat, S. (2012) Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma. Head and neck, 34 (1), 104-112 doi:10.1002/hed.21696.
doi -
Ozretić, P., Levačić Cvok, M., Musani, V., Sabol, M., Car, D. & Levanat, S. (2010) In silico analysis of potential structural and functional significance of human breast cancer gene BRCA2 sequence variants found in 5' untranslated region. Periodicum biologorum, 112 (4), 469-474.
hrcak.srce.hrhrcak.srce.hrfulir.irb.hr -
Car, D., Sabol, M., Musani, V., Ozretić, P. & Levanat, S. (2010) Epigenetic regulation of the Hedgehog-Gli signaling pathway in cancer. Periodicum biologorum, 112 (4), 419-423.
hrcak.srce.hr -
Lof-Ohlin, Z., Levanat, S., Sabol, M., Sorbe, B. & Nilsson, T. (2010) Promoter methylation in the PTCH gene in cervical epithelial cancer and ovarian cancer tissue as studied by eight novel Pyrosequencing assays. International journal of oncology, 38 (3), 685-692 doi:10.3892/ijo.2010.889.
doifulir.irb.hr -
Musani, V., Čretnik, M., Šitum, M., Basta-Juzbašić, A. & Levanat, S. (2009) Gorlin Syndrome Patient with Large Deletion in 9q22.32-q22.33 Detected by Quantitative Multiplex Fluorescent PCR. Dermatology (Basel), 219 (2), 111-118 doi:10.1159/000219247.
doi -
Čretnik, M., Poje, G., Musani, V., Krušlin, B., Ozretić, P., Tomas, D., Šitum, M. & Levanat, S. (2009) Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma. International journal of oncology, 34 (4), 1045-1050 doi:10.3892/ijo_00000230.
doi -
Willems, P., Magri, V., Čretnik, M., Fasano, M., Jakubowska, A., Levanat, S., Lubinski, J., Marras, E., Musani, V., Thierens, H., Vandersickel, V., Perletti, G. & Vral, A. (2009) Characterization of the c.190T>C missense mutation in BRCA1 codon 64 (Cys64Arg). International journal of oncology, 34 (4), 1005-1015 doi:10.3892/ijo_00000226.
doifulir.irb.hr -
Sabol, I., Čretnik, M., Hadžisejdić, I., Si-Mohammed, A., Matovina, M., Grahovac, B., Levanat, S. & Grce, M. (2009) A New Approach for the Evaluation of the Human Papillomavirus Type 16 Variability with High Resolution Melting Analysis. Journal of Virological Methods, 162 (1-2), 142-147 doi:10.1016/j.jviromet.2009.07.029.
doifulir.irb.hr -
Levačić Cvok, M., Čretnik, M., Musani, V., Ozretić, P. & Levanat, S. (2008) New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia. Clinical Chemistry and Laboratory Medicine, 46 (10), 1376-1383 doi:10.1515/CCLM.2008.307.
doifulir.irb.hr Levanat, S., Čretnik, M. & Musani, V. (2008) Hh-Gli Signaling Pathway Functions and its Therapeutic Potential in Cancer. Croatica Chemica Acta, 81 (1), 1-5.
-
Bura, M., Musani, V., Čretnik, M., Botica, I. & Levanat, S. (2008) Hedgehog-Patched pathway aberrations in a malignant triton tumor case study. Oncology Reports, 20 (2), 347-352 doi:10.3892/or_00000013.
doifulir.irb.hr -
Čretnik, M., Musani, V., Orešković, S., Leović, D. & Levanat, S. (2007) The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas. International Journal of Molecular Medicine, 19 (6), 875-883 doi:10.3892/ijmm.19.6.875.
doifulir.irb.hr
Članstva u profesionalnim udrugama / društvima
Hrvatsko društvo za humanu genetiku /HDHG) - član
Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB) - član
Hrvatsko društvo za istraživanje raka (HDIR) - rizničar
Sudjelovanje u Otvorenim danima IRB-a 2005, 2008 i 2010.
Član organizacijskog odbora MedILS-ove međunarodne ljetne škole “Hottest topics in protein research” 2008.
Asistent na radionici “EMBO Practical Course on Ubiquitin and SUMO” 2008.
Član organizacijskog odbora HDIR-1, HDIR-2 i HDIR-4 "From Bench to Clinic" - prve, druge i četvrte konferencije Hrvatskog društva za istraživanje raka, te HDIR-5 "Translating Science to Medicine: Targets and Therapeutics", pete konferencije Hrvatskog društva za istraživanje raka
Jedan od prevoditelja brošura u izdanju EuroGenTest-a (s engleskog na hrvatski jezik)
Član Vijeća asistenata IRB-a 2007-2011.