1990 - B. Sc. in Molecular Biology, Faculty of Natural Sciences, University of Zagreb, Zagreb, Croatia

1994 - M. Sc. in Molecular and Cellular Biology, University of Zagreb, Zagreb, Croatia

2001 - Ph. D. in Natural Sciences, University of Zagreb, Zagreb, Croatia

Thesis: "p53 and p21^WAF1/CIP1 mediated gene therapy of cancer"

2014 – 2018  Principal investigator “A multidisciplinary approach to discover selective drugs targeting cancer stem cells: The role of potassium transport - MultiCaST“ Croatian Foundation of Science (HrZZ, 967.000 kn)

2013 – 2016  Work package leader (WP2 – Excange&Secondments) on FP7-REGPOT-2012-2013-1 „Enhancement of the Innovation Potential in SEE through new Molecular Solutions in Research and Development (InnoMol)”, Coordinator Dr. Oliver Vugrek (total value € 4,738,978.00; WP value € 983,205)

2007 – 2013   Principal investigator of the scientific project financed from The Ministry of Science Education and Sports (MSES), Croatia: “The role of different cell death responses to DNA-damage treatment” (€≈80000)

Croatian Society of Natural Sciences Award for the M.Sc. Thesis for the year 1994

Participation in several postgraduate courses at the School of Medicine, School of Natural Sciences; School of Pharmacy and Biochemistry, School of Veterinary Medicine, University of Zagreb, Zagreb

Participation in graduate course: Methods in molecular biology, School of Natural Sciences, University of Zagreb, Zagreb

Co-leader of two Courses “Functional genomics” and “p53 gene family” at doctoral study Molecular biosciences at Rudjer Boskovic Institute, University of Osijek and Dubrovnik (2007-)

Co-leader of the Course “Functional genomics in oncology” at doctoral Study “Cancer biology” at RBI, University of Split and Dubrovnik (2007-)

1. Kralj M. Husnjak K, Körbler T, Pavelić J. Endogenous p21WAF1/CIP1 status predicts the response of human tumor cells to wild-type p53 and p21WAF1/CIP1 overexpression. Cancer Gene Ther, 10:457-467, 2003,

2. Kralj M, Pavelić J. p21WAF1/CIP1 is more effective than p53 in growth suppression of mouse renal carcinoma cell line Renca in vitro and in vivo. J Cancer Res Clin Oncol, 129:463-471, 2003.

3. Kralj M, Pavelic K. Medicine on a small scale. EMBO Reports, 4:1008-1012, 2003.

4. M. Marjanović, M. Kralj*, F. Supek, L. Frkanec, I. Piantanida, T. Šmuc, Lj. Tušek-Božić. Antitumor potential of crown ethers: structure activity relationships, cell cycle disturbances and cell death studies of a series of ionophores. J Med Chem (2007) 50:1007-1018

5. Hranjec, M; Kralj, M*; Piantanida, I; Sedić, M; Šuman, L; Pavelić, K; Karminski-Zamola, G*. Novel cyano- and amidino-substituted derivatives of styryl-2-benzimidazoles and benzimidazo[1, 2-a]quinolines. Synthesis, photochemical synthesis, DNA binding, and antitumor evaluation, part 3. J Med Chem. 50 (2007) 23: 5696.

6. Supek, F*; Kralj, M*; Marjanović, M; Šuman, L; Šmuc, T; Krizmanić, I; Žinić, B. Atypical cytostatic mechanism of N -1-sulfonylcytosine derivatives determined by in vitro screening and computational analysis. Invest New drugs. (2008) 26:97-110. * - equal contribution.

7. Kraljević Pavelić, S; Čačev, T; Kralj, M. A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. (2008) 15:576-590.

8. Kralj, M; Tušek-Božić, Lj; Frkanec, L. Biomedical Potentials of Crown Ethers: Prospective Antitumor Agents. ChemMedChem. (2008) 3:1478-1492

9. Ester, K; Hranjec, M; Piantanida, I; Ćaleta, I; Ivana, J; Pavelić, K; Kralj, M*; Karminski-Zamola, G*. Novel Derivatives of Pyridyl-Benzo[b]thiophene-2-carboxamides and Benzo[b]thieno[2, 3- c]naphthyridin-2-ones: Minor Structural Variations Provoke Major Differences of Antitumor Action Mechanisms. J Med Chem. 52:2482-2492 (2009).

10. Kraljević Pavelić, S*; Marjanović, M*; Poznić, M; Kralj, M. (2009) Adenovirally-mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment. J Cancer Res Clin Oncol. 135:1747-1761. * - equal contribution.

11. Ester K, Supek F, Majsec K, Marjanović M, Lembo D, Donalisio M, Smuc T, Jarak I, Karminski-Zamola G, Kralj M. Putative mechanisms of antitumor activity of cyano-substituted heteroaryles in HeLa cells. Invest New Drugs; (2012) 30:450–467.

12. Uzelac, L; Škalamera, Đ; Mlinarić-Majerski, K; Basarić, N*; Kralj, M*. Selective photocytotoxicity of anthrols on cancer stem-like cells: the effect of quinone methides or reactive oxygen species. Eur J Med Chem, 137 (2017) 558-574.

Books and book chapters

Book chapters

• Sobočanec, S., Šarić, A., Korolija, M., Marjanović, M., Kralj, M., Knežević, J., Čretnik, M., Balog, T., Šverko, V., Kušić, B. & Marotti, T. (2008) Native propolis in vivo: On the oxidative/antioxidative effect and the mechanism of the action. U: Oršolić, N. & Bašić, I. (ur.) Scientific evidence of the Use of Propolis in Ethnomedicine. Lahti, Research Signpost, str. 121-131.

• Kralj, M. (2005) Molecular-targeted approach to cancer therapy – the roles of p53 and p21WAF1/CIP1 genes. U: Kniewald, Z. (ur.) Immuno-modulatory drugs. Zagreb, Medicinska naklada, str. 27-36.

• Kralj, M. (1999) Methods of genetic therapy. U: Polšek, D. & Pavelić, K. (ur.) Društveni značaj genske tehnologije. Zagreb, Institut društvenih znanosti Ivo Pilar, str. 113-120.

Journal articles

Scientific and review papers

• Čačić, A., Amidžić Klarić, D., Keser, S., Radiković, M., Rukavina, Z., Wenche Jøraholmen, M., Uzelac, L., Kralj, M., Škalko-Basnet, N., Šegvić Klarić, M. & Vanić, Ž. (2023) A Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogel. Pharmaceutics, 15 (5), 1536, 17 doi:10.3390/pharmaceutics15051356.

  doiwww.mdpi.com

• Boček Pavlinac, I., Zlatić, K., Persoons, L., Daelemans, D., Banjanac, M., Radovanović, V., Butković, K., Kralj, M. & Hranjec, M. (2023) Biological activity of amidino-substituted imidazo [4,5-b]pyridines. Molecules, 28 (1), 34, 16 doi:10.3390/molecules28010034.

  doiwww.mdpi.comdx.doi.org

• Poje, G., Marinović, M., Pavić, K., Mioč, M., Kralj, M., Pessanha de Carvalho, L., Held, J., Perković, I. & Rajić, Z. (2022) Harmicens, Novel Harmine and Ferrocene Hybrids: Design, Synthesis and Biological Activity. International journal of molecular sciences, 23, 9315, 20 doi:10.3390/ijms23169315.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Sambol, M., Košćak, M., Uzelac, L., Kralj, M., Piantanida, I. & Basarić, N. (2022) Simultaneous staining of endoplasmic reticulum and lipid droplets by naphthol-aminonaphthalimide conjugates and photoinduced antiproliferative effects. Dyes and pigments, 206, 110651, 15 doi:10.1016/j.dyepig.2022.110651.

  doi

• Mioč, M., Telbisz, Á., Radman, K., Bertoša, B., Šumanovac, T., Sarkadi, B. & Kralj, M. (2022) Interaction of crown ethers with the ABCG2 transporter and their implication for multidrug resistance reversal. Histochemistry and cell biology, 158, 261-277 doi:10.1007/s00418-022-02106-z.

  doi

• Beč, A., Mioč, M., Bertoša, B., Kos, M., Debogović, P., Kralj, M., Starčević, K. & Hranjec, M. (2022) Design, synthesis, biological evaluation and QSAR analysis of novel N-substituted benzimidazole derived carboxamides. Journal of enzyme inhibition and medicinal chemistry, 37 (1), 1327-1339 doi:10.1080/14756366.2022.2070910.

  doiwww.tandfonline.comdx.doi.org

• Pršir, K., Horak, E., Kralj, M., Uzelac, L., Liekens, S., Murković Steinberg, I. & Krištafor, S. (2022) Design, synthesis, spectroscopic characterisation and in vitro cytostatic evaluation of novel bis(coumarin-1,2,3-triazolyl)benzenes and hybrid coumarin-1,2,3-triazolyl-aryl derivatives. Molecules, 27 (3), 637, 16 doi:10.3390/molecules27030637.

  doiwww.mdpi.comdx.doi.orgfulir.irb.hr

• Matovina, M., Lemmens, S., Kralj, M. & Ester, K. (2021) Polyethylenimine as a gene delivery tool in triple-negative breast cancer cell line and breast cancer stem cell model. Periodicum biologorum, 123 (3-4), 65-70 doi:10.18054/pb.v123i3-4.10472.

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• Pavić, K., Beus, M., Poje, G., Uzelac, L., Kralj, M. & Rajić, Z. (2021) Synthesis and Biological Evaluation of Harmirins, Novel Harmine–Coumarin Hybrids as Potential Anticancer Agents. Molecules, 26 (21), 6490, 19 doi:10.3390/molecules26216490.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Mikulin, I., Ljubić, I., Piantanida, I., Vasilev, A., Mondeshki, M., Kandinska, M., Uzelac, L., Martin-Kleiner, I., Kralj, M., Tumir, L. & (2021) Polycationic Monomeric and Homodimeric Asymmetric Monomethine Cyanine Dyes with Hydroxypropyl Functionality—Strong Affinity Nucleic Acids Binders. Biomolecules, 11 (8), 1075, 21 doi:10.3390/biom11081075.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Memišević, M., Zahirović, A., Višnjevac, A., Osmanović, A., Žilić, D., Kralj, M., Muratović, S., Martin-Kleiner, I., Završnik, D. & Kahrović, E. (2021) Copper(II) Salicylideneimine Complexes Revisited: From a Novel Derivative and Extended Characterization of Two Homologues to Interaction with BSA and Antiproliferative Activity. Inorganica chimica acta, 525, 120460, 9 doi:10.1016/j.ica.2021.120460.

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• Sambol, M., Benčić, P., Erben, A., Matković, M., Mihaljević, B., Piantanida, I., Kralj, M. & Basarić, N. (2021) Photochemical Reactivity of Naphthol-NaphthalimideConjugates and Their Biological Activity. Molecules, 26 (11), 3355, 26 doi:10.3390/molecules26113355.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Zlatić, K., Cindrić, M., Antol, I., Uzelac, L., Mihaljević, B., Kralj, M. & Basarić, N. (2021) Wavelength dependent photochemistry of BODIPY-phenols and their applications in fluorescent labeling of proteins. Organic & biomolecular chemistry, 19 (22), 4891-4903 doi:10.1039/D1OB00278C.

  doi

• Lončar, B., Perin, N., Mioč, M., Boček, I., Grgić, L., Kralj, M., Tomić, S., Radić Stojković, M. & Hranjec, M. (2021) Novel amino substituted tetracyclic imidazo[4,5-b]pyridine derivatives: Design, synthesis, antiproliferative activity and DNA/RNA binding study. European journal of medicinal chemistry, 217, 113342, 18 doi:10.1016/j.ejmech.2021.113342.

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• Mandić, L., Benčić, P., Mlinarić-Majerski, K., Liekens, S., Snoeck, R., Andrei, G., Kralj, M. & Basarić, N. (2020) Substituted Adamantylphthalimides: Synthesis, Antiviral and Antiproliferative Activity. Archiv der Pharmazie, 353 (6), 2000024, 10 doi:10.1002/ardp.202000024.

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• Meščić Macan, A., Perin, N., Jakopec, S., Mioč, M., Radić Stojković, M., Kralj, M., Hranjec, M. & Raić-Malić, S. (2020) Synthesis, antiproliferative activity and DNA/RNA-binding properties of mono- and bis-(1,2,3-triazolyl)-appended benzimidazo[1,2-a]quinoline derivatives. European journal of medicinal chemistry, 185, 111845, 11 doi:10.1016/j.ejmech.2019.111845.

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• Zlatić, K., Antol, I., Uzelac, L., Mikecin Dražić, A., Kralj, M., Bohne, C. & Basarić, N. (2020) Labeling of Proteins by BODIPY-Quinone Methides utilizing Anti- Kasha Photochemistry. ACS applied materials & interfaces, 12 (1), 347-351 doi:10.1021/acsami.9b19472.

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• Perin, N., Škulj, S., Martin-Kleiner, I., Kralj, M. & Hranjec, M. (2020) Synthesis and antiproliferative activity of novel 2-substituted N-methylated benzimidazoles and tetracyclic benzimidazo[1,2-a]quinolines. Polycyclic aromatic compounds, 40 (2), 343-354 doi:10.1080/10406638.2018.1441877.

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• Cindrić, M., Sović, I., Mioč, M., Hok, L., Boček, I., Roškarić, P., Butković, K., Martin-Kleiner, I., Starčević, K., Vianello, R., Kralj, M. & Hranjec, M. (2019) Experimental and computational study of the antioxidative potential of novel nitro and amino substituted benzimidazole/benzothiazole-2-carboxamides with antiproliferative activity. Antioxidants, 8 (10), 477, 22 doi:10.3390/antiox8100477.

  doidx.doi.orgwww.mdpi.comfulir.irb.hr

• Pavić, K., Rubinić, B., Rajić, Z., Fontinha, D., Prudêncio, M., Uzelac, L., Kralj, M., Held, J. & Zorc, B. (2019) Primaquine homodimers as potential antiplasmodial and anticancer agents. Bioorganic & medicinal chemistry letters, 29, 126614, 5 doi:10.1016/j.bmcl.2019.08.018.

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• Beus, M., Fontinha, D., Held, J., Rajić, Z., Uzelac, L., Kralj, M., Prudêncio, M. & Zorc, B. (2019) Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents. Molecules, 24 (15), 2812, 15 doi:10.3390/molecules24152812.

  doiwww.mdpi.comfulir.irb.hr

• Vanić, Ž., Rukavina, Z., Manner, S., Fallarero, A., Uzelac, L., Kralj, M., Amidžić Klarić, D., Bogdanov, A., Raffai, T., Virok, D., Filipović-Grčić, J. & Škalko-Basnet, N. (2019) Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections. International Journal of Nanomedicine, 14, 5957-5976 doi:10.2147/IJN.S211691.

  doiwww.dovepress.comfulir.irb.hr

• Racané, L., Butković, K., Martin-Kleiner, I., Kralj, M., Karminski-Zamola, G. & Hranjec, M. (2019) Synthesis and antiproliferative activity in vitro of amidino substituted 2-phenylbenzazoles. Croatica chemica acta, 92 (2), 181-189 doi:10.5562/cca3531.

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• Sambol, M., Ester, K., Landgraf, S., Mihaljević, B., Cindrić, M., Kralj, M. & Basarić, N. (2019) Competing photochemical reactions of bis-naphthols and their photoinduced antiproliferative activity. Photochemical & photobiological sciences, 18 (5), 1197-1211 doi:10.1039/c8pp00532j.

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• Sambol, M., Ester, K., Husak, A., Škalamera, Đ., Piantanida, I., Kralj, M. & Basarić, N. (2019) Bifunctional Phenol Quinone Methide Precursors: Synthesis and Biological Activity. Croatica chemica acta, 92 (1), 29-41 doi:10.5562/cca3455.

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• Benčić, P., Mandić, L., Džeba, I., Tartaro Bujak, I., Biczók, L., Mihaljević, B., Mlinarić-Majerski, K., Weber, I., Kralj, M. & Basarić, N. (2019) Application of 4-amino-N-adamantylphthalimide solvatochromic dye for fluorescence microscopy in selective visualization of lipid droplets and mitochondria. Sensors and actuators. B, Chemical, 286 (x), 52-61 doi:10.1016/j.snb.2019.01.102.

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• Guberović, I., Marjanović, M., Mioč, M., Ester, K., Martin-Kleiner, I., Šumanovac Ramljak, T., Mlinarić-Majerski, K. & Kralj, M. (2018) Crown ethers reverse P-glycoprotein-mediated multidrug resistance in cancer cells. Scientific Reports, 8 (1), 14467, 14 doi:10.1038/s41598-018-32770-y.

  doiwww.nature.comfulir.irb.hr

• Škalamera, Đ., Matković, M., Uzelac, L., Kralj, M., Mlinarić-Majerski, K., Bohne, C. & Basarić, N. (2018) Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery. Organic & biomolecular chemistry, 16 (46), 8908-8912 doi:10.1039/C8OB02605J.

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• Pavić, K., Rajić, Z., Mlinarić, Z., Uzelac, L., Kralj, M. & Zorc, B. (2018) Chloroquine urea derivatives: synthesis and antitumor activity in vitro. Acta pharmaceutica, 68 (4), 471-483 doi:10.2478/acph-2018-0039.

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• Matić, J., Nekola, I., Višnjevac, A., Kobetić, R., Martin-Kleiner, I., Kralj, M. & Žinić, B. (2018) C5-Morpholinomethylation of N1-sulfonylcytosines by a one-pot microwave assisted Mannich reaction. Organic & biomolecular chemistry, 16 (15), 2678-2687 doi:10.1039/C8OB00253C.

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• Cindrić, M., Perić, M., Kralj, M., Martin-Kleiner, I., David-Cordonnier, M., Čipčić Paljetak, H., Matijašić, M., Verbanac, D., Karminski-Zamola, G. & Hranjec, M. (2018) Antibacterial and antiproliferative activity of novel 2-benzimidazolyl- and 2-benzothiazolyl-substituted benzo[b]thieno-2-carboxamides. Molecular diversity, 22 (3), 637-646 doi:10.1007/s11030-018-9822-7.

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• Levatić, J., Pavić, K., Perković, I., Uzelac, L., Ester, K., Kralj, M., Kaiser, M., Rottmann, M., Supek, F. & Zorc, B. (2018) Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity. European journal of medicinal chemistry, 146, 651-667 doi:10.1016/j.ejmech.2018.01.062.

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• Vušak, D., Prugovečki, B., Milić, D., Marković, M., Petković, I., Kralj, M. & Matković-Čalogović, D. (2017) Synthesis and Crystal Structure of Solvated Complexes of Copper(II) with Serine and Phenanthroline and Their Solid- State-to-Solid- State Transformation into One Stable Solvate. Crystal growth & design, 17, 6049-6061 doi:10.1021/acs.cgd.7b01157.

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• Uzelac, L., Škalamera, Đ., Mlinarić- Majerski, K., Basarić, N. & Kralj, M. (2017) Selective photocytotoxicity of anthrols on cancer stem-like cells: the effect of quinone methides or reactive oxygen species. European journal of medicinal chemistry, 137, 558-574 doi:10.1016/j.ejmech.2017.05.063.

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• Škalamera, Đ., Mlinarić-Majerski, K., Martin-Kleiner, I., Kralj, M., Oake, J., Wan, P., Bohne, C. & Basarić, N. (2017) Photochemical formation of anthracene quinone methide derivatives. Journal of organic chemistry, 82 (12), 6006-6021 doi:10.1021/acs.joc.6b02735.

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• Vušak, D., Perin, N., Martin-Kleiner, I., Kralj, M., Karminski-Zamola, G., Hranjec, M. & Bertoša, B. (2017) Synthesis and antiproliferative activity of amino substituted benzimidazo[1,2-a]quinolines as mesylate salts designed by 3D-QSAR analysis. Molecular diversity, 21 (3), 621-636 doi:10.1007/s11030-017-9753-8.

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• Cindrić, M., Sović, I., Martin-Kleiner, I., Kralj, M., Mašek, T., Hranjec, M. & Starčević, K. (2017) Synthesis, antioxidative and antiproliferative activity of methoxy amidino substituted benzamides and benzimidazoles. Medicinal chemistry research, 26 (9), 2024-2037 doi:10.1007/s00044-017-1912-z.

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• Knežević Teofilović, N., Bihi, M., Radić Stojković, M., Tumir, L., Ester, K., Kralj, M., Majhen, D., Oršolić, N., Lepur, A., Vrbanec, D., Markotić, A., Dembić, Z., Weber, A., Piantanida, I., Vugrek, O., Diken, M. & Knežević, J. (2017) 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorganic & medicinal chemistry letters, 27 (7), 1530-1537 doi:10.1016/j.bmcl.2017.02.048.

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• Petrović Peroković, V., Car, Ž., Opačak- Bernardi, T., Martin-Kleiner, I., Kralj, M. & Tomić, S. (2017) In vitro antiproliferative study of novel adamantyl pyridin-4-ones. Molecular diversity, 21, 881-891 doi:10.1007/s11030-017-9763-6.

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• Nikolić, A., Perić, M., Ladouce, R., Mikecin, A., Martin, F., Kralj, M., Kriško, A. & Radman, M. (2016) Death by UVC Light Correlates with Protein Damage in Isogenic Human Tumor Cells: Primary Tumor SW480 versus its Metastasis SW620. Journal of proteomics & computational biology, 2 (1), 1-12. (https://www.bib.irb.hr/873644).

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• Pavić, K., Perković, I., Gilja, P., Kozlina, F., Ester, K., Kralj, M., Schols, D., Hadjipavlou- Litina, D., Pontiki, E. & Zorc, B. (2016) Design, synthesis and biological evaluation of novel primaquine-cinnamic acid conjugates of the amide and acylsemicarbazide type. Molecules, 21 (12), 1629, 24 doi:10.3390/molecules21121629.

  doiwww.mdpi.comfulir.irb.hrdoi.org

• Perković, I., Antunović, M., Marijanović, I., Pavić, K., Ester, K., Kralj, M., Vlainić, J., Kosalec, I., Schols, D., Hadjipavlou-Litina, D., Pontiki, E. & Zorc, B. (2016) Novel urea and bis-urea primaquine derivatives with hydroxyphenyl and halogenphenyl substituents: synthesis and biological evaluation. European journal of medicinal chemistry, 124, 622-636 doi:10.1016/j.ejmech.2016.08.021.

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• Perin, N., Nhili, R., Cindrić, M., Bertoša, B., Vušak, D., Martin-Kleiner, I., Laine, W., Karminski-Zamola, G., Kralj, M., David-Cordonnier, M. & Hranjec, M. (2016) Amino substituted benzimidazo[1,2-a]quinolines: Antiproliferative potency, 3D QSAR study and DNA binding properties. European journal of medicinal chemistry, 122, 530-545 doi:10.1016/j.ejmech.2016.07.007.

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• Dražić, T., Vazdar, K., Vazdar, M., Đaković, M., Mikecin, A., Kralj, M., Malnar, M., Hećimović, S. & Habuš, I. (2015) Synthesis of new 2-aminoimidazolones with antiproliferative activity via base promoted amino-β-lactam rearrangement. Tetrahedron, 71 (49), 9202-9215 doi:10.1016/j.tet.2015.10.048.

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• Sović, I., Viskić, M., Bertoša, B., Ester, K., Kralj, M., Hranjec, M. & Karminski-Zamola, G. (2015) Exploring antiproliferative activity of heteroaromatic amides and their fused derivatives using 3D-QSAR, synthesis and biological tests. Monatshefte für Chemie, 146 (9), 1503-1517 doi:10.1007/s00706-015-1478-8.

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• Kralj, M., Uzelac, L., Wang, Y., Wan, P., Tireli, M., Mlinarić-Majerski, K., Piantanida, I. & Basarić, N. (2015) Enhancement of antiproliferative activity by phototautomerization of anthrylphenols. Photochemical & photobiological sciences, 14 (6), 1082-1092 doi:10.1039/c5pp00099h.

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• Pavić, K., Perković, I., Cindrić, M., Pranjić, M., Martin-Kleiner, I., Kralj, M., Schols, D., Hadjipavlou-Litina, D., Katsori, A. & Zorc, B. (2014) Novel semicarbazides and ureas of primaquine with bulky aryl or hydroxyalkyl substituents : Synthesis, cytostatic and antioxidative activity. European journal of medicinal chemistry, 86, 502-514 doi:10.1016/j.ejmech.2014.09.013.

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• Škalamera, Đ., Mlinarić-Majerski, K., Martin-Kleiner, I., Kralj, M., Wan, P. & Basarić, N. (2014) Near-visible light generation of a quinone methide from 3-hydroxymethyl-2-anthrol. Journal of organic chemistry, 79 (10), 4390-4397 doi:10.1021/jo500290y.

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• Perin, N., Nhili, R., Ester, K., Laine, W., Karminski-Zamola, G., Kralj, M., David-Cordonnier, M. & Hranjec, M. (2014) Synthesis, antiproliferative activity and DNA binding properties of novel 5-aminobenzimidazo[1,2-a]quinoline-6-carbonitriles. European journal of medicinal chemistry, 80, 218-227 doi:10.1016/j.ejmech.2014.04.049.

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• Aleksić, M., Bertoša, B., Nhili, R., Depauw, S., Martin-Kleiner, I., David-Cordonnier, M., Tomić, S., Kralj, M. & Karminski-Zamola, G. (2014) Anilides and quinolones with nitrogen-bearing substituents from benzothiophene- and thienothiophene- series: synthesis, photochemical synthesis, cytostatic evaluation, 3D-derived QSAR analysis and DNA-binding properties. European journal of medicinal chemistry, 71, 267-281 doi:10.1016/j.ejmech.2013.11.010.

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• Basarić, N., Mlinarić-Majerski, K. & Kralj, M. (2014) Quinone methides: photochemical generation and its application in biomedicine. Current organic chemistry, 18 (1), 3-18 doi:10.2174/138527281801140121122330.

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• Perin, N., Martin-Kleiner, I., Nhili, R., Laine, W., David-Cordonnier, M., Vugrek, O., Karminski-Zamola, G., Kralj, M. & Hranjec, M. (2013) Biological activity and DNA binding studies of 2-substituted benzimidazo[1,2-a]quinolines bearing different amino side chains. MedChemComm, 4 (12), 1537-1550 doi:10.1039/c3md00193h.

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• Škalamera, Đ., Mlinarić-Majerski, K., Uzelac, L., Kralj, M., Wan, P. & Basarić, N. (2013) Photosolvolysis of bulky (4- hydroxyphenyl)naphthalene derivatives. Photochemical & photobiological sciences, 12, 2043-2056 doi:10.1039/C3PP50190F.

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• Levatić, J., Ćurak, J., Kralj, M., Šmuc, T., Osmak, M. & Supek, F. (2013) Accurate Models for P-gp Drug Recognition Induced from a Cancer Cell Line Cytotoxicity Screen. Journal of medicinal chemistry, 56 (14), 5691-5708 doi:10.1021/jm400328s.

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• Perković, I., Tršinar, S., Žanetić, J., Kralj, M., Martin-Kleiner, I., Balzarini, J., Hadjipavlou-Litina, D., Katsori, A. & Zorc, B. (2013) Novel 1-acyl-4-substituted semicarbazide derivatives of primaquine - synthesis, cytostatic, antiviral and antioxidative studies. Journal of enzyme inhibition and medicinal chemistry, 28 (3), 601-610 doi:10.3109/14756366.2012.663366.

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• González-García, J., Uzelac, L., Kralj, M., Llinares, J., García-España, E. & Piantanida, I. (2013) The size of aryl linker between two polyaza-cyclophane moieties controls the binding selectivity to ds-RNA vs ds-DNA. Organic & biomolecular chemistry, (11), 2154-2161 doi:10.1039/c3ob00032j.

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• Štrukil, V., Glasovac, Z., Đilović, I., Matković-Čalogović, D., Šuman, L., Kralj, M. & Eckert-Maksić, M. (2012) Triguanide Derivatives: Synthesis, Crystal Structure and Evaluation of the Proliferation Effect on Some Tumor Cell Lines. European journal of organic chemistry, 2012 (34), 6758-6797 doi:10.1002/ejoc.201200979.

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• Aleksić, M., Bertoša, B., Nhili, R., Uzelac, L., Jarak, I., Depauw, S., David-Cordonnier, M., Kralj, M., Tomić, S. & Karminski-Zamola, G. (2012) Novel Substituted Benzothiophene- and Thienothiophene-carboxanilides and quinolones : Synthesis, Photochemical Synthesis, DNA–binding Properties, Antitumor evaluation and 3D-derived QSAR analysis. Journal of medicinal chemistry, 55 (11), 5044-5060 doi:10.1021/jm300505h.

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• Veljković, J., Uzelac, L., Molčanov, K., Mlinarić-Majerski, K., Kralj, M., Wan, P. & Basarić, N. (2012) Sterically Congested Adamantylnaphthalene Quinone Methides. Journal of organic chemistry, 77 (10), 4596-4610 doi:10.1021/jo3002479.

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• Perković, I., Butula, I., Kralj, M., Martin-Kleiner, I., Balzarini, J., Hadjipavlou-Litina, D., Katsori, A. & Zorc, B. (2012) Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/ hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants. European journal of medicinal chemistry, 51, 227-238 doi:10.1016/j.ejmech.2012.02.046.

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• Babić, Ž., Crkvenčić, M., Rajić, Z., Mikecin, A., Kralj, M., Balzarini, J., Petrova, M., Vanderleyden, J. & Zorc, B. (2012) New Sorafenib Derivatives: Synthesis, Antiproliferative Activity Against Tumour Cell Lines and Antimetabolic Evaluation. Molecules, 17 (1), 1124-1137 doi:10.3390/molecules17011124.

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• Horvat, M., Uzelac, L., Marjanović, M., Cindro, N., Franković, O., Mlinarić-Majerski, K., Kralj, M. & Basarić, N. (2012) Evaluation of antiproliferative effect of N- (alkyladamantyl)phthalimides in vitro. Chemical biology & drug design, 79 (4), 497-506 doi:10.1111/j.1747-0285.2011.01305.x.

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• Basarić, N., Cindro, N., Bobinac, D., Uzelac, L., Mlinarić-Majerski, K., Kralj, M. & Wan, P. (2012) Zwitterionic biphenyl quinone methides in photodehydration reactions of 3-hydroxybiphenyl derivatives : laser flash photolysis and antiproliferation study. Photochemical & photobiological sciences, 11 (2), 381-396 doi:10.1039/c1pp05338h.

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• Gazivoda Kraljević, T., Klika, M., Kralj, M., Martin-Kleiner, I., Jurmanović, S., Milić, A., Padovan, J. & Raić-Malić, S. (2012) Synthesis, cytostatic activity and ADME properties of C-5 substituted and N-acyclic pyrimidine derivatives. Bioorganic & medicinal chemistry letters, 22 (1), 308-312 doi:10.1016/j.bmcl.2011.11.009.

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• Hu, W., Blecking, C., Kralj, M., Šuman, L., Piantanida, I. & Schrader, T. (2012) Dimeric Calixarenes : A New Family of Major Groove Binders. Chemistry : a European journal, 18 (12), 3589-3597 doi:10.1002/chem .201100634.

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• Ester, K., Supek, F., Majsec, K., Marjanović, M., Lembo, D., Donalisio, M., Šmuc, T., Jarak, I., Karminski-Zamola, G. & Kralj, M. (2012) Putative mechanisms of antitumor activity of cyano-substituted heteroaryles in HeLa cells. Investigational new drugs, 30 (2), 450-467 doi:10.1007/s10637-010-9571-7.

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• Basarić, N., Cindro, N., Bobinac, D., Mlinarić-Majerski, K., Uzelac, L., Kralj, M. & Wan, P. (2011) Sterically congested quinone methides in photodehydration reactions of 4-hydroxybiphenyl derivatives and investigation of their antiproliferative activity. Photochemical & photobiological sciences, 10 (12), 1910-1925 doi:10.1039/C1PP05182B.

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• Perin, N., Uzelac, L., Piantanida, I., Karminski-Zamola, G., Kralj, M. & Hranjec, M. (2011) Novel biologically active nitro and amino substituted benzimidazo[1,2-a]quinolines. Bioorganic & medicinal chemistry, 19 (21), 6329-6339 doi:10.1016/j.bmc.2011.09.002.

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• Supek, F., Šumanovac Ramljak, T., Marjanović, M., Buljubašić, M., Kragol, G., Ilić, N., Šmuc, T., Zahradka, D., Mlinarić-Majerski, K. & Kralj, M. (2011) Could LogP be a principal determinant of biological activity in 18-crown-6 ethers? Synthesis of biologically active adamantane-substituted diaza-crowns. European Journal of Medicinal Chemistry, 46 (8), 3444-3454 doi:10.1016/j.ejmech.2011.05.009.

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• Juribašić, M., Molčanov, K., Kojić-Prodić, B., Bellotto, L., Kralj, M., Zani, F. & Tušek-Božić, L. (2011) Palladium(II) complexes of quinolinylaminophosphonates: Synthesis, structural characterization, antitumor and antimicrobial activity. Journal of inorganic biochemistry, 105 (6), 867-879 doi:10.1016/j.inorgbio.2011.03.011.

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• Groger, K., Baretić, D., Piantanida, I., Marjanović, M., Kralj, M., Grabar, M., Tomić, S. & Schmuck, C. (2011) Guanidiniocarbonyl-pyrrole-aryl conjugates as nucleic acid sensors: switch of binding mode and spectroscopic responses by introducing additional binding sites into the linker. Organic & biomolecular chemistry, 9 (1), 198-209 doi:10.1039/C0OB00103A.

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• Jarak, I., Marjanović, M., Piantanida, I., Kralj, M. & Karminski-Zamola, G. (2011) Novel Pentamidine Derivatives: Synthesis, Antitumor Properties and Polynucleotide-binding Activities. European journal of medicinal chemistry, 46 (7), 2807-2815 doi:10.1016/j.ejmech.2011.04.001.

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• Rajić, Z., Hadjipavlou-Litina, D., Pontiki, E., Kralj, M., Šuman, L. & Zorc, B. (2010) The Novel Ketoprofen Amides – Synthesis and Biological Evaluation as Antioxidants, Lipoxygenase Inhibitors and Cytostatic Agents. Chemical biology & drug design, 75, 641-652 doi:10.1111/j.1747-0285.2010.00963.x.

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• Gazivoda Kraljević, T., Krištafor, S., Šuman, L., Kralj, M., Ametamey, S., Cetina, M. & Raić-Malić, S. (2010) Synthesis, X-ray crystal structure study and antitumoral evaluations of 5,6-disubstituted pyrimidine derivatives. Bioorganic & medicinal chemistry, 18 (7), 2704-2712 doi:10.1016/j.bmc.2010.02.023.

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• Hranjec, M., Pavlović, G., Marjanović, M., Kralj, M. & Karminski-Zamola, G. (2010) Benzimidazole derivatives related to 2,3-acrylonitriles, benzimidazo[1,2-a]quinolines and fluorenes: Synthesis, antitumor evaluation in vitro and crystal structure determination. European journal of medicinal chemistry, 45 (6), 2405-2417 doi:10.1016/j.ejmech.2010.02.022.

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• Racané, L., Kralj, M., Šuman, L., Stojković, R., Tralić-Kulenović, V. & Karminski-Zamola, G. (2010) Novel amidino substituted 2-phenylbenzothiazoles : Synthesis, antitumor evaluation in vitro and acute toxicity testing in vivo. Bioorganic & medicinal chemistry, 18 (3), 1038-1044 doi:10.1016/j.bmc.2009.12.054.

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• Radić Stojković, M., Marjanović, M., Pawlica, D., Dudek, L., Eilmes, J., Kralj, M. & Piantanida, I. (2010) Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives. New journal of chemistry, 34 (3), 500-507 doi:10.1039/b9nj00490d.

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• Hernandez-Folgado, L., Baretić, D., Piantanida, I., Marjanović, M., Kralj, M., Rehm, T. & Schmuck, C. (2010) Guanidiniocarbonyl-pyrrole-aryl derivatives : structure tuning for spectrophotometric recognition of specific DNA and RNA sequences and antiproliferative activity. Chemistry : a European journal, 16 (10), 3036-3056 doi:10.1002/chem.200901999.

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• Vrdoljak, V., Đilović, I., Rubčić, M., Kraljević Pavelić, S., Kralj, M., Matković-Čalogović, D., Piantanida, I., Novak, P., Rožman, A. & Cindrić, M. (2010) Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity. European journal of medicinal chemistry, 45 (1), 38-48 doi:10.1016/j.ejmech.2009.09.021.

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• Gredičak, M., Supek, F., Kralj, Marijeta, Majer, Zsuzsa, Hollosi, M., Šmuc, T., Mlinarić-Majerski, K. & Horvat, Š. (2010) Computational structure-activity study directs synthesis of novel antitumor enkephalin analogs. Amino acids (Wien), 38 (4), 1185-1191 doi:10.1007/s00726-009-0329-5.

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• Krištafor, S., Gazivoda Kraljević, T., Makuc, D., Plavec, J., Šuman, L., Kralj, M. & Raić-Malić, S. (2009) Synthesis, structural studies and antitumoral evaluation of C-6 alkyl and alkenyl side chain pyrimidine derivatives. Molecules, 14 (12), 4866-4879 doi:10.3390/molecules14124866.

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• Šimunović, M., Perković, I., Zorc, B., Ester, K., Kralj, M., Hadjipavlou-Litina, D. & Pontiki, E. (2009) Urea and carbamate derivatives of primaquine: Synthesis, cytostatic and antioxidant activities. Bioorganic and Medicinal Chemistry, 17 (15), 5605-5613 doi:10.1016/j.bmc.2009.06.030.

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• Kraljević Pavelić, S., Marjanović, M., Poznić, M. & Kralj, M. (2009) Adenovirally-mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment. Journal of Cancer Research and Clinical Oncology, 135 (12), 1747-1761 doi:10.1007/s00432-009-0621-5.

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• Ester, K., Ćurković-Perica, M. & Kralj Marijeta (2009) The phytohormone auxin induces G1 cell cycle arrest of human tumor cells. Planta medica, 75 (13), 1423-1426 doi:10.1055/s-0029-1185805.

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• Ester, K., Hranjec, M., Piantanida, I., Ćaleta, I., Ivana, J., Pavelić, K., Kralj, M. & Karminski-Zamola, G. (2009) Novel derivatives of pyridylbenzo[b]thiophene-2-carboxamides and benzo[b]thieno[2,3-c]naphthyridin-2-ones: minor structural variations provoke major differences of antitumor action mechanisms. Journal of medicinal chemistry, 52 (8), 2482-2492 doi:10.1021/jm801573v.

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• Ćaleta, I., Kralj, M., Marjanović, M., Bertoša, B., Tomić, S., Pavlović, G., Pavelić, K. & Karminski-Zamola, G. (2009) Novel Cyano- and Amidino- Benzothiazole Derivatives: Synthesis, Antitumor Evaluation, X-ray and QSAR Analysis. Journal of medicinal chemistry, 52 (6), 1744-1756 doi:10.1021/jm801566q.

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• Horvat, Š., Kralj, M., Perc, M., Jerić, I., Varga-Defterdarović, L., Jakas, A., Roščić, M., Šuman, L. & Gredičak, M. (2009) Novel side-chain glucosylated and adamantylated [Asp2/Glu2]enkephalin analogues: synthesis and in vitro growth inhibition of human tumor cells. Chemical biology & drug design, 73 (2), 253-257 doi:10.1111/j.1747-0285.2008.00763.x.

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• Noll, S., Kralj, M., Šuman, L., Stephan, H. & Piantanida, I. (2009) Synthesis of modified pyrimidine bases and positive impact of chemically reactive substituents on their in vitro antiproliferative activity. European journal of medicinal chemistry, 44 (3), 1172-1179 doi:10.1016/j.ejmech.2008.06.002.

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• Wittine, K., Benci, K., Rajić, Z., Zorc, B., Kralj, M., Marjanović, M., Pavelić, K., De Clercq, E., Andrei, G., Snoeck, R., Balzarini, J. & Mintas, M. (2009) The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations. European journal of medicinal chemistry, 44 (1), 143-151 doi:10.1016/j.ejmech.2008.03.037.

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• Supek, F., Kralj, M., Marjanović, M., Šuman, L., Šmuc, T., Krizmanić, I. & Žinić, B. (2008) Atypical cytostatic mechanism of N -1-sulfonylcytosine derivatives determined by in vitro screening and computational analysis. Investigational new drugs, 26 (2), 97-110 doi:10.1007/s10637-007-9084-1.

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• Džimbeg, G., Zorc, B., Kralj, M., Ester, K., Pavelić, K., Andrei, G., Snoeck, R., Balzarini, J., De Clercq, E. & Mintas, M. (2008) The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations. European journal of medicinal chemistry, 43 (6), 1180-1187 doi:10.1016/j.ejmech.2007.09.001.

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• Kralj, M., Tušek-Božić, L. & Frkanec, L. (2008) Biomedical Potentials of Crown Ethers: Prospective Antitumor Agents. ChemMedChem, 3 (10), 1478-1492 doi:10.1002/cmdc.200800118.

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• Hranjec, M., Piantanida, I., Kralj, M., Šuman, L., Pavelić, K. & Karminski-Zamola, G. (2008) Novel amidino-substituted thienyl- and furylvinylbenzimidazole derivatives and their photochemical conversion into corresponding diazacyclopenta[c]fluorenes. Synthesis, interactions with DNA and RNA and antitumor evaluation. Part 4. Journal of medicinal chemistry, 51 (16), 4899-4910 doi:10.1021/jm8000423.

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• Kraljević Pavelić, S., Čačev, T. & Kralj, M. (2008) A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer gene therapy, 15 (9), 576-590 doi:10.1038/cgt.2008.28.

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• Đilović, I., Rubčić, M., Vrdoljak, V., Kraljević Pavelić, S., Kralj, M., Piantanida, I. & Cindrić, M. (2008) Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity. Bioorganic & medicinal chemistry letters, 16 (9), 5189-5198 doi:10.1016/j.bmc.2008.03.006.

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• Hranjec, M., Starčević, K., Piantanida, I., Kralj, M., Marjanović, M., Hasani, M., Westman, G. & Karminski-Zamola, G. (2008) Synthesis, antitumor evaluation and DNA binding studies of novel amidino-benzimidazolyl substituted derivatives of furyl-phenyl- and thienyl-phenyl-acrylates, naphthofurans and naphthothiophenes. European journal of medicinal chemistry, 43 (12), 2877-2890 doi:10.1016/j.ejmech.2008.02.010.

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• Ćaleta, I., Kralj, M., Marjanović, M. & Karminski-Zamola, G. (2008) Synthesis and Antiproliferative Evaluation of Novel Bis-Styrylbenzothiazol-3-ium Salts. Monatshefte fuer Chemie, 139 (5), 569-573.

• Marjanović, M., Zorc, B., Pejnović, L., Zovko, M. & Kralj, M. (2007) Fenoprofen and ketoprofen amides as potential antitumor agents. Chemical biology & drug design, 69 (3), 222-226 doi:10.1111/j.1747-0285.2007.00494.x.

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• Gazivoda, T., Šokčević, M., Kralj, M., Šuman, L., Pavelić, K., De Clercq, E., Andrei, G., Snoeck, R., Balzarini, J., Mintas, M. & Raić-Malić, S. (2007) Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives. Journal of medicinal chemistry, 50 (17), 4105-4112 doi:10.1021/jm070324z.

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• Hranjec, M., Kralj, M., Piantanida, I., Sedić, M., Šuman, L., Pavelić, K. & Karminski-Zamola, G. (2007) Novel cyano- and amidino-substituted derivatives of styryl-2-benzimidazoles and benzimidazo[1,2-a]quinolines. Synthesis, photochemical synthesis, DNA binding, and antitumor evaluation, part 3. Journal of medicinal chemistry, 50 (23), 5696-5711 doi:10.1021/jm070876h.

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• Cametti, M., Piantanida, I., Žinić, M., Dalla Cort, A., Mandolini, L., Marjanović, M. & Kralj, M. (2007) Specific sensing of poly G by the aluminum– salophen complex. Journal of Inorganic Biochemistry, 101 (8), 1129-1132.

• Prekupec, S., Makuc, D., Plavec, J., Šuman, L., Kralj, M., Pavelić, K., Balzarini, J., De Clercq, E., Mintas, M. & Raić-Malić, S. (2007) Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: Synthesis, H-1 and C-13 NMR conformational studies, and antiviral and cytostatic evaluations. Journal of medicinal chemistry, 50 (13), 3037-3045 doi:10.1021/jm0614329.

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• Starčević, K., Kralj, M., Ester, K., Sabol, I., Grce, M., Pavelić, K. & Karminski-Zamola, G. (2007) Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles. Bioorganic & medicinal chemistry, 15 (13), 4419-4426 doi:10.1016/j.bmc.2007.04.032.

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• Gazivoda, T., Raić-Malić, S., Marjanović, M., Kralj, M., Pavelić, K., Balzarini, J., De Clercq, E. & Mintas, M. (2007) The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: Synthesis, cytostatic, and antiviral activity evaluations. Bioorganic & medicinal chemistry, 15 (2), 749-758 doi:10.1016/j.bmc.2006.10.046.

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• Starčević, K., Kralj, M., Ester, K. & Karminski-Zamola, G. (2007) Synthesis and cytostatic evaluation of pyridopyrimidobenzimidazole derivatives. Heterocycles, 71 (3), 647-656.

• Marjanović, M., Kralj, M., Supek, F., Frkanec, L., Piantanida, I., Šmuc, T. & Tušek-Božić, L. (2007) Antitumor potential of crown ethers: structure activity relationships, cell cycle disturbances and cell death studies of a series of ionophores. Journal of medicinal chemistry, 50 (5), 1007-1018 doi:10.1021/jm061162u.

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• Barbarić, M., Kralj, M., Marjanović, M., Husnjak, I., Pavelić, K., Filipović-Grčić, J., Zorc, D. & Zorc, B. (2007) Synthesis and in vitro antitumor effect of diclofenac and fenoprofen thiolated and nonthiolated polyaspartamide-drug conjugates. European Journal of Medicinal Chemistry, 42 (1), 20-29.

• Radić Stojković, M., Piantanida, I., Kralj, M., Marjanović, M., Žinić, M., Pawlica, D. & Eilmes, J. (2007) The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines. Bioorganic & medicinal chemistry, 15 (4), 1795-1801 doi:10.1016/j.bmc.2006.11.034.

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• Rajić, Z., Zorc, B., Raić-Malić, S., Ester, K., Kralj, M., Pavelić, K., Balzarini, J., De Clercq, E. & Mintas, M. (2006) Hydantoin derivatives of L- and D-amino acids: synthesis, antiviral and antitumoral activity evaluations. Molecules, 11 (11), 837-848 doi:10.3390/11110837.

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• Krištafor, V., Raić-Malić, S., Cetina, M., Kralj, M., Šuman, L., Pavelić, K., Balzarini, J., De Clercq, E. & Mintas, M. (2006) Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues. Bioorganic & medicinal chemistry, 14 (23), 8126-8138 doi:10.1016/j.bmc.2006.07.033.

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• Cindrić, M., Kajfež Novak, T., Kraljević, S., Kralj, M. & Kamenar, B. (2006) Structural and antitumor activity study of gamma-octamolybdates containing aminoacids and peptides. Inorganica chimica acta, 359, 1673-1680.

• Starčević, K., Ćaleta, I., Cinčić, D., Kaitner, B., Kralj, M., Ester, K. & Karminski-Zamola, G. (2006) Synthesis, crystal structure determination and antiproliferative evaluation of novel benzazoyl benzamides. Heterocycles, 68 (11), 2285-2299.

• Tumir, L., Piantanida, I., Žinić, M., Juranović Cindrić, I., Meić, Z., Kralj, M. & Tomić, S. (2006) Synthesis of phenanthridinium bis-nucleobase conjugates, interactions with poly U, nucleotides and in vitro antitumor activity of mono- and bis-nucleobase conjugates. European Journal of Medicinal Chemistry, 41 (10), 1153-1166.

• Starčević, K., Kralj, M., Piantanida, I., Šuman, L., Pavelić, K. & Karminski-Zamola, G. (2006) Synthesis, Photochemical Synthesis, DNA Binding and Antitumor Evaluation of Novel Cyano- and Amidino-Substituted Derivatives of Naphtho-Furans, Naphtho-Thiophenes, Benzo-Thieno-Furans, Benzo-Dithiophenes and their Acyclic Precursors. European Journal of Medicinal Chemistry, 41 (8), 925-939.

• Gazivoda, T., Wittine, K., Lovrić, I., Makuc, D., Plavec, J., Cetina, M., Mrvoš-Sermek, D., Šuman, L., Kralj, M., Pavelić, K., Mintas, M. & Raić-Malić, S. (2006) Synthesis, structural studies, and cytostatic evaluation of 5,6-di-O-modified L-ascorbic acid derivatives. Carbohydrate research, 341 (4), 433-442 doi:10.1016/j.carres.2005.12.010.

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• Jarak, I., Kralj, M., Piantanida, I., Šuman, L., Žinić, M., Pavelić, K. & Karminski-Zamola, G. (2006) Novel Cyano- and Amidino-Substituted Derivatives of Thieno[2, 3-b]- and Thieno[3, 2-b]thiophene-2-carboxanilides and Thieno[3’ , 2’ : 4, 5]thieno- and Thieno[2’ , 3’ : 4, 5]thieno [2, 3-c]quinolones: Synthesis, Photochemical Synthesis, DNA binding and Antitumor Evaluation.. Bioorganic & Medicinal Chemistry, 14 (8), 2859-2868.

• Kapitanović, S., Čačev, T., Antica, M., Kralj, M., Cavrić, G., Pavelić, K. & Spaventi, R. (2006) Effect of indomethacin on E-cadherin and β-catenin expression in HT-29 colon cancer cells. Experimental and molecular pathology, 80 (1), 91-96 doi:10.1016/j.yexmp.2005.04.008.

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• Malojčić, G., Piantanida, I., Marinić, M., Žinić, M., Marjanović, M., Kralj, M., Pavelić, K. & Schneider, H. (2005) A novel bis-phenanthridine triamine with pH controlled binding to nucleotides and nucleic acids. Organic & biomolecular chemistry, 3, 4373 - 4382.

• Prekupec, S., Makuc, D., Plavec, J., Kraljević, S., Kralj, M., Pavelić, K., Andrei, G., Snoeck, R., Balzarini, J., De Clercq, E., Raić-Malić, S. & Mintas, M. (2005) Antiviral and cytostatic evaluation of the novel 6-acyclic chain substituted thymine derivatives. Antiviral chemistry & chemotherapy, 16 (5), 327-338 doi:10.1177/095632020501600505.

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• Opačić, N., Barbarić, M., Zorc, B., Cetina, M., Nagl, A., Frković, D., Kralj, M., Pavelić, K., Balzarini, J., Andrei, G., Snoeck, R., De Clerq, E., Raić-Malić, S. & Mintas, M. (2005) The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: Synthesis, X-ray crystal structure study, cytostatic and antiviral activity evaluations. Journal of medicinal chemistry, 48 (2), 475-482 doi:10.1021/jm040869i.

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• Jarak, I., Kralj, M., Šuman, L., Pavlović, G., Dogan, J., Piantanida, I., Žinić, M., Pavelić, K. & Karminski-Zamola, G. (2005) Novel Cyano- and N-isopropylamidino-Substituted Derivatives of Benzo[b]thiophene- 2-carboxanilides and Benzo[b]thieno[2, 3-c]quinolones: Synthesis, Photochemical Synthesis, Crystal Structure Determination and Antitumor Evaluation. Part 2.. Journal of medicinal chemistry, 48, 2346-2360.

• Starčević, K., Karminski-Zamola, G., Piantanida, I., Žinić, M., Šuman, L. & Kralj, M. (2005) Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator. Journal of the American Chemical Society, 127, 1074-1075.

• Kralj, M., Kraljević, S., Sedić, M., Kurjak, A. & Pavelić, K. (2005) Global approach to perinatal medicine: functional genomics and proteomics. Journal of perinatal medicine, 33 (1), 5-16.

• Gazivoda, T., Plevnik, M., Plavec, J., Kraljević, S., Kralj, M., Pavelić, K., Balzarini, J., De Clercq, E., Mintas, M. & Raić-Malić, S. (2005) The novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation. Bioorganic & medicinal chemistry, 13 (1), 131-139 doi:10.1016/j.bmc.2004.09.052.

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• Pavelić, J., Herak Bosnar, M. & Kralj, M. (2004) Gene therapy: concept, current status, moral and ethical aspects. Periodicum biologorum, 106 (3), 239-244.

• Žarković, N., Žarković, K., Kralj, M., Borović, S., Sobolović, S., Poljak-Blaži, M., Čipak, A. & Pavelić, K. (2003) Anticancer and Antioxidative Effects of Micronized Zeolite Clinoptilolite. Anticancer Research, 23 (2B), 1589-1596.

• Kralj, M. & Pavelić, K. (2003) Medicine on a small scale.How molecular medicine can benefit from self-assembled and nanostructured materials. EMBO reports, 4 (11), 1008-1012.

• Kralj, M. & Pavelić, J. (2003) p21WAF1/CIP1 is more effective than p53 in growth suppression of mouse renal carcinoma cell line Renca in vitro and in vivo. Journal of cancer research and clinical oncology, 129 (8), 463-471.

• Kralj, M. (2003) Biomedical and environmental potential of nanoporous materials. Periodicum biologorum, 105 (2), 99-107.

• Kralj, M., Husnjak, K., Korbler, T. & Pavelić, J. (2003) Endogenous p21WAF1/CIP1 status predicts the response of human tumor cells to wild-type p53 and p21WAF1/CIP1 overexpression?. Cancer Gene Therapy, 10.

• Pavelić, K., Hadžija, M., Bedrica, L., Pavelić, J., Đikić, I., Katić, M., Kralj, M., Herak Bosnar, M., Kapitanović, S., Poljak-Blaži, M., Križanac, Š., Stojković, R., Jurin, M., Subotić, B. & Čolić, M. (2001) Natural zeolite clinoptilolite: new adjuvant in anticancer therapy. Journal of Molecular Medicine, 78 (12), 708-720.

• Poljak-Blaži, M., Katić, M., Kralj, M., Žarković, N., Marotti, T., Bošnjak, B., Šverko, V., Balog, T. & Pavelić, K. (2001) In vitro and in vivo effect of natural clinoptilolite on malignant tumors. Studies in Surface Science and Catalysis, 135, 5309-5316.

• Kralj, M., Kapitanović, S., Kovačević, D., Lukač, J., Spaventi, Š. & Pavelić, K. (2001) Effect of the nonsteroidal anti-inflammatory drug indomethacin on proliferation and apoptosis of colon carcinoma cells. Journal of cancer research and clinical oncology, 127 (3), 173-179 doi:10.1007/s004320000196.

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• Poljak-Blaži, M., Kralj, M., Popović Hadžija, M., Žarković, N., Žarković, K. & Waeg, G. (2000) Involvement of lipid peroxidation, oncogene expression and induction of apoptosis in the antitumorous activity of feric-sorbitol-citrate. Cancer Biotherapy & Radiopharmaceuticals, 15, 285-293.

• Kralj, M., Kojić-Prodić, B., Banić, Z., Grdiša, M., Vela, V., Šušković, B. & Pavelić, K. (1996) Synthesis, structural characterization and cytotoxic effect of 6-amino-6-deoxy-L-ascorbic acid derivatives. European journal of medicinal chemistry, 31 (1), 23-35 doi:10.1016/S0223-5234(96)80003-1.

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• Grdiša, M., Kralj, M., Eckert-Maksić, M., Maksić, Z. & Pavelić, K. (1995) 6-Amino-6-deoxyascorbic acid induces apoptosis in human tumor cells. Journal of cancer research and clinical oncology, 121 (2), 98-102 doi:10.1007/BF01202220.

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• Grdiša, M., Kralj, M., Eckert-Maksić, M. & Maksić, Z. (1995) 6-amino-6-deoxyascorbic acid induces apoptosis in human tumor cells. Journal of cancer research and clinical oncology, 121 (2), 98-102 doi:10.1007/BF01202220.

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Patents

• Ruđer Bošković Institute (2013) Adamantane derivatives of aza-crown ethers and their use in treatment of tumor, US 8, 389, 505 B2.

• Institut Ruđer Bošković (2010) Adamantane derivatives of aza-crown ethers and their use in treatment of tumor, WO 2010/146404 A1.

• Fakultet kemijskog inženjerstva i tehnologije i Institut (2005) Synthesis, photochemical synthesis and antiproliferative activity of cyano- and amidino-substituted 2-styryl-benzimidazoles and benzimido[1, 2-a]quinolines, P20050806A.

• Rudjer Boskovic Institute Quinone-methide precursors with bodipy chromophore, method of preparation, biological activity and application in fluorescent labeling.

• Kralj, M., Majerski, K., Šumanovac Ramljak, T. & Marjanović, M. Adamantane derivatives of aza-crown ethers and their use in treatment of tumor.

• Pliva, Istraživački institut Use of 5-thia-1, 4-diazobicyklo-[4.2.0.]oktan 3, 8-diokso compounds in antitumor therapy.

Theses

Doctoral dissertation

• Kralj, M. (2001) 'p53 and p21CIP1/WAF1 mediated gene therapy of cancer', doktorska disertacija, Prirodoslovno-matematički, Zagreb.

Croatian society for Human Genetics

Croatian Society for Biochemistry and Molecular Biology

Croatian society for Theoretical and Mathematical Biology

European Association for Cancer Research

Croatioan Association for Cancer Research

Genomics and Proteomics in Oncology Board Member