Visiting scientist - Zoological Institute, University of Kiel, Germany (2010-2011, Prof. Thomas C. G. Bosch)
Postdoc - Max Planck Institute for Evolutionary Biology, Plön, Germany (2008 – 2010, Diethard Tautz)
Doctorate in Genetics - University of Cologne, Institute for Genetics, Germany (2000 – 2003, Diethard Tautz)
Diploma in Biology - University of Zagreb, Faculty of Science, Croatia (1997)

HRZZ Istraživački projekti (IP-06-2016) Filostratigrafija nastanka i gubitka gena - PhyLoss

2014    City of Zagreb Award for outstanding contribution to biological sciences
2012    Order of the Croatian Morning Star for outstanding contributions to science (awarded by the President of Croatia Dr. Ivo Josipović)
2012    State Award for Science (awarded by the President of the Croatian Parliament Josip Leko)
2010 – 2012    Ruđer Bošković Institute Award (awarded three times)
2009    Unity Through Knowledge grant
2008    Fellowship of the Max-Planck Society
2008    Young Investigator Award, "Ruđer Bošković" Institute and Shimadzu
2008    Excellence in science award, Ministry of Science, Croatia
2008    Young Investigator Award, The society of university teachers – Zagreb
2008    Adris Foundation grant
2008    “Željko Trgovčević Award”, Croatian Genetic Society
2007    Excellence in science award, Ministry of Science, Croatia
2007    Young Investigator Award, International Society for Applied Biological Sciences (ISABS)

Catholic University of Croatia - Courses in Evolutionary Biology

1. Stancik IA, Šestak MS, Ji B, Axelson-Fisk M, Franjevic D, Jers C, Domazet-Lošo T, Mijakovic I (2018) Serine/Threonine protein kinases from bacteria, archaea and eukarya share a common evolutionary origin deeply rooted in the tree of life. Journal of Molecular Biology 430(1):27-32.

2. Pozhitkov AE, Neme R, Domazet-Lošo T, Leroux BG, Soni S, Tautz D, Noble PA (2017) Tracing the dynamics of gene transcripts after organismal death. Open Biology 7,160267

3. Domazet-Lošo T, Carvunis A-R, Albà MM, Šestak MS, Bakarić R, Neme R, Tautz D (2017) No evidence for phylostratigraphic bias impacting inferences on patterns of gene emergence and evolution. Molecular Biology and Evolution 34 (4), 843-856.

4. Bosch TCG, Domazet-Lošo T, Gruender S, Holstein TW, Jékely G, Klimovich A, Miller DJ, Murillo A, Rentzsch F, Richards G, Schröder K, Technau U, Yuste R (2017) Back to the basics: Pre-Bilaterian Nervous Systems Start to Fire. Trends in Neurosciences 40 (2), 92-105.

5. Domazet-Lošo M, Domazet-Lošo T (2016) gmos: Rapid detection of genome mosaicism over short evolutionary distances. PLOS One 11(11): e0166602.

6. Xu F, Domazet-Lošo T, Fan D, Dunwell TL, Li L, Fang X, Zhang G (2016) High expression of new genes in trochophore enlightening the ontogeny and evolution of spiralians. Scientific Reports 6, 34664

7. Šestak MS, Domazet-Lošo T (2015) Phylostratigraphic profiles in zebrafish uncover chordate origins of the vertebrate brain. Molecular Biology and Evolution 32, 299–312.

8. Bosch TCG, Adamska M, Augustin R, Domazet-Loso T, Foret S, Fraune S, Funayama N, Grasis J, Hamada M, Hatta M, Hobmayer B, Kawai K, Klimovich A, Manuel M, Shinzato C, Technau U, Yum S, Miller DJ. (2014) How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans. Bioessays. 36, 1185–1194, doi: 10.1002/bies.201400065.

9. Domazet-Lošo T, Klimovich A, Anokhin B, Anton-Erxleben F, Hamm MJ, Lange C, Bosch TCG (2014) Naturally occurring tumors in the basal metazoan Hydra. Nature Communications 5, 4222, doi: 10.1038/ncomms5222

10. Fuchs B, Wang W, Graspeuntner S, Li Y, Insua S, Herbst E-M, Dirksen P, Böhm A-M, Hemmrich G, Sommer F, Domazet-Lošo T, Klostermeier UC, Anton-Erxleben F, Rosenstiel P, Bosch TCG, Khalturin K (2014) Regulation of Polyp-to-Jellyfish Transition in Aurelia aurita. Current Biology 24, 263–273.
Evaluated by Faculty of 1000

11. Mendoza A de, Sebé-Pedrós A, Šestak MS, Matejčić M, Torruella G, Domazet-Lošo T, Ruiz-Trillo I (2013) Transcription factor evolution in eukaryotes and the assembly of the regulatory toolkit in multicellular lineages. PNAS 110, E4858–E4866.
Evaluated by Faculty of 1000

12. Šestak MS, Božičević V, Bakarić R, Dunjko V, Domazet-Lošo T (2013) Phylostratigraphic profiles reveal a deep evolutionary history of the vertebrate head sensory systems. Frontiers in Zoology 10:18

13. Tautz D, Neme R, Domazet-Lošo T (2013) Evolutionary origin of orphan genes. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [DOI: 10.1002/9780470015902.a0024601]

14. McFall-Ngai M, Hadfield MG, Bosch, TCG, Carey HV, Domazet-Lošo T, Douglas AE, Dubilier N, Eberl G, Fukami T, Gilbert SF, et al. (2013) Animals in a bacterial world: a new imperative for the life sciences. PNAS 110, 3229–36.

15. Franzenburg S, Fraune S, Künzel S, Baines JF, Domazet-Lošo T, Bosch TCG (2012) MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers. PNAS 109:19374-9.
Evaluated by Faculty of 1000

16. Zhang G, Fang X, Guo X, Li L, Luo R, Xu F, Yang P, Zhang L, Wang X, Qi H,Xiong Z, Que H, Xie Y, Holland PW, Paps J, Zhu Y, Wu F, Chen Y, Wang J, Peng C,Meng J, Yang L, Liu J, Wen B, Zhang N, Huang Z, Zhu Q, Feng Y, Mount A, HedgecockD, Xu Z, Liu Y, Domazet-Lošo T, et al. (2012) The oyster genome reveals stress adaptation and complexity of shell formation. Nature. 2012 490:49-54.

17. Hemmrich G, Khalturin K, Boehm AM, Puchert M, Anton-Erxleben F, Wittlieb J, Klostermeier UC, Rosenstiel P, Oberg HH, Domazet-Lošo T, Sugimoto T, Niwa H, Bosch TC (2012) Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity. Molecular Biology and Evolution 29(11):3267-80.

18. Tautz D, Domazet-Lošo T (2011) The evolutionary origin of orphan genes. Nature Reviews Genetics 12(10):692-702.

19. Domazet-Lošo T, Tautz D (2010) A phylogenetically based transcriptome age index mirrors ontogenetic divergence patter. Nature 468(7325):815–818.
Nature cover story, Nature News and Views

20. Domazet-Lošo T, Tautz D (2010) Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoans. BMC Biology 8:66
Evaluated by Faculty of 1000: Hide W: 2010. F1000.com/4160956
Commentary by Ciccarelli FD (2010). The (r)evolution of cancer genetics. BMC Biol. 2010 8:74.

21. Domazet-Lošo T, Tautz D (2008) An ancient evolutionary origin of genes associated with human genetic diseases. Molecular Biology and Evolution 25(12):2699-2707.
Evaluated by Faculty of 1000: Swalla W: 2009. F1000.com/1138977, Covered by The Economist and New Scientist

22. Domazet-Lošo T, Brajković J, Tautz D (2007) A phylostratigraphy approach to uncover the genomic history of major adaptations in metazoan lineages. Trends in Genetics 23(11):533-539.
Evaluated by Faculty of 1000: Telford M: 2007. F1000.com/1094853

23. Pozhitkov A, Noble N, Domazet-Lošo T, Nolte A, Staehler P, Beier M, Tautz D (2006) Tests of rRNA hybridization to microarrays suggest that hybridization characteristics of oligonucleotide probes for species discrimination cannot be predicted. Nucleic Acid Research 34(9):e66

24. Marais G, Domazet-Lošo T, Tautz D, Charlesworth B (2004) Correlated evolution of the synonymous and nonsynonymous sites in Drosophila. Journal of Molecular Evolution 59:771-9.

25. Domazet-Lošo T, Tautz D (2003) An evolutionary analysis of orphan genes in Drosophila. Genome Research 13:2213-9.

Books and book chapters

Book chapters

• Tautz, D., Neme, R. & Domazet-Lošo, T. (2013) Evolutionary Origin of Orphan Genes. U: Hildegard Kehrer-Sawatzki (ur.) eLS. Chichester, John Wiley & Sons, str. 1-8.

• Tautz, D., Neme, R. & Domazet-Lošo, T. (2013) Evolutionary origin of orphan genes. U: Maccarrone, M. & (ur.) eLS. Chichester, John Wiley & Sons, str. 1-10.

Journal articles

Scientific and review papers

• Čorak, N., Anniko, S., Daschkin-Steinborn, C., Krey, V., Koska, S., Futo, M., Široki, T., Woichansky, I., Opašić, L., Kifer, D., Tušar, A., Maxeiner, H., Domazet-Lošo, M., Nicolaus, C. & Domazet-Lošo, T. (2023) Pleomorphic Variants of Borreliella (syn. Borrelia) burgdorferi Express Evolutionary Distinct Transcriptomes. International journal of molecular sciences, 24 (6), 5594, 23 doi:10.3390/ijms24065594.

  doidoi.orgwww.mdpi.com

• Futo, M., Široki, T., Koska, S., Čorak, N., Tušar, A., Domazet-Lošo, M. & Tomislav Domazet-Lošo (2022) A novel time-lapse imaging method for studying developing bacterial biofilms. Scientific Reports, 12, 21120, 13 doi:10.1038/s41598-022-24431-y.

  doiwww.nature.comfulir.irb.hr

• Domazet-Lošo, T. (2022) mRNA Vaccines: Why Is the Biology of Retroposition Ignored?. Genes, 13 (5), 719, 24 doi:10.3390/genes13050719.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Futo, M., Opašić, L., Koska, S., Čorak, N., Široki, T., Ravikumar, V., Thorsell, A., Lenuzzi, M., Kifer, D., Domazet-Lošo, M., Vlahoviček, K., Mijakovic, I. & Domazet-Lošo, T. (2021) Embryo-like features in developing Bacillus subtilis biofilms. Molecular biology and evolution, 38 (1), 31-47 doi:10.1093/molbev/msaa217.

  doidoi.orgacademic.oup.comfulir.irb.hr

• Ravikumar, V., Nalpas, N., Anselm, V., Krug, K., Lenuzzi, M., Šestak, M., Domazet-Lošo, T., Mijakovic, I. & Macek, B. (2018) In-depth analysis of Bacillus subtilis proteome identifies new ORFs and traces the evolutionary history of modified proteins. Scientific Reports, 8 (1), 17246, 11 doi:10.1038/s41598-018-35589-9.

  doi

• Stancik, I., Sestak, M., Ji, B., Axelson-Fisk, M., Franjevic, D., Jers, C., Domazet- Lošo, T. & Mijakovic, I. (2018) Serine/Threonine protein kinases from bacteria, archaea and eukarya share a common evolutionary origin deeply rooted in the tree of life. Journal of molecular biology, 430 (1), 27-32 doi:10.1016/j.jmb.2017.11.004.

  doi

• Pozhitkov, A., Neme, R., Domazet-Lošo, T., Leroux, B., Soni, S., Tautz, D. & Noble, P. (2017) Tracing the dynamics of gene transcripts after organismal death. Open Biology, 7 (1), 160267, 25 doi:10.1098/rsob.160267.

  doirsob.royalsocietypublishing.orgdx.doi.org

• Domazet-Lošo, T., Carvunis, A., Mar Albà, M., Sebastijan Šestak, M., Bakarić, R., Neme, R. & Tautz, D. (2017) No Evidence for Phylostratigraphic Bias Impacting Inferences on Patterns of Gene Emergence and Evolution. Molecular biology and evolution, 34 (4), 843-856 doi:10.1093/molbev/msw284.

  doiacademic.oup.com

• Bosch, T., Klimovich, A., Domazet-Lošo, T., Gründer, S., Holstein, T., Jékely, G., Miller, D., Murillo-Rincon, A., Rentzsch, F., Richards, G., Schröder, K., Technau, U. & Yuste, R. (2017) Back to the Basics: Cnidarians Start to Fire. Trends in Neurosciences, 40 (2), 92-105 doi:10.1016/j.tins.2016.11.005.

  doi

• Domazet-Lošo, M. & Domazet-Lošo, T. (2016) gmos: Rapid Detection of Genome Mosaicism over Short Evolutionary Distances. PLoS One, 11 (11), e0166602-1 doi:10.1371/journal.pone.0166602.

  doi

• Xu, F., Domazet-Lošo, T., Fan, D., Dunwell, T., Li, L., Fang, X., Zhang, G. & (2016) High expression of new genes in trochophore enlightening the ontogeny and evolution of trochozoans. Scientific Reports, 6, 34664-1 doi:10.1038/srep34664.

  doi

• Šestak, M. & Domazet-Lošo, T. (2015) Phylostratigraphic Profiles in Zebrafish Uncover Chordate Origins of the Vertebrate Brain. Molecular biology and evolution, 32 (2), 299-312 doi:10.1093/molbev/msu319.

  doi

• Fuchs, B., Wang, W., Graspeuntner, S., Li, Y., Insua, S., Herbst, E., Dirksen, P., Böhm, A., Hemmrich, G., Sommer, F., Domazet-Lošo, T., C. Klostermeier, U., Anton- Erxleben, F., Rosenstiel, P., C.G. Bosch, T. & Khalturin, K. (2014) Regulation of Polyp-to-Jellyfish Transition in Aurelia aurita. Current biology, 24 (3), 263-273 doi:10.1016/j.cub.2013.12.003.

  doi

• C. G. Bosch, T., Adamska, M., Augustin, R., Domazet- Lošo, T., Foret, S., Fraune, S., Funayama, N., Grasis, J., Hamada, M., Hatta, M., Hobmayer, B., Kawai, K., Klimovich, A., Manuel, M., Shinzato, C., Technau, Uli, Yum, Seungshic & J. Miller, D. (2014) How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans. Bioessays, 36 (12), 1185-1194 doi:10.1002/bies.201400065.

  doi

• Domazet-Lošo, T., Klimovich, A., Anokhin, B., Anton-Erxleben, F., Hamm, M., Lange, C. & Bosch, T. (2014) Naturally occurring tumours in the basal metazoan Hydra. Nature Communications, 5, 4222-4230 doi:10.1038/ncomms5222.

  doi

• Šestak, M., Božičević, V., Bakarić, R., Dunjko, V. & Domazet-Lošo, T. (2013) Phylostratigraphic profiles reveal a deep evolutionary history of the vertebrate head sensory systems. Frontiers in Zoology, 10, 18-18 doi:10.1186/1742-9994-10-18.

  doifrontiersinzoology.biomedcentral.com

• de Mendoza, A., Sebé-Pedrós, A., Šestak, M., Matejčić, M., Torruella, G., Domazet-Lošo, T. & Ruiz-Trillo, I. (2013) Transcription factor evolution in eukaryotes and the assembly of the regulatory toolkit in multicellular lineages. Proceedings of the National Academy of Sciences of the United States of America, 110 (50), E4858-E4566 doi:10.1073/pnas.1311818110.

  doi

• McFall-Ngai, M., Hadfield, M., Bosch, T., Carey, H., Domazet-Lošo, T., ... & Wernegreen, J. (2013) Animals in a bacterial world, a new imperative for the life sciences. Proceedings of the National Academy of Sciences of the United States of America, 110 (9), 3229-3236 doi:10.1073/pnas.1218525110.

  doi

• Zhang G., Fang X., Guo X., Li, L., Luo, R., Xu, F., Yang, P., Zhang, L., Wang, X., Qi, H., Xiong, Z., Que, H., Xie, Y., Holland, P., Paps, J., Zhu, Y., Wu, F., Chen, Y., Wang, J., Peng, C., Meng, J., Yang, L., Liu, J., Wen, B., Zhang, N., Huang, Z., Zhu, Q., Feng, Y., Mount, A., Hedgecock, D., Xu, Z., Liu, Y., Domazet-Lošo, T., Du, Y. & et. al. (2012) The oyster genome reveals stress adaptation and complexity of shell formation. Nature, 490 (7418), 49-54 doi:10.1038/nature11413.

  doi

• Hemmrich, G., Khalturin, K., Boehm, A., Puchert, M., Anton-Erxleben, F., Wittlieb, J., Klostermeier, U., Rosenstiel, P., Oberg H.H., Domazet-Lošo, T., Sugimoto, T., Niwa, H. & Bosch, T. (2012) Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity. Molecular biology and evolution, 29 (11), 3267-3280 doi:10.1093/molbev/mss134.

  doi

• Franzenburg, S., Fraune, S., Künzel, S., Baines, J., Domazet-Lošo, T. & Bosch, T. (2012) MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensingbacterial colonizers.. Proceedings of the National Academy of Sciences of the United States of America, 109 (47), 19374-19379 doi:10.1073/pnas.1213110109.

  doi

• Diethard, T. & Domazet-Lošo, T. (2011) The evolutionary origin of orphan genes. Nature reviews genetics, 12 (10), 692-702 doi:10.1038/nrg3053.

  doi

• Domazet-Lošo, T. & Tautz, D. (2010) A phylogenetically based transcriptome age index mirrors ontogenetic divergence patterns. Nature, 468 (7325), 815-818 doi:10.1038/nature09632.

  doi

• Domazet-Lošo, T. & Tautz Diethard (2010) Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa. Bmc biology, 8, 66-66 doi:10.1186/1741-7007-8-66.

  doiwww.biomedcentral.com

• Domazet-Lošo, T. & Tautz, D. (2008) An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases. Molecular biology and evolution, 25 (12), 2699-2707 doi:10.1093/molbev/msn214.

  doi

• Domazet-Lošo, T., Brajković, J. & Tautz, D. (2007) A phylostratigraphy approach to uncover the genomic history of major adaptations in metazoan lineages. Trends in Genetics, 23 (11), 533-539.

• Pozhitkov, A., Noble, P., Domazet-Lošo, T., Nolte, A., Staehler, P., Beier, M. & Tautz, D. (2006) Tests of rRNA hybridization to microarrays suggest that hybridization characteristics of oligonucleotide probes for species discrimination cannot be predicted. Nucleic Acids Research, 34 (9).

• Marais, G., Domazet-Lošo, T., Tautz, D. & Charlesworth, B. (2004) Correlated evolution of synonymous and nonsynonymous sites in Drosophila. Journal of molecular evolution, 59, 771-779.

• Domazet-Lošo, T. & Diethard, T. (2003) An Evolutionary Analysis of Orphan Genes in Drosophila. Genome Research, 13, 2213-2219.

Conference proceedings papers

Scientific conference proceedings papers

• Široki, T., Koska, S., Čorak, N., Futo, M., Domazet-Lošo, T. & Domazet-Lošo, M. (2019) Correspondence analysis applied to large scale Evo-Devo data. U: Skala, K. (ur.)42th International Convention on Information, Communication and Electronic Technology (MIPRO) - proceedings.

  www.mipro.hr

Theses

Doctoral dissertation

• Domazet-Lošo, T. (2003) 'Evolution of orphan genes in Drosophila', doktorska disertacija, Mathematisch-Naturwissenschaftliche Fakultät, Köln.