Maja Herak Bosnar

Maja Herak Bosnar

PhD

senior scientist
+385 1 456 0996

1752

Krilo 5/401

Bijenička 54, 10002 Zagreb

Final-MHerakBosnareuropassCV.pdf 460.92 kB

Education

1976-1984 - elementary school, Zagreb

1984-1988 - 16. gymnasium, Zagreb

1988 - 1993 - graduate school, Faculty of Sciences and Mathematics, University of Zagreb, B.Sc. in molecular biology

1993-1996 - postgraduate study in molecular and cellular biology, Faculty of Sciences and Mathematics, University of Zagreb, M.Sc. in molecular and cellular biology

1996-2002 - doctoral study, Faculty of Sciences and Mathematics, University of Zagreb, PhD in molecular biology

Projects

2017.-2021. principal investigator - "Structure, function and evolution of Nme6/Nm23-H6 gene/protein-project of the Croatian Scientifc Foundation www.irb.hr/Nemo6 

2014-today-collaborator- New protein networks for novel therapeutic avenues in human melanoma, PI dr.sc. Neda Slade, Croatian Scientific Foundation

2013.-today,work package leader-FP7-Regpot project „Enhancement of the Innovation Potential in SEE through new Molecular Solutions in Research and Development“ InnoMol– coordinator: dr.sc. Oliver Vugrek

2007-2013. -principal investigator- The role of nm23 genes in oral squamous cell carcinoma, Ministry of Science, Technology and Sports, Republic of Croatia

2009-2010 -principal investigator- The study of intracellular localization and dynamics of NDPK A and B subunits (Nm23-H1 and Nm23-H2) – French-Croatian bilateral project “Cogito”

2008. –principal investigator- The role of nm23 genes in oral squamous cell carcinoma, Lutrija Hrvatske (Croatian Lottery)

2002.- 2006 collaborator,“Gene therapy using tumor-suppressor genes“ Ministry of Science, Technology and Sports, Republic of Croatia, principal investigator dr. sc. Jasminka Pavelić

1996.-2002 collaborator, projekt MZOŠ „Human tumor DNA bank“ – Ministry of Science, Technology and Sports, Republic of Croatia, principal investigator  acad. Šime Spaventi

1993.-1996.collaborator– „Formation of human tumor bank for basic research“ - Ministry of Science, Technology and Sports, Republic of Croatia, principal investigator, acad. Šime Spaventi

 

Awards and Achievements

Annual reward “Josip Juraj Strossmayer“ for the best scientific publication (Croatian Academy of Science and Arts and Zagreb Fair), 2007, for the textbook: 

Metode u molekularnoj biologiji(Methods in Molecular Biology) (editors): Andreja Ambriović Ristov, Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade and Dušica Vujaklija, publisher: Institut Ruđer Bošković, Zagreb, 2007.

Classes

Course holder (PhD studies)

 2008-present:  Molekularne osnove metastaziranja (Molecular Basis of Metstasis Formation), doctoral  study in Molekular Bioscience, University Josip Juraj Strossmayer Osijek), University in Dubrovnik and Rudjer Bošković Institute

2010-present: Genetika raka i biologija tumorskih stanica (Cancer Genetics and Tumor Cell Biology), doctoral study in Biology, Faculty of Science, University of Zagreb

Featured Publications

Stojanovic N, Brozovic A, Majhen D,  Herak Bosnar M, Fritz G, Osmak M, Ambriovic-Ristov A. Integrin αβ3 expression in tongue squamous cell carcinoma cells Cal27 confers anticancer drug resistance trough loss of pSrc(Y418). BBA-Molecular Cell Research, in press

 

Cetkovic H, Perina D, Harcet M, Mikoc A, Herak Bosnar M*. Nme family of proteins – clues from simple animals. N-S Arch Pharmacol 388, 133-142, 2015.

 

Franczalsky L, Monostori E, Farkas, Z, Pourkarimi E, Masoudi N, Hargitai B, Herak Bosnar M, Dezeljin M, Zsakaj A, Vellai T, Mehta A, Takacz-Vellai, K. NDK-1, the Homolog of NM23-H1/H” regulates cell migration and apoptotic engulfment in C. elegans. PLoS One, 9,e92687, 2014

 

Horvat T, Dezeljin M, Redzic I, Barisic D, Herak Bosnar M, Lauc G, Zoldos V. Reversibility of membrane N-Glycome of HeLa cells upon treatment with epigenetic inhibitors. PLoS One, 8, e54672.2013.

Deželjin M, Herak Bosnar M*. Metastasis - recent scientific insights and challenging new therapeutic approaches. Periodicum biologorum 114: 453-459, 2012.

Horvat T, Mužinić I, Barišić D, Herak Bosnar M, Zoldoš V. Epigenetic modulation od HeLa cell membrane N-glycome. BBA general subjects, 1820, SI, 1412-1419, 2012.

 

Annesley SJ, Bago R, Herak Bosnar M, Filić V, Marinović M, Weber I, Mehta A, Fisher PR. Dictyostelium discoideum nucleoside diphosphate kinase C plays a negative regulatory role in phagocytosis, macropinocytosis and exocytosis. PLoS One, 6:e26024. 2011.

 

Perina D+, Herak Bosnar M*+, Mikoč A, Müller WEG, Ćetković H. Characterization of Nme6-like gene/protein from marine sponge Suberites domuncula. N-S Arch Pharmacol 384:451-60, 2011.

+Equal contribution

 

Perina D, Herak Bosnar M, Bago R, Mikoč A, Harcet M, Deželjin M, Ćetković H. Sponge non-metastatic Group I Nme gene/protein - structure and function is conserved from sponges to humans. BMC Evol  Biol  11:87, 2011.

Membership in professional associations / societies

Member of the Oversight Commitee of  Croatian Association for Cancer Research (branch of the EACR) – 2015-today

Member of the Executive Committee of Croatian Society of Biochemistry and Molecular Biology – 2013-today

Membership in scientific societies:

Croatian Association for Cancer Research (branch of the EACR) 2009 - today

Croatian Biological Society 2007.-today

Croatian Society of Biochemistry and Molecular Biology, 1996.-today

Hrvatsko Society of Human Genetics, 1994.-today

European Urology Association, 1995-2000.

Miscellaneous

Supervisor of doctoral thesis:

Ružica Bago: Uloga gena nm23-H1 u adheziji stanica CAL 27, 2007

Zoran Peršec: The role of nm23-H1 in prostate cancer cells during the process of lipid peroxidation, 2010

Martina Deželjin – The effect of Nm23 gene expression level on metstatic potential of tumor cells in vitro, 2011

 

Supervisor of diploma thesis:

Nikolina Nakić: Formation of stable CAL 27 clones constitutively expressing the mutated form of nm23-H2, 2007

Ivana Barabaš – Formation of CAL clones with permanently silenced nm23-H2 gene

Training:

Short-term fellowship of the French Republic 1999. Laboratory for intracellular signaling and oncogenesis, Curie Institut, France

Editor and author of several chapters in the textbook:

“Metode u molekularnoj biologiji” urednice: Andreja Ambriović Ristov, Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade i Dušica Vujaklija, izdavač:Institut Ruđer Bošković, Zagreb, 2007.

  1. “nm23 gene – a target for gene therapy?” – 3rds Croatian Congress in Pharmacology, Zagreb, Croatia, September 18-21, 2001.

 

  1. Methods of visualization of gene products in living cells (GFP) (in Croatian) – 21st Memorial Meeting in Honor of Professor S. Saltikow, Zagreb, Croatia, October 10, 2003.

 

  1. Subcellular localization of Nm23/NDPK subunits in HEp-2 cells.  2nd Croatian Congress on Microscopy, Topusko, Croatia, May, 18-21, 2006.

 

  1. Herak Bosnar, Maja; de Gunzburg, Jean; Bago, Ružica; Weber, Igor; Pavelić, Jasminka; Perina, Dragutin; Mikoč, Andreja; Ćetković, Helena.; Subcellular localization of NDPKs: How far is a sponge from a human? 7th International Congress of the NDP Kinase/NM23/Awd Family, Dundee, UK, 2007.

 

  1. Herak Bosnar, Maja; de Gunzburg, J.; Bago, Ružica; Brečević, Lukrecija; Weber, Igor; Pavelić, Jasminka. NM23/NDPK Subunits in Head and Neck Tumor Cells : Where do they go? // Proceedings of Abstracts of the 12th World Congress on Advances in Oncology and 10th International Symposium of Molecular Medicine and Cancer Chemoprevention Symposium Heraklion, Crete, Greece, October 2007.

 

  1. Herak Bosnar, Maja; Perina, Dragutin; Bago, Ružica; Mikoč, Andreja; Harcet, Matija; Deželjin ,Martina; Ćetković, Helena. Characterization of ancestral-type Grope I Nm23 gene/protein - structure and function is conserved from sponges to humans // 8th International Congress of the NDP kinase/Nm23/awd Family-From Basic Science to Clinical Application 2010. Heidelberg, Germany, October 25-28, 2010.

 

  1. Herak Bosnar, Maja; Perina, Drago; Harcet, Matija; Mikoč, Andreja; Deželjin, Martina; Ćetković, Helena. Nme family members in non-bilaterian Metazoans. 9th International Congress on the NDP kinase/Nm23/ awd Family. A new frontier in cell and cancer biology. Boston July31-August 4, 2013.

 

Main organizer, chair of the Organizing Committee and a member of the Scientific Committee of the 10th International Congress of the NDP Kinase/Nm23/awd Gene Family, October 9-13 2016, Dubrovnik, Croatia

 

Member of the organizing committee:

  1. New Aspects in Molecular Medicine 3, Molecular Endocrinology, September 8-9, 1996, Zagreb, Croatia
  2. 2nd International Conference on Signal Transduction, May 26-31, 2000, Cavtat-Dubrovnik, Croatia
  3. 1st International Conference on Mechanisms of Action of Nutraceuticals, October 14-19, 2001, Zagreb, Croatia
  4. 3rd International Conference on Signal Transduction, May 17-23, 2002, Cavtat-Dubrovnik, Croatia
  5. HDBMB 2014, The Interplay of Biomolecules (biannual meeting of Croatian FEBS branch), September 24-27, 2014, Zadar Croatia

Member of the scientific committee:

  1. Second Meeting of the Croatian Association for Cancer Research, HDIR (Hrvatsko društvo za istraživanje raka, national branch of EACR) with international participation, November 8-9, 2012, Zagreb, Croatia
  2. Third Meeting of the Croatian Association for Cancer Research, HDIR (Hrvatsko društvo za istraživanje raka, national branch of EACR) with international participation, November 6-7, 2014, Zagreb, Croatia
  3. HDBMB 2014, The Interplay of Biomolecules (biannual meeting of Croatian FEBS branch), September 24-27, 2014, Zadar Croatia
  4. HDBMB2016 on the occasion of the 40th Anniversary,  (biannual meeting of Croatian FEBS branch), June 1-4, 2016, Split, Croatia
  5. Forth Meeting of the Croatian Association for Cancer Research, HDIR (Hrvatsko društvo za istraživanje raka, national branch of EACR) with international participation, November 3-4, 2016, Zagreb, Croatia

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