Dr. Maja Majerić Elenkov
Laboratory for stereoselective catalysis and biocatalysis
Bijenička c. 54, P.O.Box 180
10002 Zagreb,Croatia
Education
Dr. Sc., University of Zagreb, Faculty of Science, Croatia.
M. Sc., University of Zagreb, Faculty of Science, Croatia.
B. Sc., University of Zagreb, Faculty of Science, Croatia.
Projects
2020 – 2023 "Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije" (CAT PHARMA), KK.01.1.1.04.0013, project partner.
2020 – 2022 „Development of solvent resistant halohydrin dehalogenase for producing bioactive compounds“ - Croatian-chinese projekt, partner: Prof. Lixia Tang, University of Electronic Science and Technology of China, project leader.
2018 – 2022 „Enzymatic Synthesis of Fluorinated Chiral Building Blocks“ (EnzyFluor), HrZZ IP-2018-01-4493, project leader.
Featured Publications
Milčić, N.; Stepanić, V.; Crnolatac, I.; Findrik Blažević, Z.; Brkljača, Z.; Majerić Elenkov, M.; Inhibitory Effect of DMSO on Halohydrin Dehalogenase: Experimental and Computational Insights into the Influence of an Organic Co-solvent on the Structural and Catalytic Properties of a Biocatalyst, Chem. Euro. J. 2022, 28, e2022019.
DOI: 10.1002/chem.202201923; 10.1002/chem.202202869 (Front Cover); 10.1002/chem.202202870 (Cover Profile).
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Mehić, E.; Hok, L.; Wang, Q.; Dokli, I.; Svetec Miklenić, M.; Findrik Blažević, Z.; Tang, L.; Vianello, R.; Majerić Elenkov, M.; Expanding the scope of enantioselective halohydrin dehalogenases – group B, Adv. Synth. Catal. 2022, 364, 2576-2588.
DOI: 10.1002/adsc.202200342; 10.1002/adsc.202200715 (Front Cover)
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Dokli I.; Milčić N.; Marin P.; Svetec Miklenić M.; Sudar, M.; Tang, L.; Findrik Blažević Z.; Majerić Elenkov M.; Halohydrin dehalogenase-catalysed synthesis of fluorinated aromatic chiral building blocks. Catal. Commun. 2021, 152, 106285.
DOI: 10.1016/j.catcom.2021.106285
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Findrik Blažević Z.; Milčić Z.; Sudar, M.; Majerić Elenkov M.; Halohydrin Dehalogenases and Their Potential in Industrial Application – A Viewpoint of Enzyme Reaction Engineering, Adv. Synth. Catal. 2021, 363, 388-410.
DOI: 10.1002/adsc.202000984
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Majerić Elenkov, M.; Čičak, M.; Smolko, A.; Knežević, A.; Halohydrin dehalogenase-catalysed transformations of epifluorohydrin. Tetrahedron Lett. 2017, 59, 406-408.
DOI: 10.1016/J.TETLET.2017.12.054
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A. Mikleušević, I. Primožić, T. Hrenar, B. Salopek-Sondi, L. Tang, M. Majerić Elenkov, Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH. Tetrahedron: Asymmetry 2016, 27, 930-935.
DOI: 10.1016/J.TETASY.2016.08.003
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Mikleušević, A.; Hameršak, Z.; Salopek-Sondi, B.; Tang, L.; Janssen, D. B.; Majerić Elenkov, M.; Oxazolidinone Synthesis through Halohydrin Dehalogenase-Catalyzed Dynamic Kinetic Resolution. Adv. Synth. Catal. 2015, 357, 1709-1714.
DOI: 10.1002/ADSC.201500111
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Majerić Elenkov, M.; Primožič, I.; Hrenar, T.; Smolko, A.; Dokli, I.; Salopek-Sondi, B.; Tang, L.; Catalytic activity of halohydrin dehalogenases towards spiroepoxides. Org. Biomol. Chem. 2012, 10, 5063-5072.
DOI: 10.1039/C2OB25470K
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Majerić Elenkov, M.; Tang, L.; Hauer, B.; Janssen, D.B.; Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed resolution of epoxides, Org. Lett. 2008, 10, 2417-2420.
DOI: 10.1021/OL800698T
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Hasnaoui, G.; Majerić Elenkov, M.; Spelberg, J.H.L.; Hauer, B.; Janssen, D.B.; Halohydrin dehalogenase: a highly promiscuous enzyme and versatile biocatalyst for enantioselective epoxide ring opening, ChemBioChem. 2008, 9, 1048-1051.
DOI: 10.1002/CBIC.200700734
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Majerić Elenkov, M.; Hoeffken, W.; Tang, L.; Hauer, B.; Janssen, D.B.; Enzyme-catalysed ring opening of epoxides for the preparation of enantiopure tertiary alcohols, Adv. Synth. Catal. 2007, 349, 2279-2285.
DOI: 10.1002/ADSC.200700146
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Majerić Elenkov, M.; Tang, L.; Hauer, B.; Janssen, D.B.; Sequential kinetic resolution catalyzed by halohydrin dehalogenase, Org. Lett. 2006, 8, 4227-4229.
DOI: 10.1021/OL061369H
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Majerić Elenkov, M.; Hauer, B.; Janssen, D.B.; Enantioselective ring opening of epoxides with cyanide catalysed by halohydrin dehalogenases: A new approach to non-racemic β-hydroxy nitriles, Adv. Synth. Catal. 2006, 348, 579-585.
DOI: 10.1002/ADSC.200505333