dr. sc. Maja Majerić Elenkov
Institut Ruđer Bošković
Bijenička 54
HR-10000 Zagreb
Projekti
2020 – 2023 "Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije" (CAT PHARMA) Ministarstva znanosti i obrazovanja u sklopu operativnog programa "Konkurentnost i kohenzija 2014-2020", "Ulaganje u znanost i inovacije – prvi poziv", KK.01.1.1.04.0013, Voditelj projekta: Srećko Kirin, IRB, voditeljica radnog paketa.
2020 – 2022 „Development of solvent resistant halohydrin dehalogenase for producing bioactive compounds“ - hrvatsko-kineski bilateralni projekt, partner: Prof. Lixia Tang, University of Electronic Science and Technology of China, voditeljica projekta.
2018 – 2022 „Enzymatic Synthesis of Fluorinated Chiral Building Blocks“ (EnzyFluor) Hrvatska zaklada za znanost, HrZZ IP-2018-01-4493, voditeljica projekta.
2011 – 2013 “Protein engineering of halohydrin dehalogenases for the production of fine chemicals and pharmaceutical intermediates” - hrvatsko-kineski bilateralni projekt, voditeljica projekta.
2009 – 2011 ”Biocatalytic application of halohydrin dehalogenases for production of chiral building blocks”, UKF projekt “Moje prvo istraživanje”, voditeljica projekta.
Istaknute publikacije
Dokli I.; Milčić N.; Marin P.; Svetec Miklenić M.; Sudar, M.; Tang, L.; Findrik Blažević Z.; Majerić Elenkov M.; Halohydrin dehalogenase-catalysed synthesis of fluorinated aromatic chiral building blocks. Catal. Commun. 2021, 152, 106285.
DOI: 10.1016/j.catcom.2021.106285
Findrik Blažević Z.; Milčić Z.; Sudar, M.; Majerić Elenkov M.; Halohydrin Dehalogenases and Their Potential in Industrial Application – A Viewpoint of Enzyme Reaction Engineering, Adv. Synth. Catal. 2021, 363, 388-410.
DOI: 10.1002/adsc.202000984
Majerić Elenkov, M.; Čičak, M.; Smolko, A.; Knežević, A.; Halohydrin dehalogenase-catalysed transformations of epifluorohydrin. Tetrahedron Lett. 2017, 59, 406-408.
DOI: 10.1016/J.TETLET.2017.12.054
A. Mikleušević, I. Primožić, T. Hrenar, B. Salopek-Sondi, L. Tang, M. Majerić Elenkov, Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH. Tetrahedron: Asymmetry 2016, 27, 930-935.
DOI: 10.1016/J.TETASY.2016.08.003
Mikleušević, A.; Hameršak, Z.; Salopek-Sondi, B.; Tang, L.; Janssen, D. B.; Majerić Elenkov, M.; Oxazolidinone Synthesis through Halohydrin Dehalogenase-Catalyzed Dynamic Kinetic Resolution. Adv. Synth. Catal. 2015, 357, 1709-1714.
DOI: 10.1002/ADSC.201500111
Schallmey, M.; Jekel, P.; Tang, L.; Majerić Elenkov, M.; Höffken, H. W.; Hauer, B.; Janssen, D. B.;
A single point mutation enhances hydroxynitrile synthesis by halohydrin dehalogenase. Enzyme Microb.Technol. 2015, 70, 50-57.
DOI: 10.1016/J.ENZMICTEC.2014.12.009
Majerić Elenkov, M.; Primožič, I.; Hrenar, T.; Smolko, A.; Dokli, I.; Salopek-Sondi, B.; Tang, L.; Catalytic activity of halohydrin dehalogenases towards spiroepoxides. Org. Biomol. Chem. 2012, 10, 5063-5072.
DOI: 10.1039/C2OB25470K
Tang, L.; Zhu, X.; Zheng, H.; Jiang, R.; Majerić Elenkov, M.; Key Residues for Controlling Enantioselectivity of Halohydrin Dehalogenase from Arthrobacter sp. Strain AD2, Revealed by Structure-Guided Directed Evolution. Appl. Environ. Microbiol. 2012, 78, 2631-2637.
DOI: 10.1128/AEM.06586-11
Majerić Elenkov, M.; Tang, L.; Hauer, B.; Janssen, D.B.; Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed resolution of epoxides, Org. Lett. 2008, 10, 2417-2420.
DOI: 10.1021/OL800698T
Hasnaoui, G.; Majerić Elenkov, M.; Spelberg, J.H.L.; Hauer, B.; Janssen, D.B.; Halohydrin dehalogenase: a highly promiscuous enzyme and versatile biocatalyst for enantioselective epoxide ring opening, ChemBioChem. 2008, 9, 1048-1051.
DOI: 10.1002/CBIC.200700734
Majerić Elenkov, M.; Hoeffken, W.; Tang, L.; Hauer, B.; Janssen, D.B.; Enzyme-catalysed ring opening of epoxides for the preparation of enantiopure tertiary alcohols, Adv. Synth. Catal. 2007, 349, 2279-2285.
DOI: 10.1002/ADSC.200700146
Janssen, D.B.; Majerić Elenkov, M.; Hasnaoui, G.; Hauer, B.; Spelberg, J.H.L. Enantioselective formation and ring-opening of epoxides catalysed by halohydrin dehalogenases, Biochem. Soc. Trans. 2006, 34, 291-295.
DOI: 10.1042/BST0340291
Majerić Elenkov, M.; Tang, L.; Hauer, B.; Janssen, D.B.; Sequential kinetic resolution catalyzed by halohydrin dehalogenase, Org. Lett. 2006, 8, 4227-4229.
DOI: 10.1021/OL061369H
Majerić Elenkov, M.; Hauer, B.; Janssen, D.B.; Enantioselective ring opening of epoxides with cyanide catalysed by halohydrin dehalogenases: A new approach to non-racemic β-hydroxy nitriles, Adv. Synth. Catal. 2006, 348, 579-585.
DOI: 10.1002/ADSC.200505333