Slika LMVB

Laboratorij za molekularnu virologiju i bakteriologiju

Laboratorij se bavi molekularnim analizama infektivnih bolesti, posebice papiloma virusom čovjeka i povezanim tumorima

Magdalena Grce

Voditelj laboratorija

dr.sc. Magdalena Grce

+385 1 456 1110

Telefon:  +385 1 456 1110

Fax: +385 1 456 1010

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Misija

Misija Laboratorija za molekularnu virologiju i bakteriologiju je proširivanje znanja i razumijevanja prirode tumora čovjeka povezanih sa infektivnim agensima u svrhu poboljšanja i razvijanja novih pristupa u dijagnostici, liječenju i prevenciji tih bolesti.

Djelatnost
  • Bazična istraživanja molekularne patogeneze humanih papiloma virusa (HPV)
  • Epidemiološka istraživanja HPV-a u raznim sijelima 
  • Istraživanja epigenetike HPV-povezanih bolesti
  • Istraživanja uloge onkogena E6 i E7 HPV-a u razvoju HPV-povezanih bolesti
  • Laboratorij je zavodska jedinica za molekularnu analizu virusnih i bakterijskih infekcija u čovjeka
  • Laboratorij je zavodska jedinica za izolaciju nukleinskih kiselina pomoću automatskog sustava EZ1
  • Laboratorij održava hrvatsku banku DNA i RNA stanica prekanceroza i karcinoma povezanih s HPV-om
  • Laboratorij održava stanične i bakterijske kulture za uzgoj ili/i ekspresiju gena HPV-a
Publikacije u zadnjih 5 godina
  • Brzak BL, Cigić L, Baričević M, Sabol I, Mravak-Stipetić M, Risović D. Different Protocols of Photobiomodulation Therapy of Hyposalivation. Photomed Laser Surg. 2018 Feb;36(2):78-82. doi: 10.1089/pho.2017.4325.
  • Lončar-Brzak B, Klobučar M, Veliki-Dalić I, Sabol I, Kraljević Pavelić S, Krušlin B, Mravak-Stipetić M. Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential. Clin Oral Investig. 2018 Mar;22(2):1071-1082. doi: 10.1007/s00784-017-2190-3.
  • Sabol I, Milutin Gašperov N, Matovina M, Božinović K, Grubišić G, Fistonić I, Belci D, Alemany L, Džebro S, Dominis M, Šekerija M, Tous S, de Sanjosé S, Grce M. Cervical HPV type-specific pre-vaccination prevalence and age distribution in Croatia. PLoS One. 2017 Jul 10;12(7):e0180480. doi: 10.1371/journal.pone.0180480. eCollection 2017.
  • Szalmás A, Tomaić V, Basukala O, Massimi P, Mittal S, Kónya J, Banks L. The PTPN14 Tumor Suppressor Is a Degradation Target of Human Papillomavirus E7. J Virol. 2017 Mar 13;91(7). pii: e00057-17. doi: 10.1128/JVI.00057-17.
  • Zine El Abidine A, Tomaić V, Bel Haj Rhouma R, Massimi P, Guizani I, Boubaker S, Ennaifer E, Banks L. A naturally occurring variant of HPV-16 E7 exerts increased transforming activity through acquisition of an additional phospho-acceptor site. Virology. 2017 Jan;500:218-225. doi:10.1016/j.virol.2016.10.023.
  • Kranjec C, Tomaić V, Massimi P, Nicolaides L, Doorbar J, Banks L. The high-risk HPV E6 target scribble (hScrib) is required for HPV E6 expression in cervical tumour-derived cell lines. Papillomavirus Res. 2016 Dec;2:70-77. doi: 10.1016/j.pvr.2016.04.001.
  • Tomaić V. Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites. Cancers (Basel). 2016 Oct 19;8(10). pii: E95. Review.
  • Ganti K, Massimi P, Manzo-Merino J, Tomaić V, Pim D, Playford MP, Lizano M, Roberts S, Kranjec C, Doorbar J, Banks L. Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways. PLoS Pathog. 2016 Sep 20;12(9):e1005854. doi:10.1371/journal.ppat.1005854.
  • Petrušić N, Posavac M, Sabol I, Mravak-Stipetić M. The Effect of Tobacco Smoking on Salivation. Acta Stomatol Croat. 2015 Dec;49(4):309-15. doi: 10.15644/asc49/4/6. Gašpar M, Glavina A, Grubišić K, Sabol I, Bušić M, Mravak M; Stipetić. The Oral Cavity State in Renal Transplant Recipients. Acta Stomatol Croat. 2015 Sep;49(3):204-13. doi: 10.15644/asc49/3/2.
  • Sabol I, Smahelova J, Klozar J, Mravak-Stipetic M, Gheit T, Tommasino M, Grce M, Tachezy R. Beta-HPV types in patients with head and neck pathology and in healthy subjects. J Clin Virol. 2016Sep;82:159-65. doi: 10.1016/j.jcv.2016.07.019. Epub 2016 Jul 28
  • Vojtechova Z, Sabol I, Salakova M, Smahelova J, Zavadil J, Turek L, Grega M, Klozar J, Prochazka B, Tachezy R. Comparison of the miRNA profiles in HPV-positive and HPV-negative tonsillar tumors and a model system of human keratinocyte clones. BMC Cancer. 2016 Jul 4;16:382. doi: 10.1186/s12885-016-2430-y.
  • Čeović R, Desnica L, Pulanić D, Serventi Seiwerth R, Ilić I, Grce M, Mravak Stipetić M, Klepac Pulanić T, Bilić E, Bilić E, Milošević M, Vrhovac R, Nemet D, Pavletic SZ. High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease. Croat Med J. 2016 Jun 30;57(3):229-38.
  • Jankovic M, Sabol I, Zmak L, Jankovic VK, Jakopovic M, Obrovac M, Ticac B, Bulat LK, Grle SP, Marekovic I, Samarzija M, van Ingen J. Microbiological criteria in non-tuberculous mycobacteria pulmonary disease: a tool for diagnosis and epidemiology. Int J Tuberc Lung Dis. 2016 Jul;20(7):934-40. doi: 10.5588/ijtld.15.0633.
  • Dediol E, Sabol I, Virag M, Grce M, Muller D, Manojlović S. HPV prevalence and p16INKa overexpression in non smoking non drinking oral cavity cancer patients. Oral Dis. 2016 Mar 19. doi:10.1111/odi.12476.
  • Vojtechova Z, Sabol I, Salakova M, Turek L, Grega M, Smahelova J, Vencalek O, Lukesova E, Klozar J,Tachezy R. Analysis of the integration of human papillomaviruses in head and neck tumours in relation to patients' prognosis. Int J Cancer. 2016 Jan 15;138(2):386-95. doi: 10.1002/ijc.29712. Epub 2015 Aug 13.
  • Milutin Gašperov N, Sabol I, Planinić P, Grubišić G, Fistonić I, Ćorušić A, Grce M. Methylated Host Cell Gene Promoters and Human Papillomavirus Type 16 and 18 Predicting Cervical Lesions and Cancer. PLoS One. 2015 Jun 9;10(6):e0129452. doi: 10.1371/journal.pone.0129452. eCollection 2015.
  • Zmak L, Obrovac M, Jankovic Makek M, Sabol I, Katalinic-Jankovic V. Isolation of non-tuberculous mycobacteria among tuberculosis patients during a 5-year period in Croatia. Infect Dis (Lond). 2015 Apr;47(4):275-6. doi:10.3109/00365548.2014.987164. Epub 2015 Feb 17.
  • Mravak-Stipetić M, Lončar-Brzak B, Bakale-Hodak I, Sabol I, Seiwerth S, Majstorović M, Grce M. Clinicopathologic correlation of oral lichen planus and oral lichenoid lesions: a preliminary study. Sci World J. 2014;2014:746874. doi: 10.1155/2014/746874. Epub 2014 Oct 29.
  • Milutin Gašperov N, Farkas SA, Nilsson TK, Grce M. Epigenetic activation of immune genes in cervical cancer. Immunol Lett. 2014 Dec;162(2 Pt B):256-7. doi: 10.1016/j.imlet.2014.09.019. Epub 2014 Oct 13.
  • Grce M. [Molecular diagnosis of oral infections]. Acta Med Croatica. 2013 Dec;67(5):425-32. Review [In Croatian].
  • Zhang C, Park JS, Grce M, Hibbitts S, Palefsky JM, Konno R, Smith-McCune KK, Giovannelli L, Chu TY, Picconi MA, Piña-Sánchez P, Settheetham-Ishida W, Coutlée F, De Marco F, Woo YL, Ho WC, Wong MC, Chirenje MZ, Magure T, Moscicki AB, Sabol I, Fiander AN, Chen Z, Chan MC, Cheung TH, Burk RD, Chan PK. Geographical distribution and risk association of human papillomavirus genotype 52-variant lineages. J Infect Dis. 2014 Nov 15;210(10):1600-4. doi: 10.1093/infdis/jiu310. Epub 2014 May 30.
  • Grce M, Mravak-Stipetić M. Human papillomavirus-associated diseases. Clin Dermatol. 2014 Mar-Apr;32(2):253-8. doi: 10.1016/j.clindermatol.2013.10.006. Epub 2013 Oct 30. Review.
  • Drvar DL, Lipozenčić J, Sabol I, Mokos ZB, Ilic I, Grce M. Human papillomavirus status in extragenital nonmelanoma skin cancers. Clin Dermatol. 2014 Mar-Apr;32(2):248-52. doi:10.1016/j.clindermatol.2013.08.009.
  • Hunjak B, Sabol I, Vojnović G, Fistonić I, Erceg AB, Peršić Z, Grce M. Ureaplasma urealyticum and Ureaplasma parvum in women of reproductive age. Arch Gynecol Obstet. 2014 Feb;289(2):407-12.doi: 10.1007/s00404-013-2980-z. Epub 2013 Aug 4.
  • Farkas SA, Milutin-Gašperov N, Grce M, Nilsson TK. Genome-wide DNA methylation assay reveals novel candidate biomarker genes in cervical cancer. Epigenetics. 2013 Nov;8(11):1213-25. doi:10.4161/epi.26346. Epub 2013 Sep 12.
  • Mravak-Stipetić M, Sabol I, Kranjčić J, Knežević M, Grce M. Human papillomavirus in the lesions of the oral mucosa according to topography. PLoS One. 2013 Jul 29;8(7):e69736. doi:10.1371/journal.pone.0069736. Print 2013.
  • Jankovic M, Samarzija M, Sabol I, Jakopovic M, Katalinic Jankovic V, Zmak L, Ticac B, Marusic A, Obrovac M, van Ingen J. Geographical distribution and clinical relevance of non-tuberculous mycobacteria in Croatia. Int J Tuberc Lung Dis. 2013 Jun;17(6):836-41. doi: 10.5588/ijtld.12.0843.

Ivan Sabol
Dr. sc.

Znanstveni suradnik
+385 1 456 1110
1510

Magdalena Grce
dr.sc.

znanstvena savjetnica
+385 1 456 1110
1510 1509

Vjekoslav Tomaić
Doc.dr.sc.

znanstveni suradnik
+385 1 456 1110
1510

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  • Knežević, Marjana - doktorska disertacija 2017, magistarski rad 2008
  • Hunjak, Blaženka - doktorska disertacija 2011
  • Obrovac, Mihaela - doktorska disertacija 2011, magistarski rad 2008
  • Cindrić, Anita - diplomski rad 2012
  • Jerković, Ivana - diplomski rad 2010
  • Bacinger, Ines - diplomski rad 2008
  • Matovina, Mihaela - doktorska disertacija 2006, magistarski rad 2002
  • Halec, Gordana - diplomski rad 2006
  • Kraljević, Sandra - magistarski rad 2003

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