Biological Factors Determining Human Papillomavirus (HPV) Driven Carcinogenesis

Glavni istraživač

Kategorija
Ostali projekti
Datum početka
1.1.2017.
Datum završetka
31.12.2020.
Status
Aktivan

This is a start-up grant intended to fund young researchers who have recently returned to an ICGEB Member State to establish their own independent groups/laboratories. In particular, the purpose of this start-up grant is to support PI in setting up laboratory which will be capable of performing biochemical and mechanistic studies on the various biological aspects of the HPV-induced carcinogenesis.

 

HPV types which were shown to be causative agents of human tumors are referred to as high risk types and of these HPV-16 and -18 are associated with the majority of HPV-induced malignancies. The joint action of the two major viral oncoproteins, E6 and E7, is responsible for the development of the cancers.  Among the high-risk types, HPV-16 is the most potent viral type in causing cancer. However, there are many of HPV-16 variants found in various geographical locations, and they were shown to differ in their abilities to cause cancer.  The molecular mechanisms responsible for an increased cancer risk of a number of these HPV-16 variants are however still poorly understood.  The aim of this project is to perform biochemical and mechanistic analyses on some of the HPV-16 E6 and E7 variants, which were shown to be associated with an increased cancer risk.  In this way, we are likely to achieve a better understanding of molecular mechanisms responsible for their oncogenic potentials.

Ova stranica koristi kolačiće

neki od tih kolačića nužni su za ispravno funkcioniranje stranice, dok se drugi koriste za praćenje korištenja stranice radi poboljšanja korisničkog iskustva.

Za više informacija pogledajte naše uvjete korištenja.

  • Kolačići koji su nužni za ispravno funkcioniranje stranice. Moguće ih je onemogućiti u postavkama preglednika.