dr. sc. Zoran Štefanić

• 2008-2009 Postdoktorsko usavršavanje na Inštitutu Jožef Stefan u Ljubljani
• 21.12.2004. Obrana doktorske disertacije pod nazivom “Uloga vodikovih veza u supramolekularnoj organizaciji oksalil i ftaloil derivata aminokiselina”.
• 06.11.2000. Diplomirao fiziku na Prirodoslovno-matemetičkom fakultetu, Sveučilište u Zagrebu, s temom diplomskog rada: «Efekti rezanja konfiguracijskog prostora u bozonsko-fermionskim modelima»

2009-2010. Voditelj hrvatsko-slovenskog bilateralnog projekta “Razvoj novih algoritama za analizu aktivnih mjesta proteina“

2004 Na 22. po redu Europskom kristalografskom sastanku (22. European Crystallographic Meeting) održanom od 26. do 31. kolovoza u Budimpešti, Cambridge Crystallographic Data Centre mi je dodijelio nagradu za poster s temom iz kemijske kristalografije pod naslovom "Hydrogen Bonding Organization In Crystal Structures Of (S,S)-N,N’-Phthaloyl-Bis(Amino Acid) Derivatives"

• 2008- Voditelj kolegija “Teorija grupa u kristalografiji” u sklopu Doktorskog studija kemije, PMF, Zagreb.
• 2005-2007 Sudjelovanje u dodiplomskoj nastavi na Biološkom odsjeku PMF-a, održavanje vježbi iz kolegija Molekularna biofizika za studente 3. godine

•  Leščić Ašler, Ivana; Štefanić, Zoran; Maršavelski, Aleksandra; Vianello, Robert; Kojić-Prodić, Biserka.
  Catalytic Dyad in the SGNH Hydrolase Superfamily: In-depth Insight into Structural Parameters Tuning the Catalytic Process of Extracellular Lipase from Streptomyces rimosus. // Acs chemical biology. 12 (2017) , 7; 1928-1936.
• Štefanić, Zoran; Mikleušević, Goran; Luić, Marija; Bzowska, Agnieszka; Leščić Ašler, Ivana.
  Structural characterization of purine nucleoside phosphorylase from human pathogen Helicobacter pylori. // International journal of biological macromolecules. 101 (2017) ; 518-526.
• Mikleušević, Goran; Štefanić, Zoran; Narczyk, Marta; Wielgus-Kutrowska, Beata; Bzowska, Agnieszka; Luić, Marija.
    Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies. Biochimie. 93 (2011) , 9; 1610-1622.
• Tomašić, Vlasta; Štefanić, Zoran Cholic acid as host for long linear molecules: a series of co-crystals with n-alkylammonia. CrystEngComm. 9 (2007) ; 1124-1128.
• Luić, Marija; Štefanić, Zoran; Ceilinger, Igor; Hodošček, Milan; Janežić, Dušanka; Lenac, Tihana; Leščić Ašler, Ivana; Šepac, Dragan; Tomić, Sanja. Combined X-Ray Diffraction and QM/MM Study of the Burkholderia cepacia Lipase-Catalyzed Secondary Alcohol Esterification. Journal of Physical Chemistry B. 112 (2008) , 16; 4876-4883.
• Štefanić, Zoran; Vujaklija, Dušica; Luić, Marija Crystal structure of the single-stranded DNA binding protein from Streptomyces coelicolor. Acta Crystallographica - Section D - Biological Crystallography. 65 (2009), 9; 974-979.

Knjige i poglavlja u knjigama

Autorske knjige

• Mintas, M., Wittine, K. & Štefanić, Z. (2018) Novi lijekovi protiv raka. Zagreb, Školska knjiga.

Radovi u časopisima

Znanstveni i pregledni radovi

• Štefanić, Z., Narczyk, M., Mikleušević, G., Kazazić, S., Bzowska, A. & Luić, M. (2018) Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis. Scientific Reports, 8, 15427, 13 doi:10.1038/s41598-018-33723-1.

  doifulir.irb.hrwww.nature.com

• Bošnjaković, M., Leščić Ašler, I. & Štefanić, Z. (2018) The Role of Phosphate Binding in Purine Nucleoside Phosphorylase of Helicobacter pylori. Croatica chemica acta, 91 (2), 171-175 doi:10.5562/cca3335.

  doihrcak.srce.hr

• Narczyk, M., Bertoša, B., Papa, L., Vuković, V., Leščić Ašler, I., Wielgus-Kutrowska, B., Bzowska, A., Luić, M. & Štefanić, Z. (2018) Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features. The FEBS Journal, 285 (7), 1305-1325 doi:10.1111/febs.14403.

  doi

• Kokan, Z., Kovačević, B., Štefanić, Z., Tzvetkova, P. & Kirin, S. (2018) Controlling Orthogonal Self-Assembly through Cis-Trans Isomerization of a Non-Covalent Palladium Complex Dimer. Chemical communications, 54 (17), 2094-2097 doi:10.1039/C7CC09537F.

  doi

• Leščić Ašler, I., Štefanić, Z., Maršavelski, A., Vianello, R. & Kojić-Prodić, B. (2017) Catalytic Dyad in the SGNH Hydrolase Superfamily: In-depth Insight into Structural Parameters Tuning the Catalytic Process of Extracellular Lipase from Streptomyces rimosus. Acs chemical biology, 12 (7), 1928-1936 doi:10.1021/acschembio.6b01140.

  doi

• Štefanić, Z., Mikleušević, G., Luić, M., Bzowska, A. & Leščić Ašler, I. (2017) Structural characterization of purine nucleoside phosphorylase from human pathogen Helicobacter pylori. International journal of biological macromolecules, 101, 518-526 doi:10.1016/j.ijbiomac.2017.03.101.

  doi

• Novak, S., Morasi Piperčić, S., Makarić, S., Primožič, I., Ćurlin, M., Štefanić, Z. & Domazet Jurašin, D. (2016) Interplay of Noncovalent Interactions in Ionic Liquid/Sodium Bis(2-ethylhexyl) Sulfosuccinate Mixtures : From Lamellar to Bicontinuous Cubic Liquid Crystalline Phase. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical, 120 (49), 12557-12567 doi:10.1021/acs.jpcb.6b10515.

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• Luić, M. & Štefanić, Z. (2016) Can Crystal Symmetry and Packing Influence the Active Site Conformation of Homohexameric Purine Nucleoside Phosphorylases?. Croatica chemica acta, 89 (2), 197-202 doi:10.5562/cca2872.

  doihrcak.srce.hrhrcak.srce.hr

• Kovač, V., Radošević, K., Bebek, A., Makarević, J., Štefanić, Z., Barišić, L., Žinić, M. & Rapić, V. (2016) The first oxalamide-bridged ferrocene : facile synthesis, preliminary conformational analysis and biological evaluation. Applied organometallic chemistry, 31 (7), E3653-1 doi:10.1002/aoc.3653.

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• Skočibušić, M., Odžak, R., Štefanić, Z., Križić, I., Krišto, L., Jović, O., Hrenar, T., Primožič, I. & Jurašin, D. (2016) Structure-Property Relationship of Quinuclidinium Surfactants – Towards Multifunctional Biologically Active Molecules. Colloids and surfaces. B, Biointerfaces, 140, 548-559 doi:10.1016/j.colsurfb.2015.11.023.

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• Cetina, M., Štefanić, Z., Makarević, J. & Nura-Lama, A. (2015) Intermolecular interactions in dihydrothymine derivatives form two-dimensional and three-dimensional networks. Journal of chemical crystallography, 45 (2), 67-76 doi:10.1007/s10870-015-0567-1.

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• Tomašić, V., Biliškov, N., Mihelj, T. & Štefanić, Z. (2013) Thermal Behaviour and Structural Properties of Surfactant - Picrate Compounds: the effect of the ammonium headgroup number. Thermochimica acta, 569, 25-35 doi:10.1016/j.tca.2013.06.041.

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• Štefanić, Z., Mikleušević, G., Narczyk, M., Wielgus-Kutrowska, B., Bzowska, A. & Luić, M. (2013) Still a long way to fully understanding the molecular mechanism of Escherichia coli purine nucleoside phosphorylase. Croatica chemica acta, 86 (1), 117-127 doi:10.5562/cca2116.

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• Leščić Ašler, I., Kovačić, F., Marchetti-Deschmann, M., Allmaier, G., Štefanić, Z. & Kojić-Prodić, B. (2013) Inhibition of extracellular lipase from Streptomyces rimosus with 3, 4-dichloroisocoumarin. Journal of enzyme inhibition and medicinal chemistry, 28 (5), 1094-1104 doi:10.3109/14756366.2012.716834.

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• Molčanov, K., Portada, T., Čaplar, V., Jokić, M., Makarević, J., Šijaković Vujičić, N., Štefanić, Z., Žinić, M. & Kojić-Prodić, B. (2013) Hydrogen bonding topology influences gelating properties of malonamides. Structural chemistry, 24 (2), 597-609 doi:10.1007/s11224-012-0102-3.

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• Makarević, J., Štefanić, Z., Horvat, L. & Žinić, M. (2012) Intermolecular central to axial chirality transfer in the self-assembled biphenyl containing amino acid–oxalamide gelators. Chemical communications, 48 (59), 7047-7049 doi:10.1039/C2CC32039H.

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• Štefanić, Z., Narczyk, M., Mikleušević, G., Wielgus-Kutrowska, B., Bzowska, A. & Luić, M. (2012) New phosphate binding sites in the crystal structure of Escherichia coli purine nucleoside phosphorylase complexed with phosphate and formycin A. FEBS letters, 586 (7), 967-971 doi:10.1016/j.febslet.2012.02.039.

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• Mihelj, T., Štefanić, Z. & Tomašić, V. (2012) Thermal and structural properties of surfactant–picrate compounds. Journal of thermal analysis and calorimetry, 108 (3), 1261-1272 doi:10.1007/s10973-011-1710-7.

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• Leščić Ašler, I., Pigac, J., Vujaklija, D., Luić, M. & Štefanić, Z. (2011) Crystallization and preliminary X-ray diffraction studies of a complex of extracellular lipase from Streptomyces rimosus with the inhibitor 3, 4-dichloroisocoumarin. Acta crystallographica section f-structural biology and crystallization communications, 67 (11), 1378-1381 doi:10.1107/S1744309111032222.

  doi

• Mikleušević, G., Štefanić, Z., Narczyk, M., Wielgus-Kutrowska, B., Bzowska, A. & Luić, M. (2011) Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies. Biochimie, 93 (9), 1610-1622 doi:10.1016/j.biochi.2011.05.030,.

  doi

• Kojić-Prodić, B. & Štefanić, Z. (2010) Symmetry versus Asymmetry in the Molecules of Life: Homomeric Protein Assemblies. Symmetry-Basel, 2, 884-906 doi:10.3390/sym2020884.

  doiwww.mdpi.comfulir.irb.hr

• Štefanić, Z., Vujaklija, D. & Luić, M. (2009) Structure of the single-stranded DNA-binding protein from Streptomyces coelicolor. Acta crystallographica. Section D, Biological Crystallography, 65 (9), 974-979 doi:10.1107/S0907444909023634.

  doi

• Luić, M., Štefanić, Z., Ceilinger, I., Hodošček, M., Janežić, D., Lenac, T., Leščić Ašler, I., Šepac, D. & Tomić, S. (2008) Combined X-Ray Diffraction and QM/MM Study of the Burkholderia cepacia Lipase-Catalyzed Secondary Alcohol Esterification. Journal of Physical Chemistry B, 112 (16), 4876-4883 doi:10.1021/jp077717u.

  doi

• Džolić, Z., Margeta, R., Vinković, M., Štefanić, Z., Kojić-Prodić, B., Mlinarić-Majerski, K. & Žinić, M. (2008) N-Methylation of adamantane-substituted oxalamide unit affects its conformational rigidity: Askew conformation of the oxalamide brigde. Journal of Molecular Structure, 876 (1-3), 218-224 doi:10.1016/j.molstruc.2007.06.024.

  doi

• Tomašić, V. & Štefanić, Z. (2007) Cholic acid as host for long linear molecules : a series of co-crystals with n-alkylammonia. Crystengcomm, 9 (11), 1124-1128 doi:10.1039/B710469C.

  doi

• Štefanić, Z., Vujaklija, D., Andrišić, L., Mikleušević, G., Andrejašič, M., Turk, D. & Luić, M. (2007) Preliminary crystallographic study of Streptomyces coelicolor single-stranded DNA-binding protein. Croatica Chemica Acta, 80 (1), 35-39. (https://www.bib.irb.hr/300532).

• Štefanić, Z., Makarević, J., Jokić, M. & Kojić-Prodić, B. (2006) Complementarity principle in heteromeric ionic assembling via N-H...O, C-H...pi, and pi...pi interactions: Crystal structure of [2(benzyloxy)-2-oxo-1-phenylethyl]ammonium 4-methyl-1-benzenesulhponate. Journal of Molecular Structure, 797 (1-3), 184-188.

• Zimmermann, B., Baranović, G., Štefanić, Z. & Rožman, M. (2006) Spectroscopic Properties of Macrocyclic Oligo(Phenyldiacetylenes)-II. Synthesis and Theoretical Study of Diacetylenic Dehydrobenzoannulene Derivatives with Weak Electron-Donor and -Acceptor Groups. Journal of Molecular Structure, 794, 115-124.

• Ilić, N., Habuš, I., Barkawi, L., Park, S., Štefanić, Z., Kojić-Prodić, B., Cohen, J. & Magnus, V. (2005) Aminoethyl-substituted indole-3-acetic acids for the preparation of tagged and carrier-linked auxin. Bioorganic & medicinal chemistry, 13 (9), 3229-3240.

• Štefanić, Z., Meden, A., Lutz, M., Schreurs, A. & Kojić-Prodić, B. (2004) The twinned crystal structure of rac-(R, R)-NN'-oxalyldivalinol. Acta Crystallographica. Section C, Crystal Structure Communications, C60, 754-756.

• Kojić-Prodić, B., Štefanić, Z. & Žinić, M. (2004) Hydrogen bonding and molecular assemblies. Croatica chemica acta, 77 (3), 415-425.

• Kojić-Prodić, B., Perić, B., Štefanić, Z., Meden, A., Makarević, J., Jokić, M. & Žinić, M. (2004) Supramolecular assembling using synthons with NH-CO(S)-CS-NH and NH-CO-CO-NH functionalities: crystal structures of (S, S)-N, N'-monothiooxalyldileucine methyl ester and its dithio analogue.. Acta Crystallographica Section B, Structural science, 60, 90-96.

• Makarević, J., Jokić, M., Raza, Z., Čaplar, V., Katalenić, D., Štefanić, Z., Kojić-Prodić, B. & Žinić, M. (2004) Chiral bis(tyrosinol) and bis(p-hydroxyphenylglycinol) oxalamide gelators. influence of aromatic groups and hydrogen bonding on gelation properties. Croatica chemica acta, 77 (1-2), 403-414.

• Makarević, J., Jokić, M., Raza, Z., Štefanić, Z., Kojić-Prodić, B. & Žinić, M. (2003) Chiral bis(amino alcohol) oxalyl amide gelators-gelation properties and supramolecular organization. Racemate vs pure enantiomer gelation. Chemistry - A European Journal, 9, 5567-5580.

• Štefanić, Z., Kojić-Prodić, B., Džolić, Z., Katalenić, D., Žinić, M. & Meden, A. (2003) Hydrogen bonding in N, N'-bis[(1 S)-2-azido-1-(2-methylpropyl)ethyl]-oxalamide: twofold symmetry of R22(10) hydrogen-bonded dimers connected into an alpha-network. Acta Crystallographica C, Crystal Structure Communications, C59, 286-288.

Ocjenski radovi

Doktorske disertacije

• Štefanić, Z. (2004) 'Uloga vodikove veze u supramolekularnoj organizaciji oksalil i ftaloil derivata aminokiselina', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

• Član Hrvatske kristalografske zajednice
• Član Hrvatskog biofizičkog društva