dr. sc. Zoran Štefanić
Bijenička 54, 10000 Zagreb
Obrazovanje
- 2008-2009 Postdoktorsko usavršavanje na Inštitutu Jožef Stefan u Ljubljani
- 21.12.2004. Obrana doktorske disertacije pod nazivom “Uloga vodikovih veza u supramolekularnoj organizaciji oksalil i ftaloil derivata aminokiselina”.
- 06.11.2000. Diplomirao fiziku na Prirodoslovno-matemetičkom fakultetu, Sveučilište u Zagrebu, s temom diplomskog rada: «Efekti rezanja konfiguracijskog prostora u bozonsko-fermionskim modelima»
Projekti
2021.-2024. Voditelj HrZZ projekta ALOKOMP (Alosterički komunikacijski putevi u oligomernim enzimima)
2009-2010. Voditelj hrvatsko-slovenskog bilateralnog projekta “Razvoj novih algoritama za analizu aktivnih mjesta proteina“
Nagrade i priznanja
2004 Na 22. po redu Europskom kristalografskom sastanku (22. European Crystallographic Meeting) održanom od 26. do 31. kolovoza u Budimpešti, Cambridge Crystallographic Data Centre mi je dodijelio nagradu za poster s temom iz kemijske kristalografije pod naslovom "Hydrogen Bonding Organization In Crystal Structures Of (S,S)-N,N’-Phthaloyl-Bis(Amino Acid) Derivatives"
Nastava
- 2008- Voditelj kolegija “Teorija grupa u kristalografiji” u sklopu Doktorskog studija kemije, PMF, Zagreb.
- 2005-2007 Sudjelovanje u dodiplomskoj nastavi na Biološkom odsjeku PMF-a, održavanje vježbi iz kolegija Molekularna biofizika za studente 3. godine
Istaknute publikacije
- Leščić Ašler, Ivana; Štefanić, Zoran; Maršavelski, Aleksandra; Vianello, Robert; Kojić-Prodić, Biserka.
Catalytic Dyad in the SGNH Hydrolase Superfamily: In-depth Insight into Structural Parameters Tuning the Catalytic Process of Extracellular Lipase from Streptomyces rimosus. // Acs chemical biology. 12 (2017) , 7; 1928-1936. - Štefanić, Zoran; Mikleušević, Goran; Luić, Marija; Bzowska, Agnieszka; Leščić Ašler, Ivana.
Structural characterization of purine nucleoside phosphorylase from human pathogen Helicobacter pylori. // International journal of biological macromolecules. 101 (2017) ; 518-526. - Mikleušević, Goran; Štefanić, Zoran; Narczyk, Marta; Wielgus-Kutrowska, Beata; Bzowska, Agnieszka; Luić, Marija.
Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies. Biochimie. 93 (2011) , 9; 1610-1622. - Tomašić, Vlasta; Štefanić, Zoran Cholic acid as host for long linear molecules: a series of co-crystals with n-alkylammonia. CrystEngComm. 9 (2007) ; 1124-1128.
- Luić, Marija; Štefanić, Zoran; Ceilinger, Igor; Hodošček, Milan; Janežić, Dušanka; Lenac, Tihana; Leščić Ašler, Ivana; Šepac, Dragan; Tomić, Sanja. Combined X-Ray Diffraction and QM/MM Study of the Burkholderia cepacia Lipase-Catalyzed Secondary Alcohol Esterification. Journal of Physical Chemistry B. 112 (2008) , 16; 4876-4883.
- Štefanić, Zoran; Vujaklija, Dušica; Luić, Marija Crystal structure of the single-stranded DNA binding protein from Streptomyces coelicolor. Acta Crystallographica - Section D - Biological Crystallography. 65 (2009), 9; 974-979.
Publikacije
Knjige i poglavlja u knjigama
Autorske knjige
Wittine, K., Štefanić, Z. & Mintas, M. (2021) Personalizirana terapija karcinoma. Zagreb, Medicinska naklada.
Radovi u časopisima
Znanstveni i pregledni radovi
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Perić, B., Pantalon Juraj, N., Štefanić, Z. & Kirin, S. (2023) Structural Determination of the Hexacoordinated [Zn(L)2]2+ Complex Isomer Type Using Solution-State NMR, DFT Calculations and X-ray Crystallography. Crystals, 13, 16, 21 doi:10.3390/cryst13010016.
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Bubić, A., Narczyk, M., Petek, A., Wojtyś, M., Maksymiuk, W., Wielgus-Kutrowska, B., Winiewska-Szajewska, M., Pavkov-Keller, T., Bertoša, B., Štefanić, Z., Luić, M., Bzowska, A. & Leščić Ašler, I. (2023) The pursuit of new alternative ways to eradicate Helicobacter pylori continues: Detailed characterization of interactions in the adenylosuccinate synthetase active site. International journal of biological macromolecules, 226, 37-50 doi:10.1016/j.ijbiomac.2022.12.001.
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Alić, J., Stolar, T., Štefanić, Z., Užarević, K. & Šekutor, M. (2023) Sustainable synthesis of diamondoid ethers by high-temperature ball milling. ACS Sustainable Chemistry & Engineering, 11 (2), 617-624 doi:10.1021/acssuschemeng.2c05283.
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Narczyk, M., Wojtyś, M., Leščić Ašler, I., Žinić, B., Luić, M., Jagusztyn-Krynicka, E., Štefanić, Z. & Bzowska, A. (2022) Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium. Journal of enzyme inhibition and medicinal chemistry, 37 (1), 1083-1097 doi:10.1080/14756366.2022.2061965.
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Dunatov, M., Puškarić, A., Pavić, L., Štefanić, Z. & Androš Dubraja, L. (2022) Electrically responsive structural transformations triggered by vapour and temperature in a series of pleochroic bis(oxalato)chromium(iii) complex salts. Journal of Materials Chemistry C, 10, 8024-8033 doi:10.1039/D2TC01103D.
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Alić, J., Biljan, I., Štefanić, Z. & Šekutor, M. (2022) Preparation and Characterization of Non-Aromatic Ether Self-Assemblies on a HOPG Surface. Nanotechnology, 33 (35), 355603, 12 doi:10.1088/1361-6528/ac6e72.
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Glavaš, M., Gredičak, M., Štefanić, Z. & Jerić, I. (2022) Synthesis of 14-membered enediyne-embedded macrocycles. Organic & biomolecular chemistry, 20 (18), 3823-3834 doi:10.1039/d2ob00090c.
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Gregorić, T., Makarević, J., Štefanić, Z., Žinić, M. & Frkanec, L. (2022) Gamma Radiation- and Ultraviolet-Induced Polymerization of Bis(amino acid)fumaramide Gel Assemblies. Polymers, 14 (1), 214, 17 doi:10.3390/polym14010214.
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Vlahoviček-Kahlina, K., Štefanić, Z., Vazdar, K. & Jerić, I. (2020) N‐Alkylated C‐Glycosyl Amino Acid Derivatives: Synthesis by a One‐Pot Four‐Component Ugi Reaction. ChemPlusChem, 85 (5), 838-844 doi:10.1002/cplu.202000177.
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You, J., Carić, D., Rakvin, B., Štefanić, Z., Užarević, K. & Kveder, M. (2019) Matrix material structure dependence of the embedded electron spin decoherence. The Journal of chemical physics, 150 (16), 164124, 9 doi:10.1063/1.5090215.
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Štefanić, Z., Narczyk, M., Mikleušević, G., Kazazić, S., Bzowska, A. & Luić, M. (2018) Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis. Scientific Reports, 8, 15427, 13 doi:10.1038/s41598-018-33723-1.
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Narczyk, M., Bertoša, B., Papa, L., Vuković, V., Leščić Ašler, I., Wielgus- Kutrowska, B., Bzowska, A., Luić, M. & Štefanić, Z. (2018) Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features. The FEBS journal, 285 (7), 1305-1325 doi:10.1111/febs.14403.
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Kokan, Z., Kovačević, B., Štefanić, Z., Tzvetkova, P. & Kirin, S. (2018) Controlling Orthogonal Self-Assembly through Cis-Trans Isomerization of a Non-Covalent Palladium Complex Dimer. Chemical communications, 54 (17), 2094-2097 doi:10.1039/C7CC09537F.
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Štefanić, Z., Mikleušević, G., Luić, M., Bzowska, A. & Leščić Ašler, I. (2017) Structural characterization of purine nucleoside phosphorylase from human pathogen Helicobacter pylori. International journal of biological macromolecules, 101, 518-526 doi:10.1016/j.ijbiomac.2017.03.101.
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Novak, S., Morasi Piperčić, S., Makarić, S., Primožič, I., Ćurlin, M., Štefanić, Z. & Domazet Jurašin, D. (2016) Interplay of Noncovalent Interactions in Ionic Liquid/Sodium Bis(2-ethylhexyl) Sulfosuccinate Mixtures : From Lamellar to Bicontinuous Cubic Liquid Crystalline Phase. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical, 120 (49), 12557-12567 doi:10.1021/acs.jpcb.6b10515.
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Luić, M. & Štefanić, Z. (2016) Can Crystal Symmetry and Packing Influence the Active Site Conformation of Homohexameric Purine Nucleoside Phosphorylases?. Croatica chemica acta, 89 (2), 197-202 doi:10.5562/cca2872.
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Kovač, V., Radošević, K., Bebek, A., Makarević, J., Štefanić, Z., Barišić, L., Žinić, M. & Rapić, V. (2016) The first oxalamide-bridged ferrocene : facile synthesis, preliminary conformational analysis and biological evaluation. Applied organometallic chemistry, 31 (7), E3653-1 doi:10.1002/aoc.3653.
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Skočibušić, M., Odžak, R., Štefanić, Z., Križić, I., Krišto, L., Jović, O., Hrenar, T., Primožič, I. & Jurašin, D. (2016) Structure-Property Relationship of Quinuclidinium Surfactants – Towards Multifunctional Biologically Active Molecules. Colloids and surfaces. B, Biointerfaces, 140, 548-559 doi:10.1016/j.colsurfb.2015.11.023.
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Cetina, M., Štefanić, Z., Makarević, J. & Nura-Lama, A. (2015) Intermolecular interactions in dihydrothymine derivatives form two-dimensional and three-dimensional networks. Journal of chemical crystallography, 45 (2), 67-76 doi:10.1007/s10870-015-0567-1.
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Tomašić, V., Biliškov, N., Mihelj, T. & Štefanić, Z. (2013) Thermal Behaviour and Structural Properties of Surfactant - Picrate Compounds: the effect of the ammonium headgroup number. Thermochimica acta, 569, 25-35 doi:10.1016/j.tca.2013.06.041.
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Štefanić, Z., Mikleušević, G., Narczyk, M., Wielgus-Kutrowska, B., Bzowska, A. & Luić, M. (2013) Still a long way to fully understanding the molecular mechanism of Escherichia coli purine nucleoside phosphorylase. Croatica chemica acta, 86 (1), 117-127 doi:10.5562/cca2116.
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Leščić Ašler, I., Kovačić, F., Marchetti-Deschmann, M., Allmaier, G., Štefanić, Z. & Kojić-Prodić, B. (2013) Inhibition of extracellular lipase from Streptomyces rimosus with 3, 4-dichloroisocoumarin. Journal of enzyme inhibition and medicinal chemistry, 28 (5), 1094-1104 doi:10.3109/14756366.2012.716834.
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Molčanov, K., Portada, T., Čaplar, V., Jokić, M., Makarević, J., Šijaković Vujičić, N., Štefanić, Z., Žinić, M. & Kojić-Prodić, B. (2013) Hydrogen bonding topology influences gelating properties of malonamides. Structural chemistry, 24 (2), 597-609 doi:10.1007/s11224-012-0102-3.
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Makarević, J., Štefanić, Z., Horvat, L. & Žinić, M. (2012) Intermolecular central to axial chirality transfer in the self-assembled biphenyl containing amino acid–oxalamide gelators. Chemical communications, 48 (59), 7047-7049 doi:10.1039/C2CC32039H.
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Štefanić, Z., Narczyk, M., Mikleušević, G., Wielgus-Kutrowska, B., Bzowska, A. & Luić, M. (2012) New phosphate binding sites in the crystal structure of Escherichia coli purine nucleoside phosphorylase complexed with phosphate and formycin A. FEBS letters, 586 (7), 967-971 doi:10.1016/j.febslet.2012.02.039.
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Mihelj, T., Štefanić, Z. & Tomašić, V. (2012) Thermal and structural properties of surfactant–picrate compounds. Journal of thermal analysis and calorimetry, 108 (3), 1261-1272 doi:10.1007/s10973-011-1710-7.
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Leščić Ašler, I., Pigac, J., Vujaklija, D., Luić, M. & Štefanić, Z. (2011) Crystallization and preliminary X-ray diffraction studies of a complex of extracellular lipase from Streptomyces rimosus with the inhibitor 3, 4-dichloroisocoumarin. Acta crystallographica. Section F, Structural biology and crystallization communications, 67 (11), 1378-1381 doi:10.1107/S1744309111032222.
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Mikleušević, G., Štefanić, Z., Narczyk, M., Wielgus-Kutrowska, B., Bzowska, A. & Luić, M. (2011) Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies. Biochimie, 93 (9), 1610-1622 doi:10.1016/j.biochi.2011.05.030,.
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Kojić-Prodić, B. & Štefanić, Z. (2010) Symmetry versus Asymmetry in the Molecules of Life: Homomeric Protein Assemblies. Symmetry-Basel, 2, 884-906 doi:10.3390/sym2020884.
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Štefanić, Z., Vujaklija, D. & Luić, M. (2009) Structure of the single-stranded DNA-binding protein from Streptomyces coelicolor. Acta crystallographica. Section D, Biological crystallography, 65 (9), 974-979 doi:10.1107/S0907444909023634.
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Luić, M., Štefanić, Z., Ceilinger, I., Hodošček, M., Janežić, D., Lenac, T., Leščić Ašler, I., Šepac, D. & Tomić, S. (2008) Combined X-Ray Diffraction and QM/MM Study of the Burkholderia cepacia Lipase-Catalyzed Secondary Alcohol Esterification. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical, 112 (16), 4876-4883 doi:10.1021/jp077717u.
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Džolić, Z., Margeta, R., Vinković, M., Štefanić, Z., Kojić-Prodić, B., Mlinarić-Majerski, K. & Žinić, M. (2008) N-Methylation of adamantane-substituted oxalamide unit affects its conformational rigidity: Askew conformation of the oxalamide brigde. Journal of molecular structure, 876 (1-3), 218-224 doi:10.1016/j.molstruc.2007.06.024.
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Tomašić, V. & Štefanić, Z. (2007) Cholic acid as host for long linear molecules : a series of co-crystals with n-alkylammonia. Crystengcomm, 9 (11), 1124-1128 doi:10.1039/B710469C.
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Štefanić, Z., Vujaklija, D., Andrišić, L., Mikleušević, G., Andrejašič, M., Turk, D. & Luić, M. (2007) Preliminary crystallographic study of Streptomyces coelicolor single-stranded DNA-binding protein. Croatica chemica acta, 80 (1), 35-39. (https://www.bib.irb.hr/300532).
fulir.irb.hr Štefanić, Z., Makarević, J., Jokić, M. & Kojić-Prodić, B. (2006) Complementarity principle in heteromeric ionic assembling via N-H...O, C-H...pi, and pi...pi interactions: Crystal structure of [2(benzyloxy)-2-oxo-1-phenylethyl]ammonium 4-methyl-1-benzenesulhponate. Journal of Molecular Structure, 797 (1-3), 184-188.
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Zimmermann, B., Baranović, G., Štefanić, Z. & Rožman, M. (2006) Spectroscopic Properties of Macrocyclic Oligo(Phenyldiacetylenes)-II. Synthesis and Theoretical Study of Diacetylenic Dehydrobenzoannulene Derivatives with Weak Electron-Donor and -Acceptor Groups. Journal of molecular structure, 794, 115-124 doi:10.1016/j.molstruc.2006.01.049.
doi Ilić, N., Habuš, I., Barkawi, L., Park, S., Štefanić, Z., Kojić-Prodić, B., Cohen, J. & Magnus, V. (2005) Aminoethyl-substituted indole-3-acetic acids for the preparation of tagged and carrier-linked auxin. Bioorganic & medicinal chemistry, 13 (9), 3229-3240.
Štefanić, Z., Meden, A., Lutz, M., Schreurs, A. & Kojić-Prodić, B. (2004) The twinned crystal structure of rac-(R, R)-NN'-oxalyldivalinol. Acta Crystallographica. Section C, Crystal Structure Communications, C60, 754-756.
Kojić-Prodić, B., Štefanić, Z. & Žinić, M. (2004) Hydrogen bonding and molecular assemblies. Croatica chemica acta, 77 (3), 415-425.
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Kojić-Prodić, B., Perić, B., Štefanić, Z., Meden, A., Makarević, J., Jokić, M. & Žinić, M. (2004) Supramolecular assembling using synthons with NH-CO(S)-CS-NH and NH-CO-CO-NH functionalities: crystal structures of (S, S)-N, N'-monothiooxalyldileucine methyl ester and its dithio analogue.. Acta crystallographica. Section B, Structural science, B60 (1), 90-96 doi:10.1107/S0108768103029173.
doi Makarević, J., Jokić, M., Raza, Z., Čaplar, V., Katalenić, D., Štefanić, Z., Kojić-Prodić, B. & Žinić, M. (2004) Chiral bis(tyrosinol) and bis(p-hydroxyphenylglycinol) oxalamide gelators. influence of aromatic groups and hydrogen bonding on gelation properties. Croatica chemica acta, 77 (1-2), 403-414.
Makarević, J., Jokić, M., Raza, Z., Štefanić, Z., Kojić-Prodić, B. & Žinić, M. (2003) Chiral bis(amino alcohol) oxalyl amide gelators-gelation properties and supramolecular organization. Racemate vs pure enantiomer gelation. Chemistry - A European Journal, 9, 5567-5580.
Štefanić, Z., Kojić-Prodić, B., Džolić, Z., Katalenić, D., Žinić, M. & Meden, A. (2003) Hydrogen bonding in N, N'-bis[(1 S)-2-azido-1-(2-methylpropyl)ethyl]-oxalamide: twofold symmetry of R22(10) hydrogen-bonded dimers connected into an alpha-network. Acta Crystallographica C, Crystal Structure Communications, C59, 286-288.
Obrazovni materijali
Udžbenik
Mintas, M., Wittine, K. & Štefanić, Z. (2018) Novi lijekovi protiv raka. Zagreb. Školska knjiga.
Ocjenski radovi
Doktorske disertacije
Štefanić, Z. (2004) 'Uloga vodikove veze u supramolekularnoj organizaciji oksalil i ftaloil derivata aminokiselina', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.
Članstva u profesionalnim udrugama / društvima
- Član Hrvatske udruge kristalografa
- Član Hrvatske kristalografske zajednice
- Član Hrvatskog biofizičkog društva