dr. sc. Silva Katušić
10002 Zagreb
Hrvatska
Obrazovanje
- 1991 Zagreb Prehrambeno-biotehnološki fakultet Sveučilišta u Zagrebu, Biokemijsko inženjerstvo, Dipl.inž. biotehnologije
- 1995 Zagreb Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, područje Kemija, smjer Biokemija, Mr. sc. prirodnih znanosti
- 2000 Zagreb Prehrambeno-biotehnološki fakultet Sveučilišta u Zagrebu, Dr.sc. biotehničkih znanosti
- 2001-2004 St.Louis, MO, SAD Washington University School of Medicine, post-doc. usavršavanje
Projekti
COGITO program, hrvatsko-francuski znanstvenoistraživački projekt (2019-2021)
Naslov: The molecular links between lipidome, brain vulnerability and apolipoprotein E
Uloga: Voditelj
Hrvatska zaklada za znanost – IP-06-2016 (2017-2021)
Naslov: Molekularni mehanizam neurodegeneracije u Niemann-Pickovoj bolesti tip C
Uloga: Voditelj
Bilateralni projekt:DAAD(Njemačka)i Ministartstva znanosti,obrazovanja i športa (Republika Hrvatska) (2016-2017)
Naslov: Ispitivanje uloge BACE1 za razvoj liječenja protiv bolesti Niemann-Pick tipa C
Uloga: Voditelj
Bilateralni projekt između Hrvatske i Srbije (2016-2017)
Naslov: Ispitivanje proteolitičke razgradnje i lokalizacije BACE1 supstrata u mozgu transgeničnog mišjeg modela Alzheimerove bolesti i njihove potencijalne uloge u patogenezi bolesti
Uloga: Voditelj
Hrvatska zaklada za znanost "Projekt razvoja karijere mladih istraživača" - izobrazba novih doktora znanosti (2014-2018)
Naslov: Uloga disfunkcije lizosoma na nastanak neurodegenerativnih bolesti
Uloga:Mentor
FP7-PEOPLE-2013-IEF (Marie Curie) (2014-2016)
Naslov: Presenilin 2 - a protector against Alzheimer's disease
Uloga: Koordinator
Nagrade i priznanja
- 1991 Nagrada rektora Sveučilišta u Zagrebu za šk. godinu 1990/1991.
- 2001 Fulbrightova post-doc. stipendija
- 2002 The John Douglas French Alzheimer’s Foundation post-doc. stipendija
- 2005 NIH -Fogarty International Research Collaboration Award - SAD
- 2008 Povelja Josip Juraj Strossmayer (HAZU/ Zagrebački velesajam) za najuspješniji izdavački pothvat 2008. god. za priručnik "Metode u molekularnoj biologiji", glavna urednica Andreja Ambriović Ristov i urednice Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade, Dušica Vujaklija.
Nastava
- Predavač i voditelj laboratorijskih vježbi "Metoda lančane reakcije polimeraze" na Metodološkom tečaju u biologiji i medicini „DNA i RNA“ organiziranom na Institutu Ruđer Bošković
- Predavač i nositelj izbornog kolegija „Genetika neurodegenerativnih bolesti“ na Poslijediplomskom doktorskom studiju Biologije Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu
- Predavač i nositelj izbornog kolegija „Genetika neurodegenerativnih bolesti“ na Poslijediplomskom interdisciplinarnom Doktorskom studiju Molekularne bionanosti, Sveučilišta „J.J. Strossmayera“ u Osijeku i Instituta Ruđer Bošković
- 2016 - naslovno znanstveno-nastavno zvanje docent(područje Biomedicina i zdravstvo, polje temeljne medicinske znanosti), Poslijediplomski interdisciplinarni sveučilišni studij Molekularne bioznanosti, Sveučilište „J.J. Strossmayera“ u Osijeku
Istaknute publikacije
De Marchi F, Munitic I, Vidatic L, Papić E, Rački V, Nimac J, Jurak I, Novotni G, Rogelj B, Vuletic V, Liscic RM, Cannon JR, Buratti E, Mazzini L, Hecimovic S*. Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders. Biomedicines. 2023 Oct 14;11(10):2793. https://doi.org/10.3390/biomedicines11102793.
De Marchi F, Franjkic T, Schito P, Russo T, Nimac J, Chami AA, Mele A, Vidatic L, Kriz J, Julien JP, Apic G, Russell RB, Rogelj B, Cannon JR, Baralle M, Agosta F, Hecimovic S, Mazzini L, Buratti E, Munitic I. Emerging Trends in the Field of Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder. Biomedicines. 2023 May 31;11(6):1599. https://doi.org/10.3390/biomedicines11061599.
Dominko K, Rastija A, Smiljanic K, Mladenovic A, Lešnjaković L, Kanazir S, Milanovic D, Hecimovic S*. Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6L. Mech Ageing Dev. 2022 Oct;207:111726. https://doi.org/10.1016/j.mad.2022.111726Get rights and content.
Dominko K, Rastija A, Sobocanec S, Vidatic L, Meglaj S, Lovincic Babic A, Hutter-Paier B, Colombo AV, Lichtenthaler SF, Tahirovic S, Hecimovic S*. Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation. Int J Mol Sci. 2021 Dec 9;22(24):13256. https://doi.org/10.3390/ijms222413256.
Van Hoecke L, Van Cauwenberghe C, Dominko K, Van Imschoot G, Van Wonterghem E, Castelein J, Xie J, Claeys W, Vandendriessche C, Kremer A, Borghgraef P, De Rycke R, Hecimovic S, Vandenbroucke RE. Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C. Front Cell Neurosci. 2021 Oct 15;15:757482. https://doi.org/10.3389/fncel.2021.757482
Colombo A, Dinkel L, Müller SA, Sebastian Monasor L, Schifferer M, Cantuti-Castelvetri L, König J, Vidatic L, Bremova-Ertl T, Lieberman AP, Hecimovic S, Simons M, Lichtenthaler SF, Strupp M, Schneider SA, Tahirovic S. (2021) Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nat Commun 12, 1158 (2021). https://doi.org/10.1038/s41467-021-21428-5
Avrahami L, Paz R, Dominko K, Hecimovic S, Bucci C, Eldar-Finkelman H. (2020) GSK-3-TSC axis governs lysosomal acidification through autophagy and endocytic pathways. Cell Signal. 71:109597. doi: 10.1016/j.cellsig.2020.109597.
Dominko K, Dikic D, Hecimovic S. (2018) Enhanced activity of superoxide dismutase is a common response to dietary and genetically induced increased cholesterol levels. Nutr Neurosci. 1-13. doi: 10.1080/1028415X.2018.1511027.
Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, Kuhn PH, Colombo A, Havas D, Flunkert S, McDonald J, Gunnersen JM, Hutter-Paier B, Tahirovic S, Windisch M, Krainc D, Lichtenthaler SF, Hecimovic S. (2018) BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains. PLoS One. 13(7):e0200344. doi: 10.1371/journal.pone.0200344.
Kosicek M, Gudelj I, Horvatic A, Jovic T, Vuckovic F, Lauc G, Hecimovic S. (2018) N-glycome of the lysosomal glycocalyx is altered in Niemann-Pick Type C disease model cells. Mol Cell Proteomics. pii: mcp.RA117.000129. doi: 10.1074/mcp.RA117.000129.
Cermak S, Kosicek M, Mladenovic-Djordjevic A, Smiljanic K, Kanazir S, Hecimovic S. (2016) Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins. PLoS One. 11(11):e0167428. doi: 10.1371/journal.pone.0167428.
Drechsler S, Lynch MA, Novella S, González-Navarro H, Hecimovic S, Barini E, Tucci V, Castro RE, Vandenbroucke RE, Osuchowski M, Potter PK. (2016) With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions. Mechanisms of Ageing and Development. 160:54-68. doi: 10.1016/j.mad.2016.07.005.
Malnar M, Hecimovic S, Mattsson M, Zetterberg H. (2014) Bidirectional links between Alzheimer's disease and Niemann-Pick type C disease. Neurobiology of Disease, Neurobiol Dis 72 Pt A: 37.
Kosicek M, Wunderlich P, Walter J, Hecimovic S. (2014) GGA1 overexpression attenuates amyloidogenic processing of APP in NPC1-null cells. Biochemical and Biophysical Research Communications, 450: 160-5.
Ting SK, Benzinger T, Kepe V, Fagan A, Coppola G, Porter V, Hecimovic S, Chakraverty S, Alvarez-Retuerto AI, Goate A, Ringman JM. (2014) A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman. Journal of Alzheimers Disease. 40: 271-5.
Kosicek M, Hecimovic S. (2013) Phospholipids and Alzheimer’s disease: alterations, mechanisms and potential biomerkers. International Journal of Molecular Sciences 14: 1310-22.
Mattsson N, Olsson M, Gustavsson MK, Kosicek M, Malnar M, Månsson JE, Blomqvist M, Gobom J, Andreasson U, Brinkmalm G, Vite C, Hecimovic S, Hastings C, Blennow K, Zetterberg H, Portelius E. (2012) Amyloid-β metabolism in Niemann-Pick C disease models and patients. Metabolic Brain Disease. 27:573-585.
Malnar M, Kosicek M, Lisica A, Posavec M, Krolo A, Njavro J, Omerbasic D, Tahirovic S, Hecimovic S. (2012) Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 1822: 1270-83.
Kosicek M, Zetterberg H, Andreasen N, Peter-Katalinic J, Hecimovic S. (2012) Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease. Neuroscience Letters 516: 302-5.
Malnar M, Kosicek M, Mitterreiter S, Omerbasic D, Lichtenthaler SF, Goate A, Hecimovic S. (2010) Niemann Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 1802: 682-91.
Kosicek M, Kirsch S, Bene R, Trkanjec Z, Titlic M, Bindila L, Peter-Katalinic J, Hecimovic S. (2010) Nano-HPLC-MS analysis of phospholipids in cerebrospinal fluid of Alzheimer's disease patients - a pilot study. Analytical and Bioanalytical Chemistry 398: 2929-37.
Kosicek M, Malnar M, Goate A, Hecimovic S. (2010) Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts. Biochemical and Biophysical Research Communications 393: 404-9.
Cam JA, Zerbinatti CV, Knisely JM, Hecimovic S, Yonghe L, Bu G (2004) The LDL receptor-related protein 1B retains APP at the cell surface and reduces amyloid-b peptide production. Journal of Biological Chemistry 279: 29639-46.
Hecimovic S, Wang J, Martinez M, Goate A (2004) Mutations in APP have independent effects on Ab and CTFg generation. Neurobiology of Disease 17: 205-218.
Wang J, Brunkan AL, Hecimovic S, Walker E, Goate A (2004) Conserved “PAL” sequence in presenilins is essential for g-secretase activity, but not required for formation or stabilization of g-secretase complex. Neurobiology of Disease 15: 654-666.
Schroeter EH, Ilagan MXG, Brunkan AL, Hecimovic S, Li Y-M, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Shearman M, Goate A, Wolfe MS, Kopan R (2003) A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences U S A 100: 13075-80.
Hećimović S, Barišić I, Muller A, Petković I, Barić I, Ligutić I, Pavelić K (1997) Expand Long PCR for fragile X mutation detection. Clinical Genetics 52: 147-154.
Publikacije - Uredničke knjige
Priručnik
Metode u molekularnoj biologiji / Ambriović Ristov, Andreja (ur.) | Zagreb: Institut Ruđer Bošković, 2007
Publikacije - prilozi u knjigama
Izvorni znanstveni rad
Hećimović, Silva | Sindrom fragilnog kromosoma X // Racionalna dijagnostika nasljednih i prirođenih bolesti / Barić, Ivo ; Stavljenić Rukavina, Ana (ur.). Zagreb: Medicinska naklada, 2005. str. 51-54
Brišić, Nina ; Sertić, Jadranka ; Hećimović, Silva | Molekularna genetika u dijagnostici mišićne distrofije Duchenne/Becker // Racionalna dijagnostika nasljednih i prirođenih bolesti / Barić, Ivo ; Stavljenić Rukavina, Ana (ur.). Zagreb: Medicinska naklada, 2005. str. 71-74
Hećimović, Silva ; Barišić, Nina | Molekularna genetika u dijagnostici miotonične distrofije // Racionalna dijagnostika nasljednih i prirođenih bolesti / Barić, Ivo ; Stavljenić Rukavina, Ana (ur.). Zagreb: Medicinska naklada, 2005. str. 75-79
Hećimović, Silva ; Barišić, Nina ; Mitrović, Zoran | Racionalno korištenje metoda molekularne genetike u dijagnostici nasljednih ataksija // Racionalna dijagnostika nasljednih i prirođenih bolesti / Barić, Ivo ; Stavljenić Rukavina, Ana (ur.). Zagreb: Medicinska naklada, 2005. str. 81-88
Hećimović, Silva | Kliničke indikacije za analizu Huntingtonove bolesti metodama molekularne dijagnostike // Racionalna dijagnostika nasljednih i prirođenih bolesti / Barić, Ivo ; Stavljenić Rukavina, Ana (ur.). Zagreb: Medicinska naklada, 2005. str. 89-94
Katušić Hećimović Silva | Osnovna metoda PCR // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 361-366
Katušić Hećimović, Silva | Multipleks PCR // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 366-367
Katušić Hećimović, Silva | Nested PCR // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 367-368
Katušić Hećimović, Silva | RFLP PCR // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 368-370
Katušić Hećimović, Silva | Umnažanje odsječaka DNA bogatih C+G nukleotidima // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 370-371
Katušić Hećimović, Silva | Termostabilne DNA polimeraze // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 418-419
Katušić Hećimović, Silva | Mutageneza in vitro primjenom metode PCR // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 442-446
Katušić Hećimović, Silva | Priprema kompetentnih bakterija kalcijevim kloridom i transformacija // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 450-453
Katušić Hećimović, Silva | Priprema kompetentnih bakterija polietilenglikolom i transformacija // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 453-454
Katušić Hećimović, Silva | Izdvajanje staničnih organela i dijelova stanice diferencijalnim centrifugiranjem // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 773-776
Katušić Hećimović, Silva | Izdvajanje staničnih organela i dijelova stanice centrifugiranjem u gradijentu gustoće // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 777-780
Katušić Hećimović, Silva | Izdvajanje membranskih lipidnih domena (lipid rafts) // Metode u molekularnoj biologiji / Ambriović Ristov, Andreja ; Brozović, Anamaria ; Bruvo Mađarić, Branka et al. (ur.). Zagreb: Institut Ruđer Bošković, 2007. str. 780-782
Wang, Jun ; Hećimović, Silva ; Goate, Alison | Alzheimer’s Disease // Encyclopedia of Molecular Cell Biology and Molecular Medicine / Meyers, Robert A. (ur.). New York (NY): John Wiley & Sons, 2004. str. 214-230
Stručni rad
Katušić Hećimović, Silva ; Malnar, Martina ; Čermak, Stjepko ; Barišić, Ingeborg | Sindrom fragilnog X // Genetičko informiranje u praksi / Čulić, Vida ; Pavelić, Jasminka ; Radman, Maja (ur.). Zagreb: Medicinska naklada, 2016. str. 195-198
Katušić Hećimović, Silva ; Malnar, Martina | Molekularna analiza Huntingtonove bolesti // Genetičko informiranje u praksi / Čulić, Vida ; Pavelić, Jasminka ; Radman, Maja (ur.). Zagreb: Medicinska naklada, 2016. str. 209-212
Katušić Hećimović, Silva ; Čermak, Stjepko ; Malnar, Martina ; Barišić, Ingeborg | Miotonična distrofija tipa 1 // Genetičko informiranje u praksi / Čulić, Vida ; Pavelić, Jasminka ; Radman, Maja (ur.). Zagreb: Medicinska naklada, 2016. str. 219-222
Publikacije - prilozi u časopisima
Izvorni znanstveni rad
Hećimović, Silva ; Barišić, Ingeborg ; Mueller, Andreas ; Petković, Iskra ; Barić, Ivo ; Ligutić, Ivo ; Pavelić, Krešimir | Expand long PCR for fragile X mutation detection // Clinical genetics, 52 (1997), 3; 147-154-x
Hećimović, Silva ; Barišić, Ingeborg ; Pavelić, Krešimir | DNA analysis of the fragile X syndrome in an at risk pediatric population in Croatia: simple clinical preselection criteria can considerably improve the cost-effectiveness of fragile X screening studies // Human heredity, 48 (1998), 5; 256-265
Tanacković, Goranka ; Barišić, Ingeborg ; Gjergja-Matejić, Romana ; Hećimović, Silva ; Pavelić, Jasminka | the incidence of cystic fibrosis (CF) mutations among patients from Croatia // Clinical genetics, 58 (2000), 4; 333-335-x
Hećimović, Silva ; Barišić, Ingeborg ; Marković, Dubravko ; Škarpa, Ingrid ; Relja, Maja ; Pavelić, Krešimir | Trinucleotide Repeat Diseases - DNA molecular analysis using a simple Expand Long PCR assay // Periodicum biologorum, 100 (1998), 3; 353-360-x
Hećimović, Silva ; Vlašić, Jelena ; Barišić, Ingeborg ; Marković, Dubravko ; Čulić, Vida ; Pavelić, Krešimir | A simple and rapid analysis of triplet repeat diseases by Expand Long PCR // Clinical chemistry and laboratory medicine, 39 (2001), 12; 1259-1262
Hećimović, Silva ; Petek Tarnik, Iva ; Barić, Ivo ; Čakarun, Ž. ; Pavelić, Krešimir | Screening for fragile X syndrome: results from a school for mentally retarded children // Acta paediatrica, 91 (2002), 5; 535-539-x
Hećimović, Silva ; Bago, Ružica ; Mužinić, Dubravka ; Begović, Davor ; Pavelić, Krešimir | The first case of the FRAXE form of inherited mental retardation in Croatia // European journal of pediatrics, 161 (2002), 2; 112-113-x
Barišić, Ingeborg ; Marušić-Della Marina, Branka ; Hećimović, Silva ; Lujić, Lucija ; Gjergja-Matejić, Romana | Epilepsija i EEG zapisi u bolesnika s mutacijomm u FMR1 genu // Paediatria Croatica, 43 (1999), 3; 105-110-x
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Petković, Iskra ; Barišić, Ingeborg ; Bastić, Mislav ; Hećimović, Silva ; Bago, Ružica | Paternal origin of der(X)t(X;6) in a girl with trisomy 6p and unbalanced t(6;10) mosaicism in her mother // American journal of medical genetics. Part A, 120A (2003), 2; 266-271. doi: 10.1002/ajmg.a.20017
doionlinelibrary.wiley.com Wang, J ; Brunkan, AL ; Hećimović, Silva ; Walker, E ; Goate, A | Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complex // Neurobiology of disease, 15 (2004), 654-666-x
Cam, J.A. ; Zerbinatti, C.V. ; Knisley, J.M. ; Hećimović, Silva ; Yonghe, L. ; Bu, G. | The LDL receptor-related protein 1B retains APP at the cell surface and reduces amyloid-beta peptide production // The Journal of biological chemistry, 279 (2004), 29639-29646-x
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Hećimović, Silva ; Wang, J ; Martinez, M ; Goate, A | Mutations in APP have independent effects on Abeta and CTFgamma generation // Neurobiology of disease, 17 (2004), 205-218. doi: 10.1016/j.nbd.2004.04.018
doiwww.sciencedirect.com Song, H. ; Hećimović, Silva ; Goate, A. ; Hsu, F.F. ; Bao, S. ; Vidavsky, I. ; Ramanadham, S. ; Turk, J. | Characterization of N-terminal processing of group VIA phospholipase A2 and of potential cleavage sites of amyloid precursor protein constructs by automated identification of signature peptides in LC/MS/MS analyses of proteolytic digests // Journal of the American Society for Mass Spectrometry, 15 (2004), 1780-1793-x
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Hećimović, Silva ; Klepac, Nataša ; Vlašić, Jelena ; Vojta, Aleksandar ; Janko, Dolores ; Škarpa- Prpić, Ingrid ; Canki-Klain, Nina ; Marković, Dubravko ; Božikov, Jadranka ; Relja, Maja et al. | Genetic background of Huntington disease in Croatia: molecular analysis of CAG, CCG, and delta 642 (E2642del)polymorphisms // Human mutation, 20 (2002), 3; 233-241. doi: 10.1002/humu.9055
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Klepac, Nataša ; Relja, Maja ; Klepac, Ratimir ; Hećimović, Silva ; Babić, Tomislav ; Trkulja, Vladimir | Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington’ s disease gene carriers and healthy subjects // Journal of neurology, 254 (2007), 12; 1676-1683. doi: 10.1007/s00415-007-0611-y
doi Đokić, Helena ; Barišić, Ingeborg ; Čulić, Vida ; Lozić, Bernarda ; Hećimović, Silva | Haplotype and AGG Interspersion Analysis of the FMR1 Alleles in Croatian Population: no founder effect detected in patients with fragile X syndrome // Human biology, 80 (2008), 5; 581-587
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Malnar, Martina ; Košiček, Marko ; Mitterreiter, Stefan ; Omerbašić, Damir ; Lichtenthaler, Stefan F. ; Goate, Alison ; Hećimović Katušić, Silva | Niemann Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the β-secretase pathway // Biochimica et biophysica acta. Molecular basis of disease, 1802 (2010), 7-8; 682-691. doi: 10.1016/j.bbadis.2010.05.006
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Malnar, Martina ; Košiček, Marko ; Bene, Raphael ; Petek Tarnik, Iva ; Pavelin, Sanda ; Babić, Ivana ; Brajenović-Milić, Bojana ; Hećimović, Hrvoje ; Titlić, Marina ; Trkanjec, Zlatko et al. | Use of cerebrospinal fluid biomarker analysis and apolipoprotein E genotyping for improving Alzheimer’s disease diagnosis in a non-specialized setting // Acta neurobiologiae experimentalis, 72 (2012), 3; 264-271
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Schroeter, E.H. ; Ilagan, M.X.G. ; Brunkan, A.L. ; Hećimović, Silva ; Li, Y-M ; Xu, M. ; Lewis, H.D. ; Saxena, M.T. ; De Strooper, B. ; Coonrod, A. et al. | A presenilin dimer at the core of the gamma-secretase enzyme : insights from parallel analysis of Notch 1 and APP proteolysis // Proceedings of the National Academy of Sciences of the United States of America, 100 (2003), 22; 13075-13080. doi: 10.1073/pnas.1735338100
doiwww.pnas.org Hećimović, Silva ; Malnar, M ; Košiček, M ; Petek Karnik, Iva ; Trkanjec, Zlatko ; Titlić, Marina ; Demarin, Vida ; Goate, A | Amyloid-beta - from molecular biology to clinical practice // Neurologia Croatica. Supplement, 57 (2008), Suppl 4; 16-17
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Košiček, Marko ; Malnar, Martina ; Goate, Alison ; Katušić Hećimović, Silva | Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts // Biochemical and biophysical research communications, 393 (2010), 3; 404-409. doi: 10.1016/j.bbrc.2010.02.007
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Košiček, Marko ; Kirsch, Stefan ; Bene, Raphael ; Trkanjec, Zlatko ; Titlić, Marina ; Bindila, Laura ; Peter-Katalinić, Jasna ; Hećimović, Silva | Nano-HPLC-MS analysis of phospholipids in cerebrospinal fluid of Alzheimer’s disease patients–a pilot study // Analytical & bioanalytical chemistry, 398 (2010), 7/8; 2929-2937. doi: 10.1007/s00216-010-4273-8
doiwww.springerlink.com -
Ringman, John M. ; Gylys, Karen H. ; Medina, Luis D. ; Fox, Michelle ; Kepe, Vladimir ; Flores, Deborah L. ; Apostolova, Liana G. ; Barrio, Jorge R. ; Small, Gary ; Silverman, Daniel H. et al. | Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation // Neuroscience letters, 487 (2011), 3; 287-292. doi: 10.1016/j.neulet.2010.10.039
doidx.doi.orgwww.sciencedirect.com Reljić, Rajko ; Ries, Mihael ; Katušić, Silva ; Ries, Blanka | Comparative studies of some substituted anilines as alternative hydrogen donors in peroxidase reaction // Periodicum biologorum. Supplement, 93 (1991), 27-30
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Malnar, Martina ; Košiček, Marko ; Lisica, Ana ; Posavec, Melanija ; Krolo, Ana ; Njavro, Jasenka ; Omerbašić, Damir ; Tahirović, Sabina ; Hećimović, Silva | Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells // Biochimica et biophysica acta. Molecular basis of disease, 1822 (2012), 8; 1270-1283. doi: 10.1016/j.bbadis.2012.04.002
doiac.els-cdn.comwww.sciencedirect.comdx.doi.org -
Mattsson, Niklas ; Olsson, Maria ; Gustavsson, Mikael K. ; Košiček, Marko ; Malnar, Martina ; Månsson, Jan-Eric ; Blomqvist, Maria ; Gobom, Johan ; Andreasson, Ulf ; Brinkmalm, Gunnar et al. | Amyloid-β metabolism in Niemann-Pick C disease models and patients // Metabolic brain disease, 27 (2012), 4; 573-585. doi: 10.1007/s11011-012-9332-8
doiwww.springerlink.comlink.springer.com -
Košiček, Marko ; Zetterberg, Henrik ; Andreasen, Niels ; Peter-Katalinić, Jasna ; Hećimović, Silva | Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer’s disease // Neuroscience letters, 516 (2012), 2; 302-305. doi: 10.1016/j.neulet.2012.04.019
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von Einem, Bjorn ; Weber, Petra ; Wagner, Michael ; Malnar, Martina ; Košiček, Marko ; Hećimović, Silva ; von Arnim, Christine ; Schneckenburger, Herbert | Cholesterol dependent energy transfer between fluorescent proteins - insights into protein proximity of APP and BACE1 in different membranes in Niemann-Pick type C disease cells // International journal of molecular sciences, 13 (2012), 12; 15801-15812. doi: 10.3390/ijms131215801
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Štefulj, Jasminka ; Perić, Maja ; Malnar, Martina ; Košiček, Marko ; Schweinzer, Cornelia ; Živković, Jelena ; Scholler, Monika ; Panzenboeck, Ute ; Hećimović, Silva | Pharmacological activation of LXRs decreases amyloid-β levels in Niemann-Pick type C model cells // Current pharmaceutical biotechnology, 14 (2013), 6; 582-593
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Košiček, Marko ; Wunderlich, Patrick ; Walter, Jochen ; Hećimović, Silva | GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells // Biochemical and biophysical research communications, 450 (2014), 1; 160-165. doi: 10.1016/j.bbrc.2014.05.083
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Dražić, Tonko ; Molčanov, Krešimir ; Sachdev, Vinay ; Malnar, Martina ; Hećimović, Silva ; Patankar, Jay V. ; Obrowsky, Sascha ; Levak-Frank, Sanja ; Habuš, Ivan ; Kratky, Dagmar | Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors // European journal of medicinal chemistry, 87 (2014), 722-734. doi: 10.1016/j.ejmech.2014.10.014
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Dražić, Tonko ; Sachdev, Vinay ; Leopold, Christina ; Patankar, Jay V. ; Malnar, Martina ; Hećimović, Silva ; Levak-Frank, Sanja ; Habuš, Ivan ; Kratky, Dagmar | Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors // Bioorganic & medicinal chemistry, 23 (2015), 10; 2353-2359. doi: 10.1016/j.bmc.2015.03.067
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Dražić, Tonko ; Vazdar, Katarina ; Vazdar, Mario ; Đaković, Marijana ; Mikecin, Ana-Matea ; Kralj, Marijeta ; Malnar, Martina ; Hećimović, Silva ; Habuš, Ivan | Synthesis of new 2-aminoimidazolones with antiproliferative activity via base promoted amino-β-lactam rearrangement // Tetrahedron, 71 (2015), 49; 9202-9215. doi: 10.1016/j.tet.2015.10.048
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Ting, Simon Kang Seng ; Benzinger, Tammie ; Kepe, Vladimir ; Fagan, Anne ; Coppola, Giovanni ; Porter, Verna ; Hećimović, Silva ; Chakraverty, Suma ; lvarez-Retuerto, Ana Isabel ; Goate, Alison et al. | A Novel PSEN1 Mutation (I238M) associated with Early-Onset Alzheimer's Disease in an African-American Woman // Journal of alzheimers disease, 40 (2014), 2; 271-275. doi: 10.3233/JAD-131844
doicontent.iospress.com -
Drechsler, Susanne ; Lynch, Marina A ; Novella, Susana ; González-Navarro, Herminia ; Hećimović, Silva ; Barini, Erica ; Tucci, Valter ; Castro, Rui E ; Vandenbroucke, Roosmarijn E. ; Osuchowski, Marcin et al. | With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions // Mechanisms of ageing and development, 160 (2016), 54-68. doi: 10.1016/j.mad.2016.07.005
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Cermak, Stjepko ; Kosicek, Marko ; Mladenovic-Djordjevic, Aleksandra ; Smiljanic, Kosara ; Kanazir, Selma ; Hecimovic, Silva | Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins // PLoS One, 11 (2016), 11; e0167428-1-e0167428-17. doi: 10.1371/journal.pone.0167428
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Košiček, Marko ; Gudelj, Ivan ; Horvatić, Anita ; Jović, Tanja ; Vučković, Frano ; Lauc, Gordan ; Hećimović, Silva | N-glycome of the lysosomal glycocalyx is altered in Niemann-Pick Type C disease model cells // Molecular & cellular proteomics, 17 (2018), 4; 631-642. doi: 10.1074/mcp.RA117.000129
doiwww.mcponline.orgwww.mcponline.org -
Dominko, Kristina ; Đikić, Domagoj ; Hećimović, Silva | Enhanced activity of superoxide dismutase is a common response to dietary and genetically induced increased cholesterol levels // Nutritional neuroscience, 1 (2018), 1; 1-13. doi: 10.1080/1028415X.2018.1511027
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Čaušević, Mirsada ; Dominko, Kristina ; Malnar, Martina ; Vidatic, Lea ; Čermak, Stjepko ; Pigoni, Martina ; Kuhn, Peer-Hendrik ; Colombo, Alessio ; Havas, Daniel ; Flunkert, Stefanie et al. | BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains // PLoS One, 13 (2018), 7; e0200344, 22. doi: 10.1371/journal.pone.0200344
doifulir.irb.hrjournals.plos.orgwww.ncbi.nlm.nih.gov -
Avrahami, Limor ; Paz, Rom ; Dominko, Kristina ; Hećimović, Silva ; Bucci, Cecilia ; Eldar-Finkelman, Hagit | GSK-3-TSC axis governs lysosomal acidification through autophagy and endocytic pathways // Cellular signalling, 71 (2020), 109597, 11. doi: 10.1016/j.cellsig.2020.109597
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Colombo, A ; Dinkel, L. ; Müller, S. A. ; Sebastian Monasor, L. ; Schifferer, M. ; Cantuti-Castelvetri, L. ; König, J. ; Vidatić, Lea ; Bremova-Ertl, T. ; Lieberman, A. et al. | Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia // Nature communications, 12 (2021), 1; 1158, 20. doi: 10.1038/s41467-021-21428-5
doiwww.nature.comdoi.orgfulir.irb.hr -
Van Hoecke, L. ; Van Cauwenberghe, C. ; Dominko, Kristina ; Van Imschoot, G. ; Van Wonterghem, E. ; Castelein, J. ; Xie, J. ; Claeys, W. ; Vandendriessche, C. ; Kremer, A et al. | Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C // Frontiers in Cellular Neuroscience, 15 (2021), 757482, 14. doi: 10.3389/fncel.2021.757482
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Dominko, Kristina ; Rastija, Ana ; Sobočanec, Sandra ; Vidatić, Lea ; Meglaj, Sarah ; Lovinčić Babić, Andrea ; Hutter-Paier, Birgit ; Colombo, Alessio-Vittorio, ; Lichtenthaler, Stefan F. ; Tahirović, Sabina et al. | Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation // International journal of molecular sciences, 22 (2021), 24; 13256, 27. doi: 10.3390/ijms222413256
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Dominko, Kristina ; Rastija, Ana ; Smiljanić, Kosara ; Mladenović, Aleksandra ; Lešnjaković, Lucija ; Kanazir, Selma ; Milanović, Desanka ; Hećimović, Silva | Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6L // Mechanisms of ageing and development, 207 (2022), 111726, 11. doi: 10.1016/j.mad.2022.111726
doiwww.sciencedirect.comdoi.org
Pregledni rad (znanstveni)
Barišić, Ingeborg ; Petković, Iskra ; Hećimović, Silva | Evaluacija genetičkih uzroka mentalne retardacije // Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora, 125 (2003), 3-4; 71-77
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Malnar, Martina ; Košiček, Marko ; Hećimović, Silva | Alzheimerova bolest: od molekularnog mehanizma do rane dijagnoze // Medicina : glasilo Hrvatskoga liječničkoga zbora, Podružnica Rijeka, 45 (2009), 3; 234-243
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Košiček, Marko ; Hećimović, Silva | Phospholipids and Alzheimer’s disease: alterations, mechanisms and potential biomarkers // International journal of molecular sciences, 14 (2013), 1; 1310-1322. doi: 10.3390/ijms14011310
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Malnar, Martina ; Hećimović, Silva ; Mattsson, Niklas ; Zetterberg, Henrik | Bidirectional links between Alzheimer's disease and Niemann-Pick type C disease // Neurobiology of disease, 72 (2014), Part A; 37-47. doi: 10.1016/j.nbd.2014.05.033
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Barišić, I ; Marušić–Dellamarina, B ; Hećimović, S ; Lujić, L ; Gjergja-Matejić, R. | Ethics in clinical practice - before and today // Paediatria Croatica, 43 (1999), 1;
www.paedcro.com
Ispravak
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Ringman, John M. ; Gylys, Karen H. ; Medina, Luis D. ; Fox, Michelle ; Kepe, Vladimir ; Flores, Deborah L. ; Apostolova, Liana G. ; Barrio, Jorge R. ; Small, Gary ; Silverman, Daniel H. et al. | Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation (Neurosci. Lett. 487 (2011) 287–292) // Neuroscience letters, 491 (2011), 2; 163-163. doi: 10.1016/j.neulet.2011.01.021
doiwww.sciencedirect.com
Pregledni rad (stručni)
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Ahel, Marijan ; Antičić, Tome ; Balog, Tihomir ; Bilić, Nevenko ; Guberina, Branko ; Katušić Hećimović, Silva ; Jerić, Ivanka ; Klanjšček, Tin ; Legović, Tarzan ; Musić, Svetozar et al. | The Ruder Boskovic Institute – Today and Tomorrow // Periodicum biologorum, 112 (2010), 4; 369-374
hrcak.srce.hr
Publikacije - prilozi sa skupa (u zborniku)
Sažetak izlaganja sa skupa
Gjergja, Romana ; Barišić, Ingeborg ; Hećimović, Silva ; Tanacković, Goranka ; Sertić, Jadranka ; Knežević, Jasna ; Milić, Ana ; Pavelić, Krešimir | Genotype-phenotype correlation in Croatian cystic fibrosis patients // 2nd International Conference on Signal Transduction. European Journal of Human Genetics 9(1), 2001. 2001. str. 205-205-x
Bago, Ružica ; Hećimović, Silva ; Barišić, Ingeborg ; Čulić, Vida ; Pavelić, Krešimir | Different distribution of DXS548 and FRAXAC1 haplotypes between normal and fragile X population in Croatia // 2nd International Conference on Signal Transduction. European Journal of Human Genetics 9(1), 2001. 2001. str. 284-284-x
Petković, Iskra ; Barišić, Ingeborg ; Bago, Ružica ; Hećimović, Silva | Cytogenetic, FISH and molecular analysis in the girl with unbalanced t(X ; 6) and her mother presenting t(6 ; 10) // The Second European-American Intensive Course in Clinical and Forensic Genetics / Primorac, Dragan (ur.). Zagreb, 2001. str. 125-125-x
Petković, Iskra ; Barišić, Ingeborg ; Bago, Ružica ; Hećimović, Silva | Paternal origin of der(X)t(X ; 6) in a girl with trisomy 6p // European Human Genetics Conference 2002 in conjunction with EMPAG 2002 - European Meeting on Psychosocial Aspects of Genetics 2002. : Abstracts. European Journal of Human Genetics. 10(Suppl 1), 2002. 2002. str. 143-143-x
Gjergja, Romana ; Barišić, Ingeborg ; Hećimović, Silva ; Tanacković, Goranka ; Sertić, Jadranka ; Knežević, Jadranka ; Pavelić, Krešimir | Cystic fibrosis mutations in Croatian patients // The secnond European-American intensive course in clinical and forensic genetics / Primorac, Dragan (ur.). Zagreb: -, 2001. str. 99-99-x
Hećimović, Silva ; Wang, J ; Martinez, M ; Goate, A | Abeta and s3-like cleavage are independent processes within the TM-domain of APP // Society for Neuroscience, Program No. 122.10. Washington (MD), 2002
Brunkan, AL ; martinez, M ; Hećimović, Silva ; Goate, A | Presenilin-1 V96 is important for gamma-secretase activity // Society for Neuroscience. Washington (MD), 2003
Hećimović, Silva ; Wang, J ; Martinez, M ; Goate, A | APP intracellular domain (CTFgamma/AICD) is generated by BACE1-dependent pathway, but is independent of Abeta generation // Society for Neuroscience, program No. 406.14. Washington (MD), 2003
Hećimović, S ; Ory, D ; Goate, A | Cholesterol levels modulate formation of AICD as well as Abeta. 2005
Malnar, Martina ; Goate, Alison ; Hećimović, Silva | Increased formation of Aβ in CHO-NPC1 KO cells is not related to cholesterol levels solely // Book of Abstracts - 2nd Summer Course on Mass Spectrometry in Biotechnology and Medicine / Kirsch, Stephan (ur.). 2007. str. 63-63
Hećimović, Silva ; Omerbašić, Damir ; Posavec, Melanija ; Malnar, Martina ; Košiček, Marko ; Goate, Alison | Cholesterol accumulation upon NPC1 dysfunction alters trafficking of APP/C99 // The 2008 Golgi Meeting. 2008. str. 105-105
Košiček, Marko ; Goate, Alison ; Hećimović, Silva | The role of lipid rafts on app processing in NPC1-null cells // Workshop Adenoviruses Basic to Gene Therapy : programme and abstracts / Majhen, Dragomira ; Ambriović Ristov, Andreja (ur.). Zagreb: Hrvatsko mikrobiološko društvo, 2008. str. 18-18
Posavec, Melanija ; Krolo, Ana ; Omerbašić, Damir ; Lisica, Ana ; Malnar, Martina ; Košiček, Marko ; Hećimović, Silva | Cholesterol accumulation upon NPC1 dysfunction alters endosomal compartmentalization of β-amyloid precursor protein // EMBO Young Scientists Forum 2009. 2009
Krolo, Ana ; Lisica, Ana ; Malnar, Martina ; Košiček, Marko ; Hećimović, Silva | Accumulation of cholesterol in Niemann Pick type C cells alters APP distribution within endosome compartments // FEBS Advanced Course: Lipid signaling and disease 2009. 2009
Malnar, Martina ; Košiček, Marko ; Hećimovicć, Silva | Cholesterol accumulation upon NPC1 dysfunction alters APP expression at the cell surface leading to its increased processing through the β-secretase pathway // FEBS Advanced Course: Lipid signaling and disease 2009. 2009
Malnar, Martina ; Košiček, Marko ; Goate, Alison ; Hećimović Silva | Cholesterol effect on formation of amyloid-b peptide upon NPC1 dysfunction // Workshop Adenoviruses Basic to Gene Therapy : programme and abstracts / Majhen, Dragomira ; Ambriović Ristov, Andreja (ur.). Zagreb: Hrvatsko mikrobiološko društvo, 2008. str. 29-29
Košiček, Marko ; Bindila, Laura ; Peter-Katalinić, Jasna ; Hećimović, Silva | Cerebrospinal fluid lipidomics in Alzheimer's disease // FEBS/IUBMB workshop : Eukaryotic lipids : Treasure of Regulatory Information : Abstracts. 2010
von Arnim, Christine ; von Einem, Bjorn ; Weber, Petra ; Wagner, Michael ; Malnar, Martina ; Košiček, Marko ; Hećimović, Silva ; Schneckenburger, Herbert | Protein Proximity of APP and BACE1 and Membrane Stiffness Is Altered in Different Membranes in Niemann-Pick Type C Disease Cells. 2013
Hećimović, Silva ; Košiček, Marko ; Malnar, Martina | Cholesterol Levels Modulate Endosomal Localization of BACE1. 2013
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Dominko, Kristina ; Malnar, Martina ; Đikić, Domagoj ; Hećimović, Silva | Cholesterol-mediated oxidative stress in Niemann-Pick type C disease involves a defect in the activity of superoxide dismutase // Book of abstracs Congress of the Croatian Society of Biochemistry and Molecular Biology - HDBMB2014 / KatalinićM., Kovarik Z (ur.). Zadar: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2014. str. 87-87
hdbmb2014.imi.hrhdbmb2014.imi.hr Košiček, Marko ; Jović, Tanja ; Hećimović, Silva | Isolation and characterization of lysosomes in NPC model cells // FEBS Advanced lecture Course ; 360o Lysosome: from structure to genomics, from function to disease / Zihni Onur Uygun (ur.). Izmir: Ege University, 2014. str. 80-80
Dominko, Kristina ; Katušić Hećimović, Silva | Retromer (dys)function in Niemann-Pick type C disease models // The 6. Croatian Neuroscience Congress with international participation. 2017. str. 77-77
Rastija, Ana ; Meglaj, Sarah ; Tahirovic, Sabina ; Lichtenthaler, Stefan F. ; Hecimovic, Silva | Enhanced proteolysis by the Alzheimer's protease BACE1 in NPC1 mouse brains is due to sequestration of its substrates within early endosomes. 2021. str. 157-157
Rastija, Ana ; Vidatić, Lea ; Tahirović, Sabina ; Lichtenthaler, Stefan F. ; Hećimović, Silva | Cleavage by BACE1 is upregulated in murine primary neurons of a rare neurodegenerative disorder Niemann-Pick type C // Abstracts of papers presented at the 2020 meeting on neurodegenerative diseases : biology & therapeutics. Lahti: Cold Spring Harbor Laboratory (CSHL), 2020. str. 266-266
Vidatic, Lea ; Zovko, Ana ; Lasic, Domagoj ; Tipuric, Sandra ; Rastija, Ana ; Hecimovic, Silva | Aged mice carriers of a recessive neurodegenerative disorder Niemann-Pick type C show tau hyperphosphorylation, endolysosomal dysfunction and neuroinflammation // Abstracts of papers presented at the 2020 meeting on neurodegenerative diseases : biology & therapeutics. Lahti: Cold Spring Harbor Laboratory (CSHL), 2020. str. 322-322
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Hećimović, Silva | The links between Alzheimer's disease and Niemann-Pick type C disease // Abstracts of papers presented at the 2020 virtual meeting on Neurodegenerative Diseases: Biology & Therapeutics. Lahti: Cold Spring Harbor Laboratory (CSHL), 2020. str. 154-154
meetings.cshl.edu -
Katušić Hećimović, Silva | Deciphering molecular links between Alzheimer’s disease and Niemann-Pick type C disease // Joint ICGEB – ALS Society of Canada Symposium on Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder : Abstract Book. Department of Biotechnology, University of Rijeka, 2022. str. 25-25
www.icgeb.orgwww.optineurin-neuroimmunology.uniri.hr
Izvorni znanstveni rad
Hećimović, Silva | Fragile X syndrome – from genotype to phenotype // Suvremene spoznje u dijagnostici i liječenju genetičkih bolesti - mentalna retardacija i razvojno zaostajanje. 2007
Publikacije - prilozi sa skupa (u časopisu)
Sažetak izlaganja sa skupa
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Walker, E. ; Hećimović, Silva ; Goate, A. | Processing and activity of two naturally occuring splice variants of presenilin 2 // Neurobiology of aging. 2002. str. S216-S217
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Hećimović, Silva ; Wang, J. ; Dolios, C. ; Martinez, M. ; Wang, R. ; Goate, A. | Mutagenesis of APP reveals no correlation between Abeta and AICD production // Neurobiology of aging / Coleman, Paul D (ur.). 2004. str. S552-S552
www.sciencedirect.com Bošnjak, Jelena ; Jurašić, Miljenka Jelena ; Hećimović, Silva ; Miškov, Snježana ; Čović-Negovetić, Ružica ; Demarin, Vida | Outcome of patients with epileptic seizures as the first symptom of acute stroke // European journal of neurology / Lenzi, G.L. ; Schoenen, J. (ur.). 2007
Malnar, Martina ; Košiček, Marko ; Goate, Alison ; Hećimović, Silva | Increased Abeta Formation In CHO NPC1-null Cells Is Not Directly Related To Cholesterol Levels // Alzheimer's & Dementia. 2008. str. T349-T349
Košiček, Marko ; Goate, Alison ; Hećimović, Silva | Increased Formation Of Amyloid-beta Peptide In CHO NPC1-null Cells Does Not Involve Lipid Rafts // Alzheimer's & Dementia. 2008. str. T350-T350
Posavec, Melanija ; Omerbašić, Damir ; Goate, Alison ; Hećimović, Silva | Subcellular Distribution Of APP/C99 And Amyloid-beta Peptide Is Altered In CHO NPC1-null Cells Compared To CHOwt // Alzheimer's & Dementia. 2008. str. T353-T353
Malnar, Martina ; Košiček, Marko ; Goate, Alison ; Hećimović, Silva | The cholesterol-effect on amyloid-β formation upon NCP1 dysfunction involves altered APP localization // Neurologia Croatica. Supplement. 2008. str. 71-71
Hećimović, Silva ; Malnar, Martina ; Košiček, Marko ; Petek Tarnik, Iva ; Trkanjec, Zlatko ; Titlić, Marina ; Demarin, Vida ; Goate, Alison | Amyloid-β : from molecular biology to clinical practice // Neurologia Croatica. Supplement. 2008. str. 16-17
Košiček, Marko ; Goate, Alison ; Katušić Hećimović, Silva | The role of lipid rafts on app processing and Amyloid-β formation // Neurologia Croatica. Supplement. 2008. str. 70-70
Hećimović, Silva ; Malnar, Martina ; Košiček, Marko ; Čulić, Vida ; Lozić, Bernarda ; Barišić, Ingeborg | The fragile X syndrome : a Croatian perspective // Paediatria Croatica. Supplement. 2009. str. 56-56
Malnar, Martina ; Petek Tarnik, Iva ; Košiček, Marko ; Pavelin, Sanda ; Titlić, Marina ; Trkanjec, Zlatko ; Demarin, Vida ; Hećimović, Silva | Cerebrospinal fluid biomarker analysis in Alzheimer's disease : a pilot study in Croatia // Paediatria Croatica. Supplement. 2009. str. 69-69
Canki-Klain, Nina ; Lessel, Davor ; Šikić, Nada ; Hećimović, Silva ; Votava-Raić, Ana ; Radoš, Marko | Speech and Language Delay as Early Manifestations of Juvenile Huntington's Disease // Neurologia Croatica. 2007. str. 97-98
Hećimović, Silva ; Bene, H ; Pavelin, Sanda ; Titlić, Marina ; Trkanjec, Zlatko ; Demarin, vida | Cerebrospinal fluid biomarker analysis in Alzheimers disease // Neurologia Croatica. Supplement / Sanja Hajnšek, Damir Petravić, Željka Petelin Gadže (ur.). 2009. str. 67-67
Hećimović, Silva ; Bene, Raphael ; Pavelin, Sanda ; Titlić, Marina ; Trkanjec, Zlatko ; Demarin, Vida | Cerebrospinal fluid biomarker analysis in Alzheimer's disease // Neurologia Croatica. Supplement / Hajnšek, Sanja ; Petravić, Damir ; Petelin Gadže, Željka (ur.). 2009. str. 67-67
Košiček, Marko ; Hećimović, Silva | Cholesterol accumulation in NPC fibroblasts leads to lipid raft comartmentalization of APP and C99 // Alzheimer's & Dementia. 2009. str. 225-225
Lisica, Ana ; Krolo, Ana ; Malnar, Martina ; Košiček, Marko ; Hećimović, Silva | Loss of NPC1 leads to decreased expression of APP at the cell surface and alters APP distribution within endosome compartments // Alzheimer's & Dementia. 2009. str. 301-301
Malnar, Martina ; Steiner, Harald ; Lammich, Sven ; Hećimović, Silva | Gamma-Secretase Substrates APP, Notch1 and CD44 Show Distinct Processing in NPC Cells // Alzheimer's & Dementia. 2009. str. 223-223
Hećimović, Silva ; Bago, Ružica ; Mužinić, Dubravka ; Begović, Davor ; Pavelić, Krešimir | The first case of FRAXE mental retardation in Croatia // European journal of human genetics. 2001. str. 178-178
Gjergja, R. ; Barišić, Ingeborg ; Hećimović, Silva ; Tanacković, Goranka ; Sertić, Jandranka ; Knežević, Jelena ; Milić, Astrid ; Pavelić, Krešimir | Genotype-phenotype correlaton in Croatian Cystic Fibrosis Patients // European journal of human genetics. 2001. str. 205-205
Bago, Ružica ; Hećimović, Silva ; Barišić, Ingeborg ; Ćulić, Vida ; Pavelić, Krešimir | Different distribution of DXS548 and FRAXAC1 haplotypes between normal and fragile X populaton in Croatia // European journal of human genetics. 2001. str. 284-284
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Walker, Emily S. ; Martinez, Maribel ; Brunkan, Anne ; Hećimović, Silva ; Wang, Jun ; Goate, Alison | Presenilin 2 familial Alzheimer's disease mutations decrease A beta and CTF gamma while differentially affecting NICD production // Neurobiology of aging. 2004. str. S563-S563
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Malnar, Martina ; Lisica, Ana ; Hećimović, Silva | Lipid traffic jam in Niemann Pick type C disease causes altered endocytosis of APP // Alzheimer's & Dementia. 2011. str. 390-390
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Kosicek, Marko ; Hecimovic, Silva ; Kirsch, Stephan ; Bene, Raphael ; Trkanjec, Zlatko ; Titlic, Marina ; Bindila, Laura ; Peter-Katalinic, Jasna | Sphingomyelin is elevated in cerebrospinal fluid of Alzheimer's disease patients // Alzheimer's & Dementia. 2011. str. 140-140
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Štefulj, Jasminka ; Malnar, Martina ; Schweinzer, Cornelia ; Košiček, Marko ; Živković, Jelena ; Panzenboeck, Ute ; Hećimović Katušić, Silva | The impacts of LXR ligand TO901317 on amyloid-β levels and cholesterol metabolism in Niemann-Pick type C (NPC) model cells // Alzheimer's & Dementia. 2011. str. e72-e72 doi: 10.1016/j.jalz.2011.09.157
doiwww.alzheimersanddementia.comdoi.org Cermak, Stjepko ; Causevic, Mirsada ; Kuhn, Peer-Hendrik ; Gunnersen, Jenny ; Hutter-Paier, Birgit ; Windisch, Manfred ; Lichtenthaler, Stefan ; Hecimovic, Silva | Altered metabolism of BACE1 substrates seizure protein 6 and seizure 6-like protein 1 in Niemann-Pick type C disease // Alzheimer's & Dementia / Schneider, Lon S. (ur.). 2014. str. P877-P878
Izvorni znanstveni rad
Canki-Klain, Nina ; Miličić, Davor ; Hećimović, Silva ; Tanačković, Goranka ; Récan, Dominique ; Llense, Stephane ; Barbot, Jean-Claude ; Leturcq, F. ; Kaplan, Jean-Claude ; Šoštarko, Marija et al. | DNA analysis : contribution to diagnosis in advanced stages of DMD/BMD // Acta myologica. 2000. str. 120-x
Bago, Ružica ; Hećimović, Silva ; Barišić, Ingeborg ; Pavelić, Jasminka | Dijagnostika sindroma fragilnog X kromosoma metodama molekularne medicine // Paediatria Croatica. Supplement. 2004. str. 24-x
Bauer, Vladimir ; Mitrović, Zoran ; Sertić, Jadranka ; Canki-Klain, Nina ; Hećimović, Silva ; Jurenić, Dubravka ; Vranješ, Davorka ; Žagar, Marija ; Šoštarko, Marija | Klničke osobitosti miotonične distrofije (DM1) // Neurologia Croatica. Supplement. 2004. str. 114-115-x
Publikacije - prilozi sa skupa (neobjavljeni)
Neobjavljeni prilog sa skupa
Hećimović, Silva | Molecular biomarkers of dementias - the rode to early diagnosis // V. znanstveni skup o poremećajima mozga - Kognitivni poremećaji u neurologiji | Zagreb, Hrvatska, 16.03.2007-16.03.2007
Košiček, Marko ; Goate, Alison ; Hećimović, Silva | The role of lipid rafts on app processing and amyloid-beta formation // Summer Course on Mass Spectrometry in Biotechnology and Medicine (3 ; 2009) | Dubrovnik, Hrvatska, 05.07.2009-11.07.2009
Hecimovic, Silva | Endocytic traffic jam in Niemann Pick type C disease - a cause of increased Alzheimer's amyloid-β formation // Gordon Research Conference - Lysosomal Diseases | Galveston (TX), Sjedinjene Američke Države, 23.01.2011-28.01.2011
Malnar, Martina ; Košiček, Marko ; Tahirović, Sabina ; Katušić Hećimović, Silva | Cholesterol levels modulate trafficking of APP and BACE1 in Niemann-Pick type C cells // Gordon Research Seminar: Lysosomal diseases | Barga, Italija, 13.04.2013-14.04.2013
Malnar, Martina ; Košiček, Marko ; Tahirović, Sabina ; Katušić Hećimović Silva | Cholesterol levels modulate trafficking of APP and BACE1 in Niemann-Pick type C cells // Gordon Research Conference: Lysosomal Diseases | Barga, Italija, 14.04.2013-18.04.2013
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Malnar, Martina ; Košiček, Marko ; Mitterreiter, Stefan ; Lichtenthaler, Stefan F. ; Hećimović, Silva. | Cholesterol accumulation in Niemann-Pick type C cells favors APP processing by β-secretase and causes altered endocytic trafficking of BACE1 // Kloster Seeon meeting on BACE proteases in health and disease | Seeon-Seebruck, Njemačka, 06.10.2013-08.10.2013
www.dzne.de Katušić Hećimović, Silva | The molecular links between lysosomal storage diseases and Alzheimer’s disease // Workshop New Developments of Lysosomal storage disease diagnostics & therapeutics: LSD Protein – aggregation & interactions | Konstanz, Njemačka, 14.03.2012-16.03.2012
Katušić Hećimović, Silva | Endocytic traffick jam in Niemann Pick type C disease – a cause of increased Alzheimer’s amyloid-β peptide formation // Gordon Research Conference - Lysosomal Diseases | Galveston (TX), Sjedinjene Američke Države, 23.01.2011-28.01.2011
Katušić Hećimović, Silva | The Role of APP in Cholesterol Metabolism: A link between Niemann-Pick type C Disease and Alzheimer's Disease // Workshop MSLife: High Performance Mass Spectrometry: Integration new tools and methods with Applications in Life Sciences | Konstanz, Njemačka, 26.08.2013-28.08.2013
Katušić Hećimović, Silva ; Malnar, Martina ; Košiček, Marko | Niemann-Pick type C disease – a model to study the role of cholesterol in the pathogenesis of Alzheimer's disease // The 19th European Study Group on Lysosomal Diseases (ESGLD | Graz, Austrija, 26.09.2013-29.09.2013
Katušić Hećimović, Silva | The molecular mechanism(s) of increased amyloid-beta in Niemann Pick type C disease // Neurochem Laboratory Seminar, Sahlgren University Hospital | Göteborg, Švedska, 18.03.2011-18.03.2011
Katušić Hećimović, Silva | The link between NP-C and Alzheimer’s disease // Pharmaceuticals Ltd. Joint International Advisory Board Meeting on Niemann-Pick Type C | Zürich, Švicarska, 10.05.2012-10.05.2012
Katušić Hećimović, Silva | The link between lipids and Alzheimer’s disease: a view from Niemann Pick type C disease // JSW Life Science Seminar | Grambach, Austrija, 18.11.2010-18.11.2010
Katušić Hećimović, Silva | Lipid Profiling and its Role in the Pathogenesis of Alzheimer’s Disease // Workshop Bioaffinity – Mass Spectrometry: New Developments and Applications in Life Sciences | Konstanz, Njemačka, 04.12.2011-05.12.2011
Katušić Hećimović, Silva | Molecular mechanism(s) of increased Aß upon cholesterol accumulation in Niemann-Pick type C disease // German Center for Neurodegenerative Diseases Munich - Seminar | München, Njemačka, 10.06.2011-10.06.2011
Vidatić, Lea ; Dominko, Kristina ; Rastija, Ana ; Pigoni, Martina ; Colombo, Alessio, Gunnersen, Jenny M. ; Tahirović, Sabina ; Lichtenthaler, Stefan F. ; Hećimović, Silva | Subcellular localization of BACE1 substrates SEZ6 and SEZ6L is altered in primary neurons of Niemann-Pick type C murine model // The 14th International Conference on Alzheimer's & Parkinson's Diseases | Lisabon, Portugal, 26.03.2019-31.03.2019
Vidatić, Lea ; Lichtenthaler, Stefan F. ; Tahirović, Sabina ; Hećimović, Silva | BACE1 inhibition ameliorates neuroinflammation in organotypic brain slices of Niemann-Pick type C disease murine model // ESGLD Virtual Summer Meeting | Ujedinjeno Kraljevstvo, 28.06.2021-30.06.2021
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Vidatić, Lea ; Tipurić, Sandra ; Zovko, Ana ; Rastija, Ana ; Hecimović, Silva | Tauopathy in Niemann-Pick type C disease carriers: analysis in a mouse model // 45th FEBS Congress: Molecules of Life: Towards New Horizons (FEBS 2021) | Ljubljana, Slovenija, 03.07.2021-08.07.2021
2021.febscongress.org Dominko, Kristina ; Vidatić, Lea ; Tahirović, Sabina ; Hećimović, Silva | Retromer dysfunction in a rare neurodegenerative disorder Niemann-Pick type C // The 14th International Conference on Alzheimer's & Parkinson's Diseases | Lisabon, Portugal, 26.03.2019-31.03.2019
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Hecimovic, Silva ; Dominko, Kristina ; Rastija, Ana ; Meglaj, Sarah ; Vidatić, Lea ; Babić, Andrea ; Colombo, Alessio ; Tahirovic, Sabina ; Hecimovic, Silva | Retromer function is impaired in Niemann-Pick type C disease and is dependent on intracellular cholesterol accumulation // New Horizons in Alzheimer's Disease (Hybrid edition) | Leuven, Belgija, 27.10.2021-28.10.2021
www.vibconferences.be Hecimovic, Silva ; Dominko, Kristina ; Vidatic, Lea ; Rastija, Ana | Dysfunction of the endolysosomal pathway is a common feature of neurodegenerative diseases // FEBS Advanced Course - Molecular targets for anti-aging interventions | Spétses, Grčka, 26.09.2022-01.10.2022
Publikacije - ocjenski radovi
Doktorska disertacija
Hećimović, Silva | Razvoj metode za brzo otkrivanje dinamičnih mutacija u sindromu fragilnog X / Pavelić, Krešimir (mentor); | Zagreb, Prehrambeno-biotehnološki fakultet, . 2000
Petek Tarnik, Iva | Utjecaj polimorfizma ApoE i vaskularnih čimbenika rizika na nastanak Alzheimerove bolesti / Katušić Hećimović, Silva (mentor); Katušić Hećimović, Silva (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2010
Malnar, Martina | Mehanizam djelovanja kolesterola na cijepanje i transport proteina APP / Katušić Hećimović, Silva (mentor); | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2012
Košiček, Marko | The role of lipids in the pathogenesis of Alzheimer's disease - from molecular mechanisms to disease biomarkers / Katušić Hećimović, Silva (mentor); | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2013
Čermak, Stjepko | Uloga poremećaja funkcije lizosoma u metabolizmu prekursora amiloid-beta peptida i homeostazi kolesterola u staničnim i mišjim modelima Niemann-Pickove bolesti tipa C / Katušić Hećimović, Silva (mentor); | Zagreb, Veterinarski fakultet, Zagreb, . 2016
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Dominko, Kristina | Utjecaj unutarstaničnoga kolesterola i C-terminalnoga odsječka proteina prekursora amiloida β na funkciju retromera u modelima Alzheimerove bolesti / Jovanov Milošević, Nataša ; Katušić Hećimović, Silva (mentor); | Zagreb, Medicinski fakultet u Zagrebu, . 2020
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Rastija, Ana | Ispitivanje uloge proteaze BACE1 u patogenezi rijetke nasljedne neurodegenerativne Niemann- Pickove bolesti tipa C / Katušić Hećimović, Silva ; (mentor); | Rijeka, Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova, . 2023
urn.nsk.hrfulir.irb.hr
Diplomski rad
Košiček, Marko | Utjecaj lipidnih splavi i kolesterola na metabolizam proteina APP / Weygand-Đurašević, Ivana (mentor); Hećimović, Silva (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2007
Đokić, Helena | Sindrom fragilnog X kromosoma: analiza haplotipa i nestabilnosti slijeda tripleta CGG u genu FMR1 / Weygand-Đurašević, Ivana (mentor); Hećimović, Silva (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2006
Omerbašić, Damir | Utjecaj kolesterola na smještaj i metabolizam prekursora proteina amiloid-beta (APP) u bolestima nakupljanja lipida / Katušić Hećimović, Silva (mentor); Katušić Hećimović, Silva (neposredni voditelj). | Zagreb, Hrvatska, Prirodoslovno-matematički fakultet, Zagreb, . 2008
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Posavec, Melanija | Metabolizam proteina APP u lizsomskim bolestima nakupljanja / Katušić Hećimović, Silva (mentor); Katušić Hećimović, Silva (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2009
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Lisica, Ana | Prijenos proteina APP u organelima endocitoznog puta u stanicama CHO NPC1-null / Katušić Hećimović, Silva (mentor); Hranilović, Dubravka (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2009
zir.nsk.hr Krolo, Ana | Smještaj proteina APP u organelima endocitoznog puta u stanicama CHO NPC1-null / Katušić Hećimović, Silva (mentor); Hranilović, Dubravka (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2009
Kular, Dolores | Utjecaj nakupljanja kolesterola na metabolizam proteina APLP1 i APLP2 u stanicama CHO NPC1-null / Silva Katušić Hećimović (mentor); Marko Košiček (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2011
Njavro, Jasenka | Utjecaj nakupljanja kolesterola u stanicama CHO NPC1-/- na smještaj proteina BACE1 u organelima endocitoznog puta / Silva Katušić Hećimović (mentor); Marko Košiček ; Martina Malnar (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2011
Ćosić, Ivana | Mehanizmi cijepanja kompleksa gama-sekretaze / Silva Katušić Hećimović (mentor); Martina Malnar (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2010
Silvestrić, Ana | The analysis of presenilin cellular localization in Niemann-Pick type C cells / Zabucchi, Giuliano (mentor); Katušić Hećimović, Silva (neposredni voditelj). | Trieste, . 2014
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Dominko, Kristina | Međudjelovanje kolesterola i antioksidativnog sustava / Đikić, Domagoj (mentor); Domagoj Đikić, Katušić Hećimović, Silva (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2014
urn.nsk.hr Jović, Tanja | Izolacija i karakterizacija lizosoma u stanicama CHOwt i CHO NPC1-null / Lauc, Gordan (mentor); Katušić Hećimović, Silva (neposredni voditelj). | Zagreb, Farmaceutsko-biokemijski fakultet, . 2014
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Meglaj, Sarah | Analiza supstrata enzima BACE1 u endosomalnim frakcijama moždanih regija miševa NPC1-/- i divljeg tipa miša (NCP1+/+) / Katušić Hećimović, Silva ; Erhardt, Julija (mentor); Rastija, Ana (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2021
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Zovko, Ana | Patološke značajke u mozgu miševa nositelja bolesti Niemann-Pick tipa C / Katušić Hećimović, Silva ; Blažević, Sofia Ana (mentor); Vidatić, Lea (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2021
urn.nsk.hr Babić, Andrea | Karakterizacija disfunkcije retromernog kompleksa u staničnom modelu bolesti Niemann-Pick tip C / Katušić Hećimović, Silva ; Hranilović, Dubravka (mentor); Vidatić, Lea (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2020
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Martinović, Lovro | Otkrivanje ranih neuropatoloških promjena u miševa prenositelja bolesti Niemann-Pick tipa C / Katušić Hećimović , Silva ; Erhardt , Julija (mentor); Vidatić, Lea (neposredni voditelj). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2023
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Publikacije - druge vrste radova
Ostalo
Alfirević, Žarko ; Barić, Ivo ; Barišić, Ingeborg ; Barišić, Nina ; Begović, Davor ; Boranić, Milivoj ; Crkvenac-Gornik, Kristina ; Čačev, Tamara ; Čuković-Čavka, Silvija ; Čečuk-Jeličić, Esma et al. | Racionalna dijagnostika nasljednih i prirođenih bolesti / Barić, Ivo ; Stavljenić-Rukavina Ana (ur.). Zagreb: Medicinska naklada, 2005. 192..
Članstva u profesionalnim udrugama / društvima
- Hrvatsko društvo za biokemiju i molekularnu biologiju
- Hrvatsko društvo za Alzheimerovu bolest
- Hrvatsko društvo za humanu genetiku
- Hrvatsko društvo za kliničku genetiku
- 2009-2016 Voditelj Laboratorija za molekularnu neurofarmakologiju, Zavod za molekularnu medicinu, Institut “Ruđer Bošković”, Zagreb
- 2016 - Voditelj Laboratorija za istraživanje neurodegenerativnih bolesti, Zavod za molekularnu medicinu, Institut “Ruđer Bošković”, Zagreb