26.05.2020. habilitirala na Sveučilištu u Lübecku, u Njemačkoj i obranila habilitacijsku disertaciju pod naslovom "Unravelling mechanisms of cell survival - the importance of DNA repair - from bacteria to human cells" 

2009. obranila doktorsku disertaciju pod naslovom "Uloga produkata rekombinacijskih gena u stvaranju signala za indukciju SOS odgovora u bakteriji Escherichia coli", Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu

2004 - 2009. poslijediplomski studij iz molekularne i stanične biologije, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu

1996 - 2003. studij biotehnologije, Prehrambeno-biotehnološki fakultet, Sveučilište u Zagrebu 

Usavršavanja i rad u inozemstvu:

2016-2019. znanstvenik-istraživač, Institut für Pathologie, Universitätsklinikum Schleswig-Holstein (UKSH), Lübeck, Njemačka

2013-2016. znanstvenik-istraživač, Uniklinik Köln/CECAD, Köln, Njemačka

2012-2013. gostujući znanstvenik, Deutsches Zentrum für Luft- und Raumfahrt (DLR), Köln, Njemačka

2011. suradnik na NATO projektu, Deutsches Zentrum für Luft- und Raumfahrt (DLR), Köln, Njemačka

2003. IAESTE praktikant, Institute of Pharmaceutical Science, King's College London, University of London, London, Velika Britanija

2018-2019. "The role of CDK8 and CDK19 Mediator complex subunits in progression and metastasis of lung adenocarcinoma", Sveučilište u Lübecku, glavni istraživač

Dobitnica nagrade "Željko Trgovčević" za 2011. godinu

14.07.2022. naslovno zvanje docent na poslijediplomskom interdisciplinarnom sveučilišnom studiju Molekularne bioznanosti Sveučilišta Josipa Jurja Strossmayera u Osijeku u suradnji sa Sveučilištom u Dubrovniku i IRB

Ak. god. 2005 / 2006: sudjelovala u nastavi na Prirodoslovno-matematičkom fakultetu Sveučilišta u Zagrebu pri Biološkom odsjeku na kolegiju "Molekularna genetika"

Ak. god. 2003 / 2004: sudjelovala u nastavi na Prehrambeno-biotehnološkom fakultetu Sveučilišta u Zagrebu pri Zavodu za kemiju i biokemiju na kolegiju "Analitička kemija"

Horvat A*, Tadijan A*, Vlašić I*, Slade N. p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies. Cancers (Basel). 2021; 13(12):2885. 

Sadžak A*, Vlašić I*, Kiralj Z, Batarelo M, Oršolić N, Jazvinšćak Jembrek M, Kušen I, Šegota S. Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. Molecules. 2021;26(4):845. 

Tadijan A, Precazzini F, Hanžić N, Radić M, Gavioli N, Vlašić I, Ozretić P, Pinto L, Škreblin L, Barban G, Slade N, Ciribilli Y. Altered Expression of Shorter p53 Family Isoforms Can Impact Melanoma Aggressiveness. Cancers (Basel). 2021;13(20):5231. 

Kirfel J, Kümpers CC, Fähnrich A, Heidel C, Jokic M, Vlasic I, Marwitz S, Goldmann T, Pasternack H, Bohnet S, Jonigk D, Kühnel MP, Offermann A, Busch H, Perner S. PD-L1 Dependent Immunogenic Landscape in Hot Lung Adenocarcinomas Identified by Transcriptome Analysis. Cancers (Basel). 2021;13(18):4562.

Meder L, Schuldt P, Thelen M, Schmitt A, Dietlein F, Klein S, Borchmann S, Wennhold K, Vlasic I, Oberbeck S, Riedel R, Florin A, Golfmann K, Schlößer HA, Odenthal M, Buettner R, Wolf J, Hallek M, Herling M, von Bergwelt-Baildon M, Reinhardt HC, Ullrich RT. Combined VEGF and PD-L1 Blockade Displays Synergistic Treatment Effects in an Autochthonous Mouse Model of Small Cell Lung Cancer. Cancer Res. 2018; 78(15):4270-4281.

Offermann A*, Vlasic I*, Syring I, Vogel W, Ruiz C, Zellweger T, Rentsch CA, Hagedorn S, Behrends J, Nowak M, Merseburger A, Bubendorf L, Kirfel J, Duensing S, Shaikhibrahim Z, Perner S. MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling. Oncotarget. 2017; 8(5):7964-7976.

Brägelmann J, Klümper N, Offermann A, von Mässenhausen A, Böhm D, Deng M, Queisser A, Sanders C, Syring I, Merseburger AS, Vogel W, Sievers E, Vlasic I, Carlsson J, Andrén O, Brossart P, Duensing S, Svensson MA, Shaikhibrahim Z, Kirfel J, Perner S. Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer. Clin Cancer Res. 2017; 23(7):1829-1840. 

Jokić M*, Vlašić I*, Rinneburger M*, Klümper N, Spiro J, Vogel W, Offermann A, Kümpers C, Fritz C, Schmitt A, Riabinska A, Wittersheim M, Michels S, Ozretić L, Florin A, Welcker D, Akyuz MD, Nowak M, Erkel M, Wolf J, Büttner R, Schumacher B, Thomale J, Persigehl T, Maintz D, Perner S, Reinhardt HC. Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner. Mol Cancer Res. 2016; 14(11):1110-1123.

Vlašić I, Mertens R, Seco EM, Carrasco B, Ayora S, Reitz G, Commichau FM, Alonso JC, Moeller R. Bacillus subtilis RecA and its accessory factors, RecF, RecO, RecR and RecX, are required for spore resistance to DNA double-strand break. Nucleic Acids Res. 2014; 42(4):2295-2307. 

George J, Lim JS, Jang SJ, Cun Y, Ozretić L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park K, Yang D, Karnezis A, Vaka D, Torres A, Wang M S, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer B, Bos M, Michels S, Vlašić I,  Seidel D, Pinther B, Schaub P, Becker C, Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vélez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansén S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK. Comprehensive genomic profiles of small cell lung cancer. Nature. 2015; 524(7563): 47-53.

Radovi u časopisima

Znanstveni i pregledni radovi

• Vlašić, I., Horvat, A., Tadijan, A. & Slade, N. (2023) p53 Family in Resistance to Targeted Therapy of Melanoma. International Journal of Molecular Sciences, 24 (1), 1-16 doi:10.3390/ijms24010065.

  doi

• Tadijan, A., Vlašić, I., Vlainić, J., Đikić, D., Oršolić, N. & Jazvinšćak Jembrek, M. (2022) Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions. Antioxidants, 11 (10), 2049, 36 doi:10.3390/antiox11102049.

  doiwww.mdpi.com

• Radić, M., Vlašić, I., Jazvinšćak Jembrek, M., Horvat, A., Tadijan, A., Sabol, M., Dužević, M., Herak Bosnar, M. & Slade, N. (2022) Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance. International journal of molecular sciences, 23 (17), 9910, 19 doi:10.3390/ijms23179910.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Kirfel, J., Charlotte Kümpers, C., Fähnrich, A., Heidel, C., Jokić, M., Vlašić, I., Marwitz, S., Goldmann, T., Pasternack, H., Bohnet, S., Jonigk, D., Kühnel, M., Offermann, A., Busch, H. & Perner, S. (2021) PD-L1 Dependent Immunogenic Landscape in Hot Lung Adenocarcinomas Identified by Transcriptome Analysis. Cancers, 13 (18), 4562, 16 doi:10.3390/cancers13184562.

  doifulir.irb.hrwww.mdpi.com

• Tadijan, A., Precazzini, F., Hanžić, N., Radić, M., Gavioli, N., Vlašić, I., Ozretić, P., Pinto, L., Škreblin, L., Barban, G., Slade, N. & Ciribilli, Y. (2021) Altered Expression of Shorter p53 Family Isoforms Can Impact Melanoma Aggressiveness. Cancers, 13 (20), 5231, 25 doi:10.3390/cancers13205231.

  doiwww.mdpi.comfulir.irb.hr

• Horvat, A., Tadijan, A., Vlašić, I. & Slade, N. (2021) p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies. Cancers, 13 (12), 2885, 42 doi:10.3390/cancers13122885.

  doiwww.mdpi.comwww.ncbi.nlm.nih.govfulir.irb.hr

• Sadžak, A., Vlašić, I., Kiralj, Z., Batarelo, M., Oršolić, N., Jazvinšćak Jembrek, M., Kušen, I. & Šegota, S. (2021) Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper. Molecules, 26 (4), 845, 28 doi:10.3390/molecules26040845.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Meder, L., Schuldt, P., Thelen, M., Schmitt, A., Dietlein, F., Klein, S., Borchmann, S., Wennhold, K., Vlasic, I., Oberbeck, S., Riedel, R., Florin, A., Golfmann, K., Schlößer, H., Odenthal, M., Buettner, R., Wolf, J., Hallek, M., Herling, M., Bergwelt-Baildon, M., Reinhardt, H. & Ullrich, T. (2018) Combined VEGF and PD-L1 Blockade Displays Synergistic Treatment Effects in an Autochthonous Mouse Model of Small Cell Lung Cancer. Cancer research (Baltimore), 78 (15), 4270-4281.

• Offermann, A., Vlašić, I., Syring, I., Vogel, W., Ruiz, C., Zellweger, T., Rentsch, C., Hagedorn, S., Behrends, J., Nowak, M., Merseburger, A., Bubendorf, L., Kirfel, J., Duensing, S., Shaikhibrahim, Z. & Perner, S. (2017) MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling. Oncotarget, 8 (5), 7964-7976 doi:10.18632/oncotarget.13860.

  doi

• Brägelmann, J., Klümper, N., Offermann, A., von Mässenhausen, A., Böhm, D., Deng, M., Queisser, A., Sanders, C., Syring, I., S Merseburger, A., Vogel, W., Sievers, E., Vlašić, I., Carlsson, J., Andrén, O., Brossart, P., Duensing, S., A Svensson, M., Shaikhibrahim, Z., Kirfel, J. & Perner, S. (2017) Pan-cancer analysis of the Mediator complex transcriptome identifies CDK19 and CDK8 as therapeutic targets in advanced prostate cancer. Clinical cancer research, 23 (7), 1829-1840 doi:10.1158/1078-0432.CCR-16-0094.

  doi

• Jokić, M., Vlašić, I., Rinneburger, M., Klümper, N., Spiro, J., Vogel, W., Offermann, A., Kümpers, C., Fritz, C., Schmitt, A., Riabinska, A., Wittersheim, M., Michels, S., Ozretić, L., Florin, A., Welcker, D., Akyuz, M., Nowak, M., Erkel, M., Wolf, J., Büttner, R., Schumacher, B., Thomale, J., Persigehl, T., Maintz, D., Perner, S. & Reinhardt, H. (2016) Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a TP53 Context-specific Manner. Molecular cancer research, 14 (11), 1110-1123 doi:10.1158/1541-7786.MCR-16-0094.

  doi

• Šimatović, A., Mitrikeski, P., Vlašić, I., Sopta, M. & Brčić-Kostić, K. (2016) The Walker A motif mutation recA4159 abolishes the SOS response and recombination in a recA730 mutant of Escherichia coli. Research in microbiology, 167 (6), 462-471 doi:10.1016/j.resmic.2016.04.005.

  doi

• George, J., Lim, J., Jang, S., Cun, Y., Ozretić, L., Kong, G., Leenders, F., Lu, X., Fernández-Cuesta, L., Bosco, G., Müller, C., Dahmen, I., Jahchan, N., Park, K., Yang, D., Karnezis, A., Vaka, D., Torres, A., Wang, M., Korbel, J., Menon, R., Chun, S., Kim, D., Wilkerson, M., Hayes, N., Engelmann, D., Pützer, B., Bos, M., Michels, S., Vlašić, I., Seidel, D., Pinther, B., Schaub, P., Becker, C., Altmüller, J., Yokota, J., Kohno, T., Iwakawa, R., Tsuta, K., Noguchi, M., Muley, T., Hoffmann, H., Schnabel, P., Petersen, I., Chen, Y., Soltermann, A., Tischler, V., Choi, C., Kim, Y., Massion, P., Zou, Y., Jovanović, D., Kontić, M., Wright, G., Russell, P., Solomon, B., Koch, I., Lindner, M., Muscarella, L., la Torre, A., Field, J., Jakopović, M., Knežević, J., Castaños-Vélez, E., Roz, L., Pastorino, U., Brustugun, O., Lund-Iversen, M., Thunnissen, E., Köhler, J., Schuler, M., Botling, J., Sandelin, M., Sanchez-Cespedes, M., Salvesen, H., Achter, V., Lang, U., Bogus, M., Schneider, P., Zander, T. & Ansén, S. (2015) Comprehensive genomic profiles of small cell lung cancer. Nature, 524 (7563), 47-53 doi:10.1038/nature14664.

  doi

• Vlašić, I., Mertens, R., Seco, E., Carrasco, B., Ayora, S., Reitz, G., Commichau, F., Alonso, J. & Moeller, R. (2014) Bacillus subtilis RecA and its accessory factors, RecF, RecO, RecR and RecX, are required for spore resistance to DNA double-strand break. Nucleic acids research, 42 (4), 2295-2307 doi:10.1093/nar/gkt1194.

  doifulir.irb.hr

• Vlašić, I. & Brčić-Kostić, K. (2014) Rescuing a sinking ship: The role of recombination gene products in SOS induction in Escherichia coli. Periodicum biologorum, 116 (2), 159-166.

  hrcak.srce.hrfulir.irb.hr

• Vlašić, I., Šimatović, A. & Brčić-Kostić, K. (2012) The hybrid recombinational repair pathway operates in a χ activity deficient recC1004 mutant of Escherichia coli. Biochimie, 94 (9), 1918-1925 doi:10.1016/j.biochi.2012.05.008.

  doi

• Moeller, R., Vlašić, I., Reitz, G. & Nicholson, W. (2012) Role of altered rpoB alleles in Bacillus subtilis sporulation and spore resistance to heat, hydrogen peroxide, formaldehyde, and glutaraldehyde. Archives of microbiology, 194, 759-767 doi:10.1007/s00203-012-0811-4.

  doi

• Vlašić, I., Šimatović, A. & Brčić-Kostić, K. (2011) Genetic Requirements for High Constitutive SOS Expression in recA730 Mutants of Escherichia coli. Journal of bacteriology, 193 (18), 4643-4651 doi:10.1128/JB.00368-11.

  doi

• Vlašić, I., Šimatović, A. & Brčić-Kostić, K. (2011) The recA730 dependent suppression of recombination deficiency in RecA loading mutants of Escherichia coli. Research in microbiology, 162 (3), 262-269 doi:10.1016/j.resmic.2010.12.001.

  doi

• Vlašić, I., Ivančić-Baće, I., Imešek, M., Mihaljević, B. & Brčić-Kostić, K. (2008) RecJ nuclease is required for SOS induction after introduction of a double-strand break in a RecA loading deficient recB mutant of Escherichia coli. Biochimie, 90 (9), 1347-1355 doi:10.1016/j.biochi.2008.04.002.

  doi

• Ivančić-Baće, I., Vlašić, I., Čogelja-Čajo, G., Brčić-Kostić, K. & Salaj-Šmic, E. (2006) Roles of PriA protein and double-strand DNA break repair functions in UV-induced restriction alleviation in Escherichia coli. Genetics, 174 (4), 2137-2149. (https://www.bib.irb.hr/256890).

• Ivančić-Baće, I., Vlašić, I., Salaj-Šmic, E. & Brčić-Kostić, K. (2006) Genetic Evidence for the Requirement of RecA Loading Activity in SOS Induction after UV Irradiation in Escherichia coli. Journal of Bacteriology, 188 (14), 5024-5032.

• Meyer, P., Prodromou, C., Liao, C., Hu, B., Roe, S., Vaughan, K., Vlašić, I., Panaretou, B., Piper, W. & Pearl, H. (2004) Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO journal, 23, 511-519.

Ocjenski radovi

Doktorske disertacije

• Vlašić, I. (2009) 'Uloga produkata rekombinacijskih gena u stvaranju signala za indukciju SOS odgovora u bakteriji Escherichia coli', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

Članica Hrvatskog društva za istraživanje raka (HDIR, podružnica EACR-a)

Članica Hrvatskog društva za biokemiju i molekularnu biologiju