dr. sc. Ivo Crnolatac
Institut Ruđer Bošković
Bijenička c. 54, Zagreb
Obrazovanje
2003 – 2007 Doktorat, Fakultet farmaceutskih znanosti, Katoličko Sveučilište Leuven, Belgija
2002 – 2003 Magisterij, Fakultet farmaceutskih znanosti, Katoličko Sveučilište Leuven, Belgija
1990 – 1995 Dipl.ing. kemijske tehnologije, Fakultet kemijskog inženjerstva i tehnologije, smjer: Organski tehnološki procesi, Sveučilište u Zagrebu
Istaknute publikacije
1. Purification of Nano-Porous Silicon for Biomedical Applications
Koynov S, Pereira RN, Crnolatac I, Kovalev D, Huygens A, Chirvony V, Stutzmann M, de Witte P
Advanced Engineering Materials 13(6): B225–B233 2011 June.
2. Differential accumulation of hypericin in spheroids composed of T-24 transitional cell carcinoma cells expressing different levels of e-cadherin.
Huygens A, Crnolatac I, Develter J, Van Cleynenbreugel B, Van der Kwast T, and de Witte PA
The Journal of urology 179(5):2014-9 2008 May
3. Influence of the glycosaminoglycan layer on the permeation of hypericin in rat bladders in vivo.
Huygens A, Crnolatac I, Maes J, Van Cleynenbreugel B, Van Poppel H, Roskams T, and de Witte PA
BJU international 100(5):1176-81 2007 Nov
4. In vitro accumulation and permeation of hypericin and lipophilic analogues in 2-D and 3-D cellular systems.
Crnolatac I, Huygens A, Agostinis P, Kamuhabwa AR, Maes J, van Aerschot A, and De Witte PA
International journal of oncology 30(2):319-24 2007 Feb
5. Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives.
Crnolatac I, Huygens A, van Aerschot A, Busson R, Rozenski J, and de Witte PA
Bioorganic & medicinal chemistry 13(23):6347-53 2005 Dec 1
Publikacije
Knjige i poglavlja u knjigama
Poglavlja u knjigama
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Crnolatac, I. (2020) Getting charged for the mitochondrial uptake. U: Grigoryeva, N. (ur.) Fluorescence Methods for Investigation of Living Cells and Microorganisms. London, IntechOpen Limited, str. 1-25 doi:10.5772/intechopen.92872.
doimts.intechopen.com
Radovi u časopisima
Znanstveni i pregledni radovi
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Jelić Matošević, Z., Radman, K., Loubser, J., Crnolatac, I., Piantanida, I., Cukrowski, I., Ašler, I. & Bertoša, B. (2023) Structural Dynamics of the Bacillus subtilis MntR Transcription Factor Is Locked by Mn2+ Binding. International Journal of Molecular Sciences, 24 (2), 957, 21 doi:10.3390/ijms24020957.
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Fabijanić, I., Kurutos, A., Tomašić Paić, A., Tadić, V., Kamounah, F., Horvat, L., Brozovic, A., Crnolatac, I. & Radić Stojković, M. (2023) Selenium-Substituted Monomethine Cyanine Dyes as Selective G-Quadruplex Spectroscopic Probes with Theranostic Potential. Biomolecules, 13 (128), 13-00128, 20 doi:10.3390/biom13010128.
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Rep, V., Štulić, R., Koštrun, S., Kuridža, B., Crnolatac, I., Radić Stojković, M., Čipčić Paljetak, H., Perić, M., Matijašić, M. & Raić-Malić, S. (2022) Novel tetrahydropyrimidinyl-substituted benzimidazoles and benzothiazoles: synthesis, antibacterial activity, DNA interactions and ADME profiling. RSC Medicinal Chemistry, 13 (12), 1504-1525 doi:10.1039/d2md00143h.
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Zonjić, I., Kurutos, A., Mihovilović, P., Crnolatac, I., Tumir, L., Tomašić Paić, A., Kralj, J., Horvat, L., Brozovic, A., Stojković, R. & Radić Stojković, M. (2022) Formation of triplex rA/dA-containing nucleic acid helices induced by new thiazole orange analogues and their biological evaluation. H-aggregate formation conditioned by rA sequence. Dyes and pigments, 207, 110715, 14 doi:10.1016/j.dyepig.2022.110715.
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Milčić, N., Stepanić, V., Crnolatac, I., Findrik Blažević, Z., Brkljača, Z. & Majerić Elenkov, M. (2022) Inhibitory effect of DMSO on halohydrin dehalogenase: Experimental and computational insights into the influence of an organic co-solvent on the structural and catalytic properties of a biocatalyst. Chemistry : a European journal, 28 (56), e202201923, 11 doi:10.1002/chem.202201923.
doi Brkljača, Z., Ćehić, M., Portada, T., Butumović, M., Bakarić, D. & Crnolatac, I. (2022) Monitoring lipid phase transition temperatures using fluorescent probes and temperature-dependent fluorescence spectroscopy. Dyes and pigments, 206, 110621, 10.
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Zonjić, I., Radić Stojković, M., Crnolatac, I., Tomašić Paić, A., Pšeničnik, S., Vasilev, A., Kandinska, M., Mondeshki, M., Baluschev, S., Landfester, K., Glavaš-Obrovac, L., Jukić, M., Kralj, J., Brozovic, A., Horvat, L. & Tumir, L. (2022) Styryl dyes with N-Methylpiperazine and N-Phenylpiperazine Functionality: AT-DNA and G-quadruplex binding ligands and theranostic agents. Bioorganic chemistry, 127, 105999, 15 doi:10.1016/j.bioorg.2022.105999.
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Petters, I., Modrušan, M., Vidović, N., Crnolatac, I., Cindro, N., Piantanida, I., Speranza, G., Horvat, G. & Tomišić, V. (2022) Anion-Sensing Properties of Cyclopentaphenylalanine. Molecules, 27 (12), 3918, 16 doi:10.3390/molecules27123918.
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Zonjić, I., Tumir, L., Crnolatac, I., Šupljika, F., Racané, L., Tomić, S. & Radić Stojković, M. (2022) Recognition of ATT Triplex and DNA:RNA Hybrid Structures by Benzothiazole Ligands. Biomolecules, 12 (3), 1600173, 20 doi:10.3390/biom12030374.
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Berger, S., Rühe, J., Schwarzmann, J., Phillipps, A., Richard, A., Ferger, M., Krummenacher, I., Tumir, L., Ban, Ž., Crnolatac, I., Majhen, D., Barišić, I., Piantanida, I., Schleier, D., Griesbeck, S., Friedrich, A., Braunschweig, H. & Marder, T. (2021) Bithiophene-Cored, mono-, bis-, and tris-(Trimethylammonium)-Substituted, bis-Triarylborane Chromophores: Effect of the Number and Position of Charges on Cell Imaging and DNA/RNA Sensing. Chemistry : a European journal, 27, 14057-14072 doi:10.1002/chem.202102308.
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Maleš, P., Brkljača, Z., Crnolatac, I. & Bakarić, D. (2021) Application of MCR-ALS with EFA on FT-IR Spectra of Lipid Bilayers in the Assessment of Phase Transition Temperatures: Potential for Discernment of Coupled Events. Colloids and surfaces. B, Biointerfaces, 201, 111645, 8 doi:10.1016/j.colsurfb.2021.111645.
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Crnolatac, I., Giestas, L., Horvat, G., Parola, A. & Piantanida, I. (2020) Flavylium dye as pH tunable fluorescent and CD probe for double-stranded DNA and RNA. Chemosensors, 8 (4), 129, 10 doi:10.3390/chemosensors8040129.
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Tumir, L., Zonjić, I., Žuna, K., Radić Brkanac, S., Jukić, M., Huđek, A., Durgo, K., Crnolatac, I., Glavaš-Obrovac, L., Cardullo, N., Pulvirenti, L., Muccilli, V., Tringali, C. & Radić Stojković, M. (2020) Synthesis, DNA/RNA-interaction and biological activity of benzo[k,l]xanthene lignans. Bioorganic chemistry, 104, 104190, 12 doi:10.1016/j.bioorg.2020.104190.
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Sadžak, A., Brkljača, Z., Crnolatac, I., Baranović, G. & Šegota, S. (2020) Flavonol clustering in model lipid membranes: DSC, AFM, force spectroscopy and MD simulations study. Colloids and surfaces. B, Biointerfaces, 193, 111147, 21 doi:10.1016/j.colsurfb.2020.111147.
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Masnikosa, R., Milutinović, M., Crnolatac, I., Tot, A., Veličković, S., Bojić-Trbojević, Ž. & Rilak- Simović, A. (2020) Anti-adhesive action of novel ruthenium(II) chlorophenyl terpyridine complexes with a high affinity for double-stranded DNA: in vitro and in silico. Journal of inorganic biochemistry, 208, 111090, 13 doi:10.1016/j.jinorgbio.2020.111090.
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Amini, H., Ban, Ž., Ferger, M., Lorenzen, S., Rauch, F., Friedrich, A., Crnolatac, I., Kenđel, A., Miljanić, S., Piantanida, I. & Marder, T. (2020) Tetracationic bis-triarylborane 1, 3-butadiyne as a combined fluorimetric and Raman probe for simultaneous and selective sensing of various DNA, RNA and proteins. Chemistry : a European journal, 26, 6017-6028 doi:10.1002/chem.201905328.
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Jakšić, D., Šegvić Klarić, M., Crnolatac, I., Šijaković Vujičić, N., Smrečki, V., Górecki, M., Pescitelli, G. & Piantanida, I. (2019) Unique Aggregation of Sterigmatocystin in Water Yields Strong and Specific Circular Dichroism Response Allowing Highly Sensitive and Selective Monitoring of Bio-Relevant Interactions. Marine drugs, 17 (11), 629, 17 doi:10.3390/md17110629.
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Botti, V., Cesaretti, A., Ban, Ž., Crnolatac, I., Consiglio, G., Elisei, F. & Piantanida, I. (2019) Fine structural tuning of styryl-based dyes for fluorescence and CD-based sensing of various ds-DNA/RNA sequences. Organic & biomolecular chemistry, 17 (35), 8243-8258 doi:10.1039/C9OB01186B.
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Šegota, S., Baranović, G., Mustapić, M., Strasser, V., Domazet Jurašin, D., Crnolatac, I., Md Shahriar, A., Dutour Sikirić, M. & (2019) The role of spin-phonon coupling in enhanced desorption kinetics of antioxidant flavonols from magnetic nanoparticles aggregates. Journal of magnetism and magnetic materials, 490, 125-130 doi:10.1016/j.jmmm.2019.165530.
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Ban, Ž., Žinić, B., Matković, M., Tomašić Paić, A., Crnolatac, I. & Piantanida, I. (2019) Pyrrolocytosine-pyrene conjugates as fluorescent and CD probes for a fine sensing of ds- polynucleotide secondary structure and specific recognition of poly G. New journal of chemistry, 43, 8204-8214 doi:10.1039/C8NJ05286G.
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Rožman, A., Crnolatac, I., Deligeorgiev, T. & Piantanida, I. (2019) Strong impact of chloro substituent on TOTO and YOYO ds-DNA/RNA sensing. Journal of luminescence, 205, 87-96 doi:10.1016/j.jlumin.2018.08.074.
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Kurutos, A., Orehovec, I., Saftić, D., Horvat, L., Crnolatac, I., Piantanida, I. & Deligeorgiev, T. (2018) Cell penetrating, mitochondria targeting multiply charged DABCO-cyanine dyes. Dyes and pigments, 158, 517-525 doi:10.1016/j.dyepig.2018.05.035.
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Kurutos, A., Orehovec, I., Tomašić Paić, A., Crnolatac, I., Horvat, L., Gadjev, N., Piantanida, I. & Deligeorgiev, T. (2018) New series of non-toxic DNA intercalators, mitochondria targeting fluorescent dyes. Dyes and pigments, 148, 452-459 doi:10.1016/j.dyepig.2017.09.049.
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Štimac, A., Lapić, J., Blasina, V., Lukinac, M., Djaković, S., Crnolatac, I., Frkanec, L. & Frkanec, R. (2018) Adamantyl ferrocene derivatives: antioxidant abilities and effects on model lipid membranes. Applied organometallic chemistry, 32 (2), 4042, 14 doi:10.1002/aoc.4042.
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Nišavić, M., Stoiljković, M., Crnolatac, I., Milošević, M., Rilak, A. & Masnikosa, R. (2018) Highly water-soluble ruthenium(II) terpyridine coordination compounds form stable adducts with blood-borne metal transporting proteins. Arabian Journal of Chemistry, 11 (3), 291-304 doi:10.1016/j.arabjc.2016.07.021.
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Šarić, A., Crnolatac, I., Bouillaud, F., Sobocanec, S., Mikecin, A., Mačak Šafranko, Ž., Deligeorgiev, T., Piantanida, I., Balog, T. & Petit, P. (2017) Non-toxic fluorescent phosphonium probes to detect mitochondrial potential. Methods and applications in fluorescence, 5 (1), 015007, 13 doi:10.1088/2050-6120/aa5e64.
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Crnolatac, I., Rogan, I., Majić, B., Tomić, S., Deligeorgiev, T., Horvat, G., Makuc, D., Plavec, J., Pescitelli, G. & Piantanida, I. (2016) Small molecule probes finely differentiate between various ds- and ss-DNA and RNA by fluorescence, CD and NMR response. Analytica chimica acta, 940, 128-135 doi:10.1016/j.aca.2016.08.021.
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Miljanić, S., Kenđel, A., Novak, M., Deliqeorqiev, T., Crnolatac, I., Piantanida, I. & Chiş, V. (2016) Distinguishing binding modes of a new phosphonium dye with DNA by surface-enhanced Raman spectroscopy. RSC Advances, 6, 41927-41936 doi:10.1039/C6RA03586H.
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Kurutos, A., Crnolatac, I., Orehovec, I., Gadjev, N., Piantanida, I. & Deligeorgiev, T. (2016) Novel synthetic approach to asymmetric monocationic trimethine cyanine dyes derived from N-ethyl quinolinum moiety. Combined fluorescent and ICD probes for AT-DNA labelling. Journal of luminescence, 174, 70-76 doi:10.1016/j.jlumin.2016.01.035.
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Šola, I., Piantanida, I., Crnolatac, I. & Rusak, G. (2015) Europium improves the transport of quercetin through Arabidopsis thaliana. Biologia plantarum, 59 (3), 554-559 doi:10.1007/s10535-015-0508-z.
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Crnolatac, I., Tumir, L., Lesev, N., Vasilev, A., Deligeorgiev, T., Mišković, K., Glavaš-Obrovac, L., Vugrek, O. & Piantanida, I. (2013) Probing the structural properties of DNA/RNA grooves by sterically restricted phosphonium dyes ; screening of dye cell toxicity and uptake. ChemMedChem, 8 (7), 1093-1103 doi:10.1002/cmdc.201300085.
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Tumir, L., Crnolatac, I., Deligeorgiev, T., Vasilev, A., Kaloyanova, S., Grabar Branilović, M., Tomić, S. & Piantanida, I. (2012) Kinetic differentiation between homo- and alternating AT-DNA by sterically restricted phosphonium dyes. Chemistry : a European journal, 18 (13), 3859-3864 doi:10.1002/chem.201102968.
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Roelants, M., Huygens, A., Crnolatac, I., Van Cleynenbreugel, B., Lerut, E., Van Poppel, H. & de Witte, P. (2012) Evans blue as a selective dye marker for white-light diagnosis of non-muscle-invasive bladder cancer : an in vitro study. BJU international, 109 (2), 300-305 doi:10.1111/j.1464-410X.2011.10465.x.
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Kaloyanova, S., Crnolatac, I., Lesev, N., Piantanida, I. & Deligeorgiev, T. (2012) Synthesis and study of nucleic acids interactions of novel monomethine cyanine dyes. Dyes and pigments, 92 (3), 1184-1191 doi:10.1016/j.dyepig.2011.08.019.
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Koynov, S., Pereira, R., Crnolatac, I., Kovalev, D., Huygens, A., Chirvony, V., Stutzmann, M. & de Witte, P. (2011) Purification of Nano-Porous Silicon for Biomedical Applications. Advanced engineering materials, 13 (6), B225-B233 doi:10.1002/adem.201080091.
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Huygens, A., Crnolatac, I., Develter, J., Van Cleynenbreugel, B., Van der Kwast, T. & de Witte, P. (2008) Differential Accumulation of Hypericin in Spheroids Composed of T-24 Transitional Cell Carcinoma Cells Expressing Different Levels of E-Cadherin. The Journal of urology, 179 (5), 2014-2019 doi:10.1016/j.juro.2007.12.038.
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Huygens, A., Crnolatac, I., Maes, J., Van Cleynenbreugel, B., Van Poppel, H., Roskams, T. & de Witte, P. (2007) Influence of the glycosaminoglycan layer on the permeation of hypericin in rat bladders in vivo.. BJU international, 100 (5), 1176-1181 doi:10.1111/j.1464-410X.2007.07167.x.
doi Crnolatac, I., Huygens, A., Agostinis, P., Kamuhabwa, A., Maes, J., Van Aerschot, A. & de Witte, P. (2007) In vitro accumulation and permeation of hypericin and lipophilic analogues in 2-D and 3-D cellular systems. International journal of oncology, 30 (2), 319-324.
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Crnolatac, I., Huygens, A., van Aerschot, A., Busson, R., Rozenski, J. & de Witte, P. (2005) Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives.. Bioorganic & medicinal chemistry, 13 (23), 6347-6353 doi:10.1016/j.bmc.2005.09.003.
doi Hranueli, D., Perić, N., Petković, H., Biuković, G., Toman, Z., Pigac, J., Borovička, B., Bago, A., Crnolatac, I., Maršić, T., Zhou, L., Matošić, S., Waterman, G., Cullum, J. & Hunter, S. (1999) Novel hybrid polyketide compounds produced by genetic engineering of the oxytetracycline biosynthetic pathway. Food technology and biotechnology, 37 (2), 117-125. (https://www.bib.irb.hr/35065).
Radovi u zbornicima skupova
Znanstveni radovi u zbornicima skupova
Crnolatac, I., Huygens, A. & de Witte, P. (2008) Intracellular uptake and intraspheroidal distribution of hypericin and hydrophilic analogues using E-cadherin transfected T-24 human bladder cancer cells. U: Proceedings of SPIE.