dr. sc. Davor Zahradka

1991  Zagreb, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, dipl. inž. biologije (molekularna biologija)

1994  Zagreb, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, mr. sc. (molekularna i stanična biologija)

1999  Zagreb, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, dr. sc. (biologija)

2002  Pariz, Francuska, Institut Jacques Monod, poslijedoktorsko usavršavanje u grupi dr. Richarda D'Arija (bakterijska molekularna genetika)

2014-2018 "Rekombinacija, popravak DNA i očuvanje integriteta genoma: novi putevi" (IP-11-2013-2978), Hrvatska zaklada za znanost - voditelj

2007-2013 "Molekularni mehanizmi rekombinacije i popravka DNA" (098-0982913-2862), Ministarstvo znanosti, obrazovanja i sporta RH - voditelj

2002-2006 "Regulacija rekombinacije i rekombinacijskog popravka DNA", Ministarstvo znanosti, obrazovanja i sporta RH - suradnik

1998 - 2000  "Uloga rekombinacije DNA u regulaciji stanične diobe bakterije Escherichia coli", poticajni projekt za mlade znanstvenike, Ministarstvo znanosti i tehnologije RH - voditelj

2002 stipendija NATO Science Program (za poslijedoktorsko usavršavanje)

1990  Rektorova nagrada Sveučilišta u Zagrebu

Kolegij "Genetička rekombinacija i popravak DNA", Poslijediplomski doktorski studij biologije, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu (suvoditelj)

Kolegij “Mehanizmi oštećenja i popravka DNA”, Interdisciplinarni doktorski studij "Molekularne bioznanosti", Sveučilište u Osijeku, Sveučilište u Dubrovniku i Institut Ruđer Bošković, Zagreb (suvoditelj)  

Buljubašić, M., Hlevnjak, A., Repar, J., Đermić, D., Filić, V., Weber, I., Zahradka, K., Zahradka, D. (2019) RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli. DNA Repair 83: 102670. doi: 10.1016/j.dnarep.2019.102670 

Repar, J., Supek, F., Klanjscek, T., Warnecke, T., Zahradka, K., Zahradka, D. (2017) Elevated rate of genome rearrangements in radiation-resistant bacteria. Genetics 205: 1677-1689.

Repar, J., Briški, N., Buljubašić, M., Zahradka, K., Zahradka, D. (2013) Exonuclease VII is involved in “reckless” DNA degradation in UV-irradiated Escherichia coli. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 750:96-104.

Buljubašić, M., Repar, J., Zahradka, K., Đermić, D., Zahradka, D. (2012) RecF recombination pathway in Escherichia coli cells lacking RecQ, UvrD and HelD helicases. DNA Repair 11: 419-430.

Repar, J., Cvjetan, S., Slade, D., Radman, M., Zahradka, D., Zahradka, K. (2010) RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans. DNA Repair 9: 1151-1161.

Zahradka, K., Buljubašić, M., Petranović, M., Zahradka, D. (2009) Roles of ExoI and SbcCD nucleases in "reckless" DNA degradation in recA mutants of Escherichia coli. Journal of Bacteriology 191: 1677-1687.

Zahradka, K., Šimić, S., Buljubašić, M., Petranović, M., Đermić, D., Zahradka, D. (2006) sbcB15 and delsbcB mutations activate two types of RecF recombination pathway in Escherichia coli. Journal of Bacteriology 188: 7562-7571.

Viguera, E., Petranović, M., Zahradka, D., Germain, K., Ehrlich, D. S., Michel, B. (2003) Lethality of bypass polymerases in Escherichia coli cells with a defective clamp loader complex of DNA polymerase III. Molecular Microbiology 50: 193-204.

Zahradka, D., Zahradka, K., Petranović, M., Đermić, D., Brčić-Kostić, K. (2002) The RuvABC resolvase is indispensable for recombinational repair in sbcB15 mutants of Escherichia coli. Journal of Bacteriology 184: 4141-4147.

Zahradka, D., Vlahović, K., Petranović, M., Petranović, D. (1999) Chromosome segregation and cell division defects in recBC sbcBC ruvC mutants of Escherichia coli. Journal of Bacteriology 181: 6179-6183. 

Radovi u časopisima

Znanstveni i pregledni radovi

• Buljubašić, M., Hlevnjak, A., Repar, J., Đermić, D., Filić, V., Weber, I., Zahradka, K. & Zahradka, D. (2019) RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli. DNA repair, 83, 102670, 16 doi:10.1016/j.dnarep.2019.102670.

  doiwww.sciencedirect.com

• Feliciello, I., Zahradka, D., Zahradka, K., Ivanković, S., Puc, N. & Đermić, D. (2018) RecF, UvrD, RecX and RecN proteins suppress DNA degradation at DNA double-strand breaks in Escherichia coli. Biochimie, 148, 116-126 doi:10.1016/j.biochi.2018.03.005.

  doi

• Đermić, E., Zahradka, D., Vujaklija, D., Ivanković, S. & Đermić, D. (2017) 3'-terminated Overhangs Regulate DNA Double-Strand Break Processing in Escherichia coli. G3-Genes Genomes Genetics, 7 (9), 3091-3102 doi:10.1534/g3.117.043521.

  doi

• Repar, J., Supek, F., Klanjšček, T., Warnecke, T., Zahradka, K. & Zahradka, D. (2017) Elevated rate of genome rearrangements in radiation-resistant bacteria. Genetics, 205 (4), 1677-1689 doi:10.1534/genetics.116.196154.

  doi

• Repar, J., Šućurović, S., Zahradka, K., Zahradka, D. & Ćurković-Perica, M. (2013) Stress resistance of Escherichia coli and Bacillus subtilis is modulated by auxins. Canadian journal of microbiology, 59 (11), 766-770 doi:10.1139/cjm-2013-0266.

  doi

• Buljubašić, M., Zahradka, D. & Zahradka, K. (2013) RecQ helicase acts before RuvABC, RecG and XerC proteins during recombination in recBCD sbcBC mutants of Escherichia coli. Research in microbiology, 164 (10), 987-997 doi:10.1016/j.resmic.2013.08.008.

  doi

• Repar, J., Zahradka, D. & Zahradka, K. (2013) Accuracy of genome reassembly in gamma-irradiated Escherichia coli. Food technology and biotechnology, 51 (3), 327-337.

  fulir.irb.hr

• Repar, J., Briški, N., Buljubašić, M., Zahradka, K. & Zahradka, D. (2013) Exonuclease VII is involved in "reckless" DNA degradation in UV-irradiated Escherichia coli. Mutation research. Genetic toxicology and environmental mutagenesis, 750 (1/2), 96-104 doi:10.1016/j.mrgentox.2012.10.005.

  doi

• Buljubašić, M., Repar, J., Zahradka, K., Đermić, D. & Zahradka, D. (2012) RecF recombination pathway in Escherichia coli cells lacking RecQ, UvrD and HelD helicases. DNA repair, 11 (4), 419-430 doi:10.1016/j.dnarep.2012.01.011.

  doi

• Supek, F., Šumanovac Ramljak, T., Marjanović, M., Buljubašić, M., Kragol, G., Ilić, N., Šmuc, T., Zahradka, D., Mlinarić-Majerski, K. & Kralj, M. (2011) Could LogP be a principal determinant of biological activity in 18-crown-6 ethers? Synthesis of biologically active adamantane-substituted diaza-crowns. European Journal of Medicinal Chemistry, 46 (8), 3444-3454 doi:10.1016/j.ejmech.2011.05.009.

  doi

• Repar, J., Cvjetan, S., Slade, D., Radman, M., Zahradka, D. & Zahradka, K. (2010) RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans. DNA repair, 9 (11), 1151-1161 doi:10.1016/j.dnarep.2010.08.003.

  doi

• Zahradka, K., Buljubašić, M., Petranović, M. & Zahradka, D. (2009) Roles of ExoI and SbcCD nucleases in "reckless" DNA degradation in recA mutants of Escherichia coli. Journal of bacteriology, 191 (5), 1677-1687 doi:10.1128/JB.01877-07.

  doijb.asm.org

• Đermić, D., Zahradka, D. & Petranović, M. (2006) Exonuclease requirements for recombination of lambda phage in recD mutants of Escherichia coli. Genetics, 173 (4), 2399-2402.

• Zahradka, K., Šimić, S., Buljubašić, M., Petranović, M., Đermić, D. & Zahradka, D. (2006) sbcB15 and delsbcB mutations activate two types of RecF recombination pathway in Escherichia coli. Journal of Bacteriology, 188, 7562-7571.

• Đermić, D., Đermić, E., Zahradka, D., Petranović, M. & Lerš, N. (2006) Gamma-irradiated RecD overproducers become permanent recB-/C- phenocopies for extrachromosomal DNA processing due to prolonged titration of RecBCD enzyme on damaged Escherichia coli chromosome. Biochimie, 88 (3-4), 379-386. (https://www.bib.irb.hr/229862).

• Đermić, D., Halupecki, E., Zahradka, D. & Petranović, M. (2005) RecBCD enzyme overproduction impairs DNA repair and homologous recombination in Escherichia coli. Research in microbiology, 156 (3), 304-311.

• Viguera, E., Petranović, M., Zahradka, D., Germain, K., Erlich, D. & Michel, B. (2003) Lethality of bypass DNA polymerases in Escherichia coli cells with a defective clamp loader complex of DNA polymerase III. Molecular microbiology, 50 (1), 193-204.

• Zahradka, K., Zahradka, D., Đermić, D., Džidić, S. & Petranović, M. (2002) The inactivation of free phages in UV-irradiated Escherichia coli. Periodicum Biologorum, 104 (4), 399-403.

• Zahradka, D., Zahradka, K., Džidić, S., Đermić, D. & Petranović, M. (2002) The rus-1 mutation suppresses cytological defects in recBC sbcBC ruv mutants of Escherichia coli. Periodicum Biologorum, 104 (4), 389-397.

• Ivančić-Baće, I., Škrobot, N., Zahradka, D., Salaj-Šmic, E. & Brčić-Kostić, K. (2002) Genetic requirements for conjugational recombination in the presence of lambda Gam protein in Escherichia coli. Food Technology and Biotechnology, 40 (4), 261-265.

  fulir.irb.hr

• Zahradka, D., Zahradka, K., Petranović, M., Đermić, D. & Brčić-Kostić, K. (2002) The RuvABC resolvase is indispensable for recombinational repair in sbcB15 mutants of Escherichia coli. Journal of Bacteriology, 184 (15), 4141-4147.

• Petranović, M., Zahradka, K., Zahradka, D., Petranović, D., Nagy, B., Salaj-Šmic, E. & Petranović, D. (2001) Genetic evidence that the elevated levels of Escherichia coli helicase II antagonize recombinational DNA repair. Biochimie, 83 (-), 1041-1047.

• Zahradka, K., Zahradka, D. & Petranović, M. (2001) Loss of lambda prophage recombinogenicity in UV-irradiated Escherichia coli : the role of host genes ruvA, ruvB, ruvC and recG. Research in microbiology, 152, 873-881.

• Vlahović, K., Petranović, M., Zahradka, D. & Petranović, D. (2000) Progressive loss of lambda prophage recombinogenicity in UV-irradiated Escherichia coli : the role of RecBCD enzyme. Research in microbiology, 151 (9), 727-738.

• Petranović, M., Vlahović, K., Zahradka, D., Džidić, S. & Radman, M. (2000) Mismatch repair in Xenopus egg extracts is not strand-directed by DNA methylation. Neoplasma, 47 (6), 375-381.

• Zahradka, D., Vlahović, K., Petranović, M. & Petranović, D. (1999) Chromosome segregation and cell division defects in recBC sbcBC ruvC mutants of Escherichia coli. Journal of bacteriology, 181 (19), 6179-6183.

• Vlahović, K., Petranović, M., Zahradka, D. & Petranović, D. (1998) Effects of ruv and recG mutations on lambda prophage thermoinducibility in UV-irradiated Escherichia coli. Periodicum biologorum, 100 (3), 383-388.

Ocjenski radovi

Doktorske disertacije

• Zahradka, D. (1999) 'Uloga genetičke rekombinacije u regulaciji stanične diobe bakterije Escherichia coli', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

Hrvatsko genetičko društvo

Hrvatsko društvo za biokemiju i molekularnu biologiju

Hrvatsko mikrobiološko društvo